Search filters

List of works by Joseph Schlessinger

'Tuning' of type I interferon-induced Jak-STAT1 signaling by calcium-dependent kinases in macrophages

scientific article

A critical role for the protein tyrosine phosphatase receptor type Z in functional recovery from demyelinating lesions

scientific article (publication date: November 2002)

A family of phosphodiesterase inhibitors discovered by cocrystallography and scaffold-based drug design

scientific article

A glutamine switch mechanism for nucleotide selectivity by phosphodiesterases

scientific article

A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling

scientific journal article

A point mutation at the ATP-binding site of the EGF-receptor abolishes signal transduction

scientific article published on March 1988

A putative molecular-activation switch in the transmembrane domain of erbB2.

scientific article

A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation

scientific article

A structure-based model for ligand binding and dimerization of EGF receptors

scholarly article

A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1 ⬇️

scientific article published on October 1, 1991

Activation and regulation of the insulin receptor kinase

scientific article

Activation of Pyk2 by stress signals and coupling with JNK signaling pathway

scientific article

Activation of insulin-epidermal growth factor (EGF) receptor chimerae regulates EGF receptor binding affinity

scientific article published on February 1992

Activation of phospholipase C gamma by PI 3-kinase-induced PH domain-mediated membrane targeting.

scientific article published in January 1998

Activation of the JNK pathway is essential for transformation by the Met oncogene

scientific article

Activation of the nonreceptor protein tyrosine kinase Ack by multiple extracellular stimuli

scientific article

Aggregation-induced activation of the epidermal growth factor receptor protein tyrosine kinase

scientific article published on August 1993

Alk and Ltk ligands are essential for iridophore development in zebrafish mediated by the receptor tyrosine kinase Ltk.

scientific article published on 23 October 2017

All autophosphorylation sites of epidermal growth factor (EGF) receptor and HER2/neu are located in their carboxyl-terminal tails. Identification of a novel site in EGF receptor

scientific journal article

All signaling is local?

scientific article published in August 2002

Aryl extensions of thienopyrimidinones as fibroblast growth factor receptor 1 kinase inhibitors ⬇️

scientific article published on April 27, 2011

Asymmetric receptor contact is required for tyrosine autophosphorylation of fibroblast growth factor receptor in living cells

scientific article

Asymmetric tyrosine kinase arrangements in activation or autophosphorylation of receptor tyrosine kinases

scientific article

Augmentor α and β (FAM150) are ligands of the receptor tyrosine kinases ALK and LTK: Hierarchy and specificity of ligand-receptor interactions

scientific article

Autophosphorylation of FGFR1 kinase is mediated by a sequential and precisely ordered reaction

scientific article published in March 2006

Autoregulatory mechanisms in protein-tyrosine kinases

scientific article published on May 1998

BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein

scientific article

Biological activities of EGF-receptor mutants with individually altered autophosphorylation sites

scientific article published on October 1988

Biologically active synthetic fragments of epidermal growth factor: localization of a major receptor-binding region ⬇️

scientific article published on March 1, 1984

Catalytic specificity of protein-tyrosine kinases is critical for selective signalling

scientific article (publication date: 9 February 1995)

Cell signaling by receptor tyrosine kinases

scientific article

Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma

scientific article

Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors ⬇️

scientific article published on September 1, 1990

Common and distinct elements in cellular signaling via EGF and FGF receptors

scientific article published in November 2004

Conformation of an Shc-derived phosphotyrosine-containing peptide complexed with the Grb2 SH2 domain

scientific article published on 01 October 1997

Constitutive activated Cdc42-associated kinase (Ack) phosphorylation at arrested endocytic clathrin-coated pits of cells that lack dynamin

scientific article

Contacts between membrane proximal regions of the PDGF receptor ectodomain are required for receptor activation but not for receptor dimerization

scholarly article

Crk protein binds to PDGF receptor and insulin receptor substrate-1 with different modulating effects on PDGF- and insulin-dependent signaling pathways

scientific journal article

Crystal structure at 2.2 A resolution of the pleckstrin homology domain from human dynamin

scientific article

Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization

scientific article

Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain.

scientific article

Crystal structure of the ARF-GAP domain and ankyrin repeats of PYK2-associated protein beta

scientific article

Crystal structures of free and ligand-bound focal adhesion targeting domain of Pyk2

scientific article

Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity

scientific article

Cytoplasmic domains determine signal specificity, cellular routing characteristics and influence ligand binding of epidermal growth factor and insulin receptors

scientific article published on October 1989

Data publication with the structural biology data grid supports live analysis

scientific article

Defective microtubule-dependent podosome organization in osteoclasts leads to increased bone density in Pyk2(-/-) mice

scientific article

Design of protein-binding proteins from the target structure alone

scientific article published on 24 March 2022

Differential TAM receptor-ligand-phospholipid interactions delimit differential TAM bioactivities

scientific article

Direct contacts between extracellular membrane-proximal domains are required for VEGF receptor activation and cell signaling

scientific article

Discovery of Novel Fibroblast Growth Factor Receptor 1 Kinase Inhibitors by Structure-Based Virtual Screening

scientific article

Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity

scientific article

Distinct cellular properties of oncogenic KIT receptor tyrosine kinase mutants enable alternative courses of cancer cell inhibition

scientific article published on August 2016

Early and multiple origins of metastatic lineages within primary tumors

scientific article published on 8 February 2016

Epidermal growth factor receptor dimerization and activation require ligand-induced conformational changes in the dimer interface

scientific article

Evidence for SH3 domain directed binding and phosphorylation of Sam68 by Src

scientific article (publication date: 19 August 1999)

Evidence for epidermal growth factor (EGF)-induced intermolecular autophosphorylation of the EGF receptors in living cells

scientific article published on August 1990

Exome sequencing identifies recurrent mutations in NF1 and RASopathy genes in sun-exposed melanomas

scientific article published on 27 July 2015

Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma

scientific article

FGF1 and FGF19 reverse diabetes by suppression of the hypothalamic-pituitary-adrenal axis

scientific article published on 28 April 2015

FGF23 contains two distinct high-affinity binding sites enabling bivalent interactions with α-Klotho

scientific article published on 30 November 2020

FGFR3-targeted mAb therapy for bladder cancer and multiple myeloma

scientific article

FRS2 alpha attenuates FGF receptor signaling by Grb2-mediated recruitment of the ubiquitin ligase Cbl.

scientific article

FRS2 family docking proteins with overlapping roles in activation of MAP kinase have distinct spatial-temporal patterns of expression of their transcripts

scientific article

FRS2α regulates Erk levels to control a self-renewal target Hes1 and proliferation of FGF-responsive neural stem/progenitor cells

scientific article

Formation of signal transfer complexes between stem cell and platelet-derived growth factor receptors and SH2 domain proteins in vitro

scientific article

GRB2 and phospholipase C-gamma 1 associate with a 36- to 38-kilodalton phosphotyrosine protein after T-cell receptor stimulation

scientific article

Generation of recombinant cytoplasmic domain of epidermal growth factor receptor with intrinsic protein tyrosine kinase activity

scientific article published on April 1990

Growth factor signaling by receptor tyrosine kinases

scientific article (publication date: September 1992)

Heparin is an activating ligand of the orphan receptor tyrosine kinase ALK.

scientific article

Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferation

scientific article published on 01 December 1994

Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor

scientific article

Identification of a new Pyk2 target protein with Arf-GAP activity

scientific article

Identification of a novel family of targets of PYK2 related to Drosophila retinal degeneration B (rdgB) protein

scientific article

Identification of six novel autophosphorylation sites on fibroblast growth factor receptor 1 and elucidation of their importance in receptor activation and signal transduction

scientific article

Identification of the Binding Site for Acidic Phospholipids on the PH Domain of Dynamin: Implications for Stimulation of GTPase Activity

Impaired HLA Class I Antigen Processing and Presentation as a Mechanism of Acquired Resistance to Immune Checkpoint Inhibitors in Lung Cancer

scientific article published on 12 October 2017

Improved survival of patients with hypermutation in uterine serous carcinoma

scientific article published on 24 January 2015

Independent binding of peptide ligands to the SH2 and SH3 domains of Grb2

scientific article

Induction of urokinase-type plasminogen activator by fibroblast growth factor (FGF)-2 is dependent on expression of FGF receptors and does not require activation of phospholipase Cgamma1

scientific article published in Journal of Biological Chemistry

Inhibition of ErbB3 by a monoclonal antibody that locks the extracellular domain in an inactive configuration

scientific article

Insights into the molecular basis for fibroblast growth factor receptor autoinhibition and ligand-binding promiscuity

scientific article

Insulin and antibodies against insulin receptor cap on the membrane of cultured human lymphocytes

scientific article published in Nature

Insulin-EGF receptor chimerae mediate tyrosine transphosphorylation and serine/threonine phosphorylation of kinase-deficient EGF receptors

scientific article published on 01 May 1991

Intermolecular transphosphorylation between insulin receptors and EGF-insulin receptor chimerae

scientific article

Internalization of fibroblast growth factor receptor is inhibited by a point mutation at tyrosine 766.

scientific article published on June 1994

JAK2 JH2 Fluorescence Polarization Assay and Crystal Structures for Complexes with Three Small Molecules

scientific article published on 17 May 2017

Kinetic parameters of the protein tyrosine kinase activity of EGF-receptor mutants with individually altered autophosphorylation sites

scientific article published on October 1988

Kit receptor dimerization is driven by bivalent binding of stem cell factor

scientific journal article

Lacrimo-auriculo-dento-digital syndrome is caused by reduced activity of the fibroblast growth factor 10 (FGF10)-FGF receptor 2 signaling pathway

scientific article

Landscape of somatic single-nucleotide and copy-number mutations in uterine serous carcinoma

scientific article published on 28 January 2013

Ligand-induced, receptor-mediated dimerization and activation of EGF receptor

scientific journal article

Loss of TRIM33 causes resistance to BET bromodomain inhibitors through MYC- and TGF-β-dependent mechanisms

scientific article published on 18 July 2016

Measurement of the binding of tyrosyl phosphopeptides to SH2 domains: a reappraisal

scientific article

Mechanism for the activation of the anaplastic lymphoma kinase receptor

scientific article published on 24 November 2021

Metabolic effects induced by epidermal growth factor (EGF) in cells expressing EGF receptor mutants

scientific article published on April 1989

Mutational landscape of uterine and ovarian carcinosarcomas implicates histone genes in epithelial-mesenchymal transition

scientific article published on 10 October 2016

Mutations in different components of FGF signaling in LADD syndrome

scientific article

Novel recognition mode between Vav and Grb2 SH3 domains

scientific article

Nuclear magnetic resonance analysis of the conformational state of cancer mutant of fibroblast growth factor receptor 1 tyrosine kinase domain.

scientific article

Nuclear signaling by receptor tyrosine kinases: the first robin of spring

scientific article published on October 2006

On the nature of low- and high-affinity EGF receptors on living cells

scholarly article

PC12 cells overexpressing the insulin receptor undergo insulin-dependent neuronal differentiation

scientific article published on 01 August 1994

PH domains: diverse sequences with a common fold recruit signaling molecules to the cell surface

scientific article published on May 1996

Phosphatidylinositol 3-kinase mediates epidermal growth factor-induced activation of the c-Jun N-terminal kinase signaling pathway.

scientific article published on October 1997

Point mutation at the ATP binding site of EGF receptor abolishes protein-tyrosine kinase activity and alters cellular routing

scientific article published on October 1987

Point mutation in FGF receptor eliminates phosphatidylinositol hydrolysis without affecting mitogenesis

scientific article

Point mutation in the fibroblast growth factor receptor eliminates phosphatidylinositol hydrolysis without affecting neuronal differentiation of PC12 cells

scientific article

Presence of SH2 domains of phospholipase C gamma 1 enhances substrate phosphorylation by increasing the affinity toward the epidermal growth factor receptor ⬇️

scientific article published on May 15, 1992

Proline-rich tyrosine kinase-2 is critical for CD8 T-cell short-lived effector fate

scientific article

Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions

scientific article

Pyk2 Is Required for Neutrophil Degranulation and Host Defense Responses to Bacterial Infection ⬇️

scientific article published on December 27, 2010

Pyk2 is a downstream mediator of the IL-2 receptor-coupled Jak signaling pathway

scientific journal article

RAC1P29S is a spontaneously activating cancer-associated GTPase

scientific article

Receptor protein tyrosine phosphatase gamma is a marker for pyramidal cells and sensory neurons in the nervous system and is not necessary for normal development

scientific article

Receptor tyrosine kinases: legacy of the first two decades

scientific article published on March 2014

Reduced activation of RAF-1 and MAP kinase by a fibroblast growth factor receptor mutant deficient in stimulation of phosphatidylinositol hydrolysis

scientific article published on March 1995

Regression of Chemotherapy-Resistant Polymerase ε (POLE) Ultra-Mutated and MSH6 Hyper-Mutated Endometrial Tumors with Nivolumab

scientific article published on 02 August 2016

Regulation of growth factor activation by proteoglycans: what is the role of the low affinity receptors?

scientific article published on November 1995

Regulation of signal transduction and signal diversity by receptor oligomerization

scientific article published on November 1994

Reminiscences on the "Classic" 1976 FRAP Article in Biophysical Journal

Role of SH2-containing proteins in cellular signaling by receptor tyrosine kinases

scientific article published on January 1, 1992

SH2 and PTB domains in tyrosine kinase signaling

scientific article

SH2 domains prevent tyrosine dephosphorylation of the EGF receptor: identification of Tyr992 as the high-affinity binding site for SH2 domains of phospholipase C gamma

scientific article

SU6668 is a potent antiangiogenic and antitumor agent that induces regression of established tumors.

scientific article published on August 2000

Scaffold association factor B (SAFB) is required for expression of prenyltransferases and RAS membrane association

scientific article published on 30 November 2020

Scanning electron microscopy of cells and tissues under fully hydrated conditions

scholarly article

Scratching the surface with the PH domain.

scientific article

Separate endocytic pathways of kinase-defective and -active EGF receptor mutants expressed in same cells

scientific article published on May 1990

Shc Binding to Nerve Growth Factor Receptor Is Mediated by the Phosphotyrosine Interaction Domain

scientific article published in Journal of Biological Chemistry

Signal Transduction by Epidermal Growth Factor Receptor

scientific article published on 01 January 1988

Signal transduction by receptors with tyrosine kinase activity

scientific article (publication date: 20 April 1990)

Signal transduction by the alpha 6 beta 4 integrin: distinct beta 4 subunit sites mediate recruitment of Shc/Grb2 and association with the cytoskeleton of hemidesmosomes

scientific article

Signal transduction. Autoinhibition control

scientific article

Skeletal overgrowth is mediated by deficiency in a specific isoform of fibroblast growth factor receptor 3.

scholarly article

Solution structure of Grb2 reveals extensive flexibility necessary for target recognition

scientific article

Solution structure of pleckstrin homology domain of dynamin by heteronuclear NMR spectroscopy

scientific article

Solution structure of the SH2 domain of Grb2 complexed with the Shc-derived phosphotyrosine-containing peptide

scientific article

Solution structure of the SH2 domain of Grb2/Ash complexed with EGF receptor-derived phosphotyrosine-containing peptide

scientific article published on 01 June 1999

Spatial control of EGF receptor activation by reversible dimerization on living cells

scientific article published on 7 March 2010

Specific and high-affinity binding of inositol phosphates to an isolated pleckstrin homology domain

scientific article

Specific phosphopeptide binding regulates a conformational change in the PI 3-kinase SH2 domain associated with enzyme activation

scientific article

Specific role for the PH domain of dynamin-1 in the regulation of rapid endocytosis in adrenal chromaffin cells

scientific article published on April 1997

Stabilization of an active dimeric form of the epidermal growth factor receptor by introduction of an inter-receptor disulfide bond

scientific article published on April 1994

Structural analysis of the mechanism of phosphorylation of a critical autoregulatory tyrosine residue in FGFR1 kinase domain.

scientific article

Structural basis for FGF receptor dimerization and activation

scientific article

Structural basis for KIT receptor tyrosine kinase inhibition by antibodies targeting the D4 membrane-proximal region

scientific article

Structural basis for activation of the receptor tyrosine kinase KIT by stem cell factor

scientific article

Structural basis for reduced FGFR2 activity in LADD syndrome: Implications for FGFR autoinhibition and activation

scientific article

Structural basis for the activity of drugs that inhibit phosphodiesterases

scientific article

Structural biology of receptor tyrosine kinase kit

scientific article

Structural diversity and binding of FGF receptors

scientific article

Structure of the FGF receptor tyrosine kinase domain reveals a novel autoinhibitory mechanism

scientific article

Structure of the high affinity complex of inositol trisphosphate with a phospholipase C pleckstrin homology domain

scientific article

Structure, domain organization, and different conformational states of stem cell factor-induced intact KIT dimers

scientific article published on 21 January 2014

Structures of β-klotho reveal a 'zip code'-like mechanism for endocrine FGF signalling

scientific article published on 17 January 2018

Suppression of EGFR endocytosis by dynamin depletion reveals that EGFR signaling occurs primarily at the plasma membrane ⬇️

scientific article published on February 27, 2012

The Dark Side of Cell Signaling: Positive Roles for Negative Regulators

scientific article published on March 2016

The EGFR family: not so prototypical receptor tyrosine kinases

scientific article published on April 2014

The biochemical response of the heart to hypertension and exercise

scientific article published in November 2004

The catalytic activity of the CD45 membrane-proximal phosphatase domain is required for TCR signaling and regulation

scientific article published on September 1994

The docking protein FRS2alpha controls a MAP kinase-mediated negative feedback mechanism for signaling by FGF receptors

scientific journal article

The docking protein FRS2α is a critical regulator of VEGF receptors signaling

scientific article

The docking protein Gab1 is an essential component of an indirect mechanism for fibroblast growth factor stimulation of the phosphatidylinositol 3-kinase/Akt antiapoptotic pathway

scientific article

The docking protein Gab1 is the primary mediator of EGF-stimulated activation of the PI-3K/Akt cell survival pathway

scientific article

The expression of a novel receptor-type tyrosine phosphatase suggests a role in morphogenesis and plasticity of the nervous system

scientific article published on 01 October 1993

The genesis of Zelboraf: Targeting mutant B-Raf in melanoma ⬇️

scientific article published on October 1, 2012

The phosphotyrosine interaction domain of Shc binds an LXNPXY motif on the epidermal growth factor receptor

scientific article

The precise sequence of FGF receptor autophosphorylation is kinetically driven and is disrupted by oncogenic mutations

scientific article published on 17 February 2009

The proto-oncogene c-Cbl is a negative regulator of DNA synthesis initiated by both receptor and cytoplasmic tyrosine kinases

scientific article published on May 1999

The selectivity of receptor tyrosine kinase signaling is controlled by a secondary SH2 domain binding site

scientific article

The strength and cooperativity of KIT ectodomain contacts determine normal ligand-dependent stimulation or oncogenic activation in cancer

scientific article published on 24 December 2014

The tethered configuration of the EGF receptor extracellular domain exerts only a limited control of receptor function

scholarly article

Thermodynamic Studies of SHC Phosphotyrosine Interaction Domain Recognition of the NPXpY Motif

scientific article published in Journal of Biological Chemistry

Tony Pawson (1952-2013).

scientific article

Trans-activation of EphA4 and FGF receptors mediated by direct interactions between their cytoplasmic domains

scholarly article

Transmembrane signaling by receptor oligomerization

scientific article published in January 1998

Transphosphorylation as a possible mechanism for insulin and epidermal growth factor receptor activation.

scientific article published on October 1990

Two EGF molecules contribute additively to stabilization of the EGFR dimer

scientific article

Two signaling molecules share a phosphotyrosine-containing binding site in the platelet-derived growth factor receptor

scientific article

Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate

scientific article

Tyrosine phosphorylation of Pyk2 is selectively regulated by Fyn during TCR signaling

scientific article

Tyrosine phosphorylation of the c-cbl proto-oncogene protein product and association with epidermal growth factor (EGF) receptor upon EGF stimulation

scientific article

Paulina is supported by:

About Paulina

Help