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List of works by Peter Wipf

2,2,6,6-Tetramethylpiperidin-1-yloxycarbonyl: A Protecting Group for Primary, Secondary, and Heterocyclic Amines

scientific article published on 17 October 2018

2-Guanidinoquinazolines as new inhibitors of the STAT3 pathway

scientific article

5-Hydroxyindoles by Intramolecular Alkynol–Furan Diels–Alder Cycloaddition ⬇️

scientific article published on November 16, 2012

A Bifunctional Dimethylsulfoxide Substitute Enhances the Aqueous Solubility of Small Organic Molecules ⬇️

scientific article published on December 22, 2011

A Five-Component Biginelli-Diels-Alder Cascade Reaction

A Focused Library of Tetrahydropyrimidinone Amides via a Tandem Biginelli-Ugi Multi-Component Process

article published in 2006

A Mitochondrial-Targeted Nitroxide Is a Potent Inhibitor of Ferroptosis

scientific article

A New Synthesis of 4,5,6,7-Tetrahydropyrazolo[1,5-c]pyrimidines by a Retro-Mannich Cascade Rearrangement

A Novel Small Molecule Targets Androgen Receptor and Its Splice Variants in Castration-Resistant Prostate Cancer

scientific article published on 25 September 2019

A Topical Mitochondria-Targeted Redox-Cycling Nitroxide Mitigates Oxidative Stress-Induced Skin Damage

scientific article published on 24 October 2016

A case study from the chemistry core of the Pittsburgh Molecular Library Screening Center: the Polo-like kinase polo-box domain (Plk1-PBD).

scientific article

A cell-active inhibitor of mitogen-activated protein kinase phosphatases restores paclitaxel-induced apoptosis in dexamethasone-protected cancer cells

scientific article

A chemical genetics approach identifies PTP4A3 as a regulator of colon cancer cell adhesion

article

A common pharmacophore for a diverse set of colchicine site inhibitors using a structure-based approach

scientific article

A microwave assisted intramolecular-furan-Diels-Alder approach to 4-substituted indoles

scientific article published on 11 November 2008

A mitochondria-targeted nitroxide/hemigramicidin S conjugate protects mouse embryonic cells against gamma irradiation

scientific article published on March 2008

A precursor-specific role for Hsp40/Hsc70 during tail-anchored protein integration at the endoplasmic reticulum

scientific article published on 29 July 2008

A pregnane X receptor agonist with unique species-dependent stereoselectivity and its implications in drug development

scientific article

A screen for modulators of large T antigen’s ATPase activity uncovers novel inhibitors of Simian Virus 40 and BK virus replication ⬇️

scientific article published on August 7, 2012

A screening method for chiral selectors that does not require covalent attachment

scientific article published in February 2006

A solid phase protocol of the biginelli dihydropyrimidine synthesis suitable for combinatorial chemistry

A targeted library screen reveals a new inhibitor scaffold for protein kinase D

scientific article

A threonine turnstile defines a dynamic amphiphilic binding motif in the AAA ATPase p97 allosteric binding site

scientific article published on 29 March 2017

ACS Medicinal Chemistry Letters: Technology Notes

scientific article published on 12 January 2017

ATF4 Regulates CD4+ T Cell Immune Responses through Metabolic Reprogramming

scientific article

Allosteric Indole Amide Inhibitors of p97: Identification of a Novel Probe of the Ubiquitin Pathway

scientific article published on 22 December 2015

Allosteric Modulation of Phosphatase Activity May Redefine Therapeutic Value

scientific article published on 19 August 2016

Allylic Amines as Key Building Blocks in the Synthesis of (E)-Alkene Peptide Isosteres ⬇️

scientific article published on January 1, 2012

Amelioration of radiation-induced oral cavity mucositis and distant bone marrow suppression in fanconi anemia Fancd2-/- (FVB/N) mice by intraoral GS-nitroxide JP4-039.

scientific article

Amelioration of radiation-induced pulmonary fibrosis by a water-soluble bifunctional sulfoxide radiation mitigator (MMS350).

scientific article published on 14 October 2013

An ESR analysis of the mechanism of pericyclic reactions of bicyclobutane

scientific article

An experimental survey of the transition between two-state and downhill protein folding scenarios

scholarly article

An uncharged oxetanyl sulfoxide as a covalent modifier for improving aqueous solubility

scientific article published on 27 June 2014

Anti-malarial activity of a non-piperidine library of next-generation quinoline methanols

scientific article

Antimyeloma Effects of the Heat Shock Protein 70 Molecular Chaperone Inhibitor MAL3-101

scientific article

Antioxidant Approaches to Management of Ionizing Irradiation Injury

scientific article

Asymmetric total syntheses of tuberostemonine, didehydrotuberostemonine, and 13-epituberostemonine

scientific article published in January 2005

Binding of a small molecule at a protein-protein interface regulates the chaperone activity of hsp70-hsp40.

scientific article

Biological evaluation of newly synthesized quinoline-5,8-quinones as Cdc25B inhibitors

scientific article published on 16 June 2006

Biphenyl C-cyclopropylalkylamides: New scaffolds for targeting estrogen receptor beta

scientific article

Bis-cyclopropane analog of disorazole C1 is a microtubule-destabilizing agent active in ABCB1-overexpressing human colon cancer cells

scientific article published on 19 October 2015

Bridged tetrahydroisoquinolines as selective NADPH oxidase 2 (Nox2) inhibitors

scientific article

Can Radiosensitivity Associated with Defects in DNA Repair be Overcome by Mitochondrial-Targeted Antioxidant Radioprotectors

scientific article

Cdc25B dual-specificity phosphatase inhibitors identified in a high-throughput screen of the NIH compound library

scientific article published in June 2009

Cell-active dual specificity phosphatase inhibitors identified by high-content screening

scientific article published on August 2003

Cell-active dual specificity phosphatase inhibitors identified by high-content screening

scientific article published on January 2005

Cellular analysis of disorazole C and structure-activity relationship of analogs of the natural product

scientific article published in January 2006

Chemical induction of Hsp70 reduces α-synuclein aggregation in neuroglioma cells

scientific article

Chemical methodology as a source of small-molecule checkpoint inhibitors and heat shock protein 70 (Hsp70) modulators

scientific article

Chemical modulation of Kv7 potassium channels

publication published on 14 January 2021

Chemistry and biology of curacin A.

scientific article published on January 2004

Chemistry and biology of wortmannin

scientific article published on 20 April 2005

Chrysophaentins are competitive inhibitors of FtsZ and inhibit Z-ring formation in live bacteria

scientific article published on 25 July 2013

Claisen Rearrangements

Co(II)-salen catalyzed stereoselective cyclopropanation of fluorinated styrenes

scientific article published on 03 November 2019

Combination of a thioxodihydroquinazolinone with cisplatin eliminates ovarian cancer stem cell-like cells (CSC-LCs) and shows preclinical potential

scientific article published on 26 December 2017

Combined chemical-genetic approach identifies cytosolic HSP70 dependence in rhabdomyosarcoma

scientific article

Complete reversal of Lambert-Eaton myasthenic syndrome synaptic impairment by the combined use of a K+ channel blocker and a Ca2+ channel agonist

scientific article

Computational design, synthesis and biological evaluation of para-quinone-based inhibitors for redox regulation of the dual-specificity phosphatase Cdc25B.

scientific article published on 15 July 2008

Condensation reactions of guanidines with bis-electrophiles: Formation of highly nitrogenous heterocycles

scientific article

Contributions of academic laboratories to the discovery and development of chemical biology tools

scientific article

Convergent approach to (E)-alkene and cyclopropane peptide isosteres

scientific article

Cytochrome c/cardiolipin relations in mitochondria: a kiss of death

journal article published in 2009

Deciphering of mitochondrial cardiolipin oxidative signaling in cerebral ischemia-reperfusion

journal article published in 2015

Density functional theory calculation of 13C NMR shifts of diazaphenanthrene alkaloids: reinvestigation of the structure of samoquasine A.

scientific article

Design, Synthesis, and Biological Evaluation of PKD Inhibitors

scientific article

Development and Implementation of a High-Throughput High-Content Screening Assay to Identify Inhibitors of Androgen Receptor Nuclear Localization in Castration-Resistant Prostate Cancer Cells

scientific article

Development and implementation of a 384-well homogeneous fluorescence intensity high-throughput screening assay to identify mitogen-activated protein kinase phosphatase-1 dual-specificity protein phosphatase inhibitors

scientific article

Development of a 384-well colorimetric assay to quantify hydrogen peroxide generated by the redox cycling of compounds in the presence of reducing agents

scientific article published on August 2008

Dihydropyrimidinones and -thiones with improved activity against human polyomavirus family members

scientific article

Dimethylzinc-mediated addition of alkenylzirconocenes to alpha-keto and alpha-imino esters

scientific article published on July 2003

Discovery and Characterization of a Biologically Active Non-ATP-Competitive p38 MAP Kinase Inhibitor

scientific article published on 4 November 2015

Discovery and characterization of novel small molecule inhibitors of human Cdc25B dual specificity phosphatase

scientific article

Discovery and validation of a new class of small molecule Toll-like receptor 4 (TLR4) inhibitors

scientific article (publication date: 2013)

Discovery of diverse small molecule chemotypes with cell-based PKD1 inhibitory activity

scientific article

Diversity-Oriented Synthesis of a Library of Substituted Tetrahydropyrones Using Oxidative Carbon-Hydrogen Bond Activation and Click Chemistry ⬇️

scientific article published on May 2, 2011

Diversity-oriented synthesis of azaspirocycles

scientific article

Dual specificity protein phosphatases: therapeutic targets for cancer and Alzheimer's disease

scientific article

Dual-specificity phosphatases as targets for antineoplastic agents

scientific article

Effectiveness of Analogs of the GS-Nitroxide, JP4-039, as Total Body Irradiation Mitigators

scientific article (publication date: 2 January 2017)

Effects of Ferroptosis on the Metabolome in Cardiac Cells: The Role of Glutaminolysis

scientific article published in 2022

Effects of thoracic irradiation on pulmonary endothelial compared to alveolar type-II cells in fibrosis-prone C57BL/6NTac mice ⬇️

scientific article published on May 1, 2013

Eight-Step Enantioselective Total Synthesis of (-)-Cycloclavine

scientific article published on 18 November 2016

Elucidating Mitochondrial Electron Transport Chain Supercomplexes in the Heart During Ischemia-Reperfusion

scientific article published on 11 November 2016

Endo entry to the nortricyclyl-norbornenyl cation system: stereochemistry in the fragmentation of endo-5-norbornenyl-2-oxychlorocarbene

scientific article

Evaluating beta-turn mimics as beta-sheet folding nucleators

scientific article

Evaluation of Different Formulations and Routes for the Delivery of the Ionizing Radiation Mitigator GS-Nitroxide (JP4-039)

scholarly article published in In Vivo

Evaluation of a Novel Calcium Channel Agonist for Therapeutic Potential in Lambert-Eaton Myasthenic Syndrome ⬇️

scientific article published on June 19, 2013

Evaluation of potential ionizing irradiation protectors and mitigators using clonogenic survival of human umbilical cord blood hematopoietic progenitor cells

scientific article

Fluorous parallel synthesis of a piperazinedione-fused tricyclic compound library

scientific article

Formal Alder-ene reaction of a bicyclo[1.1.0]butane in the synthesis of the tricyclic quaternary ammonium core of daphniglaucins

scientific article published on June 2008

Formation of 6-Azaindoles by Intramolecular Diels-Alder Reaction of Oxazoles and Total Synthesis of Marinoquinoline A

scientific article published on 27 February 2020

GS-Nitroxide (JP4-039)-Mediated Radioprotection of Human Fanconi Anemia Cell Lines ⬇️

scientific article published on September 22, 2011

Genetically encoded redox sensor identifies the role of ROS in degenerative and mitochondrial disease pathogenesis ⬇️

scientific article published on August 25, 2011

Grob-Type Fragmentation Releases Paracyclophane Ring Strain in a Late-Stage Precursor of Haouamine A

scientific article published on 19 February 2019

Growth arrest by the antitumor steroidal lactone withaferin A in human breast cancer cells is associated with down-regulation and covalent binding at cysteine 303 of β-tubulin

scientific article published on 02 December 2013

HCS campaign to identify selective inhibitors of IL-6-induced STAT3 pathway activation in head and neck cancer cell lines

scientific article

HPLC determinations of enantiomeric ratios

scientific article published in January 2007

Heat shock protein defenses in the neocortex and allocortex of the telencephalon

scientific article published on 18 February 2015

Heat shock protein responses to aging and proteotoxicity in the olfactory bulb.

scientific article

Hemigramicidin-TEMPO conjugates: novel mitochondria-targeted anti-oxidants

scientific article published on 29 May 2007

Hemigramicidin-TEMPO conjugates: novel mitochondria-targeted antioxidants

scientific article published on September 2007

Homoallylic amines by reductive inter- and intramolecular coupling of allenes and nitriles ⬇️

scientific article published on June 17, 2011

Identification of a potent and selective pharmacophore for Cdc25 dual specificity phosphatase inhibitors

scientific article published in April 2002

Identification of potent chemotypes targeting Leishmania major using a high-throughput, low-stringency, computationally enhanced, small molecule screen

scientific article

Identifying a resistance determinant for the antimitotic natural products disorazole C1 and A1.

scientific article

Improved Total-Body Irradiation Survival by Delivery of Two Radiation Mitigators that Target Distinct Cell Death Pathways

scientific article published on 15 November 2017

In vitro cytotoxicity, pharmacokinetics, tissue distribution, and metabolism of small-molecule protein kinase D inhibitors, kb-NB142-70 and kb-NB165-09, in mice bearing human cancer xenografts

scientific article

Independent mechanistic inhibition of cdc25 phosphatases by a natural product caulibugulone

scientific article published on 3 October 2006

Indole synthesis by palladium-catalyzed tandem allylic isomerization - furan Diels-Alder reaction

scientific article published on 16 August 2017

Induction of TGF-β by Irradiation or Chemotherapy in Fanconi Anemia (FA) Mouse Bone Marrow Is Modulated by Small Molecule Radiation Mitigators JP4-039 and MMS350.

scientific article

Inhibition of Simian Virus 40 replication by targeting the molecular chaperone function and ATPase activity of T antigen

scientific article published on 04 February 2009

Inhibition of metalloprotease botulinum serotype A from a pseudo-peptide binding mode to a small molecule that is active in primary neurons

scientific article published on 8 November 2006

Intraoral Mitochondrial-Targeted GS-Nitroxide, JP4-039, Radioprotects Normal Tissue in Tumor-Bearing Radiosensitive Fancd2(-/-) (C57BL/6) Mice

scientific article published on 20 January 2016

Investigational inhibitors of PTP4A3 phosphatase as antineoplastic agents

scientific article

Is Cdc25 a druggable target?

scientific article published on December 2008

Isolation, biology and chemistry of the disorazoles: new anti-cancer macrodiolides

scientific article

Iterative Structure-Based Peptide-Like Inhibitor Design against the Botulinum Neurotoxin Serotype A

scientific article

Lambert-Eaton myasthenic syndrome: mouse passive-transfer model illuminates disease pathology and facilitates testing therapeutic leads

scientific article published on 10 November 2017

Large-Scale Asymmetric Synthesis of the Bioprotective Agent JP4-039 and Analogs ⬇️

scientific article published on March 31, 2011

Linear and Nonlinear Support Vector Machine for the Classification of Human 5-HT1A Ligand Functionality

scientific article

Lipidomics Characterization of Biosynthetic and Remodeling Pathways of Cardiolipins in Genetically and Nutritionally Manipulated Yeast Cells

scientific article published on 16 December 2016

Lipidomics identifies cardiolipin oxidation as a mitochondrial target for redox therapy of brain injury

journal article published in 2012

Lipophilicity screening of novel drug-like compounds and comparison to clogP ⬇️

scientific article published on October 5, 2012

Liquid chromatography-tandem mass spectrometric assay for the quantitation of the novel radiation protective agent and radiation mitigator JP4-039 in murine plasma

scientific article published on 12 December 2017

Mechanism of action of selective inhibitors of IL-6 induced STAT3 pathway in head and neck cancer cell lines

scientific article

Metal Complexes of Marine Peptide Metabolites: A Novel Ag4 Cluster

scholarly article by Peter Wipf et al published 2 August 1994 in Angewandte Chemie International Edition

Metamorphic enzyme assembly in polyketide diversification

scientific article

Metathesis reactions of pyrazolotriazinones generate dynamic combinatorial libraries

scientific article published in September 2005

Microbial and chemical transformation studies of the bioactive marine sesquiterpenes (S)-(+)-curcuphenol and -curcudiol isolated from a deep reef collection of the Jamaican sponge Didiscus oxeata

scientific article

Microtubule binding and disruption and induction of premature senescence by disorazole C(1).

scientific article published on 09 December 2008

Microwave assisted tandem reactions for the synthesis of 2-hydrazolyl-4-thiazolidinones

scientific article published on February 2009

Microwave-assisted "libraries from libraries" approach toward the synthesis of allyl- and C-cyclopropylalkylamides

scientific article

Mitochondria as a target in treatment

scientific article

Mitochondria-targeted antioxidant preserves contractile properties and mitochondrial function of skeletal muscle in aged rats

scientific article

Mitochondria-targeted disruptors and inhibitors of cytochrome c/cardiolipin peroxidase complexes: a new strategy in anti-apoptotic drug discovery

journal article published in 2009

Mitochondrial targeted β-lapachone induces mitochondrial dysfunction and catastrophic vacuolization in cancer cells

scientific article

Mitochondrial targeting of XJB-5-131 attenuates or improves pathophysiology in HdhQ150 animals with well-developed disease phenotypes

scientific article

Mitochondrial targeting of electron scavenging antioxidants: regulation of selective oxidation vs random chain reactions

journal article published in 2009

Mitochondrial targeting of radioprotectants using peptidyl conjugates

scientific article published on 7 December 2006

Mitochondrial targeting of selective electron scavengers: synthesis and biological analysis of hemigramicidin-TEMPO conjugates

scientific article

Mitotic slippage in non-cancer cells induced by a microtubule disruptor, disorazole C1.

scientific article

Molecular pharmacology and antitumor activity of PX-866, a novel inhibitor of phosphoinositide-3-kinase signaling

scientific journal article

Molecular pharmacology and antitumor activity of palmarumycin-based inhibitors of thioredoxin reductase

scientific article

Mutations in the phosphatidylinositol-3-kinase pathway predict for antitumor activity of the inhibitor PX-866 whereas oncogenic Ras is a dominant predictor for resistance

scientific article published on January 2009

N-Acetyl-l-Cysteine Protects Astrocytes against Proteotoxicity without Recourse to Glutathione

scientific article published on 22 August 2017

NAD(P)H:quinone oxidoreductase-1-dependent and -independent cytotoxicity of potent quinone Cdc25 phosphatase inhibitors

scientific article published on 12 January 2004

Nanoassembly of Surfactants with Interfacial Drug-Interactive Motifs as Tailor-Designed Drug Carriers ⬇️

scientific article published on December 17, 2012

Nanoparticles in cellular drug delivery

scientific article published on 26 February 2009

Natural Product Chemistry and Cancer Drug Discovery

Natural product based inhibitors of the thioredoxin-thioredoxin reductase system

scientific article published on 11 May 2004

New Cav2 calcium channel gating modifiers with agonist activity and therapeutic potential to treat neuromuscular disease

scientific article published on 12 December 2017

New opportunities for pregnane X receptor (PXR) targeting in drug development. lessons from Enantio- and species-specific PXR ligands identified from a discovery library of amino acid analogues

scientific article

New pyrazolopyrimidine inhibitors of protein kinase d as potent anticancer agents for prostate cancer cells

scientific article

Next-Generation Cell-Active Inhibitors of the Undrugged Oncogenic PTP4A3 Phosphatase

scientific article published on 10 October 2019

Novel applications of alkenyl zirconocenes

scientific article published on April 2002

Novel benzofuran inhibitors of human mitogen-activated protein kinase phosphatase-1.

scientific article

Novel protein kinase D inhibitors cause potent arrest in prostate cancer cell growth and motility

scientific article published on 5 May 2010

Optical Rotation of Noncovalent Aggregates [J. Am. Chem. Soc.2003,125, 15696−15697].

scientific article published in 2004

Optical rotation of noncovalent aggregates

scientific article published in December 2003

Optical signatures of molecular dissymmetry: combining theory with experiments to address stereochemical puzzles

scientific article

Optimization of Phenyl Indole Inhibitors of the AAA+ ATPase p97

Optimization of pyrazole-containing 1,2,4-triazolo-[3,4-b]thiadiazines, a new class of STAT3 pathway inhibitors

scientific article

Oxidative lipidomics of hyperoxic acute lung injury: mass spectrometric characterization of cardiolipin and phosphatidylserine peroxidation

scientific article

Parallel synthesis of oxazolines and thiazolines by tandem condensation-cyclodehydration of carboxylic acids with amino alcohols and aminothiols

scientific article

Peptide-Like Molecules (PLMs): A Journey from Peptide Bond Isosteres to Gramicidin S Mimetics and Mitochondrial Targeting Agents

scientific article

Peroxisome proliferator-activated receptor gamma agonist pioglitazone prevents the hyperglycemia caused by phosphatidylinositol 3-kinase pathway inhibition by PX-866 without affecting antitumor activity

scientific article published on January 2009

Pharmacologic profiling of phosphoinositide 3-kinase inhibitors as mitigators of ionizing radiation-induced cell death

scientific article

Pharmacological Mitigation of Tissue Damage during Brain Microdialysis ⬇️

scientific article published on August 20, 2013

Pharmacology and antitumor activity of a quinolinedione Cdc25 phosphatase inhibitor DA3003-1 (NSC 663284).

scientific article published on September 2007

Pharmacophore Refinement Guides the Rational Design of Nanomolar-Range Inhibitors of the Botulinum Neurotoxin Serotype A Metalloprotease

scientific article

Phosphatases as targets for cancer treatment.

scientific article published on December 2009

Photoactivated Tungsten Hexacarbonyl-Catalyzed Conversion of Alkynols to Glycals ⬇️

scientific article published on November 14, 2003

Photooxygenation of an amino-thienopyridone yields a more potent PTP4A3 inhibitor

scientific article

Plasmodium falciparum encodes a single cytosolic type I Hsp40 that functionally interacts with Hsp70 and is upregulated by heat shock ⬇️

scientific article (publication date: July 2011)

Polyketide decarboxylative chain termination preceded by o-sulfonation in curacin a biosynthesis

scientific article published on November 2009

Post-translational import of protein into the endoplasmic reticulum of a trypanosome: an in vitro system for discovery of anti-trypanosomal chemical entities

scientific article published on April 2009

Potent and selective disruption of protein kinase D functionality by a benzoxoloazepinolone

scientific article

Profiling the NIH Small Molecule Repository for compounds that generate H2O2 by redox cycling in reducing environments

scientific article

Protein kinase D as a potential new target for cancer therapy

scientific article

Protein kinase d as a potential chemotherapeutic target for colorectal cancer

scientific article

Pyrimidinone-peptoid hybrid molecules with distinct effects on molecular chaperone function and cell proliferation

scientific article published on 14 December 2007

Radiologic differences between bone marrow stromal and hematopoietic progenitor cell lines from Fanconi Anemia (Fancd2(-/-)) mice

scientific article published on 07 January 2014

Redox regulation of Cdc25B by cell-active quinolinediones

scientific article

Regioselective Palladium-Catalyzed Cross-Coupling Reactions of 2,4,7-Trichloroquinazoline ⬇️

scientific article published on March 1, 2010

Residue Preference Mapping of Ligand Fragments in the Protein Data Bank ⬇️

scientific article published on March 18, 2011

Reversible thiazolidine exchange: a new reaction suitable for dynamic combinatorial chemistry

scientific article

Rhodium(I)-catalyzed cycloisomerizations of bicyclobutanes

scientific article published on 8 May 2008

Ring-strain-enabled reaction discovery: new heterocycles from bicyclo[1.1.0]butanes

scientific article published on 16 March 2015

SD-208, a novel protein kinase D inhibitor, blocks prostate cancer cell proliferation and tumor growth in vivo by inducing G2/M cell cycle arrest

scientific article

Screening of antimicrobial agents for in vitro radiation protection and mitigation capacity, including those used in supportive care regimens for bone marrow transplant recipients.

scientific article

Select pyrimidinones inhibit the propagation of the malarial parasite, Plasmodium falciparum

scientific article published on 20 January 2009

Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer

scientific article

Silver(I)-catalyzed addition of zirconocenes to glycal epoxides. A new synthesis of alpha-C-glycosides

scientific article published in February 2005

Small Molecule Antagonists of the Nuclear Androgen Receptor for the Treatment of Castration-Resistant Prostate Cancer

scientific article published on 27 May 2016

Small Molecule Regulation of Phosphatase-Dependent Cell Signaling Pathways ⬇️

scientific article published on January 1, 2003

Small molecule modulators of endogenous and co-chaperone-stimulated Hsp70 ATPase activity.

scientific article

Small molecule targeting of PTPs in cancer

scientific article published on 21 September 2017

Specific RITA Modification Produces Hyperselective Cytotoxicity While Maintaining In Vivo Antitumor Efficacy

scientific article published on 24 July 2019

Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging.

scientific article published on 13 April 2018

Stereochemical control in the ester enolate Claisen rearrangement. 1. Stereoselectivity in silyl ketene acetal formation

article

Stochastic voyages into uncharted chemical space produce a representative library of all possible drug-like compounds

scientific article

Strategies for discovery of small molecule radiation protectors and radiation mitigators

scientific article

Structural Basis of Functional Group Activation by Sulfotransferases in Complex Metabolic Pathways ⬇️

scientific article published on September 26, 2012

Structural Basis of Polyketide Synthase O-Methylation

scientific article published on 03 December 2018

Structural requirements for optimized delivery, inhibition of oxidative stress, and antiapoptotic activity of targeted nitroxides

scientific article published on 19 December 2006

Structure-Activity Study of Bioisosteric Trifluoromethyl and Pentafluorosulfanyl Indole Inhibitors of the AAA ATPase p97.

scientific article

Structure-activity and high-content imaging analyses of novel tubulysins

scientific article published on August 2007

Structure-activity relationships amongst 4-position quinoline methanol antimalarials that inhibit the growth of drug sensitive and resistant strains of Plasmodium falciparum

scientific article

Structure-activity relationships of 4-position diamine quinoline methanols as intermittent preventative treatment (IPT) against Plasmodium falciparum

scientific article

Structure-based virtual screening identifies small molecule inhibitor of the profilin1-actin interaction

scientific article published on 27 December 2017

Studies toward a library of tetrahydrofurans: click and MCR products of mono- and bis-tetrahydrofurans

scientific article

Synaptic Pathophysiology and Treatment of Lambert-Eaton Myasthenic Syndrome

scientific article

Synthesis and Evaluation of Potent KCNQ2/3-Specific Channel Activators

scientific article published on 22 March 2016

Synthesis and Ring-Chain-Ring Tautomerism of Bisoxazolidines, Thiazolidinyloxazolidines, and Spirothiazolidines ⬇️

scientific article published on June 14, 2011

Synthesis and Structure-Activity Relationships of Benzothienothiazepinone Inhibitors of Protein Kinase D

scientific article

Synthesis and biological activity of a focused library of mitogen-activated protein kinase phosphatase inhibitors

scientific article published in January 2007

Synthesis and biological activity of prodrug inhibitors of the thioredoxin-thioredoxin reductase system

scientific article published on 28 September 2005

Synthesis and biological evaluation of 3-aminoisoquinolin-1(2H)-one based inhibitors of the dual-specificity phosphatase Cdc25B.

scientific article

Synthesis and biological evaluation of a selective N- and p/q-type calcium channel agonist

scientific article

Synthesis and biological evaluation of caulibugulones A-E.

scientific article

Synthesis and biological evaluation of structurally highly modified analogues of the antimitotic natural product curacin A.

scientific article published in April 2002

Synthesis and biological evaluation of synthetic viridins derived from C(20)-heteroalkylation of the steroidal PI-3-kinase inhibitor wortmannin

scientific article published on 14 June 2004

Synthesis and biological evaluation of the first pentafluorosulfanyl analogs of mefloquine

scientific article published on 7 August 2009

Synthesis and chemical diversity analysis of bicyclo[3.3.1]non-3-en-2-ones

scientific article

Synthesis and hetero-Michael addition reactions of 2-alkynyl oxazoles and oxazolines

scientific article published on 25 November 2004

Synthesis and structure–activity relationships of small molecule inhibitors of the simian virus 40 T antigen oncoprotein, an anti-polyomaviral target

scientific article

Synthesis of (+/-)-thiohalenaquinone by iterative metalations of thiophene

scientific article

Synthesis of 1,2,4-triazines and the triazinoisoquinolinedione DEF ring system of noelaquinone ⬇️

scientific article published on April 4, 2012

Synthesis of Functionalized Isoindolinones: Addition of In Situ Generated Organoalanes to Acyliminium Ions

scientific article published on October 2007

Synthesis of a library of tricyclic azepinoisoindolinones ⬇️

scientific article published on July 13, 2012

Synthesis of analogs of the radiation mitigator JP4-039 and visualization of BODIPY derivatives in mitochondria ⬇️

scientific article published on July 7, 2013

Synthesis of anti-inflammatory α-and β-linked acetamidopyranosides as inhibitors of toll-like receptor 4 (TLR4).

scientific article published on June 2015

Synthesis of heterocyclic triads by Pd-catalyzed cross-couplings and evaluation of their cell-specific toxicity profile

scientific article published on 18 March 2014

Synthesis of hydroxylated bicyclic amino acids from L-tyrosine: octahydro-1H-indole carboxylates

scientific article

Synthesis of pyrrolo[1,3]diazepines by a dipolar cycloaddition - retro-Mannich domino reaction

scientific article published on December 2009

Synthesis of the 3-Aza-[7]-paracyclophane Core of Haouamine A and B

scientific article published in 2006

TargetHunter: An In Silico Target Identification Tool for Predicting Therapeutic Potential of Small Organic Molecules Based on Chemogenomic Database ⬇️

scientific article published on January 5, 2013

Targeting Mitochondrial Oxidative Stress to Mitigate UV-Induced Skin Damage

scholarly article by Rhonda M Brand et al published 2018 in Frontiers in Pharmacology

Targeting mitochondria

scientific article published on January 2008

Targeting of XJB-5-131 to Mitochondria Suppresses Oxidative DNA Damage and Motor Decline in a Mouse Model of Huntington’s Disease ⬇️

scientific article published on November 29, 2012

Targeting ovarian cancer and endothelium with an allosteric PTP4A3 phosphatase inhibitor

scientific article published on 30 December 2017

Terminal Alkene Formation by the Thioesterase of Curacin A Biosynthesis: STRUCTURE OF A DECARBOXYLATING THIOESTERASE

scientific article

The GS-nitroxide JP4-039 improves intestinal barrier and stem cell recovery in irradiated mice

scientific article published in February 2018

The antisignaling agent SC-alpha alpha delta 9, 4-(benzyl-(2-[(2,5-diphenyloxazole-4-carbonyl)amino]ethyl)carbamoyl)- 2-decanoylaminobutyric acid, is a structurally unique phospholipid analogue with phospholipase C inhibitory activity.

scientific article published in September 2002

The chiroptical signature of achiral metal clusters induced by dissymmetric adsorbates

scientific article published on 17 November 2005

The combination of thioxodihydroquinazolinones and platinum drugs reverses platinum resistance in tumor cells by inducing mitochondrial apoptosis independent of Bax and Bak

scientific article published on 30 December 2014

The cytotoxic effects of regorafenib in combination with protein kinase D inhibition in human colorectal cancer cells

scientific article published on March 2015

The phosphatidylinositol-3-kinase inhibitor PX-866 overcomes resistance to the epidermal growth factor receptor inhibitor gefitinib in A-549 human non-small cell lung cancer xenografts

scientific article

Three-dimensional database mining identifies a unique chemotype that unites structurally diverse botulinum neurotoxin serotype A inhibitors in a three-zone pharmacophore.

scientific article published in December 2008

Titanocene(III)-catalyzed formation of indolines and azaindolines

scientific article published on 10 September 2008

Total Synthesis and Biological Evaluation of Tubulysin Analogues

scientific article published on 22 July 2016

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