List of works - Gabriela Chiosis

A Hyperactive Signalosome in Acute Myeloid Leukemia Drives Addiction to a Tumor-Specific Hsp90 Species

scientific article

A global view of Hsp90 functions

scientific article published on January 2013

A purine analog synergizes with chloroquine (CQ) by targeting Plasmodium falciparum Hsp90 (PfHsp90)

scientific article (publication date: 2013)

A purine scaffold Hsp90 inhibitor destabilizes BCL-6 and has specific antitumor activity in BCL-6-dependent B cell lymphomas

scientific article

Advances in the clinical development of heat shock protein 90 (Hsp90) inhibitors in cancers

scientific article

Advances in the discovery and development of heat-shock protein 90 inhibitors for cancer treatment

scientific article published on May 2011

Affinity purification probes of potential use to investigate the endogenous Hsp70 interactome in cancer

scientific article

Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90

scientific article

Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function

scientific article

Anti-cancer therapeutic approaches based on intracellular and extracellular heat shock proteins

scientific article

Assay for isolation of inhibitors of her2-kinase expression

scientific article

Assay strategies for the discovery and validation of therapeutics targeting Brugia pahangi Hsp90

scientific article

BCL6 repression of EP300 in human diffuse large B cell lymphoma cells provides a basis for rational combinatorial therapy

scientific article

Chaperome heterogeneity and its implications for cancer study and treatment

scientific article published in Journal of Biological Chemistry

Chaperone-dependent Neurodegeneration: A Molecular Perspective on Therapeutic Intervention

scientific article published on April 2013

Chemical Tools to Investigate Mechanisms Associated with HSP90 and HSP70 in Disease

scientific article published on January 2016

Combinatorial targeting of nuclear export and translation of RNA inhibits aggressive B-cell lymphomas

scientific article published on 24 November 2015

Design of a flexible cell-based assay for the evaluation of heat shock protein 70 expression modulators

scientific article

Design of a fluorescence polarization assay platform for the study of human Hsp70

scientific article published on 16 May 2008

Design, synthesis, and evaluation of small molecule Hsp90 probes

scientific article

Development and application of Hsp90 inhibitors

scientific article

Development of Purine-Scaffold Small Molecule Inhibitors of Hsp90 ⬇️

scientific article published on October 1, 2003

Development of a purine-scaffold novel class of Hsp90 binders that inhibit the proliferation of cancer cells and induce the degradation of Her2 tyrosine kinase

scientific article

Discovery and development of heat shock protein 90 inhibitors

scientific article

Discovery and development of purine-scaffold Hsp90 inhibitors

scientific article published on January 2006

Discovery of aminoquinolines as a new class of potent inhibitors of heat shock protein 90 (Hsp90): Synthesis, biology, and molecular modeling ⬇️

scientific article published on 27 May 2008

Editorial (Thematic Issue: Heat Shock Proteins in Disease - From Molecular Mechanisms to Therapeutics).

scientific article published on January 2016

Endoplasmic reticulum heat shock protein gp96 maintains liver homeostasis and promotes hepatocellular carcinogenesis

scientific article

Environment-responsive nanophores for therapy and treatment monitoring via molecular MRI quenching

scientific article

Evaluation of 8-arylsulfanyl, 8-arylsulfoxyl, and 8-arylsulfonyl adenine derivatives as inhibitors of the heat shock protein 90.

scientific article

Ex vivo treatment response of primary tumors and/or associated metastases for preclinical and clinical development of therapeutics

scientific article published on 2 October 2014

Experimental and structural testing module to analyze paralogue-specificity and affinity in the Hsp90 inhibitors series

scientific article published on 21 August 2013

Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators

scientific article published on 28 September 2006

Gold/alpha-lactalbumin nanoprobes for the imaging and treatment of breast cancer

scientific article published on 13 July 2020

HSP90 inhibitors as therapy for multiple myeloma

scientific article published on 28 April 2011

HSP90 is a therapeutic target in JAK2-dependent myeloproliferative neoplasms in mice and humans

scientific article

HSP90 supports tumor growth and angiogenesis through PRKD2 protein stabilization

scientific article

Heat shock protein 70 inhibitors. 1. 2,5'-thiodipyrimidine and 5-(phenylthio)pyrimidine acrylamides as irreversible binders to an allosteric site on heat shock protein 70

scientific article

Heat shock protein 90 in neurodegenerative diseases

scientific article

Heat shock protein 90-sheltered overexpression of insulin-like growth factor 1 receptor contributes to malignancy of thymic epithelial tumors

scientific article published on 3 March 2011

Heat shock protein 90: translation from cancer to Alzheimer's disease treatment?

scientific article

Heat shock protein gp96 regulates Toll-like receptor 9 proteolytic processing and conformational stability

scientific article

Heat shock protein-90 inhibitors: a chronicle from geldanamycin to today's agents.

scientific article

Heterodimeric JAK-STAT activation as a mechanism of persistence to JAK2 inhibitor therapy

scientific article published on September 2012

High-throughput screening fluorescence polarization assay for tumor-specific Hsp90.

scientific article

Hsp70 molecular chaperones: emerging roles in human disease and identification of small molecule modulators

scientific article published on January 2006

Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models

scholarly article

Hsp90: the vulnerable chaperone

scientific article published in October 2004

Identification of an allosteric pocket on human hsp70 reveals a mode of inhibition of this therapeutically important protein

scientific article published on 14 November 2013

Identification of novel quaternary domain interactions in the Hsp90 chaperone, GRP94.

scientific article

Identification of potent water soluble purine-scaffold inhibitors of the heat shock protein 90.

scientific article published on January 2006

Improved targeting of JAK2 leads to increased therapeutic efficacy in myeloproliferative neoplasms

scientific article published on 27 January 2014

Kaiso contributes to DNA methylation-dependent silencing of tumor suppressor genes in colon cancer cell lines

scientific article published on September 2008

Measuring the pharmacodynamic effects of a novel Hsp90 inhibitor on HER2/neu expression in mice using Zr-DFO-trastuzumab

scientific article

Microtiter cell-based assay for detection of agents that alter cellular levels of Her2 and EGFR.

scientific article

Microwave-assisted one step synthesis of 8-arylmethyl-9H-purin-6-amines

scientific article

Molecular chaperone gp96 is a novel therapeutic target of multiple myeloma

scientific article published on 27 September 2013

Molecular imaging of the efficacy of heat shock protein 90 inhibitors in living subjects

scientific article

Monitoring afatinib treatment in HER2-positive gastric cancer with 18F-FDG and 89Zr-trastuzumab PET.

scientific article published on 11 April 2013

Multifunctional MRI/PET Nanobeacons Derived from the in Situ Self-Assembly of Translational Polymers and Clinical Cargo through Coalescent Intermolecular Forces

scientific article

Mutations in the Yeast Hsp70, Ssa1, at P417 Alter ATP Cycling, Interdomain Coupling, and Specific Chaperone Functions

scientific article

NECA derivatives exploit the paralog-specific properties of the site 3 side pocket of Grp94, the endoplasmic reticulum Hsp90

scientific article published on 09 September 2019

New arylthioindoles: potent inhibitors of tubulin polymerization. 2. Structure-activity relationships and molecular modeling studies

scientific article published on February 2006

Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2

scientific article

Pharmacologically controlling protein-protein interactions through epichaperomes for therapeutic vulnerability in cancer

scientific article published on 25 November 2021

Pharmacoproteomics identifies combinatorial therapy targets for diffuse large B cell lymphoma

scientific article

Pre-clinical efficacy of PU-H71, a novel HSP90 inhibitor, alone and in combination with bortezomib in Ewing sarcoma

scientific article published on 15 December 2013

Protein chaperones: a composition of matter review (2008 - 2013).

scientific article

Purine-scaffold Hsp90 inhibitors

scientific article

Purine-scaffold Hsp90 inhibitors.

scientific article

RNAi Screening of the Glucose-Regulated Chaperones in Cancer with Self-Assembled siRNA Nanostructures

scientific article published on 26 September 2016

Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies

scholarly article

Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer

scientific article

Selective targeting of the stress chaperome as a therapeutic strategy

scientific article

Small molecule microarrays: from proteins to mammalian cells - are we there yet?

scientific article

Structure-activity relationship in a purine-scaffold compound series with selectivity for the endoplasmic reticulum Hsp90 paralog Grp94

scientific article published on 22 April 2015

Synthesis and evaluation of cell-permeable biotinylated PU-H71 derivatives as tumor Hsp90 probes

scientific article

Synthesis of purine-scaffold fluorescent probes for heat shock protein 90 with use in flow cytometry and fluorescence microscopy

scientific article

Synthesis of reblastatin, autolytimycin, and non-benzoquinone analogues: potent inhibitors of heat shock protein 90.

scientific article

Targeting Hsp90: small-molecule inhibitors and their clinical development

scientific article published on 31 July 2008

Targeting chaperones in transformed systems--a focus on Hsp90 and cancer

scientific article

Targeting of KRAS mutant tumors by HSP90 inhibitors involves degradation of STK33.

scientific article published on 26 March 2012

Targeting the Hsp90-associated viral oncoproteome in gammaherpesvirus-associated malignancies

scientific article published on 13 August 2013

Targeting wide-range oncogenic transformation via PU24FCl, a specific inhibitor of tumor Hsp90.

scientific article published on June 2004

The anti-myeloma activity of a novel purine scaffold HSP90 inhibitor PU-H71 is via inhibition of both HSP90A and HSP90B1 ⬇️

scientific article published on October 26, 2010

The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2.

scientific article

The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction

scientific article published on 16 January 2020

The epichaperome: the power of many as the power of one.

scientific article published on 26 October 2016

The novel HSP90 inhibitor, PU-H71, suppresses glial cell activation but weakly affects clinical signs of EAE.

scientific article

The yeast Hsp110, Sse1p, exhibits high-affinity peptide binding

scientific article

Tumor selectivity of Hsp90 inhibitors: the explanation remains elusive

scientific article published on June 2006

Tumor-specific HSP90 inhibition as a therapeutic approach in JAK-mutant acute lymphoblastic leukemias

scientific article

Vancomycin resistance: occurrence, mechanisms and strategies to combat it.

scientific article

α7 helix region of αI domain is crucial for integrin binding to endoplasmic reticulum chaperone gp96: a potential therapeutic target for cancer metastasis

scientific article published on 13 May 2013

List of works by Gabriela Chiosis

A Hyperactive Signalosome in Acute Myeloid Leukemia Drives Addiction to a Tumor-Specific Hsp90 Species

A global view of Hsp90 functions

A purine analog synergizes with chloroquine (CQ) by targeting Plasmodium falciparum Hsp90 (PfHsp90)

A purine scaffold Hsp90 inhibitor destabilizes BCL-6 and has specific antitumor activity in BCL-6-dependent B cell lymphomas

Advances in the clinical development of heat shock protein 90 (Hsp90) inhibitors in cancers

Advances in the discovery and development of heat-shock protein 90 inhibitors for cancer treatment

Affinity purification probes of potential use to investigate the endogenous Hsp70 interactome in cancer

Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90

Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function

Anti-cancer therapeutic approaches based on intracellular and extracellular heat shock proteins

Assay for isolation of inhibitors of her2-kinase expression

Assay strategies for the discovery and validation of therapeutics targeting Brugia pahangi Hsp90

BCL6 repression of EP300 in human diffuse large B cell lymphoma cells provides a basis for rational combinatorial therapy

Chaperome heterogeneity and its implications for cancer study and treatment

Chaperone-dependent Neurodegeneration: A Molecular Perspective on Therapeutic Intervention

Chemical Tools to Investigate Mechanisms Associated with HSP90 and HSP70 in Disease

Combinatorial targeting of nuclear export and translation of RNA inhibits aggressive B-cell lymphomas

Design of a flexible cell-based assay for the evaluation of heat shock protein 70 expression modulators

Design of a fluorescence polarization assay platform for the study of human Hsp70

Design, synthesis, and evaluation of small molecule Hsp90 probes

Development and application of Hsp90 inhibitors

Development of Purine-Scaffold Small Molecule Inhibitors of Hsp90 ⬇️

Development of a purine-scaffold novel class of Hsp90 binders that inhibit the proliferation of cancer cells and induce the degradation of Her2 tyrosine kinase

Discovery and development of heat shock protein 90 inhibitors

Discovery and development of purine-scaffold Hsp90 inhibitors

Discovery of aminoquinolines as a new class of potent inhibitors of heat shock protein 90 (Hsp90): Synthesis, biology, and molecular modeling ⬇️

Editorial (Thematic Issue: Heat Shock Proteins in Disease - From Molecular Mechanisms to Therapeutics).

Endoplasmic reticulum heat shock protein gp96 maintains liver homeostasis and promotes hepatocellular carcinogenesis

Environment-responsive nanophores for therapy and treatment monitoring via molecular MRI quenching

Evaluation of 8-arylsulfanyl, 8-arylsulfoxyl, and 8-arylsulfonyl adenine derivatives as inhibitors of the heat shock protein 90.

Ex vivo treatment response of primary tumors and/or associated metastases for preclinical and clinical development of therapeutics

Experimental and structural testing module to analyze paralogue-specificity and affinity in the Hsp90 inhibitors series

Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators

Gold/alpha-lactalbumin nanoprobes for the imaging and treatment of breast cancer

HSP90 inhibitors as therapy for multiple myeloma

HSP90 is a therapeutic target in JAK2-dependent myeloproliferative neoplasms in mice and humans

HSP90 supports tumor growth and angiogenesis through PRKD2 protein stabilization

Heat shock protein 70 inhibitors. 1. 2,5'-thiodipyrimidine and 5-(phenylthio)pyrimidine acrylamides as irreversible binders to an allosteric site on heat shock protein 70

Heat shock protein 90 in neurodegenerative diseases

Heat shock protein 90-sheltered overexpression of insulin-like growth factor 1 receptor contributes to malignancy of thymic epithelial tumors

Heat shock protein 90: translation from cancer to Alzheimer's disease treatment?

Heat shock protein gp96 regulates Toll-like receptor 9 proteolytic processing and conformational stability

Heat shock protein-90 inhibitors: a chronicle from geldanamycin to today's agents.

Heterodimeric JAK-STAT activation as a mechanism of persistence to JAK2 inhibitor therapy

High-throughput screening fluorescence polarization assay for tumor-specific Hsp90.

Hsp70 molecular chaperones: emerging roles in human disease and identification of small molecule modulators

Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models

Hsp90: the vulnerable chaperone

Identification of an allosteric pocket on human hsp70 reveals a mode of inhibition of this therapeutically important protein

Identification of novel quaternary domain interactions in the Hsp90 chaperone, GRP94.

Identification of potent water soluble purine-scaffold inhibitors of the heat shock protein 90.

Improved targeting of JAK2 leads to increased therapeutic efficacy in myeloproliferative neoplasms

Kaiso contributes to DNA methylation-dependent silencing of tumor suppressor genes in colon cancer cell lines

Measuring the pharmacodynamic effects of a novel Hsp90 inhibitor on HER2/neu expression in mice using Zr-DFO-trastuzumab

Microtiter cell-based assay for detection of agents that alter cellular levels of Her2 and EGFR.

Microwave-assisted one step synthesis of 8-arylmethyl-9H-purin-6-amines

Molecular chaperone gp96 is a novel therapeutic target of multiple myeloma

Molecular imaging of the efficacy of heat shock protein 90 inhibitors in living subjects

Monitoring afatinib treatment in HER2-positive gastric cancer with 18F-FDG and 89Zr-trastuzumab PET.

Multifunctional MRI/PET Nanobeacons Derived from the in Situ Self-Assembly of Translational Polymers and Clinical Cargo through Coalescent Intermolecular Forces

Mutations in the Yeast Hsp70, Ssa1, at P417 Alter ATP Cycling, Interdomain Coupling, and Specific Chaperone Functions

NECA derivatives exploit the paralog-specific properties of the site 3 side pocket of Grp94, the endoplasmic reticulum Hsp90

New arylthioindoles: potent inhibitors of tubulin polymerization. 2. Structure-activity relationships and molecular modeling studies

Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2

Pharmacologically controlling protein-protein interactions through epichaperomes for therapeutic vulnerability in cancer

Pharmacoproteomics identifies combinatorial therapy targets for diffuse large B cell lymphoma

Pre-clinical efficacy of PU-H71, a novel HSP90 inhibitor, alone and in combination with bortezomib in Ewing sarcoma

Protein chaperones: a composition of matter review (2008 - 2013).

Purine-scaffold Hsp90 inhibitors

Purine-scaffold Hsp90 inhibitors.

RNAi Screening of the Glucose-Regulated Chaperones in Cancer with Self-Assembled siRNA Nanostructures

Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies

Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer

Selective targeting of the stress chaperome as a therapeutic strategy

Small molecule microarrays: from proteins to mammalian cells - are we there yet?

Structure-activity relationship in a purine-scaffold compound series with selectivity for the endoplasmic reticulum Hsp90 paralog Grp94

Synthesis and evaluation of cell-permeable biotinylated PU-H71 derivatives as tumor Hsp90 probes

Synthesis of purine-scaffold fluorescent probes for heat shock protein 90 with use in flow cytometry and fluorescence microscopy

Synthesis of reblastatin, autolytimycin, and non-benzoquinone analogues: potent inhibitors of heat shock protein 90.