Search filters

List of works by Mark Magnuson

5-amino-imidazole carboxamide riboside acutely potentiates glucose-stimulated insulin secretion from mouse pancreatic islets by KATP channel-dependent and -independent pathways

scientific article published in May 2005

A Rictor-Myo1c complex participates in dynamic cortical actin events in 3T3-L1 adipocytes

scientific article

A functional link between glucokinase binding to insulin granules and conformational alterations in response to glucose and insulin

scientific article published on 5 July 2002

A nonclassical bHLH Rbpj transcription factor complex is required for specification of GABAergic neurons independent of Notch signaling

scientific article published on January 2008

A recombinase-mediated cassette exchange-derived cyan fluorescent protein reporter allele for Pdx1.

scientific article

Allosteric activators of glucokinase: potential role in diabetes therapy

scientific article published in July 2003

Alterations in the regulation of androgen-sensitive Cyp 4a monooxygenases cause hypertension

scientific article

Analysis of the Cre-mediated recombination driven by rat insulin promoter in embryonic and adult mouse pancreas

scientific article published in February 2000

Anks4b, a novel target of HNF4α protein, interacts with GRP78 protein and regulates endoplasmic reticulum stress-induced apoptosis in pancreatic β-cells

scientific journal article

Caveats and considerations for performing pancreas-specific gene manipulations in the mouse

scientific article published in November 2007

Cell specific differences in DNase I hypersensitivity between the two promoters of the rat glucokinase gene

scientific article

Cell-specific Expression and Regulation of a Glucokinase Gene Locus Transgene

scientific article published in Journal of Biological Chemistry

Cell-specific roles of glucokinase in glucose homeostasis.

scientific article

Characterization of the Pal motifs in the upstream glucokinase promoter: binding of a cell type-specific protein complex correlates with transcriptional activation

scientific article published on June 1996

Cholinergic regulation of fuel-induced hormone secretion and respiration of SUR1-/- mouse islets

scientific article

Chronic β-Cell Depolarization Impairs β-Cell Identity by Disrupting a Network of Ca2+-Regulated Genes.

scientific article published on 26 May 2017

Cloning and characterization of the mouse glucokinase gene locus and identification of distal liver-specific DNase I hypersensitive sites.

scientific article published on October 1995

Coding nucleotide sequence of rat malic enzyme mRNA and tissue specific regulation by thyroid hormone

scientific article published on January 1989

Conditional inactivation of the MEN1 gene leads to pancreatic and pituitary tumorigenesis but does not affect normal development of these tissues

scientific journal article

Conditional inactivation of the TGF-beta type II receptor using Cre:Lox

scientific article

Conditional knockout of macrophage PPARgamma increases atherosclerosis in C57BL/6 and low-density lipoprotein receptor-deficient mice

scientific article published on 9 June 2005

Control of pancreatic β cell regeneration by glucose metabolism.

scientific article published on April 2011

Cytokine-driven beta-cell production in vivo

scientific article published in January 2014

Cytosolic phosphoenolpyruvate carboxykinase does not solely control the rate of hepatic gluconeogenesis in the intact mouse liver

scientific article

DNA excision in liver by an albumin-Cre transgene occurs progressively with age

article

Defining a Novel Role for the PDX1 Transcription Factor in Islet β Cell Maturation and Proliferation During Weaning ⬇️

scientific article

Deletion of PPARgamma in adipose tissues of mice protects against high fat diet-induced obesity and insulin resistance

scientific article

Differential structure of atrial and ventricular KATP: atrial KATP channels require SUR1.

scientific article

Directed differentiation of embryonic stem cells into bladder tissue

scientific article

Disruption of PPARgamma signaling results in mouse prostatic intraepithelial neoplasia involving active autophagy.

scientific article

Dopamine biosynthesis is selectively abolished in substantia nigra/ventral tegmental area but not in hypothalamic neurons in mice with targeted disruption of the Nurr1 gene

scientific journal article

Dual lineage-specific expression of Sox17 during mouse embryogenesis.

scientific article published on October 2012

Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase

scientific journal article

Dysregulation of the norepinephrine transporter sustains cortical hypodopaminergia and schizophrenia-like behaviors in neuronal rictor null mice

scientific article

Early pancreatic development requires the vertebrate Suppressor of Hairless (RBPJ) in the PTF1 bHLH complex

scientific journal article

Ectopically expressed PDX-1 in liver initiates endocrine and exocrine pancreas differentiation but causes dysmorphogenesis.

scientific article

Effects of Increased Glucokinase Gene Copy Number on Glucose Homeostasis and Hepatic Glucose Metabolism

scientific article published in Journal of Biological Chemistry

Efficient DNA cassette exchange in mouse embryonic stem cells by staggered positive-negative selection

scientific article published on 01 August 2004

Energy homeostasis and gastrointestinal endocrine differentiation do not require the anorectic hormone peptide YY.

scientific article

Engineering artificial signaling centers to polarize embryoid body differentiation

scientific article published on 29 September 2011

Essential role of the tyrosine kinase substrate phospholipase C-gamma1 in mammalian growth and development

scientific article

Fat cell-specific ablation of rictor in mice impairs insulin-regulated fat cell and whole-body glucose and lipid metabolism ⬇️

scientific article

Frataxin deficiency in pancreatic islets causes diabetes due to loss of beta cell mass

scientific article

Frataxin deficiency in pancreatic islets causes diabetes due to loss of β cell mass

article published in 2003

Gene-altered mice and metabolic flux control

scientific article

Generation and functional confirmation of a conditional null PPARgamma allele in mice

scientific article published in February 2002

Generation of Nkx2.2:lacZ mice using recombination-mediated cassette exchange technology

scientific article

Generation of a conditional allele of the mouse prostaglandin EP4 receptor

scientific article published in September 2004

Generation of islet-like cells from mouse gall bladder by direct ex vivo reprogramming

scientific article published on 18 February 2013

Genetic rescue of Cdk4 null mice restores pancreatic beta-cell proliferation but not homeostatic cell number

scientific journal article

Ghrelin expression in the mouse pancreas defines a unique multipotent progenitor population

scientific article published in 2012

Glucokinase thermolability and hepatic regulatory protein binding are essential factors for predicting the blood glucose phenotype of missense mutations

scientific article published on 12 March 2007

Glucose regulates cyclin D2 expression in quiescent and replicating pancreatic β-cells through glycolysis and calcium channels

scientific article

Hepatic energy state is regulated by glucagon receptor signaling in mice

scientific article published on August 2009

Hepatic glucokinase is required for the synergistic action of ChREBP and SREBP-1c on glycolytic and lipogenic gene expression

scientific article published on 25 February 2004

Hepatic glucose sensing: does flux matter?

scientific article published in March 2008

Hepatocyte nuclear factor 3beta (Foxa2) is dispensable for maintaining the differentiated state of the adult hepatocyte

scientific article

Hepatocyte nuclear factor-4alpha is essential for glucose-stimulated insulin secretion by pancreatic beta-cells

scientific article published on 23 December 2005

Hepatocyte-specific mutation establishes retinoid X receptor alpha as a heterodimeric integrator of multiple physiological processes in the liver.

scientific article

Identification of Protor as a novel Rictor-binding component of mTOR complex-2

scientific article

Imaging Beta cell development in real-time using pancreatic explants from mice with green fluorescent protein-labeled pancreatic Beta cells

scientific article published in January 2005

Impaired glucagon secretory responses in mice lacking the type 1 sulfonylurea receptor

scientific article published on 7 June 2005

Impaired insulin secretion and beta-cell loss in tissue-specific knockout mice with mitochondrial diabetes.

scientific article published in November 2000

Impaired insulin secretion and glucose tolerance in beta cell-selective Ca(v)1.2 Ca2+ channel null mice

scientific journal article

Impaired tricarboxylic acid cycle activity in mouse livers lacking cytosolic phosphoenolpyruvate carboxykinase

scientific article

Inactivation of TGF-beta signaling in hepatocytes results in an increased proliferative response after partial hepatectomy.

scientific article published on April 2005

Inactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase.

scientific article

Informatic and functional approaches to identifying a regulatory region for the cardiac sodium channel

scientific article

Insights into the biochemical and genetic basis of glucokinase activation from naturally occurring hypoglycemia mutations

scientific article

Insights into the structure and regulation of glucokinase from a novel mutation (V62M), which causes maturity-onset diabetes of the young

scientific article

Insulin secretory defects and impaired islet architecture in pancreatic beta-cell-specific STAT3 knockout mice

scientific article

Isolation and characterization of the mouse cytosolic phosphoenolpyruvate carboxykinase (GTP) gene: evidence for tissue-specific hypersensitive sites

scientific article

Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity [corrected]

scholarly article

Liver-specific reactivation of the inactivated Hnf-1alpha gene: elimination of liver dysfunction to establish a mouse MODY3 model

scientific article

Loss of Foxd3 results in decreased β-cell proliferation and glucose intolerance during pregnancy

scientific article published on 27 September 2011

Loss of Myt1 function partially compromises endocrine islet cell differentiation and pancreatic physiological function in the mouse

scientific journal article

MafA and MafB regulate genes critical to beta-cells in a unique temporal manner

scientific article published on 13 July 2010

Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways

scientific article published on June 2010

Mice lacking alpha-calcitonin gene-related peptide exhibit normal cardiovascular regulation and neuromuscular development

scientific journal article

Mind bomb 1 is required for pancreatic β-cell formation

scientific journal article

Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability

scientific journal article

Multiple, temporal-specific roles for HNF6 in pancreatic endocrine and ductal differentiation

scientific article published on 18 September 2009

Muscle-specific deletion of rictor impairs insulin-stimulated glucose transport and enhances Basal glycogen synthase activity

scientific article

Mutants of glucokinase cause hypoglycaemia- and hyperglycaemia syndromes and their analysis illuminates fundamental quantitative concepts of glucose homeostasis

scientific article published on October 1999

Neonatal diabetes mellitus due to complete glucokinase deficiency

scientific article published in May 2001

New complexity in differentiating stem cells toward hepatic and pancreatic fates

scientific article published on 11 August 2009

Nkx2.2 repressor complex regulates islet β-cell specification and prevents β-to-α-cell reprogramming

scientific article published on November 2011

Nkx2.2:Cre knock-in mouse line: a novel tool for pancreas- and CNS-specific gene deletion

scientific article published on October 2013

Nkx6.1 controls a gene regulatory network required for establishing and maintaining pancreatic Beta cell identity

scientific article

Obesity and the beta cell: lessons from leptin

scientific article published on October 2007

Oestrogen protects FKBP12.6 null mice from cardiac hypertrophy

scientific article published in March 2002

Of mice and MEN1: Insulinomas in a conditional mouse knockout

scientific article published on September 2003

Ongoing Notch signaling maintains phenotypic fidelity in the adult exocrine pancreas.

scientific article

Optical imaging of pancreatic beta cells in living mice expressing a mouse insulin I promoter-firefly luciferase transgene

scientific article published in October 2005

Pancreas-specific Cre driver lines and considerations for their prudent use

scientific article

Pancreatic Inflammation Redirects Acinar to β Cell Reprogramming.

scientific article published on November 2016

Pancreatic beta-cell glucokinase: closing the gap between theoretical concepts and experimental realities.

scientific article

Pancreatic glucokinase is activated by insulin-like growth factor-I.

scientific article published on 22 February 2007

Pancreatic islet-autonomous insulin and smoothened-mediated signalling modulate identity changes of glucagon α-cells

scientific article published on 22 October 2018

Partial promoter substitutions generating transcriptional sentinels of diverse signaling pathways in embryonic stem cells and mice

scientific article published on 10 August 2012

Pdx-1 and Ptf1a concurrently determine fate specification of pancreatic multipotent progenitor cells

scientific article published on 26 January 2008

Phosphoenolpyruvate carboxykinase is necessary for the integration of hepatic energy metabolism

scientific article

Ptf1a determines horizontal and amacrine cell fates during mouse retinal development

scientific journal article

Quantification of factors influencing fluorescent protein expression using RMCE to generate an allelic series in the ROSA26 locus in mice

scientific article

Quantitative subcellular imaging of glucose metabolism within intact pancreatic islets

scientific article published on 01 February 1996

RIP-Cre revisited, evidence for impairments of pancreatic beta-cell function

scientific article

Recombinase-mediated cassette exchange to rapidly and efficiently generate mice with human cardiac sodium channels.

scientific article

Replacement of Rbpj with Rbpjl in the PTF1 complex controls the final maturation of pancreatic acinar cells

scientific article

Research resource: dkCOIN, the National Institute of Diabetes, Digestive and Kidney Diseases (NIDDK) consortium interconnectivity network: a pilot program to aggregate research resources generated by multiple research consortia

scientific article

Response to Comment on: Kumar et al. Fat Cell–Specific Ablation of Rictor in Mice Impairs Insulin-Regulated Fat Cell and Whole-Body Glucose and Lipid Metabolism. Diabetes 2010;59:1397–1406.

scientific article published on 22 March 2011

Restitution of defective glucose-stimulated insulin release of sulfonylurea type 1 receptor knockout mice by acetylcholine

scientific article published on 21 January 2004

Rictor is a novel target of p70 S6 kinase-1.

scientific article

Rictor phosphorylation on the Thr-1135 site does not require mammalian target of rapamycin complex 2.

scientific article

Rictor/mTORC2 is essential for maintaining a balance between beta-cell proliferation and cell size ⬇️

scientific article

Role of sulfonylurea receptor type 1 subunits of ATP-sensitive potassium channels in myocardial ischemia/reperfusion injury

scientific article published on 3 March 2008

Salt-sensitive hypertension and reduced fertility in mice lacking the prostaglandin EP2 receptor

scientific article published on 01 February 1999

Selective deletion of Pten in pancreatic beta cells leads to increased islet mass and resistance to STZ-induced diabetes

scientific article published on April 2006

Setd5 is essential for mammalian development and the co-transcriptional regulation of histone acetylation

scientific article

Spatiotemporal patterns of multipotentiality in Ptf1a-expressing cells during pancreas organogenesis and injury-induced facultative restoration

scientific article published on 16 January 2013

Striking In vivo phenotype of a disease-associated human SCN5A mutation producing minimal changes in vitro

scientific article published on 8 August 2011

Substrate-induced nuclear export and peripheral compartmentalization of hepatic glucokinase correlates with glycogen deposition

scientific article

Sugar binding to recombinant wild-type and mutant glucokinase monitored by kinetic measurement and tryptophan fluorescence

scientific article published in July 2008

Sulfonylurea receptor type 1 knock-out mice have intact feeding-stimulated insulin secretion despite marked impairment in their response to glucose

scientific article published on 30 July 2002

Sustained Neurog3 expression in hormone-expressing islet cells is required for endocrine maturation and function

scientific article published on June 2009

Targeted deletion of a cis-regulatory region reveals differential gene dosage requirements for Pdx1 in foregut organ differentiation and pancreas formation

scientific article

Targeted disruption of hepatic frataxin expression causes impaired mitochondrial function, decreased life span and tumor growth in mice

scientific journal article

Targeted elimination of peroxisome proliferator-activated receptor gamma in beta cells leads to abnormalities in islet mass without compromising glucose homeostasis

scientific article published on October 2003

Targeted inactivation of hepatocyte growth factor receptor c-met in beta-cells leads to defective insulin secretion and GLUT-2 downregulation without alteration of beta-cell mass

scientific article published in July 2005

Targeted oncogenesis of hormone-negative pancreatic islet progenitor cells

scientific article

The Pal elements in the upstream glucokinase promoter exhibit dyad symmetry and display cell-specific enhancer activity when multimerised

scientific article published on 10 September 2004

The Pdx1-Bound Swi/Snf Chromatin Remodeling Complex Regulates Pancreatic Progenitor Cell Proliferation and Mature Islet β-Cell Function

scientific article published on 14 June 2019

The imidazoline RX871024 stimulates insulin secretion in pancreatic beta-cells from mice deficient in K(ATP) channel function

scientific article published in June 2001

The network of glucokinase-expressing cells in glucose homeostasis and the potential of glucokinase activators for diabetes therapy

scientific article

Thiazolidinediones expand body fluid volume through PPARgamma stimulation of ENaC-mediated renal salt absorption

scientific article published on 10 July 2005

Tissue-specific deletion of Foxa2 in pancreatic beta cells results in hyperinsulinemic hypoglycemia

scientific article

Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes

scientific article

Tissue-specific regulation of glucokinase gene expression

scientific article

Tissue-specific regulation of two functional malic enzyme mRNAs by triiodothyronine

scientific journal article

Transcriptional Maintenance of Pancreatic Acinar Identity, Differentiation, and Homeostasis by PTF1A.

scientific article published on 3 October 2016

Transgene-associated human growth hormone expression in pancreatic β-cells impairs identification of sex-based gene expression differences

scientific article published on 11 December 2018

Variable expression of hepatic glucokinase in mice is due to a regulational locus that cosegregates with the glucokinase gene

scientific article published in October 1997

mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice

scientific article

pdx-1 function is specifically required in embryonic beta cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasis

scientific journal article

Paulina is supported by:

About Paulina

Help