Search filters

List of works by Ian Orme

4 Specific Models

A Toll-Like Receptor-2-Directed Fusion Protein Vaccine against Tuberculosis.

scientific article

A Toll-like receptor-2-directed fusion protein vaccine against tuberculosis

scientific article published on July 2007

A bone marrow-derived murine macrophage model for evaluating efficacy of antimycobacterial drugs under relevant physiological conditions

scientific article

A defined tuberculosis vaccine candidate boosts BCG and protects against multidrug-resistant Mycobacterium tuberculosis

scientific article

A limited antigen-specific cellular response is sufficient for the early control of Mycobacterium tuberculosis in the lung but is insufficient for long-term survival

scientific article

A mouse model of tuberculosis reinfection

scientific article published on 17 March 2012

A mutant of Mycobacterium tuberculosis lacking the 19-kDa lipoprotein Rv3763 is highly attenuated in vivo but retains potent vaccinogenic properties

scientific article published on 13 August 2007

A new antibiotic with potent activity targets MscL.

scientific article published on 4 February 2015

A new unifying theory of the pathogenesis of tuberculosis

scientific article published on 4 August 2013

A novel nonclassic beta2-microglobulin-restricted mechanism influencing early lymphocyte accumulation and subsequent resistance to tuberculosis in the lung

scientific article published in August 2000

A recombinant Mycobacterium smegmatis induces potent bactericidal immunity against Mycobacterium tuberculosis

scientific article published on 4 September 2011

Acquired immunity to heavy infection with Mycobacterium bovis bacillus Calmette-Guérin and its relationship to the development of nonspecific unresponsiveness in vitro

scientific article published on 01 October 1984

Activities of TMC207, rifampin, and pyrazinamide against Mycobacterium tuberculosis infection in guinea pigs

scientific article

Activities of rifabutin, clarithromycin, and ethambutol against two virulent strains of Mycobacterium avium in a mouse model

scientific article

Adaptive immunity to mycobacteria

scientific article published on February 2004

Adequate Expression of Protective Immunity in the Absence of Granuloma Formation inMycobacterium tuberculosis-Infected Mice with a Disruption in the Intracellular Adhesion Molecule 1 Gene ⬇️

scientific article published on April 1, 1998

Adoptive protection of the Mycobacterium tuberculosis-infected lung. Dissociation between cells that passively transfer protective immunity and those that transfer delayed-type hypersensitivity to tuberculin

scientific article published on 01 March 1984

Aerogenic vaccination of mice with Mycobacterium bovis BCG

scientific article published on 01 June 1986

An anti-inflammatory role for gamma delta T lymphocytes in acquired immunity to Mycobacterium tuberculosis

scientific article published in February 1997

Animal Models of Mycobacteria Infection

scientific article published on 01 August 2011

Animal Models of Tuberculosis: An Overview

scientific article

Animal and cell-culture models for the study of mycobacterial infections and treatment ⬇️

scientific article published on November 1, 1994

Animal model of Mycobacterium abscessus lung infection

scientific article

Animal models of M. tuberculosis Infection

scientific article published on 01 November 2007

Animal models of mycobacteria infection

scientific article

BCG-Prime and boost with Esx-5 secretion system deletion mutant leads to better protection against clinical strains of Mycobacterium tuberculosis

scientific article published on 22 September 2020

BCG: myths, realities, and the need for alternative vaccine strategies

scientific article published on 18 February 2012

Beijing sublineages of Mycobacterium tuberculosis differ in pathogenicity in the guinea pig.

scientific article

Biology of clinical strains of Mycobacterium tuberculosis with varying levels of transmission

scientific article published on 9 February 2018

Boosting vaccine for tuberculosis

scientific article

CD4 is required for the development of a protective granulomatous response to pulmonary tuberculosis

scientific article published in March 2002

CD8- and CD95/95L-dependent mechanisms of resistance in mice with chronic pulmonary tuberculosis

scientific article published in February 2001

CD95 Expression in Aged Mice Infected with Tuberculosis ⬇️

scientific article published on October 1, 1998

CD95 signaling is not required for the down regulation of cellular responses to systemic Mycobacterium tuberculosis infection

scientific article published in January 2000

Capacity of Mycobacterium avium isolates to grow well or poorly in murine macrophages resides in their ability to induce secretion of tumor necrosis factor ⬇️

scientific article published on October 1, 1992

Changes in integrin/adhesion molecule expression, but not in the T-cell receptor repertoire, in old mice infected with tuberculosis

scientific article published in September 1998

Characteristics of protective immunity engendered by vaccination of mice with purified culture filtrate protein antigens of Mycobacterium tuberculosis.

scientific article published on July 1995

Characterization of W-Beijing isolates of Mycobacterium tuberculosis from the Western Cape.

scientific article published on 19 October 2013

Characterization of the protective T-cell response generated in CD4-deficient mice by a live attenuated Mycobacterium tuberculosis vaccine

scientific article published on 31 October 2006

Characterization of virulence, colony morphotype and the glycopeptidolipid of Mycobacterium avium strain 104

scientific article published on 01 January 2002

Chemokine response in mice infected with Mycobacterium tuberculosis.

scientific article

Cigarette smoke increases susceptibility to tuberculosis--evidence from in vivo and in vitro models

scientific article published on 28 February 2011

Clinical strains of Mycobacterium tuberculosis display a wide range of virulence in guinea pigs

scientific article

Comparative studies evaluating mouse models used for efficacy testing of experimental drugs against Mycobacterium tuberculosis

scientific article

Comparison of activities of fluoroquinolones in murine macrophages infected with Mycobacterium tuberculosis

scientific article

Comprehensive analysis of methods used for the evaluation of compounds against Mycobacterium tuberculosis

scientific article published on 30 August 2012

Correction: Mycobacterium tuberculosis Universal Stress Protein Rv2623 Regulates Bacillary Growth by ATP-Binding: Requirement for Establishing Chronic Persistent Infection

scientific article published on 16 September 2009

Cough-generated aerosols of Mycobacterium tuberculosis: a new method to study infectiousness

scientific article published on 4 December 2003

Crossprotection against nontuberculous mycobacterial infections by Mycobacterium tuberculosis memory immune T lymphocytes

scientific article published on January 1986

Cu,Zn superoxide dismutase of Mycobacterium tuberculosis contributes to survival in activated macrophages that are generating an oxidative burst

scientific journal article

Current progress in tuberculosis vaccine development

scientific article

Cytokine secretion by CD4 T lymphocytes acquired in response to Mycobacterium tuberculosis infection

scientific article published on 01 July 1993

Cytokine/chemokine cascades in immunity to tuberculosis

scientific article

DNA vaccines against tuberculosis

scientific article published on 01 January 1998

Decreased survival of guinea pigs infected with Mycobacterium tuberculosis after multiple BCG vaccinations

scientific article published on 24 August 2005

Defined tuberculosis vaccine, Mtb72F/AS02A, evidence of protection in cynomolgus monkeys

scholarly article

Demonstration of acquired resistance in Bcgr inbred mouse strains infected with a low dose of BCG montreal.

scientific article published on April 1984

Development of New Vaccines and Drugs For TB: Limitations and Potential Strategic Errors ⬇️

scientific article published on February 1, 2011

Differential Mycobacterium bovis BCG vaccine-derived efficacy in C3Heb/FeJ and C3H/HeOuJ mice exposed to a clinical strain of Mycobacterium tuberculosis

scientific article

Differential immune responses and protective efficacy induced by components of a tuberculosis polyprotein vaccine, Mtb72F, delivered as naked DNA or recombinant protein

scientific article published in June 2004

Differential polarization of alveolar macrophages and bone marrow-derived monocytes following chemically and pathogen-induced chronic lung inflammation.

scientific article

Disruption of granulocyte macrophage-colony stimulating factor production in the lungs severely affects the ability of mice to control Mycobacterium tuberculosis infection

article

Disruption of the Cellular Inflammatory Response to Listeria monocytogenes Infection in Mice with Disruptions in Targeted Genes ⬇️

scientific article published on May 1, 1998

Disseminated disease severity as a measure of virulence of Mycobacterium tuberculosis in the guinea pig model

scientific article published on 05 March 2008

Disseminated tuberculosis in interferon gamma gene-disrupted mice

scientific article (publication date: December 1993)

Dissemination of enteric Mycobacterium avium infections in mice rendered immunodeficient by thymectomy and CD4 depletion or by prior infection with murine AIDS retroviruses ⬇️

scientific article published on November 1, 1992

Drug treatment combined with BCG vaccination reduces disease reactivation in guinea pigs infected with Mycobacterium tuberculosis

scientific article published on 11 January 2012

Drug-resistant strains of Mycobacterium tuberculosis exhibit a range of virulence for mice

scientific article

Dynamics of macrophage cell populations during murine pulmonary tuberculosis

scientific article published on 01 September 2003

Effect of bacillus Calmette-Guérin vaccination on CD4+Foxp3+ T cells during acquired immune response to Mycobacterium tuberculosis infection

scientific article published on 20 November 2015

Effect of rifabutin on disseminated Mycobacterium avium infections in thymectomized, CD4 T-cell-deficient mice

scientific article

Effective preexposure tuberculosis vaccines fail to protect when they are given in an immunotherapeutic mode

scientific article

Effector mechanisms involved in cytokine-mediated bacteriostasis of Mycobacterium avium infections in murine macrophages

scientific article published on 01 November 1993

Efficacy of Mycobacterium bovis BCG vaccination in mice undergoing prior pulmonary infection with atypical mycobacteria

scientific article published on April 1984

Enhanced macrophage activity in granulomatous lesions of immune mice challenged with Mycobacterium tuberculosis

scientific article published on 01 April 2006

Enhanced priming of adaptive immunity by a proapoptotic mutant of Mycobacterium tuberculosis

scientific article published in August 2007

Evaluation of Once-Weekly Therapy for Tuberculosis Using Isoniazid plus Rifamycins in the Mouse Aerosol Infection Model ⬇️

scientific article published on November 1, 1998

Evaluation of a 2-pyridone, KRQ-10018, against Mycobacterium tuberculosis in vitro and in vivo

scientific article published on 11 February 2008

Evaluation of new vaccines for tuberculosis in the guinea pig model

scientific article

Evaluation of new vaccines in the mouse and guinea pig model of tuberculosis

scientific article

Evaluation of standard chemotherapy in the guinea pig model of tuberculosis

scientific article

Evidence for Oxidative Stress and Defective Antioxidant Response in Guinea Pigs with Tuberculosis ⬇️

scientific article published on October 18, 2011

Evidence for a Defective Accumulation of Protective T Cells in Old Mice Infected with Mycobacterium tuberculosis ⬇️

scientific article published on 01 March 1993

Evidence for a reduced chemokine response in the lungs of beige mice infected with Mycobacterium avium

scientific article published in April 1997

Evolution of CD4 T-cell subsets following infection of naive and memory immune mice with Mycobacterium tuberculosis

scientific article published on May 1994

Exogenous Re-infection by Multiple Exposures to Mycobacterium tuberculosis Contributes to Subsequent Development of Active Tuberculosis

scholarly article by Diane J. Ordway et al published 1 January 2005 in American Journal of Immunology

Expression of antimicrobial drug tolerance by attached communities of Mycobacterium tuberculosis

scientific article

Expression of memory immunity in the lung following re-exposure to Mycobacterium tuberculosis

scientific article published in January 1997

Expression of the nitric oxide synthase 2 gene is not essential for early control of Mycobacterium tuberculosis in the murine lung

scientific article

Factors associated with severe granulomatous pneumonia in Mycobacterium tuberculosis-infected mice vaccinated therapeutically with hsp65 DNA.

scientific article

Florid pulmonary inflammatory responses in mice vaccinated with Antigen-85 pulsed dendritic cells and challenged by aerosol with Mycobacterium tuberculosis

scientific article published in November 2002

Foamy macrophages within lung granulomas of mice infected with Mycobacterium tuberculosis express molecules characteristic of dendritic cells and antiapoptotic markers of the TNF receptor-associated factor family

scientific article published on 01 September 2005

GI-19007, a Novel Saccharomyces cerevisiae-Based Therapeutic Vaccine against Tuberculosis

scientific article

Gamma interferon production by bovine gamma delta T cells following stimulation with mycobacterial mycolylarabinogalactan peptidoglycan

scientific article

Genetic control of natural resistance to nontuberculous mycobacterial infections in mice

scientific article published on October 1986

Gr1(int)CD11b+ myeloid-derived suppressor cells in Mycobacterium tuberculosis infection

scientific article

Granuloma formation is required to contain bacillus growth and delay mortality in mice chronically infected with Mycobacterium tuberculosis

scientific article published in November 1999

Host immune response to rapidly growing mycobacteria, an emerging cause of chronic lung disease

scientific article published on 15 January 2010

Host response to nontuberculous mycobacterial infections of current clinical importance

scientific article

Human IL-32 expression protects mice against a hypervirulent strain of Mycobacterium tuberculosis

scientific article published on 27 March 2015

Identification of Mycobacterium tuberculosis vaccine candidates using human CD4+ T-cells expression cloning

scientific article

Identification of altered integrin alpha/beta chain expression on T cells from old mice infected with Mycobacterium tuberculosis

scientific article published in July 2002

Identification of novel immunogenic Mycobacterium tuberculosis peptides that stimulate mononuclear cells from immune donors

scientific article published on 01 August 1999

Immune Responses of HIV-1 Tat Transgenic Mice to Mycobacterium Tuberculosis W-Beijing SA161.

scientific article

Immune response to Mycobacterium tuberculosis and identification of molecular markers of disease.

scientific article published on 11 September 2008

Immune response to atypical mycobacteria: immunocompetence of heavily infected mice measured in vivo fails to substantiate immunosuppression data obtained in vitro

scientific article published on January 1984

Immunogenicity and protective efficacy of DNA vaccines encoding secreted and non-secreted forms of Mycobacterium tuberculosis Ag85A.

scientific article

Immunogenicity and protective efficacy of a tuberculosis DNA vaccine

scientific article

Immunological basis for reactivation of tuberculosis in mice

scientific article

Immunopathogenesis of Mycobacterium avium infection ⬇️

scientific article published on 05 August 1998

Immunopathogenesis of pulmonary granulomas in the guinea pig after infection with Mycobacterium tuberculosis

scientific article

Importance of Confirming Data on the In Vivo Efficacy of Novel Antibacterial Drug Regimens against Various Strains of Mycobacterium tuberculosis ⬇️

scientific article published on December 5, 2011

In vitro effects of interleukin-4 on interferon-gamma-induced macrophage activation ⬇️

scientific article published on August 1, 1992

In vivo IL-10 production reactivates chronic pulmonary tuberculosis in C57BL/6 mice.

scientific article published in December 2002

In vivo adaptation of the Wayne model of latent tuberculosis

scientific article published on 5 February 2007

Incorporation of CpG oligodeoxynucleotide fails to enhance the protective efficacy of a subunit vaccine against Mycobacterium tuberculosis

scientific article published in January 2004

Increased Foxp3 expression in guinea pigs infected with W-Beijing strains of M. tuberculosis

scientific article

Increased expression of host iron-binding proteins precedes iron accumulation and calcification of primary lung lesions in experimental tuberculosis in the guinea pig

scientific article

Increased neutrophil influx but no impairment of protective immunity to tuberculosis in mice lacking the CD44 molecule

scientific article

Increased severity of tuberculosis in Guinea pigs with type 2 diabetes: a model of diabetes-tuberculosis comorbidity

scientific article

Induction of a type 1 immune response to a recombinant antigen from Mycobacterium tuberculosis expressed in Mycobacterium vaccae

scientific article published on May 1997

Induction of immunity by DNA vaccination: application to influenza and tuberculosis

scholarly article by J B Ulmer et al published February 1997 in Behring Institute Mitteilungen. Behring institute research communications

Infection with Mycobacterium kansasii and efficacy of vaccination against tuberculosis ⬇️

scientific article published on December 1, 1983

Inflammation and lymphocyte activation during mycobacterial infection in the interferon-gamma-deficient mouse

scientific article published in July 2001

Influence of Mycobacterium bovis BCG vaccination on cellular immune response of guinea pigs challenged with Mycobacterium tuberculosis

scientific article published on 28 May 2008

Influence of increased age on the development of herpes stromal keratitis ⬇️

scientific article published on 01 October 2003

Inhibition of growth Mycobacterium avium in murine and human mononuclear phagocytes by migration inhibitory factor

scientific article published on May 1994

Inhibition of growth of Mycobacterium avium in murine and human mononuclear phagocytes by migration inhibitory factor

scientific article

Interleukin 12 (IL-12) is crucial to the development of protective immunity in mice intravenously infected with mycobacterium tuberculosis

scientific article

Interleukin-10 production by lung macrophages in CBA xid mutant mice infected with Mycobacterium tuberculosis

scientific article published on 01 June 2005

Interleukin-6 induces early gamma interferon production in the infected lung but is not required for generation of specific immunity to Mycobacterium tuberculosis infection

scientific article

Intracellular trafficking in Mycobacterium tuberculosis and Mycobacterium avium-infected macrophages

scientific article published on 01 September 1994

Intrapulmonary delivery of XCL1-targeting small interfering RNA in mice chronically infected with Mycobacterium tuberculosis

scientific article published on 18 December 2008

Kinetics of accumulation of gamma delta receptor-bearing T lymphocytes in mice infected with live mycobacteria ⬇️

scientific article published on November 1, 1991

Lack of IL-10 alters inflammatory and immune responses during pulmonary Mycobacterium tuberculosis infection.

scientific article published on 12 February 2009

Lack of evidence for a reduction in the efficacy of subcutaneous BCG vaccination in mice infected with nontuberculous mycobacteria

scientific article published on 01 March 1986

Lack of protection in mice and necrotizing bronchointerstitial pneumonia with bronchiolitis in guinea pigs immunized with vaccines directed against the hsp60 molecule of Mycobacterium tuberculosis

scientific article

Letter to the editor

scientific article published on 19 September 2014

Local pulmonary immunotherapy with siRNA targeting TGFβ1 enhances antimicrobial capacity in Mycobacterium tuberculosis infected mice

scientific article published on 31 December 2010

Location of persisting mycobacteria in a Guinea pig model of tuberculosis revealed by r207910.

scientific article

Low-dose aerosol infection model for testing drugs for efficacy against Mycobacterium tuberculosis

scientific article

Lymphadenitis as a major element of disease in the guinea pig model of tuberculosis

scientific article published on 10 February 2006

Magnetic resonance imaging of pulmonary lesions in guinea pigs infected with Mycobacterium tuberculosis

scientific article published on October 2004

Memory T cell subsets in tuberculosis: what should we be targeting?

scientific article published on 17 June 2014

Memory T lymphocytes generated by Mycobacterium bovis BCG vaccination reside within a CD4 CD44lo CD62 ligand(hi) population

scientific article

Metabolomic signatures in guinea pigs infected with epidemic-associated W-Beijing strains of Mycobacterium tuberculosis

scientific article published on 30 August 2012

Metronidazole lacks antibacterial activity in guinea pigs infected with Mycobacterium tuberculosis

scientific article published on 11 August 2008

Metronidazole therapy in mice infected with tuberculosis

scientific article (publication date: May 1999)

Mice fed lipid-encapsulated Mycobacterium bovis BCG are protected against aerosol challenge with Mycobacterium tuberculosis

scientific article

Mice lacking bioactive IL-12 can generate protective, antigen-specific cellular responses to mycobacterial infection only if the IL-12 p40 subunit is present

scientific article published in February 2002

Mouse and Guinea Pig Models of Tuberculosis

scientific article

Mouse and guinea pig models for testing new tuberculosis vaccines

scientific article published on 22 January 2005

Mycobacteria lacking the RD1 region do not induce necrosis in the lungs of mice lacking interferon-gamma.

scientific article published in October 2006

Mycobacterium bovis BCG-mediated protection against W-Beijing strains of Mycobacterium tuberculosis is diminished concomitant with the emergence of regulatory T cells

scientific article

Mycobacterium tuberculosis Nucleoside Diphosphate Kinase Inactivates Small GTPases Leading to Evasion of Innate Immunity ⬇️

scientific article published on July 18, 2013

Mycobacterium tuberculosis aerogenic rechallenge infections in B cell-deficient mice

scientific article published in January 1997

Mycobacterium tuberculosis universal stress protein Rv2623 regulates bacillary growth by ATP-Binding: requirement for establishing chronic persistent infection

scientific article

NIH pre-clinical screening program: overview and current status

scientific article

NK cells respond to pulmonary infection with Mycobacterium tuberculosis, but play a minimal role in protection

scientific article published in December 2003

NOS2-derived nitric oxide regulates the size, quantity and quality of granuloma formation in Mycobacterium avium-infected mice without affecting bacterial loads

scientific article published in November 1999

Natural infection of guinea pigs exposed to patients with highly drug-resistant tuberculosis ⬇️

scientific article published on April 7, 2011

Neutrophils play a protective nonphagocytic role in systemic Mycobacterium tuberculosis infection of mice

scientific article

Non-invasive diagnosis of early pulmonary disease in PECAM-deficient mice using infrared pulse oximetry

scientific article published on 28 July 2009

Old mice are able to control low-dose aerogenic infections with Mycobacterium tuberculosis ⬇️

scientific article published on September 1, 1995

Old mice express a transient early resistance to pulmonary tuberculosis that is mediated by CD8 T cells

scientific article

Oral therapy using nanoparticle-encapsulated antituberculosis drugs in guinea pigs infected with Mycobacterium tuberculosis

scientific article

Passive transfer of tuberculin sensitivity from anergic mice

scientific article published on December 1984

Pentoxifylline treatment of mice with chronic pulmonary tuberculosis accelerates the development of destructive pathology

scientific article

Phenotypic definition of effector and memory T-lymphocyte subsets in mice chronically infected with Mycobacterium tuberculosis

scientific article

Pillars Article: The Kinetics of Emergence and Loss of Mediator T Lymphocytes Acquired in Response to Infection with Mycobacterium Tuberculosis. J. Immunol. 1987. 138: 293-298.

scientific article published on August 2017

Post-exposure vaccination against Mycobacterium tuberculosis

scientific article

Potential complications to TB vaccine testing in animal models

scientific article published on June 2009

Preclinical testing of new drugs for tuberculosis: current challenges

scientific article published on 07 January 2008

Preclinical testing of new vaccines for tuberculosis: a comprehensive review

scientific article

Preclinical testing of the nitroimidazopyran PA-824 for activity against Mycobacterium tuberculosis in a series of in vitro and in vivo models

scientific article

Prevalence of serum antibody to the type-specific glycopeptidolipid antigens of Mycobacterium avium in human immunodeficiency virus-positive and -negative individuals

scientific article published on May 1991

Progression of chronic pulmonary tuberculosis in mice aerogenically infected with virulent Mycobacterium tuberculosis ⬇️

scientific article published on January 1, 1997

Prophylactic effect in mice of BCG vaccination against nontuberculous mycobacterial infections

scientific article published on June 1985

Prospects for new vaccines against tuberculosis

scientific article

Protection against Mycobacterium tuberculosis infection by adoptive immunotherapy. Requirement for T cell-deficient recipients

scientific article

Protection of mice and guinea pigs against tuberculosis induced by immunization with a single Mycobacterium tuberculosis recombinant antigen, MTB41

scientific article published on 30 March 2005

Proteomic approaches to antigen discovery

scientific article published in January 2004

Pulmonary lymphatics are primary sites of Mycobacterium tuberculosis infection in guinea pigs infected by aerosol

scientific article

Pulmonary necrosis resulting from DNA vaccination against tuberculosis

scientific article

Rapid accumulation of eosinophils in lung lesions in guinea pigs infected with Mycobacterium tuberculosis.

scientific article

Rapid in vivo screening of experimental drugs for tuberculosis using gamma interferon gene-disrupted mice

scientific article

Rapid microbiologic and pharmacologic evaluation of experimental compounds against Mycobacterium tuberculosis

scientific article

Reduced up-regulation of memory and adhesion/integrin molecules in susceptible mice and poor expression of immunity to pulmonary tuberculosis

scientific article published in October 2002

Relative levels of M-CSF and GM-CSF influence the specific generation of macrophage populations during infection with Mycobacterium tuberculosis

scientific article published on 01 April 2008

Resistance of various strains of mycobacteria to killing by activated macrophages in vivo.

scientific article published on September 1983

Role for matrix metalloproteinase 9 in granuloma formation during pulmonary Mycobacterium tuberculosis infection

scientific article

Role of chemokine ligand 2 in the protective response to early murine pulmonary tuberculosis

scientific article

Role of gamma delta T cells in immunopathology of pulmonary Mycobacterium avium infection in mice

scientific article

Role of gamma interferon and tumor necrosis factor alpha during T-cell-independent and -dependent phases of Mycobacterium avium infection.

scientific article

Role of mononuclear phagocytes in expression of resistance and susceptibility to Mycobacterium avium infections in mice

scientific article published on December 1986

SWR mice are highly susceptible to pulmonary infection with Mycobacterium tuberculosis

scientific article published on September 2003

Safety issues regarding new vaccines for tuberculosis, with an emphasis on post-exposure vaccination

scientific article published on 02 November 2005

Significant increases in the levels of liver enzymes in mice treated with anti-tuberculosis drugs

scientific article published in August 2005

Similar responses by macrophages from young and old mice infected with Mycobacterium tuberculosis

scientific article published on 01 December 1998

Stable T-cell population expressing an effector cell surface phenotype in the lungs of mice chronically infected with Mycobacterium tuberculosis.

scientific article

Statistical limitations to the Cornell model of latent tuberculosis infection for the study of relapse rates

scientific article published on 01 January 2004

Structural basis of capacity of lipoarabinomannan to induce secretion of tumor necrosis factor

scientific article published on March 1992

Sulfolipid deficiency does not affect the virulence of Mycobacterium tuberculosis H37Rv in mice and guinea pigs

scientific article

Susceptibility of a panel of virulent strains of Mycobacterium tuberculosis to reactive nitrogen intermediates

scientific article

T cell response in acquired protective immunity to Mycobacterium tuberculosis infection

scientific article published on 01 March 1991

T lymphocyte surface expression of exhaustion markers as biomarkers of the efficacy of chemotherapy for tuberculosis

scientific article

T lymphocytes mediating protection and cellular cytolysis during the course of Mycobacterium tuberculosis infection. Evidence for different kinetics and recognition of a wide spectrum of protein antigens ⬇️

scientific article published on January 1, 1992

TB vaccine development: after the flood

article

Temporal and spatial arrangement of lymphocytes within lung granulomas induced by aerosol infection with Mycobacterium tuberculosis.

scientific article

Testing of experimental compounds in a relapse model of tuberculosis using granulocyte-macrophage colony-stimulating factor gene-disrupted mice

scientific article published on 13 October 2008

The Achilles heel of BCG.

scientific article published on 24 July 2010

The Efficacy of the BCG Vaccine against Newly Emerging Clinical Strains of Mycobacterium tuberculosis

scientific article published on 14 September 2015

The Intravenous Model of Murine Tuberculosis is Less Pathogenic Than the Aerogenic Model Owing to a More Rapid Induction of Systemic Immunity

article

The balance between protective and pathogenic immune responses in the TB-infected lung

scientific article

The cellular immune response to Mycobacterium tuberculosis infection in the guinea pig.

scientific article published in August 2007

The course of Mycobacterium tuberculosis infection in the lungs of mice lacking expression of either perforin- or granzyme-mediated cytolytic mechanisms

scientific article published on April 1997

The endothelin system has a significant role in the pathogenesis and progression of Mycobacterium tuberculosis infection.

scientific article

The expression of early resistance to an infection with Mycobacterium tuberculosis by old mice is dependent on IFN type II (IFN-gamma) but not IFN type I.

scientific article

The formation of the granuloma in tuberculosis infection

scientific article

The hypervirulent Mycobacterium tuberculosis strain HN878 induces a potent TH1 response followed by rapid down-regulation

scientific article published on 01 July 2007

The onset of adaptive immunity in the mouse model of tuberculosis and the factors that compromise its expression

scientific article

The principal sigma factor sigA mediates enhanced growth of Mycobacterium tuberculosis in vivo

scientific journal article

The progression of chronic tuberculosis in the mouse does not require the participation of B lymphocytes or interleukin-4

scientific article published on 01 March 2001

The protective effect of the Mycobacterium bovis BCG vaccine is increased by coadministration with the Mycobacterium tuberculosis 72-kilodalton fusion polyprotein Mtb72F in M. tuberculosis-infected guinea pigs

scientific article

The role of interleukin-12 in acquired immunity to Mycobacterium tuberculosis infection.

scientific article published in March 1995

The study of Mycobacterium leprae infection in interferon-gamma gene--disrupted mice as a model to explore the immunopathologic spectrum of leprosy

scientific article published in February 2002

The use of animal models to guide rational vaccine design

scientific article

Therapeutic vaccination against relevant high virulence clinical isolates of Mycobacterium tuberculosis

scientific article published on 07 September 2013

Toll-like receptor-induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens

scientific article

Tracking antigen-specific CD8 T lymphocytes in the lungs of mice vaccinated with the Mtb72F polyprotein

scientific article

Transcriptional profiling of TLR-4/7/8-stimulated guinea pig splenocytes and whole blood by bDNA assay ⬇️

scientific article published on August 3, 2011

Transient loss of resistance to pulmonary tuberculosis in p47(phox-/-) mice

scientific journal article

Trying to See the Forest through the Trees: Deciphering the Nature of Memory Immunity to Mycobacterium tuberculosis

scientific article published on 8 March 2018

Tuberculosis in aged gammadelta T cell gene disrupted mice

scientific article published in February 2001

Tuberculosis vaccine types and timings

scientific article

Tuberculosis vaccines: current progress

scientific article published in January 2005

Uptake and Accumulation of Oxidized Low-Density Lipoprotein during Mycobacterium tuberculosis Infection in Guinea Pigs ⬇️

scientific article published on March 30, 2012

Use of specific rRNA oligonucleotide probes for microscopic detection of Mycobacterium tuberculosis in culture and tissue specimens

scientific article

Vaccination of guinea pigs using mce operon mutants of Mycobacterium tuberculosis ⬇️

scientific article published on April 22, 2011

Vaccination of guinea pigs with BCGΔBCG1419c transiently reduces hematogenous spread of M. tuberculosis to the spleen

scientific article published on 01 December 2018

Vaccine Development for Tuberculosis: Current Progress ⬇️

scientific article published on July 1, 2013

Vaccines to prevent tuberculosis infection rather than disease: Physiological and immunological aspects

scientific article

Virulent clinical isolates of Mycobacterium tuberculosis grow rapidly and induce cellular necrosis but minimal apoptosis in murine macrophages.

scientific article

Whole genome response in guinea pigs infected with the high virulence strain Mycobacterium tuberculosis TT372

scientific article

XCL1 (lymphotactin) chemokine produced by activated CD8 T cells during the chronic stage of infection with Mycobacterium tuberculosis negatively affects production of IFN-γ by CD4 T cells and participates in granuloma stability

scientific article published on 15 August 2007

bis-Molybdopterin guanine dinucleotide is required for persistence of Mycobacterium tuberculosis in guinea pigs

scientific article

Paulina is supported by:

About Paulina

Help