List of works - Ferdinando Di Cunto

A de novo X;8 translocation creates a PTK2-THOC2 gene fusion with THOC2 expression knockdown in a patient with psychomotor retardation and congenital cerebellar hypoplasia

scientific journal article

A new approach for the identification of processed pseudogenes

scientific article published in May 2010

A signature inferred from Drosophila mitotic genes predicts survival of breast cancer patients

scientific article

ASPM and CITK regulate spindle orientation by affecting the dynamics of astral microtubules. ⬇️

scientific article published on 25 August 2016

ASPM and CITK regulate spindle orientation by affecting the dynamics of astral microtubules.

scientific article published on October 2017

Ab initio identification of putative human transcription factor binding sites by comparative genomics

scientific article

Additive functions in boolean models of gene regulatory network modules

scientific article

Are Cells Really Operating at the Edge of Chaos?

scientific article published in 2011

Automatic hippocampus localization in histological images using Differential Evolution-based deformable models

scientific article published in February 2013

Automatic hippocampus localization in histological images using PSO-based deformable models

scientific article published in 2011

Automatic segmentation of hippocampus in histological images of mouse brains using deformable models and random forest

scientific article published in June 2012

CITK Loss Inhibits Growth of Group 3 and Group 4 Medulloblastoma Cells and Sensitizes Them to DNA-Damaging Agents

scientific article published on 26 February 2020

CLOE: identification of putative functional relationships among genes by comparison of expression profiles between two species

scientific article

Candidate gene prioritization based on spatially mapped gene expression: an application to XLMR

scientific article

Citron Kinase Deficiency Leads to Chromosomal Instability and TP53-Sensitive Microcephaly

scientific article published on February 2017

Citron kinase controls abscission through RhoA and anillin

scientific article

Citron kinase in spindle orientation and primary microcephaly.

scientific article published on 10 November 2016

Citron kinase is a cell cycle-dependent, nuclear protein required for G2/M transition of hepatocytes

scientific journal article

Citron kinase-dependent F-actin maintenance at midbody secondary ingression sites mediates abscission.

scientific article published on 27 March 2018

Citron rho-interacting kinase, a novel tissue-specific ser/thr kinase encompassing the Rho-Rac-binding protein Citron

scientific article

Citron-N is a neuronal Rho-associated protein involved in Golgi organization through actin cytoskeleton regulation

scientific journal article

Citron-kinase, a protein essential to cytokinesis in neuronal progenitors, is deleted in the flathead mutant rat.

scientific article published on 2 April 2002

Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs

scientific article

Comparison of 3 Tfr2-deficient murine models suggests distinct functions for Tfr2-alpha and Tfr2-beta isoforms in different tissues.

scientific article published on 23 February 2010

Computational approaches to disease-gene prediction: rationale, classification and successes.

scientific article published on 30 January 2012

Computational identification of transcription factor binding sites by functional analysis of sets of genes sharing overrepresented upstream motifs

scientific article

Correction to: The SRCIN1/p140Cap adaptor protein negatively regulates the aggressiveness of neuroblastoma

scientific article published on 01 April 2020

Correlating overrepresented upstream motifs to gene expression: a computational approach to regulatory element discovery in eukaryotes

scientific article

Disease-gene discovery by integration of 3D gene expression and transcription factor binding affinities

scientific article published on 24 December 2012

Drosophila citron kinase is required for the final steps of cytokinesis.

scientific article published on 15 September 2004

Drug repositioning for orphan genetic diseases through Conserved Anticoexpressed Gene Clusters (CAGCs)

scientific article

Essential role of citron kinase in cytokinesis of spermatogenic precursors

scientific journal article

Evaluation of Candidate Genes from Orphan FEB and GEFS+ Loci by Analysis of Human Brain Gene Expression Atlases ⬇️

scientific article published on August 17, 2011

Functional annotation and identification of candidate disease genes by computational analysis of normal tissue gene expression data.

scientific article

Genes regulated by hepatocyte growth factor as targets to sensitize ovarian cancer cells to cisplatin

article

HSP27 is required for invasion and metastasis triggered by hepatocyte growth factor.

scientific article

IRF4 Mediates the Oncogenic Effects of STAT3 in Anaplastic Large Cell Lymphomas.

scientific article published on 18 January 2018

Identification of DeltaNp63alpha protein interactions by mass spectrometry

scientific article

Identification of Drosophila mitotic genes by combining co-expression analysis and RNA interference

scientific article

Inhibitory Function of p21 Cip1/WAF1 in Differentiation of Primary Mouse Keratinocytes Independent of Cell Cycle Control ⬇️

scientific article published on May 15, 1998

MECP2 mutations affect ciliogenesis: a novel perspective for Rett syndrome and related disorders

scientific article published on 08 May 2020

Methyl-CpG binding protein 2 (MeCP2) localizes at the centrosome and is required for proper mitotic spindle organization

scientific journal article

Microarray and Large-Scale In Silico–Based Identification of Genes Functionally Related to Haptoglobin and/or Hemopexin

article

Mutations in Citron Kinase Cause Recessive Microlissencephaly with Multinucleated Neurons

scientific article

Of rings and spines: The multiple facets of Citron proteins in neural development

scientific article published on 29 November 2017

PPP4R2 regulates neuronal cell differentiation and survival, functionally cooperating with SMN.

scientific article published on 3 May 2012

Precision Revisited: Targeting Microcephaly Kinases in Brain Tumors ⬇️

scientific article published on 28 April 2019

Prediction of human disease genes by human-mouse conserved coexpression analysis

scientific article

RNAs competing for microRNAs mutually influence their fluctuations in a highly non-linear microRNA-dependent manner in single cells ⬇️

scientific article published on 20 February 2017

Role of citron kinase in dendritic morphogenesis of cortical neurons

scientific journal article

Shortening of 3′UTRs Correlates with Poor Prognosis in Breast and Lung Cancer ⬇️

scientific article published on February 8, 2012

Structure of msj-1 gene in mice and humans: A possible role in the regulation of male reproduction

article

The DCR protein TTC3 affects differentiation and Golgi compactness in neurons through specific actin-regulating pathways

scientific article

The Down syndrome critical region protein TTC3 inhibits neuronal differentiation via RhoA and Citron kinase

scientific article

The MeCP2/YY1 interaction regulates ANT1 expression at 4q35: novel hints for Rett syndrome pathogenesis.

scientific article

The RNA binding protein ESRP1 fine-tunes the expression of pluripotency-related factors in mouse embryonic stem cells

scientific article

The RhoA-associated protein Citron-N controls dendritic spine maintenance by interacting with spine-associated Golgi compartments.

scientific article published on 29 February 2008

The RhoU/Wrch1 Rho GTPase gene is a common transcriptional target of both the gp130/STAT3 and Wnt-1 pathways

scientific article published on 26 June 2009

The SRCIN1/p140Cap adaptor protein negatively regulates the aggressiveness of neuroblastoma

scientific article published on 08 July 2019

The collagen chaperone HSP47 is a new interactor of APP that affects the levels of extracellular beta-amyloid peptides

scientific article

Tissue-specific control of midbody microtubule stability by Citron kinase through modulation of TUBB3 phosphorylation

scientific article

Validating a Threshold-Based Boolean Model of Regulatory Networks on a Biological Organism

Visual search of neuropil-enriched RNAs from brain in situ hybridization data through the image analysis pipeline hippo-ATESC.

scientific article

ZIKA virus elicits P53 activation and genotoxic stress in human neural progenitors similar to mutations involved in severe forms of genetic microcephaly and p53

scientific article (publication date: 27 October 2016)

p140Cap regulates memory and synaptic plasticity through Src-mediated and citron-N-mediated actin reorganization.

scientific article published in January 2014

List of works by Ferdinando Di Cunto

A de novo X;8 translocation creates a PTK2-THOC2 gene fusion with THOC2 expression knockdown in a patient with psychomotor retardation and congenital cerebellar hypoplasia

A new approach for the identification of processed pseudogenes

A signature inferred from Drosophila mitotic genes predicts survival of breast cancer patients

ASPM and CITK regulate spindle orientation by affecting the dynamics of astral microtubules. ⬇️

ASPM and CITK regulate spindle orientation by affecting the dynamics of astral microtubules.

Ab initio identification of putative human transcription factor binding sites by comparative genomics

Additive functions in boolean models of gene regulatory network modules

Are Cells Really Operating at the Edge of Chaos?

Automatic hippocampus localization in histological images using Differential Evolution-based deformable models

Automatic hippocampus localization in histological images using PSO-based deformable models

Automatic segmentation of hippocampus in histological images of mouse brains using deformable models and random forest

CITK Loss Inhibits Growth of Group 3 and Group 4 Medulloblastoma Cells and Sensitizes Them to DNA-Damaging Agents

CLOE: identification of putative functional relationships among genes by comparison of expression profiles between two species

Candidate gene prioritization based on spatially mapped gene expression: an application to XLMR

Citron Kinase Deficiency Leads to Chromosomal Instability and TP53-Sensitive Microcephaly

Citron kinase controls abscission through RhoA and anillin

Citron kinase in spindle orientation and primary microcephaly.

Citron kinase is a cell cycle-dependent, nuclear protein required for G2/M transition of hepatocytes

Citron kinase-dependent F-actin maintenance at midbody secondary ingression sites mediates abscission.

Citron rho-interacting kinase, a novel tissue-specific ser/thr kinase encompassing the Rho-Rac-binding protein Citron

Citron-N is a neuronal Rho-associated protein involved in Golgi organization through actin cytoskeleton regulation

Citron-kinase, a protein essential to cytokinesis in neuronal progenitors, is deleted in the flathead mutant rat.

Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs

Comparison of 3 Tfr2-deficient murine models suggests distinct functions for Tfr2-alpha and Tfr2-beta isoforms in different tissues.

Computational approaches to disease-gene prediction: rationale, classification and successes.

Computational identification of transcription factor binding sites by functional analysis of sets of genes sharing overrepresented upstream motifs

Correction to: The SRCIN1/p140Cap adaptor protein negatively regulates the aggressiveness of neuroblastoma

Correlating overrepresented upstream motifs to gene expression: a computational approach to regulatory element discovery in eukaryotes

Disease-gene discovery by integration of 3D gene expression and transcription factor binding affinities

Drosophila citron kinase is required for the final steps of cytokinesis.

Drug repositioning for orphan genetic diseases through Conserved Anticoexpressed Gene Clusters (CAGCs)

Essential role of citron kinase in cytokinesis of spermatogenic precursors

Evaluation of Candidate Genes from Orphan FEB and GEFS+ Loci by Analysis of Human Brain Gene Expression Atlases ⬇️

Functional annotation and identification of candidate disease genes by computational analysis of normal tissue gene expression data.

Genes regulated by hepatocyte growth factor as targets to sensitize ovarian cancer cells to cisplatin

HSP27 is required for invasion and metastasis triggered by hepatocyte growth factor.

IRF4 Mediates the Oncogenic Effects of STAT3 in Anaplastic Large Cell Lymphomas.

Identification of DeltaNp63alpha protein interactions by mass spectrometry

Identification of Drosophila mitotic genes by combining co-expression analysis and RNA interference

Inhibitory Function of p21 Cip1/WAF1 in Differentiation of Primary Mouse Keratinocytes Independent of Cell Cycle Control ⬇️

MECP2 mutations affect ciliogenesis: a novel perspective for Rett syndrome and related disorders

Methyl-CpG binding protein 2 (MeCP2) localizes at the centrosome and is required for proper mitotic spindle organization

Microarray and Large-Scale In Silico–Based Identification of Genes Functionally Related to Haptoglobin and/or Hemopexin

Mutations in Citron Kinase Cause Recessive Microlissencephaly with Multinucleated Neurons

Of rings and spines: The multiple facets of Citron proteins in neural development

PPP4R2 regulates neuronal cell differentiation and survival, functionally cooperating with SMN.

Precision Revisited: Targeting Microcephaly Kinases in Brain Tumors ⬇️

Prediction of human disease genes by human-mouse conserved coexpression analysis

RNAs competing for microRNAs mutually influence their fluctuations in a highly non-linear microRNA-dependent manner in single cells ⬇️

Role of citron kinase in dendritic morphogenesis of cortical neurons

Shortening of 3′UTRs Correlates with Poor Prognosis in Breast and Lung Cancer ⬇️

Structure of msj-1 gene in mice and humans: A possible role in the regulation of male reproduction

The DCR protein TTC3 affects differentiation and Golgi compactness in neurons through specific actin-regulating pathways

The Down syndrome critical region protein TTC3 inhibits neuronal differentiation via RhoA and Citron kinase

The MeCP2/YY1 interaction regulates ANT1 expression at 4q35: novel hints for Rett syndrome pathogenesis.

The RNA binding protein ESRP1 fine-tunes the expression of pluripotency-related factors in mouse embryonic stem cells

The RhoA-associated protein Citron-N controls dendritic spine maintenance by interacting with spine-associated Golgi compartments.

The RhoU/Wrch1 Rho GTPase gene is a common transcriptional target of both the gp130/STAT3 and Wnt-1 pathways

The SRCIN1/p140Cap adaptor protein negatively regulates the aggressiveness of neuroblastoma

The collagen chaperone HSP47 is a new interactor of APP that affects the levels of extracellular beta-amyloid peptides

Tissue-specific control of midbody microtubule stability by Citron kinase through modulation of TUBB3 phosphorylation

Validating a Threshold-Based Boolean Model of Regulatory Networks on a Biological Organism

Visual search of neuropil-enriched RNAs from brain in situ hybridization data through the image analysis pipeline hippo-ATESC.

ZIKA virus elicits P53 activation and genotoxic stress in human neural progenitors similar to mutations involved in severe forms of genetic microcephaly and p53

p140Cap regulates memory and synaptic plasticity through Src-mediated and citron-N-mediated actin reorganization.