List of works - Mark Magnuson

Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase

scientific journal article

Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes

scientific article

Thiazolidinediones expand body fluid volume through PPARgamma stimulation of ENaC-mediated renal salt absorption

scientific article published on 10 July 2005

Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways

scientific article published on June 2010

Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability

scientific journal article

DNA excision in liver by an albumin-Cre transgene occurs progressively with age

article

Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity [corrected]

scholarly article

Identification of Protor as a novel Rictor-binding component of mTOR complex-2

scientific article

mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice

scientific article

Deletion of PPARgamma in adipose tissues of mice protects against high fat diet-induced obesity and insulin resistance

scientific article

Allosteric activators of glucokinase: potential role in diabetes therapy

scientific article published in July 2003

Conditional inactivation of the TGF-beta type II receptor using Cre:Lox

scientific article

Impaired insulin secretion and beta-cell loss in tissue-specific knockout mice with mitochondrial diabetes.

scientific article published in November 2000

Hepatic glucokinase is required for the synergistic action of ChREBP and SREBP-1c on glycolytic and lipogenic gene expression

scientific article published on 25 February 2004

Oestrogen protects FKBP12.6 null mice from cardiac hypertrophy

scientific article published in March 2002

Control of pancreatic β cell regeneration by glucose metabolism.

scientific article published on April 2011

Dopamine biosynthesis is selectively abolished in substantia nigra/ventral tegmental area but not in hypothalamic neurons in mice with targeted disruption of the Nurr1 gene

scientific journal article

Neonatal diabetes mellitus due to complete glucokinase deficiency

scientific article published in May 2001

RIP-Cre revisited, evidence for impairments of pancreatic beta-cell function

scientific article

Essential role of the tyrosine kinase substrate phospholipase C-gamma1 in mammalian growth and development

scientific article

Cytosolic phosphoenolpyruvate carboxykinase does not solely control the rate of hepatic gluconeogenesis in the intact mouse liver

scientific article

Fat cell-specific ablation of rictor in mice impairs insulin-regulated fat cell and whole-body glucose and lipid metabolism

scientific article

Spatiotemporal patterns of multipotentiality in Ptf1a-expressing cells during pancreas organogenesis and injury-induced facultative restoration

scientific article published on 16 January 2013

Ptf1a determines horizontal and amacrine cell fates during mouse retinal development

scientific journal article

MafA and MafB regulate genes critical to beta-cells in a unique temporal manner

scientific article published on 13 July 2010

Inactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase.

scientific article

Sulfonylurea receptor type 1 knock-out mice have intact feeding-stimulated insulin secretion despite marked impairment in their response to glucose

scientific article published on 30 July 2002

Alterations in the regulation of androgen-sensitive Cyp 4a monooxygenases cause hypertension

scientific article

Muscle-specific deletion of rictor impairs insulin-stimulated glucose transport and enhances Basal glycogen synthase activity

scientific article

Pancreatic beta-cell glucokinase: closing the gap between theoretical concepts and experimental realities.

scientific article

Salt-sensitive hypertension and reduced fertility in mice lacking the prostaglandin EP2 receptor

scientific article published on 01 February 1999

Sustained Neurog3 expression in hormone-expressing islet cells is required for endocrine maturation and function

scientific article published on June 2009

Hepatocyte-specific mutation establishes retinoid X receptor alpha as a heterodimeric integrator of multiple physiological processes in the liver.

scientific article

Of mice and MEN1: Insulinomas in a conditional mouse knockout

scientific article published on September 2003

Tissue-specific deletion of Foxa2 in pancreatic beta cells results in hyperinsulinemic hypoglycemia

scientific article

Analysis of the Cre-mediated recombination driven by rat insulin promoter in embryonic and adult mouse pancreas

scientific article published in February 2000

Nkx2.2 repressor complex regulates islet β-cell specification and prevents β-to-α-cell reprogramming

scientific article published on November 2011

Phosphoenolpyruvate carboxykinase is necessary for the integration of hepatic energy metabolism

scientific article

Rictor is a novel target of p70 S6 kinase-1.

scientific article

Early pancreatic development requires the vertebrate Suppressor of Hairless (RBPJ) in the PTF1 bHLH complex

scientific journal article

Targeted deletion of a cis-regulatory region reveals differential gene dosage requirements for Pdx1 in foregut organ differentiation and pancreas formation

scientific article

pdx-1 function is specifically required in embryonic beta cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasis

scientific journal article

Pdx-1 and Ptf1a concurrently determine fate specification of pancreatic multipotent progenitor cells

scientific article published on 26 January 2008

Nkx6.1 controls a gene regulatory network required for establishing and maintaining pancreatic Beta cell identity

scientific article

Conditional knockout of macrophage PPARgamma increases atherosclerosis in C57BL/6 and low-density lipoprotein receptor-deficient mice

scientific article published on 9 June 2005

Impaired tricarboxylic acid cycle activity in mouse livers lacking cytosolic phosphoenolpyruvate carboxykinase

scientific article

Targeted elimination of peroxisome proliferator-activated receptor gamma in beta cells leads to abnormalities in islet mass without compromising glucose homeostasis

scientific article published on October 2003

Hepatocyte nuclear factor 3beta (Foxa2) is dispensable for maintaining the differentiated state of the adult hepatocyte

scientific article

A nonclassical bHLH Rbpj transcription factor complex is required for specification of GABAergic neurons independent of Notch signaling

scientific article published on January 2008

Impaired insulin secretion and glucose tolerance in beta cell-selective Ca(v)1.2 Ca2+ channel null mice

scientific journal article

List of works by Mark Magnuson

Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase

Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes

Thiazolidinediones expand body fluid volume through PPARgamma stimulation of ENaC-mediated renal salt absorption

Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways

Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability

DNA excision in liver by an albumin-Cre transgene occurs progressively with age

Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity [corrected]

Identification of Protor as a novel Rictor-binding component of mTOR complex-2

mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice

Deletion of PPARgamma in adipose tissues of mice protects against high fat diet-induced obesity and insulin resistance

Allosteric activators of glucokinase: potential role in diabetes therapy

Conditional inactivation of the TGF-beta type II receptor using Cre:Lox

Impaired insulin secretion and beta-cell loss in tissue-specific knockout mice with mitochondrial diabetes.

Hepatic glucokinase is required for the synergistic action of ChREBP and SREBP-1c on glycolytic and lipogenic gene expression

Oestrogen protects FKBP12.6 null mice from cardiac hypertrophy

Control of pancreatic β cell regeneration by glucose metabolism.

Dopamine biosynthesis is selectively abolished in substantia nigra/ventral tegmental area but not in hypothalamic neurons in mice with targeted disruption of the Nurr1 gene

Neonatal diabetes mellitus due to complete glucokinase deficiency

RIP-Cre revisited, evidence for impairments of pancreatic beta-cell function

Essential role of the tyrosine kinase substrate phospholipase C-gamma1 in mammalian growth and development

Cytosolic phosphoenolpyruvate carboxykinase does not solely control the rate of hepatic gluconeogenesis in the intact mouse liver

Fat cell-specific ablation of rictor in mice impairs insulin-regulated fat cell and whole-body glucose and lipid metabolism

Spatiotemporal patterns of multipotentiality in Ptf1a-expressing cells during pancreas organogenesis and injury-induced facultative restoration

Ptf1a determines horizontal and amacrine cell fates during mouse retinal development

MafA and MafB regulate genes critical to beta-cells in a unique temporal manner

Inactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase.

Sulfonylurea receptor type 1 knock-out mice have intact feeding-stimulated insulin secretion despite marked impairment in their response to glucose

Alterations in the regulation of androgen-sensitive Cyp 4a monooxygenases cause hypertension

Muscle-specific deletion of rictor impairs insulin-stimulated glucose transport and enhances Basal glycogen synthase activity

Pancreatic beta-cell glucokinase: closing the gap between theoretical concepts and experimental realities.

Salt-sensitive hypertension and reduced fertility in mice lacking the prostaglandin EP2 receptor

Sustained Neurog3 expression in hormone-expressing islet cells is required for endocrine maturation and function

Hepatocyte-specific mutation establishes retinoid X receptor alpha as a heterodimeric integrator of multiple physiological processes in the liver.

Of mice and MEN1: Insulinomas in a conditional mouse knockout

Tissue-specific deletion of Foxa2 in pancreatic beta cells results in hyperinsulinemic hypoglycemia

Analysis of the Cre-mediated recombination driven by rat insulin promoter in embryonic and adult mouse pancreas

Nkx2.2 repressor complex regulates islet β-cell specification and prevents β-to-α-cell reprogramming

Phosphoenolpyruvate carboxykinase is necessary for the integration of hepatic energy metabolism

Rictor is a novel target of p70 S6 kinase-1.

Early pancreatic development requires the vertebrate Suppressor of Hairless (RBPJ) in the PTF1 bHLH complex

Targeted deletion of a cis-regulatory region reveals differential gene dosage requirements for Pdx1 in foregut organ differentiation and pancreas formation

pdx-1 function is specifically required in embryonic beta cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasis

Pdx-1 and Ptf1a concurrently determine fate specification of pancreatic multipotent progenitor cells

Nkx6.1 controls a gene regulatory network required for establishing and maintaining pancreatic Beta cell identity

Conditional knockout of macrophage PPARgamma increases atherosclerosis in C57BL/6 and low-density lipoprotein receptor-deficient mice

Impaired tricarboxylic acid cycle activity in mouse livers lacking cytosolic phosphoenolpyruvate carboxykinase

Targeted elimination of peroxisome proliferator-activated receptor gamma in beta cells leads to abnormalities in islet mass without compromising glucose homeostasis

Hepatocyte nuclear factor 3beta (Foxa2) is dispensable for maintaining the differentiated state of the adult hepatocyte

A nonclassical bHLH Rbpj transcription factor complex is required for specification of GABAergic neurons independent of Notch signaling

Impaired insulin secretion and glucose tolerance in beta cell-selective Ca(v)1.2 Ca2+ channel null mice