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List of works by Leslie Leinwand

A 29 residue region of the sarcomeric myosin rod is necessary for filament formation.

scientific article published in February 1997

A PGC-1α isoform induced by resistance training regulates skeletal muscle hypertrophy

scientific article

A beta1-adrenergic receptor CaM kinase II-dependent pathway mediates cardiac myocyte fetal gene induction.

scientific article published on 24 February 2006

A genetic screen identifies novel non-compatible loxP sites.

scientific article

A murine model for hypertrophic cardiomyopathy

scientific article published on 01 January 1995

A mutation in the beta-myosin rod associated with hypertrophic cardiomyopathy has an unexpected molecular phenotype.

scientific article published on 12 November 2009

A randomized library approach to identifying functional lox site domains for the Cre recombinase.

scientific article

A role for proinflammatory cytokines and fractalkine in analgesia, tolerance, and subsequent pain facilitation induced by chronic intrathecal morphine

scientific journal article

A second term for the editors. Status and goals for the review process

scientific article published on 01 July 1996

A transposon-like element in human DNA

scientific article published in Nature

A truncated cardiac troponin T molecule in transgenic mice suggests multiple cellular mechanisms for familial hypertrophic cardiomyopathy ⬇️

scientific article published on June 15, 1998

Absence of trisomy 15 in chemically induced murine T-cell lymphomas

scientific article published on 01 January 1986

Activation of serum/glucocorticoid-induced kinase 1 (SGK1) is important to maintain skeletal muscle homeostasis and prevent atrophy.

scientific article published on 19 November 2012

Acute effects of desmin mutations on cytoskeletal and cellular integrity in cardiac myocytes

scientific journal article

Adenovirus type 5 and 7 capsid chimera: fiber replacement alters receptor tropism without affecting primary immune neutralization epitopes

scientific article published in April 1996

Advances in cardiovascular gene transfer.

scientific article published on January 1997

Akt and MAPK signaling mediate pregnancy-induced cardiac adaptation.

scientific article

Alterations in gene expression in the rat heart after chronic pathological and physiological loads

scientific article published on 01 January 1994

Anti-inflammatory cytokine gene therapy decreases sensory and motor dysfunction in experimental Multiple Sclerosis: MOG-EAE behavioral and anatomical symptom treatment with cytokine gene therapy.

scientific article published on 20 September 2008

Antibody-mediated autoimmune myocarditis depends on genetically determined target organ sensitivity

scientific article

Assignment of the gene for adenosine kinase to chromosome 14 in <i>Mus musculus</i> by somatic cell hybridization ⬇️

scientific article published on January 1, 1978

Assignment of the gene for dipeptidase 2 to Mus musculus chromosome 18 by somatic cell hybridization

scientific article published on June 1, 1978

Assignment of the gene for glyoxylase I to mouse chromosome 17 by somatic cell genetics

scientific article published on 01 August 1978

Assignment of the gene governing cellular ouabain resistance to Mus musculus chromosome 3 using human/mouse microcell hybrids.

scientific article published on February 1979

Assignment of the genes for triose phosphate isomerase to chromosome 6 and tripeptidase-1 to chromosome 10 in Mus musculus by somatic cell hybridization

scientific journal article

Assignment of the receptor for ecotropic murine leukemia virus to mouse chromosome 5 ⬇️

scientific article published on August 1, 1978

Behavior of genes directly injected into the rat heart in vivo

scientific article published on January 1, 1992

Bioinformatics assessment of beta-myosin mutations reveals myosin's high sensitivity to mutations

scientific article published on May 2008

Blocking cardiac growth in hypertrophic cardiomyopathy induces cardiac dysfunction and decreased survival only in males.

scientific article published on 29 September 2006

COOH-terminal truncated human cardiac MyBP-C alters myosin filament organization

scientific article published on 01 March 2001

Calcineurin activity is required for cardiac remodelling in pregnancy

scientific article published on 28 August 2013

Cancer causes cardiac atrophy and autophagy in a sexually dimorphic manner.

scientific article

Cardiac HDAC6 catalytic activity is induced in response to chronic hypertension

scientific article

Cardiac adaptations to chronic exercise in mice

scientific article published on 01 September 1994

Cardiac and skeletal muscle adaptations to voluntary wheel running in the mouse.

scientific article published in May 2001

Cardiac myosin heavy chains lacking the light chain binding domain cause hypertrophic cardiomyopathy in mice.

scientific article published in June 1999

Cardiomyopathy in transgenic myf5 mice

scientific article published on 01 March 1996

Cell type specific targeted intracellular delivery into muscle of a monoclonal antibody that binds myosin IIb.

scientific article

Cellular and molecular biology of the cardiovascular system

scientific article published on 01 July 1992

Characterization of cell subpopulations expressing progenitor cell markers in porcine cardiac valves.

scientific article

Characterization of diverse forms of myosin heavy chain expressed in adult human skeletal muscle

scientific article

Chromosomal assignment of the mouse kappa light chain genes ⬇️

scientific article published on June 1, 1979

Coexpression and assembly of myosin heavy chain and myosin light chain in Escherichia coli.

scientific article

Comparative sequence analysis of the complete human sarcomeric myosin heavy chain family: implications for functional diversity

scientific article

Competencies: A Cure for Pre-Med Curriculum

scientific article published on 01 November 2011

Complete nucleotide sequence of full length cDNA for rat alpha cardiac myosin heavy chain

scientific article published on September 1989

Controlling neuropathic pain by adeno-associated virus driven production of the anti-inflammatory cytokine, interleukin-10

scientific article

Crosslinked hyaluronan scaffolds as a biologically active carrier for valvular interstitial cells.

scientific article published in May 2005

DNA- and adenovirus-mediated gene transfer into cardiac muscle.

scientific article published on January 1997

Designing scaffolds for valvular interstitial cells: cell adhesion and function on naturally derived materials.

scientific article published in October 2004

Different pathways regulate expression of the skeletal myosin heavy chain genes.

scientific article

Direct gene transfer into the mouse heart

scientific article published on 01 May 1997

Discordance between gene regulation in vitro and in vivo.

scientific article published on January 1992

Distinct Cardiac Transcriptional Profiles Defining Pregnancy and Exercise ⬇️

scientific article published on July 31, 2012

Distinct behavior of cardiac myosin heavy chain gene constructs in vivo. Discordance with in vitro results.

scientific article

Diversity in transcriptional start site selection and alternative splicing affects the 5'-UTR of mouse striated muscle myosin transcripts.

scientific article published on 4 July 2006

Diversity of myosin-based motility: multiple genes and functions

scientific article published on 01 January 1994

Echocardiographic assessment of left ventricular mass and systolic function in mice

scientific article published on 01 May 1995

Effect of aging and hypertension on myosin biochemistry and gene expression in the rat heart ⬇️

scientific article published on March 1, 1991

Effects of Pathogenic Proline Mutations on Myosin Assembly ⬇️

scientific article published on December 6, 2011

Effects of spaceflight on murine skeletal muscle gene expression.

scientific article published on 12 December 2008

Eight years behind the masthead

Erratum to: Identification of functional differences between recombinant human α and β cardiac myosin motors.

scientific article published on December 2012

Estimate of the abundance of cardiomyopathic mutations in the β-myosin gene

scientific article

Estrogenic compounds are not always cardioprotective and can be lethal in males with genetic heart disease

scientific article

Evidence that opioids may have toll-like receptor 4 and MD-2 effects

scientific article

Exercise can prevent and reverse the severity of hypertrophic cardiomyopathy.

scientific article published on 26 January 2006

Expression of cardiac troponin T with COOH-terminal truncation accelerates cross-bridge interaction kinetics in mouse myocardium.

scientific article published on 27 May 2004

Expression of connexin43 in the developing rat heart.

scientific article published in March 1991

Expression of the beta (slow)-isoform of MHC in the adult mouse heart causes dominant-negative functional effects

scientific article published on 01 February 2000

Fast myosin heavy chains expressed in secondary mammalian muscle fibers at the time of their inception.

scientific article published on September 1994

Fatty acids identified in the Burmese python promote beneficial cardiac growth.

scientific article

Fighting fat with muscle: bulking up to slim down.

scientific article published on February 2008

Four sarcomeric myosin heavy chain genes are expressed by human fetal skeletal muscle cells differentiating in culture

scientific article published in January 1992

Frank Ruddle (1929-2013)

scientific article published on June 2013

Full-length rat alpha and beta cardiac myosin heavy chain sequences. Comparisons suggest a molecular basis for functional differences

scientific article published on 01 December 1989

Functional analysis of a cardiac myosin rod in Dictyostelium discoideum

scientific article published on 01 January 1994

Functional analysis of human cardiac gap junction channel mutants

scientific journal article

Functional analysis of myosin missense mutations in familial hypertrophic cardiomyopathy.

scientific article

Functional analysis of myosin mutations that cause familial hypertrophic cardiomyopathy.

scientific article

Future research directions in idiopathic pulmonary fibrosis: summary of a National Heart, Lung, and Blood Institute working group.

scientific article

Gated magnetic resonance imaging of normal and hypertrophied murine hearts

scientific article published on 01 May 1997

Gender and aging in a transgenic mouse model of hypertrophic cardiomyopathy

scientific article published on 01 March 2001

Generation of a full-length human perinatal myosin heavy-chain-encoding cDNA

scientific article

Growth and Muscle Defects in Mice Lacking Adult Myosin Heavy Chain Genes ⬇️

scientific article published on December 1, 1997

Hibernating squirrel muscle activates the endurance exercise pathway despite prolonged immobilization

scientific article published on 16 January 2013

Hope for a broken heart?

scientific article published on September 2003

Human nonmuscle myosin heavy chain mRNA: generation of diversity through alternative polyadenylylation

scientific article

Hydrogels preserve native phenotypes of valvular fibroblasts through an elasticity-regulated PI3K/AKT pathway

scientific article

Hypertrophy, fibrosis, and sudden cardiac death in response to pathological stimuli in mice with mutations in cardiac troponin T.

scientific article published on 4 October 2004

Hypertrophy, pathology, and molecular markers of cardiac pathogenesis.

scientific article published in April 1998

IIb or not IIb? Regulation of myosin heavy chain gene expression in mice and men ⬇️

scientific article published on February 1, 2011

Identification of a cis-acting regulatory element conferring inducibility of the atrial natriuretic factor gene in acute pressure overload.

scientific article published on September 1997

Identification of functional differences between recombinant human α and β cardiac myosin motors

scientific article

Immunogenicity of intrathecal plasmid gene delivery: cytokine release and effects on transgene expression

scientific article published on September 2009

Immunological priming potentiates non-viral anti-inflammatory gene therapy treatment of neuropathic pain.

scientific article published on 02 July 2009

Impaired skeletal muscle regeneration in the absence of fibrosis during hibernation in 13-lined ground squirrels

scientific article

Influence of sex hormones and phytoestrogens on heart disease in men and women

scientific article

Interferon-γ causes cardiac myocyte atrophy via selective degradation of myosin heavy chain in a model of chronic myocarditis

scientific article published on 8 October 2012

Interplay between exonic splicing enhancers, mRNA processing, and mRNA surveillance in the dystrophic Mdx mouse

scientific article

Intracellular calcium and myosin isoform transitions. Calcineurin and calcium-calmodulin kinase pathways regulate preferential activation of the IIa myosin heavy chain promoter

scientific article (publication date: 22 November 2002)

Intrathecal injection of naked plasmid DNA provides long-term expression of secreted proteins

scientific article published on 21 October 2008

Isolation and characterization of human myosin heavy chain genes

scientific article

Loaded wheel running and muscle adaptation in the mouse.

scientific article published on 25 February 2005

Localization of types I, III and IV collagen mRNAs in rat heart cells by in situ hybridization

scientific article published on 01 January 1989

Loss of desmin leads to impaired voluntary wheel running and treadmill exercise performance.

scientific article published on 3 July 2003

Low molecular weight RNAs hydrogen-bonded to nuclear and cytoplasmic poly(A)-terminated RNA from cultured Chinese hamster ovary cells

scientific article published on September 1, 1978

Mapping class I gene sequences in the major histocompatibility complex

scientific article published on 01 July 1982

Measuring microRNA reporter activity in skeletal muscle using hydrodynamic limb vein injection of plasmid DNA combined with in vivo imaging.

scientific article published on August 2013

Mechanisms of the pathogenesis of troponin T-based familial hypertrophic cardiomyopathy.

scientific article

Medicine. Chemically tuned myosin motors.

scientific article published in March 2011

Metabolic crosstalk between the heart and liver impacts familial hypertrophic cardiomyopathy.

scientific article published on 24 February 2014

Modulation of vascular endothelial gene expression by physical training in patients with chronic heart failure

scientific article published on 01 June 2000

Molecular and genetic approaches to studying exercise performance and adaptation.

scientific article

Molecular characterization and functional expression of the human cardiac gap junction channel

scientific article

Molecular consequences of the R453C hypertrophic cardiomyopathy mutation on human β-cardiac myosin motor function

scientific article published on 24 June 2013

Molecular genetic characterization of a developmentally regulated human perinatal myosin heavy chain

scientific article

Morphological and functional alterations in ventricular myocytes from male transgenic mice with hypertrophic cardiomyopathy.

scientific article published on 11 December 2003

Multigene family for sarcomeric myosin heavy chain in mouse and human DNA: localization on a single chromosome

scientific article published on 01 August 1983

Mutations in the beta-myosin rod cause myosin storage myopathy via multiple mechanisms

scientific article

Mutations in the sensitive giant titin result in a broken heart.

scientific article published in July 2012

Myh7b/miR-499 gene expression is transcriptionally regulated by MRFs and Eos

scientific journal article

MyoD, Myf5, and the calcineurin pathway activate the developmental myosin heavy chain genes.

scientific article published on 3 April 2006

Myoblast therapy

scientific article published on 01 August 1992

Myocyte enhancer factor-2 and serum response factor binding elements regulate fast Myosin heavy chain transcription in vivo.

scientific article

Myofibroblasts: molecular crossdressers.

scientific article

Myosin 7b is a regulatory long noncoding RNA (lncMYH7b) in the human heart

scientific article published on 01 January 2021

Myosin Heavy Chains IIa and IId Are Functionally Distinct in the Mouse ⬇️

scientific article published on May 18, 1998

Myosin filament assembly requires a cluster of four positive residues located in the rod domain ⬇️

scientific article published on June 21, 2012

Myosin heavy chain gene expression in human heart failure

scientific article published in November 1997

Myosin heavy chain is not selectively decreased in murine cancer cachexia

scientific article published on 30 August 2011

Myosin motor domains carrying mutations implicated in early or late onset hypertrophic cardiomyopathy have similar properties

scientific article published on 03 October 2019

New mechanistic and therapeutic targets for pediatric heart failure: report from a National Heart, Lung, and Blood Institute working group.

scientific article

Nuclear mechanosensing drives chromatin remodelling in persistently activated fibroblasts

scientific article published on 19 April 2021

Ochre suppressor transfer RNA restored dystrophin expression in mdx mice

scientific article published on 01 January 1997

Ochre suppressor transfer RNA restored dystrophin expression in mdx mice

scientific article published on 01 January 2000

Organization and expression of non-Alu family interspersed repetitive DNA sequences in the mouse genome

scientific article published on 01 March 1984

Organization of human and mouse skeletal myosin heavy chain gene clusters is highly conserved

scientific article

Organization of the human skeletal myosin heavy chain gene cluster ⬇️

scientific article published on December 15, 1992

PEG-Anthracene Hydrogels as an On-Demand Stiffening Matrix To Study Mechanobiology

scientific article published on 11 June 2019

Partnering up for cardiac hypertrophy.

scientific article

Phenotypic and molecular expression of albumin in rat hepatoma X L cell hybrids ⬇️

scientific article published on September 1, 1978

Post-transcriptional regulation of rat alpha cardiac myosin heavy chain gene expression.

scientific article published in February 1994

Potential limitations of transcription terminators used as transgene insulators in adenoviral vectors.

scientific article

Pregnancy as a cardiac stress model

scientific article published on 20 January 2014

Progression from hypertrophic to dilated cardiomyopathy in mice that express a mutant myosin transgene.

scientific article

Prospects for gene therapy with direct injection of polynucleotides.

scientific article published on November 1995

Quantitative determination of adenovirus-mediated gene delivery to rat cardiac myocytes in vitro and in vivo.

scientific article published on December 1993

Rat liver fat-storing cell lines express sarcomeric myosin heavy chain mRNA and protein.

scientific article

Rational promoter selection for gene transfer into cardiac cells.

scientific article published on July 2003

Redirecting valvular myofibroblasts into dormant fibroblasts through light-mediated reduction in substrate modulus.

scientific article

Regulation of Physiological and Metabolic Function of Muscle by Female Sex Steroids ⬇️

scientific article published on September 1, 2012

Regulation of growth and differentiation of a rat hepatoma cell line by the synergistic interactions of hormones and collagenous substrata

scientific article

Remodeling the cardiac transcriptional landscape with diet ⬇️

scientific article published on April 12, 2011

Repetitive nucleotide sequence insertions into a novel calmodulin-related gene and its processed pseudogene.

scientific article

Rescuing cardiac malfunction: the roles of the chaperone-like small heat shock proteins.

scientific article published on December 2008

Restoration of CREB function is linked to completion and stabilization of adaptive cardiac hypertrophy in response to exercise.

scientific article published on 2 March 2007

Right ventricular function and failure: report of a National Heart, Lung, and Blood Institute working group on cellular and molecular mechanisms of right heart failure.

scientific article

Roles of transforming growth factor-β1 and OB-cadherin in porcine cardiac valve myofibroblast differentiation.

scientific article

Sarcomeric Gene Expression and Contractility in Myofibroblasts ⬇️

scientific article published on December 15, 1997

Sarcomeric myosin heavy chain expressed in nonmuscle cells forms thick filaments in the presence of substoichiometric amounts of light chains.

scientific article published on January 1993

Sequence of the complete P protein gene and part of the M protein gene from the histidine transport operon of Escherichia coli compared to that of Salmonella typhimurium.

scientific article

Sequence organization of variant mouse 4.5 S RNA genes and pseudogenes

scientific article published on March 1, 1992

Serum deprivation improves seeding and repopulation of acellular matrices with valvular interstitial cells.

scientific article published in October 2005

Sex is a potent modifier of the cardiovascular system

scientific article

Sex-based cardiac physiology.

scientific article published on January 2009

Skeletal muscle adaptations in response to voluntary wheel running in myosin heavy chain null mice ⬇️

scientific article published on January 1, 2002

Skeletal muscle adaptations to microgravity exposure in the mouse.

scientific article published on 25 July 2003

Skeletal myosin heavy chain function in cultured lung myofibroblasts

scientific article

Small RNA Molecules Related to the Alu Family of Repetitive DNA Sequences ⬇️

scientific article published on November 1, 1982

Soy diet worsens heart disease in mice.

scientific article

Spatial and temporal changes in myosin heavy chain gene expression in skeletal muscle development.

scientific article published in December 1999

Stimulation of in Vitro Translation of Messenger RNA by Actinomycin D and Cordycepin ⬇️

scientific article published on July 22, 1977

Stop codon suppression via inhibition of eRF1 expression.

scientific article published on June 2003

Suppression of eukaryotic translation termination by selected RNAs.

scientific article

Suppressor tRNAs: protocols and applications for cardiac gene transfer.

scientific article published in January 2003

Task Force on Strategic Research Direction: Basic Science Subgroup key science topics report

scientific article published on 01 November 2002

The ATPase cycle of human muscle myosin II isoforms: Adaptation of a single mechanochemical cycle for different physiological roles

scientific article published on 06 August 2019

The Chinese hamster Alu-equivalent sequence: a conserved highly repetitious, interspersed deoxyribonucleic acid sequence in mammals has a structure suggestive of a transposable element.

scientific article published on July 1981

The Ku protein complex interacts with YY1, is up-regulated in human heart failure, and represses alpha myosin heavy-chain gene expression.

scientific article published on October 2004

The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity

scientific article

The effects of biological sex and diet on the development of heart failure.

scientific article published on December 2007

The human connexin gene family of gap junction proteins: distinct chromosomal locations but similar structures.

scientific article

The hypertrophic cardiomyopathy myosin mutation R453C alters ATP binding and hydrolysis of human cardiac β-myosin

scientific article

The impact of developmental stage, route of administration and the immune system on adenovirus-mediated gene transfer

scientific article published on November 1, 1994

The role of Akt/GSK-3beta signaling in familial hypertrophic cardiomyopathy

scientific article published on 21 February 2009

The role of MEKK1 in hypertrophic cardiomyopathy.

scientific article

The superfast human extraocular myosin is kinetically distinct from the fast skeletal IIa, IIb, and IId isoforms.

scientific article

The vertebrate myosin heavy chain: genetics and assembly properties.

scientific article published on February 1997

Three slow myosin heavy chains sequentially expressed in developing mammalian skeletal muscle.

scientific article published on July 1993

Ubiquitous, interspersed repeated sequences in mammalian genomes.

scientific article

Use of integrin-linked kinase to extend function of encapsulated pancreatic tissue.

scientific article

Valvular myofibroblast activation by transforming growth factor-beta: implications for pathological extracellular matrix remodeling in heart valve disease.

scientific article

Whole transcriptome analysis of the fasting and fed Burmese python heart: insights into extreme physiological cardiac adaptation

scientific article

Yin Yang 1 is increased in human heart failure and represses the activity of the human alpha-myosin heavy chain promoter

scientific article published on 16 May 2003

Yin Yang 1 represses alpha-myosin heavy chain gene expression in pathologic cardiac hypertrophy.

scientific article published in January 2005

miR-206 Enforces a Slow Muscle Phenotype

scientific article published on 03 July 2020

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