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List of works by Christopher D. Lima

A dual interface determines the recognition of RNA polymerase II by RNA capping enzyme.

scientific article

Atomic structure and nonhomologous end-joining function of the polymerase component of bacterial DNA ligase D

scholarly article

Bridging the Gap between SCF and Ubiquitin Transfer

scientific article published on 01 June 2002

CUE'd up for Monoubiquitin.

scientific article

Capturing a substrate in an activated RING E3/E2-SUMO complex

scientific article published on 10 August 2016

Celebrating 20 years of Structure

scientific article

Characterization of PKCI and comparative studies with FHIT, related members of the HIT protein family

scientific article

Conformational changes in E. coli DNA topoisomerase I

scientific article

Crystal structure and functional analysis of lipoamide dehydrogenase from Mycobacterium tuberculosis

scientific journal article

Crystal structure of PapA5, a phthiocerol dimycocerosyl transferase from Mycobacterium tuberculosis.

scientific article

Crystal structure of the Schizosaccharomyces pombe U7BR E2-binding region in complex with Ubc7

scientific article published on 02 August 2019

Crystal structures of two putative phosphoheptose isomerases.

scientific article published on June 2006

DNA asymmetry promotes SUMO modification of the single-stranded DNA-binding protein RPA

scientific article published on 29 September 2021

Designed semisynthetic protein inhibitors of Ub/Ubl E1 activating enzymes.

scientific article published on February 2010

Determinants of Small Ubiquitin-like Modifier 1 (SUMO1) Protein Specificity, E3 Ligase, and SUMO-RanGAP1 Binding Activities of Nucleoporin RanBP2

scientific article

Discovery and engineering of enhanced SUMO protease enzymes

scientific article published in Journal of Biological Chemistry

Encephalitozoon cuniculi mRNA cap (guanine N-7) methyltransferase: methyl acceptor specificity, inhibition BY S-adenosylmethionine analogs, and structure-guided mutational analysis

scientific article

Enzymology of RNA cap synthesis

scientific article

Exo- and endoribonucleolytic activities of yeast cytoplasmic and nuclear RNA exosomes are dependent on the noncatalytic core and central channel.

scientific article

Growing an Editorial Board for an Ever Expanding Field

scientific article published on 01 April 2015

Helicase-Dependent RNA Decay Illuminated by a Cryo-EM Structure of a Human Nuclear RNA Exosome-MTR4 Complex

scientific article published on 01 June 2018

Inducing interactions with the CTD

scientific article published on 01 February 2005

Insights into E3 ligase activity revealed by a SUMO-RanGAP1-Ubc9-Nup358 complex

scientific article (publication date: 2 June 2005)

Insights into the structure, mechanism, and regulation of scavenger mRNA decapping activity

scientific journal article

Lipoamide Channel-Binding Sulfonamides Selectively Inhibit Mycobacterial Lipoamide Dehydrogenase

scientific article

Lysine activation and functional analysis of E2-mediated conjugation in the SUMO pathway.

scientific article published on 28 May 2006

Mechanism of type II DNA topoisomerases: a tale of two gates.

scientific article published on June 1994

Mycobacterial polyketide-associated proteins are acyltransferases: proof of principle with Mycobacterium tuberculosis PapA5

scientific journal article

Nuclear RNA Exosome at 3.1 Å Reveals Substrate Specificities, RNA Paths, and Allosteric Inhibition of Rrp44/Dis3.

scientific article published on 20 October 2016

Preparation of SUMO proteases and kinetic analysis using endogenous substrates

scientific article published on January 2009

Purification and activity assays for Ubc9, the ubiquitin-conjugating enzyme for the small ubiquitin-like modifier SUMO.

scientific article published in January 2005

Purification of SUMO conjugating enzymes and kinetic analysis of substrate conjugation.

scientific article published on January 2009

RNA Ligase Structures Reveal the Basis for RNA Specificity and Conformational Changes that Drive Ligation Forward

scientific article published on 01 October 2006

RNA substrate specificity and structure-guided mutational analysis of bacteriophage T4 RNA ligase 2.

scientific article published on 13 April 2004

Recognition of Lys48-Linked Di-ubiquitin and Deubiquitinating Activities of the SARS Coronavirus Papain-like Protease

scientific article published on May 2016

Recognition of SUMO-modified PCNA requires tandem receptor motifs in Srs2

scientific article

Reconstitution of RNA exosomes from human and Saccharomyces cerevisiae cloning, expression, purification, and activity assays.

scientific article published on January 2008

Reconstitution of S. cerevisiae RNA Exosome Complexes Using Recombinantly Expressed Proteins

scientific article published on 01 January 2020

Reconstitution of the Human Nuclear RNA Exosome

scientific article published on 01 January 2020

Reconstitution of the Schizosaccharomyces pombe RNA Exosome

scientific article published on 01 January 2020

Reconstitution, activities, and structure of the eukaryotic RNA exosome

scientific article

Regulating UBP-Mediated Ubiquitin Deconjugation

scientific article published on 01 January 2003

SARS hCoV papain-like protease is a unique Lys48 linkage-specific di-distributive deubiquitinating enzyme

scientific article published on June 2015

SUMO takes control of a ubiquitin-specific protease

scientific article published on June 2008

SUMO-2 and PIAS1 modulate insoluble mutant huntingtin protein accumulation

scientific article published on 18 July 2013

Single-particle EM reveals extensive conformational variability of the Ltn1 E3 ligase.

scientific article published on 14 January 2013

Specific and covalent targeting of conjugating and deconjugating enzymes of ubiquitin-like proteins

scientific article

Strategies for Generating RNA Exosome Complexes from Recombinant Expression Hosts

scientific article published on 01 January 2020

Strategies to Trap Enzyme-Substrate Complexes that Mimic Michaelis Intermediates During E3-Mediated Ubiquitin-Like Protein Ligation.

scientific article

Structural Genomics

scientific article published on 01 November 2007

Structural Insights to How Mammalian Capping Enzyme Reads the CTD Code ⬇️

scientific article published on June 16, 2011

Structural analysis of Saccharomyces cerevisiae myo-inositol phosphate synthase

scholarly article

Structural and biochemical analysis of the Obg GTP binding protein

scientific article

Structural and functional insights to ubiquitin-like protein conjugation.

scientific article

Structural basis for E2-mediated SUMO conjugation revealed by a complex between ubiquitin-conjugating enzyme Ubc9 and RanGAP1

scientific article

Structural basis for MTR4-ZCCHC8 interactions that stimulate the MTR4 helicase in the nuclear exosome-targeting complex.

scientific article

Structural basis for RNA surveillance by the human nuclear exosome targeting (NEXT) complex

scientific article published in 2022

Structural basis for adenylation and thioester bond formation in the ubiquitin E1

scientific article published on 24 June 2019

Structural basis for catalytic activation by the human ZNF451 SUMO E3 ligase

scientific journal article

Structural basis for nick recognition by a minimal pluripotent DNA ligase

scientific article

Structural biology: A protein engagement RING.

scientific article published in September 2012

Structural components and architectures of RNA exosomes

scientific article

Structural genomics: A pipeline for providing structures for the biologist

scientific article

Structure Meets the Membrane

scientific article published on 01 October 2011

Structure and Activities of the Eukaryotic RNA Exosome.

scientific article published on 29 September 2012

Structure and function of the yeast listerin (Ltn1) conserved N-terminal domain in binding to stalled 60S ribosomal subunits

scientific article published on 06 July 2016

Structure and mechanism of RNA ligase

scientific article

Structure and mechanism of mRNA cap (guanine-N7) methyltransferase

scientific article

Structure and reconstitution of yeast Mpp6-nuclear exosome complexes reveals that Mpp6 stimulates RNA decay and recruits the Mtr4 helicase.

scientific article published on 25 July 2017

Structure of Escherichia coli uridine phosphorylase at 2.0 A

scientific article

Structure of an Rrp6–RNA exosome complex bound to poly(A) RNA

scientific article

Structure of an mRNA capping enzyme bound to the phosphorylated carboxy-terminal domain of RNA polymerase II

scientific article

Structure of the Human SENP7 Catalytic Domain and Poly-SUMO Deconjugation Activities for SENP6 and SENP7

scientific article

Structure of the Siz/PIAS SUMO E3 ligase Siz1 and determinants required for SUMO modification of PCNA

scientific article

Structure, function, and mechanism of the phenylacetate pathway hot dog-fold thioesterase PaaI.

scientific article published on 7 February 2006

Structure-based analysis of catalysis and substrate definition in the HIT protein family

scientific article

Substrate selectivity by the exonuclease Rrp6p

scientific article published on 26 December 2019

Taking it step by step: mechanistic insights from structural studies of ubiquitin/ubiquitin-like protein modification pathways

scientific article published on 4 October 2007

Targeting RNA for processing or destruction by the eukaryotic RNA exosome and its cofactors

scientific article published on January 2017

The RNA Exosome Targets the AID Cytidine Deaminase to Both Strands of Transcribed Duplex DNA Substrates ⬇️

scientific article published on January 20, 2011

The Rrp6 C-terminal domain binds RNA and activates the nuclear RNA exosome.

scientific article

The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition

scientific article

The eukaryotic RNA exosome

scientific article published on 11 February 2014

The polynucleotide ligase and RNA capping enzyme superfamily of covalent nucleotidyltransferases.

scientific article

Ubiquitin-like Protein Conjugation: Structures, Chemistry, and Mechanism

scientific article published on 24 February 2017

Ulp1 Endopeptidase

Ulp1-SUMO crystal structure and genetic analysis reveal conserved interactions and a regulatory element essential for cell growth in yeast

scientific article published in May 2000

ketu mutant mice uncover an essential meiotic function for the ancient RNA helicase YTHDC2.

scientific article published on 23 January 2018

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