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List of works by Jan Paeshuyse

3-(imidazo[1,2-a:5,4-b']dipyridin-2-yl)aniline inhibits pestivirus replication by targeting a hot spot drug binding pocket in the RNA-dependent RNA polymerase

scientific article published on 9 March 2016

3-Biphenylimidazo[1,2-a]pyridines or [1,2-b]pyridazines and analogues, novel Flaviviridae inhibitors

scientific article published on 19 April 2013

A novel, highly selective inhibitor of pestivirus replication that targets the viral RNA-dependent RNA polymerase

scientific article

A pyrazolotriazolopyrimidinamine inhibitor of bovine viral diarrhea virus replication that targets the viral RNA-dependent RNA polymerase.

scientific article

Acute Encephalitis, a Poliomyelitis-like Syndrome and Neurological Sequelae in a Hamster Model for Flavivirus Infections

scientific article

Advanced engineering of third-generation lysins and formulation strategies for clinical applications

scientific article published on 04 September 2020

African Swine Fever in Cameroon: A Review

scientific article published in 2021

African Swine Fever: Prevalence, Farm Characteristics, Farmer’s Insight and Attitude toward Reporting of African Swine Fever Cases in the Northwest, West, Littoral and Southwest Regions of Cameroon

scientific article published in 2021

Angiogenic activity of hepatitis B and C viruses.

scientific article published on 17 January 2012

Antiviral 2,5-disubstituted imidazo[4,5-c]pyridines: from anti-pestivirus to anti-hepatitis C virus activity

scientific article published on 19 October 2006

Antiviral 2,5-disubstituted imidazo[4,5-c]pyridines: further optimization of anti-hepatitis C virus activity

scientific article published on 13 July 2007

Artemisinin analogues as potent inhibitors of in vitro hepatitis C virus replication

scientific article (publication date: 2013)

Assessment of the activity of directly acting antivirals and other products against different genotypes of hepatitis C virus prevalent in resource-poor countries

scientific article

Bicyclic and Tricyclic "Expanded" Nucleobase Analogues of Sofosbuvir: New Scaffolds for Hepatitis C Therapies

scientific article published on 9 June 2015

Comparative In Vitro Anti-Hepatitis C Virus Activities of a Selected Series of Polymerase, Protease, and Helicase Inhibitors

scientific article (publication date: September 2008)

Construction of Antibody Phage Libraries and Their Application in Veterinary Immunovirology

scientific article published on 03 June 2020

DEB025 (Alisporivir) inhibits hepatitis C virus replication by preventing a cyclophilin A induced cis-trans isomerisation in domain II of NS5A

scientific article (publication date: 27 October 2010)

Debio 025, a cyclophilin binding molecule, is highly efficient in clearing hepatitis C virus (HCV) replicon-containing cells when used alone or in combination with specifically targeted antiviral therapy for HCV (STAT-C) inhibitors

scientific article

Deciphering the Role of Bovine Viral Diarrhea Virus Non-Structural NS4B Protein in Viral Pathogenesis

scientific article published on 31 October 2020

Erratum to “Human pluripotent stem cell-derived hepatocytes support complete replication of hepatitis C virus” [J Hepatol 2012;57:246–251]

scholarly article published in Journal of Hepatology

Exchanging the yellow fever virus envelope proteins with Modoc virus prM and E proteins results in a chimeric virus that is neuroinvasive in SCID mice

scientific article published on July 2004

Functional elucidation of antibacterial phage ORFans targeting Pseudomonas aeruginosa

scientific article published on 26 August 2014

Hemin potentiates the anti-hepatitis C virus activity of the antimalarial drug artemisinin

scientific article published on 13 July 2006

Highly potent and selective inhibition of bovine viral diarrhea virus replication by γ-carboline derivatives

scientific article published on 24 September 2010

Human pluripotent stem cell-derived hepatocytes support complete replication of hepatitis C virus

scientific article published on 17 April 2012

Imidazo[4,5-c]pyridines inhibit the in vitro replication of the classical swine fever virus and target the viral polymerase.

scientific article published on 22 October 2007

Impact of Direct Virus-Induced Neuronal Dysfunction and Immunological Damage on the Progression of Flavivirus (Modoc) Encephalitis in a Murine Model

scholarly article by Pieter Leyssen et al published January 2003 in Journal of NeuroVirology

Impact of direct virus-induced neuronal dysfunction and immunological damage on the progression of flavivirus (Modoc) encephalitis in a murine model

scientific article published in February 2003

Impact of phage predation on <i>P. aeruginosa</i> adhered to human airway epithelium: major transcriptomic changes in metabolism and virulence-associated genes

scientific article published in 2023

In vitro Anti-hepatitis C Virus (HCV) Activities and Resistance Profile of Debio 025, A Non-immunosuppressive Cyclophilin Binding Molecule

scientific article published in 2009

In vitro combinations containing Tegobuvir are highly efficient in curing cells from HCV replicon and in delaying/preventing the development of drug resistance

scientific article published on 30 May 2015

Infection of SCID mice with Montana Myotis leukoencephalitis virus as a model for flavivirus encephalitis

scientific article published on August 2002

Inhibition of hepatitis C virus replication by semi-synthetic derivatives of glycopeptide antibiotics

scientific article published on 24 March 2011

Inhibition of subgenomic hepatitis C virus RNA replication by acridone derivatives: identification of an NS3 helicase inhibitor

scientific article published on May 2009

Interferons, Interferon Inducers, and Interferon-Ribavirin in Treatment of Flavivirus-Induced Encephalitis in Mice

scientific article

Iterative Chemical Engineering of Vancomycin Leads to Novel Vancomycin Analogs With a High in Vitro Therapeutic Index.

scientific article published on 7 June 2018

Linear and branched alkyl-esters and amides of gallic acid and other (mono-, di- and tri-) hydroxy benzoyl derivatives as promising anti-HCV inhibitors.

scientific article published on 17 January 2015

Mechanistic characterization of GS-9190 (Tegobuvir), a novel nonnucleoside inhibitor of hepatitis C virus NS5B polymerase

scientific article

Molecular Characterization of ASFV and Differential Diagnosis of Erysipelothrix in ASFV-Infected Pigs in Pig Production Regions in Cameroon

scientific article published in 2022

New pyrazolobenzothiazine derivatives as hepatitis C virus NS5B polymerase palm site I inhibitors

scientific article

Preclinical characterization of naturally occurring polyketide cyclophilin inhibitors from the sanglifehrin family

scientific article published on 7 March 2011

Proof of concept for the reduction of classical swine fever infection in pigs by a novel viral polymerase inhibitor

scientific article published on 4 March 2009

Quinolinecarboxamides Inhibit the Replication of the Bovine Viral Diarrhea Virus by Targeting a Hot Spot for the Inhibition of Pestivirus Replication in the RNA-Dependent RNA Polymerase

scientific article published on 12 March 2020

Rational design of antiviral drug combinations based on equipotency using HCV subgenomic replicon as an in vitro model.

scientific article published on 14 November 2017

Ribavirin Antagonizes the In Vitro Anti-Hepatitis C Virus Activity of 2'-C-Methylcytidine, the Active Component of Valopicitabine

scientific article

Ribavirin for the treatment of chronic hepatitis C virus infection: a review of the proposed mechanisms of action ⬇️

scientific article published on November 29, 2011

Short and efficient access to imidazo[1,2-a]pyrrolo[3,2-c]pyridine derivatives

Statins potentiate the in vitro anti-hepatitis C virus activity of selective hepatitis C virus inhibitors and delay or prevent resistance development

scientific article published on July 2009

Stem cell-derived hepatocytes: A novel model for hepatitis E virus replication

scientific article

Structure-based discovery of pyrazolobenzothiazine derivatives as inhibitors of hepatitis C virus replication

scientific article

Substituted 2,6-bis(benzimidazol-2-yl)pyridines: a novel chemical class of pestivirus inhibitors that targets a hot spot for inhibition of pestivirus replication in the RNA-dependent RNA polymerase

scientific article published on 27 March 2014

Substituted 5-Benzyl-2-phenyl-5H-imidazo[4,5-c]pyridines: A New Class of Pestivirus Inhibitors

Substituted 5-benzyl-2-phenyl-5H-imidazo[4,5-c]pyridines: a new class of pestivirus inhibitors

scientific article published on 9 August 2006

Substituted imidazopyridines as potent inhibitors of HCV replication

scientific article published on 26 February 2009

Synthesis and anti-BVDV activity of acridones as new potential antiviral agents

scientific article published in April 2006

Synthesis and antiviral activity of an imidazo[1,2-a]pyrrolo[2,3-c]pyridine series against the bovine viral diarrhea virus

scientific article published on 20 January 2010

The Imidazopyrrolopyridine Analogue AG110 Is a Novel, Highly Selective Inhibitor of Pestiviruses That Targets the Viral RNA-Dependent RNA Polymerase at a Hot Spot for Inhibition of Viral Replication

scientific article (publication date: October 2007)

The Phage-Encoded N-Acetyltransferase Rac Mediates Inactivation of Pseudomonas aeruginosa Transcription by Cleavage of the RNA Polymerase Alpha Subunit

scientific article published on 02 September 2020

The non-immunosuppressive cyclosporin DEBIO-025 is a potent inhibitor of hepatitis C virus replication in vitro

scientific article

The reduction of CSFV transmission to untreated pigs by the pestivirus inhibitor BPIP: a proof of concept.

scientific article published on 21 June 2009

The role of phosphatidylinositol 4-kinases and phosphatidylinositol 4-phosphate during viral replication

scientific article published on 08 August 2012

The versatile nature of the 6-aminoquinolone scaffold: identification of submicromolar hepatitis C virus NS5B inhibitors

scientific article

qDNase assay: A quantitative method for real-time assessment of DNase activity on coated surfaces

scientific article published on 26 October 2020

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