List of works - Kristin Beebe

Activation of Hsp90 Enzymatic Activity and Conformational Dynamics through Rationally Designed Allosteric Ligands.

scientific article published on 18 August 2015

Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90

scientific article

An Hsp90 co-chaperone protein in yeast is functionally replaced by site-specific posttranslational modification in humans

scientific article

An acetylation site in the middle domain of Hsp90 regulates chaperone function

scientific article published on January 2007

Asymmetric Hsp90 N domain SUMOylation recruits Aha1 and ATP-competitive inhibitors

scientific article published on January 2014

Azaspirene, a fungal product, inhibits angiogenesis by blocking Raf-1 activation

scientific article published on 10 July 2008

Calcium-dependent inhibition of polo-like kinase 3 activity by CIB1 in breast cancer cells

scientific article

Client Proteins and Small Molecule Inhibitors Display Distinct Binding Preferences for Constitutive and Stress-Induced HSP90 Isoforms and Their Conformationally Restricted Mutants

scientific article

Combinatorial drug design targeting multiple cancer signaling networks controlled by mitochondrial Hsp90

scientific article

Combined HSP90 and kinase inhibitor therapy: Insights from The Cancer Genome Atlas.

scientific article

Computational polypharmacology analysis of the heat shock protein 90 interactome.

scientific article

Concise modular asymmetric synthesis of deguelin, tephrosin and investigation into their mode of action

scientific article published on August 2010

Divergent synthesis of a pochonin library targeting HSP90 and in vivo efficacy of an identified inhibitor

scientific article

Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy

scientific article published on 01 February 2020

Dynamic tyrosine phosphorylation modulates cycling of the HSP90-P50(CDC37)-AHA1 chaperone machine

scientific article

Emetine Promotes von Hippel-Lindau-Independent Degradation of Hypoxia-Inducible Factor-2α in Clear Cell Renal Carcinoma ⬇️

scientific article published on September 2, 2010

HSP90 inhibitors disrupt a transient HSP90-HSF1 interaction and identify a noncanonical model of HSP90-mediated HSF1 regulation.

scientific article

Hsp90 middle domain phosphorylation initiates a complex conformational program to recruit the ATPase-stimulating cochaperone Aha1.

scientific article published on 12 June 2019

Impact of heat-shock protein 90 on cancer metastasis

scientific article published on June 2009

Inhibition of HSP90 with pochoximes: SAR and structure-based insights

scientific article

Integration of gene dosage and gene expression in non-small cell lung cancer, identification of HSP90 as potential target

scientific article

Loss of Hsp90 association up-regulates Src-dependent ErbB2 activity

scientific article published on 9 October 2006

Low-penetrant RB allele in small-cell cancer shows geldanamycin instability and discordant expression with mutant ras

scientific article published on 30 May 2008

Molecular chaperone TRAP1 regulates a metabolic switch between mitochondrial respiration and aerobic glycolysis

scientific article

Mps1 Mediated Phosphorylation of Hsp90 Confers Renal Cell Carcinoma Sensitivity and Selectivity to Hsp90 Inhibitors

scientific article published on 19 January 2016

Pharmacologic dissection of the overlapping impact of heat shock protein family members on platelet function

scientific article published on 05 February 2020

Phase 1 study of the HSP90 inhibitor onalespib in combination with AT7519, a pan-CDK inhibitor, in patients with advanced solid tumors

scientific article published on 23 October 2020

Phosphorylation induced cochaperone unfolding promotes kinase recruitment and client class-specific Hsp90 phosphorylation

scientific article published on 17 January 2018

Posttranslational modification and conformational state of heat shock protein 90 differentially affect binding of chemically diverse small molecule inhibitors

scientific article

Regulation and function of the human HSP90AA1 gene

scientific article

Selective inhibition of HER2-positive breast cancer cells by the HIV protease inhibitor nelfinavir

scientific article

Sensitivity of epidermal growth factor receptor and ErbB2 exon 20 insertion mutants to Hsp90 inhibition

scientific article published on 21 August 2007

Swe1Wee1-dependent tyrosine phosphorylation of Hsp90 regulates distinct facets of chaperone function

scientific article

Synthesis and structure-activity relationship studies of novel dihydropyridones as androgen receptor modulators

scientific article published on 30 October 2013

Targeting Hsp90 in Non-Cancerous Maladies.

scientific article published on 13 April 2016

The Development of Hsp90β-Selective Inhibitors to Overcome Detriments Associated with <i>pan</i>-Hsp90 Inhibition

scientific article published on 11 January 2021

The HSP90 inhibitor ganetespib synergizes with the MET kinase inhibitor crizotinib in both crizotinib-sensitive and -resistant MET-driven tumor models

scientific article published on 11 October 2013

The mitochondrial HSP90 paralog TRAP1 forms an OXPHOS-regulated tetramer and is involved in mitochondrial metabolic homeostasis

scientific article published on 27 January 2020

Threonine 22 phosphorylation attenuates Hsp90 interaction with cochaperones and affects its chaperone activity

scientific article

List of works by Kristin Beebe

Activation of Hsp90 Enzymatic Activity and Conformational Dynamics through Rationally Designed Allosteric Ligands.

Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90

An Hsp90 co-chaperone protein in yeast is functionally replaced by site-specific posttranslational modification in humans

An acetylation site in the middle domain of Hsp90 regulates chaperone function

Asymmetric Hsp90 N domain SUMOylation recruits Aha1 and ATP-competitive inhibitors

Azaspirene, a fungal product, inhibits angiogenesis by blocking Raf-1 activation

Calcium-dependent inhibition of polo-like kinase 3 activity by CIB1 in breast cancer cells

Client Proteins and Small Molecule Inhibitors Display Distinct Binding Preferences for Constitutive and Stress-Induced HSP90 Isoforms and Their Conformationally Restricted Mutants

Combinatorial drug design targeting multiple cancer signaling networks controlled by mitochondrial Hsp90

Combined HSP90 and kinase inhibitor therapy: Insights from The Cancer Genome Atlas.

Computational polypharmacology analysis of the heat shock protein 90 interactome.

Concise modular asymmetric synthesis of deguelin, tephrosin and investigation into their mode of action

Divergent synthesis of a pochonin library targeting HSP90 and in vivo efficacy of an identified inhibitor

Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy

Dynamic tyrosine phosphorylation modulates cycling of the HSP90-P50(CDC37)-AHA1 chaperone machine

Emetine Promotes von Hippel-Lindau-Independent Degradation of Hypoxia-Inducible Factor-2α in Clear Cell Renal Carcinoma ⬇️

HSP90 inhibitors disrupt a transient HSP90-HSF1 interaction and identify a noncanonical model of HSP90-mediated HSF1 regulation.

Hsp90 middle domain phosphorylation initiates a complex conformational program to recruit the ATPase-stimulating cochaperone Aha1.

Impact of heat-shock protein 90 on cancer metastasis

Inhibition of HSP90 with pochoximes: SAR and structure-based insights

Integration of gene dosage and gene expression in non-small cell lung cancer, identification of HSP90 as potential target

Loss of Hsp90 association up-regulates Src-dependent ErbB2 activity

Low-penetrant RB allele in small-cell cancer shows geldanamycin instability and discordant expression with mutant ras

Molecular chaperone TRAP1 regulates a metabolic switch between mitochondrial respiration and aerobic glycolysis

Mps1 Mediated Phosphorylation of Hsp90 Confers Renal Cell Carcinoma Sensitivity and Selectivity to Hsp90 Inhibitors

Pharmacologic dissection of the overlapping impact of heat shock protein family members on platelet function

Phase 1 study of the HSP90 inhibitor onalespib in combination with AT7519, a pan-CDK inhibitor, in patients with advanced solid tumors

Phosphorylation induced cochaperone unfolding promotes kinase recruitment and client class-specific Hsp90 phosphorylation

Posttranslational modification and conformational state of heat shock protein 90 differentially affect binding of chemically diverse small molecule inhibitors

Regulation and function of the human HSP90AA1 gene

Selective inhibition of HER2-positive breast cancer cells by the HIV protease inhibitor nelfinavir

Sensitivity of epidermal growth factor receptor and ErbB2 exon 20 insertion mutants to Hsp90 inhibition

Swe1Wee1-dependent tyrosine phosphorylation of Hsp90 regulates distinct facets of chaperone function

Synthesis and structure-activity relationship studies of novel dihydropyridones as androgen receptor modulators

Targeting Hsp90 in Non-Cancerous Maladies.

The Development of Hsp90β-Selective Inhibitors to Overcome Detriments Associated with <i>pan</i>-Hsp90 Inhibition

The HSP90 inhibitor ganetespib synergizes with the MET kinase inhibitor crizotinib in both crizotinib-sensitive and -resistant MET-driven tumor models

The mitochondrial HSP90 paralog TRAP1 forms an OXPHOS-regulated tetramer and is involved in mitochondrial metabolic homeostasis

Threonine 22 phosphorylation attenuates Hsp90 interaction with cochaperones and affects its chaperone activity