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List of works by Pieter Leyssen

3',5'Di-O-trityluridine inhibits in vitro flavivirus replication

scientific article published on 5 March 2013

3'-Deoxy phosphoramidate dinucleosides as improved inhibitors of hepatitis C virus subgenomic replicon and NS5B polymerase activity

scientific article published on September 2010

3-(imidazo[1,2-a:5,4-b']dipyridin-2-yl)aniline inhibits pestivirus replication by targeting a hot spot drug binding pocket in the RNA-dependent RNA polymerase

scientific article published on 9 March 2016

3-Biphenylimidazo[1,2-a]pyridines or [1,2-b]pyridazines and analogues, novel Flaviviridae inhibitors

scientific article published on 19 April 2013

3C Protease of Enterovirus 68: Structure-Based Design of Michael Acceptor Inhibitors and Their Broad-Spectrum Antiviral Effects against Picornaviruses

scientific article

A Dengue type 2 reporter virus assay amenable to high-throughput screening

scientific article published on 05 September 2020

A novel benzonitrile analogue inhibits rhinovirus replication

scientific article

A novel class of chikungunya virus small molecule inhibitors that targets the viral capping machinery

scientific article published on 27 April 2020

A novel druggable interprotomer pocket in the capsid of rhino- and enteroviruses

scientific article published on 11 June 2019

A novel method for high-throughput screening to quantify antiviral activity against viruses that induce limited CPE

scientific article published on 28 April 2012

A novel, broad-spectrum inhibitor of enterovirus replication that targets host cell factor phosphatidylinositol 4-kinase IIIβ.

scientific article published on 29 July 2013

A novel, highly selective inhibitor of pestivirus replication that targets the viral RNA-dependent RNA polymerase

scientific article

A rapid and convenient variant of fusion-PCR to construct chimeric flaviviruses

scientific article published on March 2003

A reassessment of mycophenolic acid as a lead compound for the development of inhibitors of chikungunya virus replication

article

Acute Encephalitis, a Poliomyelitis-like Syndrome and Neurological Sequelae in a Hamster Model for Flavivirus Infections

scientific article

Alpha-ketoamides as broad-spectrum inhibitors of coronavirus and enterovirus replication

scientific article

Anti-enterovirus activity and structure–activity relationship of a series of 2,6-dihalophenyl-substituted 1H,3H-thiazolo[3,4-a]benzimidazoles

scientific article published in 2007

Antibacterial, Antifungal, Antiviral, and Anthelmintic Activities of Medicinal Plants of Nepal Selected Based on Ethnobotanical Evidence

scientific article published on 22 April 2020

Antimicrobial, Anthelmintic, and Antiviral Activity of Plants Traditionally Used for Treating Infectious Disease in the Similipal Biosphere Reserve, Odisha, India

scientific article

Antiplasmodial, Anti-chikungunya virus and Antioxidant Activities of 64 endemic Plants from the Mascarene Islands

article

Antiviral Activity of Broad-Spectrum and Enterovirus-Specific Inhibitors against Clinical Isolates of Enterovirus D68.

scientific article

Antiviral Activity of Diterpene Esters on Chikungunya Virus and HIV Replication

scientific article published on 13 May 2015

Antiviral Activity of Flexibilane and Tigliane Diterpenoids from Stillingia lineata ⬇️

scientific article published on 6 May 2015

Antiviral activity of [1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-ones against chikungunya virus targeting the viral capping nsP1.

scientific article published on 12 June 2017

Antiviral and Cytotoxic Activity of Different Plant Parts of Banana (Musa spp.).

scientific article published on 15 May 2020

Antiviral chlorinated daphnane diterpenoid orthoesters from the bark and wood of Trigonostemon cherrieri

scientific article published on 29 August 2012

Assessing medicinal plants traditionally used in the Chirang Reserve Forest, Northeast India for antimicrobial activity

article

Benzouracil-coumarin-arene conjugates as inhibiting agents for chikungunya virus

scientific article

Bioactivity-Based Molecular Networking for the Discovery of Drug Leads in Natural Product Bioassay-Guided Fractionation.

scientific article published on 2 March 2018

Biodiversity as a Source of Potent and Selective Inhibitors of Chikungunya Virus Replication

Bioengineering and semisynthesis of an optimized cyclophilin inhibitor for treatment of chronic viral infection

scientific article

Chemical constituents of Anacolosa pervilleana and their antiviral activities

scientific article published on 14 May 2012

Chemical modification of the plant isoprenoid cytokinin N(6)-isopentenyladenosine yields a selective inhibitor of human enterovirus 71 replication

scientific article published on 25 November 2014

Comparative In Vitro Anti-Hepatitis C Virus Activities of a Selected Series of Polymerase, Protease, and Helicase Inhibitors

scientific article (publication date: September 2008)

Comparative analysis of the anti-chikungunya virus activity of novel bryostatin analogs confirms the existence of a PKC-independent mechanism

scientific article published on 21 September 2016

Complete genome sequence of Montana Myotis leukoencephalitis virus, phylogenetic analysis and comparative study of the 3' untranslated region of flaviviruses with no known vector

scientific article published in August 2002

Complete genome sequence, taxonomic assignment, and comparative analysis of the untranslated regions of the Modoc virus, a flavivirus with no known vector

scientific article published on February 2002

Computer-aided identification, design and synthesis of a novel series of compounds with selective antiviral activity against chikungunya virus

scientific article

Computer-aided identification, synthesis and evaluation of substituted thienopyrimidines as novel inhibitors of HCV replication

scientific article

Conformationally locked nucleoside analogues based on the bridgehead substituted 7-oxonorbornane and their antiviral properties

Correction to 3′-Deoxy Phosphoramidate Dinucleosides as Improved Inhibitors of Hepatitis C Virus Subgenomic Replicon and NS5B Polymerase Activity

scholarly article published in Journal of Medicinal Chemistry

Coumarin-purine ribofuranoside conjugates as new agents against hepatitis C virus

scientific article

Design, synthesis and evaluation against Chikungunya virus of novel small-molecule antiviral agents

scientific article published on 6 January 2018

Design, synthesis, and biological evaluation of novel coxsackievirus B3 inhibitors

scientific article published on 29 April 2010

Design, synthesis, optimization and antiviral activity of a class of hybrid dengue virus E protein inhibitors

scientific article published on 2 March 2015

Development of New Sulfur-Containing Conjugated Compounds as Anti-HCV Agents

article

Discovery of Multitarget Agents Active as Broad-Spectrum Antivirals and Correctors of Cystic Fibrosis Transmembrane Conductance Regulator for Associated Pulmonary Diseases

scientific article

Discovery of Multitarget Antivirals Acting on Both the Dengue Virus NS5-NS3 Interaction and the Host Src/Fyn Kinases

scientific article published on 15 June 2015

Discovery of a novel HCV helicase inhibitor by a de novo drug design approach

scientific article

Discovery of novel multi-target indole-based derivatives as potent and selective inhibitors of chikungunya virus replication

scientific article published on 31 October 2016

Efficacy of cidofovir in a murine model of disseminated progressive vaccinia

scientific article

Efficient synthesis and anti-enteroviral activity of 9-arylpurines

scientific article published on 17 January 2012

Enterovirus Inhibition by Hinged Aromatic Compounds with Polynuclei

scientific article published on 22 August 2020

Environmentally Friendly Procedure Based on Supercritical Fluid Chromatography and Tandem Mass Spectrometry Molecular Networking for the Discovery of Potent Antiviral Compounds from Euphorbia semiperfoliata.

scientific article published on 19 September 2017

Euphorbia dendroides Latex as a Source of Jatrophane Esters: Isolation, Structural Analysis, Conformational Study, and Anti-CHIKV Activity

scientific article published on 27 October 2016

Evaluation of SARS-CoV-2 3C-like protease inhibitors using self-assembled monolayer desorption ionization mass spectrometry

scientific article published on 04 September 2020

Exchanging the yellow fever virus envelope proteins with Modoc virus prM and E proteins results in a chimeric virus that is neuroinvasive in SCID mice

scientific article published on July 2004

Exploration of the anti-enterovirus activity of a series of pleconaril/pirodavir-like compounds

scientific article published on 11 June 2015

Exploration of the in vitro antiviral activity of a series of new pyrimidine analogues on the replication of HIV and HCV.

scientific article

Exploring the importance of zinc binding and steric/hydrophobic factors in novel HCV replication inhibitors

scientific article published on 16 January 2016

Fitness and virulence of a coxsackievirus mutant that can circumnavigate the need for phosphatidylinositol 4-kinase class III beta

scientific article

Flacourtosides A-F, phenolic glycosides isolated from Flacourtia ramontchi

scientific article published on 22 March 2012

Fluorination of Naturally Occurring N⁶-Benzyladenosine Remarkably Increased Its Antiviral Activity and Selectivity.

scientific article

From norbornane-based nucleotide analogs locked in South conformation to novel inhibitors of feline herpes virus

scientific article published on 13 April 2014

H1PVAT is a novel and potent early-stage inhibitor of poliovirus replication that targets VP1.

scientific article

Identification and Analysis of Antiviral Compounds Against Poliovirus

scientific article published in January 2016

Identification of [1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-ones as novel inhibitors of Chikungunya virus replication

scientific article

Identification of a series of compounds with potent antiviral activity for the treatment of enterovirus infections

scientific article

Identification of allosteric inhibitors blocking the hepatitis C virus polymerase NS5B in the RNA synthesis initiation step

scientific article

Impact of Direct Virus-Induced Neuronal Dysfunction and Immunological Damage on the Progression of Flavivirus (Modoc) Encephalitis in a Murine Model

scholarly article by Pieter Leyssen et al published January 2003 in Journal of NeuroVirology

Impact of direct virus-induced neuronal dysfunction and immunological damage on the progression of flavivirus (Modoc) encephalitis in a murine model

scientific article published in February 2003

In Vitro Selection and Characterization of Hepatitis C Virus Replicons Double or Triple Resistant to Various Non-nucleoside HCV Polymerase Inhibitors

scientific article published in 2010

In silico identification, design and synthesis of novel piperazine-based antiviral agents targeting the hepatitis C virus helicase

scientific article published on 23 October 2016

In vitro characterisation of a pleconaril/pirodavir-like compound with potent activity against rhinoviruses.

scientific article published on 14 July 2015

In vitro selection and characterization of HCV replicons resistant to multiple non-nucleoside polymerase inhibitors

scientific article published on 20 May 2011

In vivo monitoring of acute flavivirus (Modoc) encephalitis with regional and whole-brain quantitative diffusion magnetic resonance imaging

scientific article published on August 2004

Infection of SCID mice with Montana Myotis leukoencephalitis virus as a model for flavivirus encephalitis

scientific article published on August 2002

Inhibition of Chikungunya Virus-Induced Cell Death by Salicylate-Derived Bryostatin Analogues Provides Additional Evidence for a PKC-Independent Pathway

scientific article published on 22 February 2016

Inhibition of the Replication of Different Strains of Chikungunya Virus by 3-Aryl-[1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-ones.

scientific article

Interferons, Interferon Inducers, and Interferon-Ribavirin in Treatment of Flavivirus-Induced Encephalitis in Mice

scientific article

Intra-host emergence of an enterovirus A71 variant with enhanced PSGL1 usage and neurovirulence

scientific article published on 01 January 2019

Investigation of Premyrsinane and Myrsinane Esters in Euphorbia cupanii and Euphobia pithyusa with MS2LDA and Combinatorial Molecular Network Annotation Propagation

scientific article published on 05 June 2019

Isolation of Premyrsinane, Myrsinane, and Tigliane Diterpenoids from Euphorbia pithyusa Using a Chikungunya Virus Cell-Based Assay and Analogue Annotation by Molecular Networking

scientific article

Itraconazole inhibits enterovirus replication by targeting the oxysterol-binding protein

scientific article

Jatrophane diterpenes as inhibitors of chikungunya virus replication: structure-activity relationship and discovery of a potent lead

scientific article published on 13 June 2014

LC-MS²-Based dereplication of Euphorbia extracts with anti-Chikungunya virus activity

scientific article published on 4 July 2015

Linear and branched alkyl-esters and amides of gallic acid and other (mono-, di- and tri-) hydroxy benzoyl derivatives as promising anti-HCV inhibitors.

scientific article published on 17 January 2015

Modification of the length and structure of the linker of N(6)-benzyladenosine modulates its selective antiviral activity against enterovirus 71.

scientific article published on 26 January 2016

Molecular strategies to inhibit the replication of RNA viruses

scientific article published on 04 February 2008

Mutations in the chikungunya virus non-structural proteins cause resistance to favipiravir (T-705), a broad-spectrum antiviral

scientific article

NMR-based conformational analysis of 2',6-disubstituted uridines and antiviral evaluation of new phosphoramidate prodrugs

scientific article

New 1-phenyl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides inhibit hepatitis C virus replication via suppression of cyclooxygenase-2.

scientific article

New pyrazolobenzothiazine derivatives as hepatitis C virus NS5B polymerase palm site I inhibitors

scientific article

Norbornane-based nucleoside and nucleotide analogues locked in North conformation

scientific article published on 15 November 2014

Novel 1,2,4-triazole and imidazole derivatives of L-ascorbic and imino-ascorbic acid: synthesis, anti-HCV and antitumor activity evaluations

scientific article published on 15 February 2012

Novel substituted 9-norbornylpurines and their activities against RNA viruses

scientific article published in 2012

Novel symmetrical phenylenediamines as potential anti-hepatitis C virus agents.

scientific article published on 4 November 2016

Optimization of a Class of Tryptophan Dendrimers That Inhibit HIV Replication Leads to a Selective, Specific, and Low-Nanomolar Inhibitor of Clinical Isolates of Enterovirus A71.

scientific article published on 31 May 2016

PHYTOCHIK: Biodiversity As A Source of Selective Inhibitors of CHIKV Replication

article published in 2011

PI4KIII inhibitor enviroxime impedes the replication of the hepatitis C virus by inhibiting PI3 kinases

scholarly article by Leen Delang et al published 14 September 2018 in Journal of Antimicrobial Chemotherapy

Phosphatidylinositol 4-kinase III beta is essential for replication of human rhinovirus and its inhibition causes a lethal phenotype in vivo

scientific article published on 06 May 2013

Preclinical characterization of naturally occurring polyketide cyclophilin inhibitors from the sanglifehrin family

scientific article published on 7 March 2011

Prostratin and 12-O-tetradecanoylphorbol 13-acetate are potent and selective inhibitors of Chikungunya virus replication

scientific article published on 7 December 2012

Protein kinases C as potential host targets for the inhibition of chikungunya virus replication

scientific article

Pyridobenzothiazole derivatives as new chemotype targeting the HCV NS5B polymerase

scientific article

Quinolinecarboxamides Inhibit the Replication of the Bovine Viral Diarrhea Virus by Targeting a Hot Spot for the Inhibition of Pestivirus Replication in the RNA-Dependent RNA Polymerase

scientific article published on 12 March 2020

Rational modifications on a benzylidene-acrylohydrazide antiviral scaffold, synthesis and evaluation of bioactivity against Chikungunya virus

scientific article published on 23 February 2018

Reaching beyond HIV/HCV: nelfinavir as a potential starting point for broad-spectrum protease inhibitors against dengue and chikungunya virus

article

Rodent models for the study of therapy against flavivirus infections

scientific article published in August 2004

S-aryltriazole acyclonucleosides: synthesis and biological evaluation against hepatitis C virus

scientific article published on 28 April 2010

SAR studies of 9-norbornylpurines as Coxsackievirus B3 inhibitors

scientific article

STAT2 signaling as double-edged sword restricting viral dissemination but driving severe pneumonia in SARS-CoV-2 infected hamsters

scientific article published on 24 April 2020

STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters

scientific article published on 17 November 2020

Sangamides, a new class of cyclophilin-inhibiting host-targeted antivirals for treatment of HCV infection

Selective serotonin reuptake inhibitor fluoxetine inhibits replication of human enteroviruses B and D by targeting viral protein 2C.

scientific article published on 18 January 2013

Shape-based virtual screening, synthesis and evaluation of novel pyrrolone derivatives as antiviral agents against HCV.

scientific article

Simplified Bryostatin Analogues Protect Cells from Chikungunya Virus-Induced Cell Death

scientific article published on 22 February 2016

Statins potentiate the in vitro anti-hepatitis C virus activity of selective hepatitis C virus inhibitors and delay or prevent resistance development

scientific article published on July 2009

Straightforward synthesis of triazoloacyclonucleotide phosphonates as potential HCV inhibitors

scientific article published on 16 October 2010

Structurally Diverse Diterpenoids from Sandwithia guyanensis

scientific article published in March 2018

Structure Elucidation of Coxsackievirus A16 in Complex with GPP3 Informs a Systematic Review of Highly Potent Capsid Binders to Enteroviruses

scientific article

Structure-activity relationship studies on a Trp dendrimer with dual activities against HIV and enterovirus A71. Modifications on the amino acid.

scientific article published on 22 December 2016

Structure-activity relationship study of arbidol derivatives as inhibitors of chikungunya virus replication

scientific article

Structure-based discovery of pyrazolobenzothiazine derivatives as inhibitors of hepatitis C virus replication

scientific article

Substituted 2,6-bis(benzimidazol-2-yl)pyridines: a novel chemical class of pestivirus inhibitors that targets a hot spot for inhibition of pestivirus replication in the RNA-dependent RNA polymerase

scientific article published on 27 March 2014

Synergy of entry inhibitors with direct-acting antivirals uncovers novel combinations for prevention and treatment of hepatitis C.

scientific article

Synthesis and Structure-Activity Relationships of Imidazole-Coumarin Conjugates against Hepatitis C Virus

scientific article published on 18 February 2016

Synthesis of novel azanorbornylpurine derivatives

Synthesis of novel purine-based coxsackievirus inhibitors bearing polycylic substituents at the N-9 position

scientific article

Synthesis of novel thienonorbornylpurine derivatives

Synthesis, biological activity and structure-activity relationship of 4,5-dimethoxybenzene derivatives inhibitor of rhinovirus 14 infection

scientific article published on 17 February 2014

The Imidazopyrrolopyridine Analogue AG110 Is a Novel, Highly Selective Inhibitor of Pestiviruses That Targets the Viral RNA-Dependent RNA Polymerase at a Hot Spot for Inhibition of Viral Replication

scientific article (publication date: October 2007)

The RNA template channel of the RNA-dependent RNA polymerase as a target for development of antiviral therapy of multiple genera within a virus family

scientific article

The anti-yellow fever virus activity of ribavirin is independent of error-prone replication

scientific article

The capsid binder Vapendavir and the novel protease inhibitor SG85 inhibit enterovirus 71 replication

scientific article

The enterovirus 3C protease inhibitor SG85 efficiently blocks rhinovirus replication and is not cross-resistant with rupintrivir

scientific article published on 8 June 2015

The predominant mechanism by which ribavirin exerts its antiviral activity in vitro against flaviviruses and paramyxoviruses is mediated by inhibition of IMP dehydrogenase

scientific article published on February 2005

The versatile nature of the 6-aminoquinolone scaffold: identification of submicromolar hepatitis C virus NS5B inhibitors

scientific article

Tigliane diterpenes from Croton mauritianus as inhibitors of chikungunya virus replication

scientific article published on 28 May 2014

Tiyoüreler, açiltiyoüreler ve 4-tiyazolidinonların sentezi, karakterizasyonu ve antikanser ve antiviral etkilerinin değerlendirilmesi

Towards the design of combination therapy for the treatment of enterovirus infections

scientific article published on 3 April 2011

Trigocherrierin A, a potent inhibitor of chikungunya virus replication.

scientific article published on 24 March 2014

Trigocherrin A, the first natural chlorinated daphnane diterpene orthoester from Trigonostemon cherrieri ⬇️

scientific article published on 19 December 2011

Understanding the Mechanism of the Broad-Spectrum Antiviral Activity of Favipiravir (T-705): Key Role of the F1 Motif of the Viral Polymerase

scientific article published on 5 April 2017

VP1 crystal structure-guided exploration and optimization of 4,5-dimethoxybenzene-based inhibitors of rhinovirus 14 infection

scientific article published on 19 March 2016

Viral engagement with host receptors blocked by a novel class of tryptophan dendrimers that targets the 5-fold-axis of the enterovirus-A71 capsid

scientific article published on 09 May 2019

α-Ketoamides as Broad-Spectrum Inhibitors of Coronavirus and Enterovirus Replication: Structure-Based Design, Synthesis, and Activity Assessment

scientific article published on 24 February 2020

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