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List of works by Lewis E. Kay

(13)CHD2-CEST NMR spectroscopy provides an avenue for studies of conformational exchange in high molecular weight proteins

scientific article published on 14 August 2015

13CHD2 methyl group probes of millisecond time scale exchange in proteins by 1H relaxation dispersion: an application to proteasome gating residue dynamics

scientific article published on 01 August 2010

1H,13C-1H,1H dipolar cross-correlated spin relaxation in methyl groups

scientific article

A "three-pronged" binding mechanism for the SAP/SH2D1A SH2 domain: structural basis and relevance to the XLP syndrome

scientific article

A 2D ¹³C-CEST experiment for studying slowly exchanging protein systems using methyl probes: an application to protein folding

scientific article published on 12 June 2012

A Dynamic molecular basis for malfunction in disease mutants of p97/VCP.

scientific article

A Methyl-TROSY-Based 1 H Relaxation Dispersion Experiment for Studies of Conformational Exchange in High Molecular Weight Proteins

scientific article published on 04 April 2019

A Suite of Triple Resonance NMR Experiments for the Backbone Assignment of 15N, 13C, 2H Labeled Proteins with High Sensitivity

scientific article published in 1994

A Transient and Low-Populated Protein-Folding Intermediate at Atomic Resolution ⬇️

scientific article published on September 10, 2010

A combined HNCA/HNCO experiment for 15N labeled proteins with 13C at natural abundance

scientific article published in October 2003

A comparative CEST NMR study of slow conformational dynamics of small GTPases complexed with GTP and GTP analogues

scientific article published on 22 August 2013

A computational study of the effects of (13) C-(13) C scalar couplings on (13) C CEST NMR spectra: towards studies on a uniformly (13) C-labeled protein

scientific article

A hydrocarbon ruler measures palmitate in the enzymatic acylation of endotoxin

scientific article

A new class of CEST experiment based on selecting different magnetization components at the start and end of the CEST relaxation element: an application to 1H CEST.

scientific article published on 19 January 2018

A pH-Dependent Conformational Switch Controls N. meningitidis ClpP Protease Function

scientific article published on 24 November 2020

A processive rotary mechanism couples substrate unfolding and proteolysis in the ClpXP degradation machinery

scientific article published on 09 January 2020

A simple method for measuring signs of (1)H (N) chemical shift differences between ground and excited protein states

scientific article published on 29 April 2010

A simple strategy for 13C,1H labeling at the Ile-γ2 methyl position in highly deuterated proteins ⬇️

scientific article published on October 14, 2010

A single-quantum methyl 13C-relaxation dispersion experiment with improved sensitivity

scientific article published on 27 April 2007

A solution NMR study showing that active site ligands and nucleotides directly perturb the allosteric equilibrium in aspartate transcarbamoylase

scholarly article

A special "JMR Perspectives" issue: foresights in biomolecular solution-state NMR spectroscopy - from spin gymnastics to structure and dynamics

scientific article published in April 2014

A suite of 2H NMR spin relaxation experiments for the measurement of RNA dynamics

scientific article published in May 2005

Abp1p and Fyn SH3 domains fold through similar low-populated intermediate states

scientific article

Accurate measurement of alpha proton chemical shifts of excited protein states by relaxation dispersion NMR spectroscopy

scientific article published in February 2009

Addressing the overlap problem in the quantitative analysis of two dimensional NMR spectra: application to (15)N relaxation measurements

scientific article

Alternate binding modes for a ubiquitin-SH3 domain interaction studied by NMR spectroscopy

scientific article

An 15N NMR spin relaxation dispersion study of the folding of a pair of engineered mutants of apocytochrome b562.

scientific article published in April 2005

An Economical Method for Production of 2H,13CH3-Threonine for Solution NMR Studies of Large Protein Complexes: Application to the 670 kDa Proteasome ⬇️

scientific article published on September 11, 2012

An HNCA Pulse Scheme for the Backbone Assignment of 15N,13C,2H-Labeled Proteins: Application to a 37-kDa Trp Repressor-DNA Complex

scientific article published in 1994

An NMR Experiment for Measuring Methyl−Methyl NOEs in13C-Labeled Proteins with High Resolution

scientific article published in 1998

An Optimized Relaxation-Based Coherence Transfer NMR Experiment for the Measurement of Side-Chain Order in Methyl-Protonated, Highly Deuterated Proteins ⬇️

scientific article published on November 15, 2011

An R(1ρ) expression for a spin in chemical exchange between two sites with unequal transverse relaxation rates

scientific article published on 23 January 2013

An analysis of the effects of 1HN-(1)HN dipolar couplings on the measurement of amide bond vector orientations in invisible protein states by relaxation dispersion NMR

scientific article published on 01 July 2009

An enhanced sensitivity methyl 1H triple-quantum pulse scheme for measuring diffusion constants of macromolecules

scientific article

An exchange-free measure of 15N transverse relaxation: an NMR spectroscopy application to the study of a folding intermediate with pervasive chemical exchange

scientific article published on 28 August 2007

An improved 15N relaxation dispersion experiment for the measurement of millisecond time-scale dynamics in proteins

article

An isotope labeling strategy for methyl TROSY spectroscopy

scientific article published in February 2004

Application of methyl-TROSY NMR to test allosteric models describing effects of nucleotide binding to aspartate transcarbamoylase

scientific article published on 4 February 2009

Architecture of the high mobility group nucleosomal protein 2-nucleosome complex as revealed by methyl-based NMR.

scientific article

Assessment of the effects of increased relaxation dispersion data on the extraction of 3-site exchange parameters characterizing the unfolding of an SH3 domain

scientific article

Assignment of Ile, Leu, and Val methyl correlations in supra-molecular systems: an application to aspartate transcarbamoylase

scientific article published in November 2009

Assignment of15N,13Cα,13Cβ, and HN Resonances in an15N,13C,2H Labeled 64 kDa Trp Repressor−Operator Complex Using Triple-Resonance NMR Spectroscopy and2H-Decoupling

scientific article published in 1996

Atomistic picture of conformational exchange in a T4 lysozyme cavity mutant: an experiment-guided molecular dynamics study† †Electronic supplementary information (ESI) available: Additional figures, a table and details regarding the NMR experiments,

scientific article published on 7 January 2016

Binding kinetics of histone chaperone Chz1 and variant histone H2A.Z-H2B by relaxation dispersion NMR spectroscopy

scientific article published on March 2009

Biophysics in Canada

scientific article published in November 2017

Bringing dynamic molecular machines into focus by methyl-TROSY NMR.

scientific article

CPMG relaxation dispersion NMR experiments measuring glycine 1H alpha and 13C alpha chemical shifts in the 'invisible' excited states of proteins

scientific article published on 25 March 2009

Characterization of conformational exchange of a histidine side chain: protonation, rotamerization, and tautomerization of His61 in plastocyanin from Anabaena variabilis.

scientific article published on 7 June 2008

Characterization of the hydrodynamic properties of the folding transition state of an SH3 domain by magnetization transfer NMR spectroscopy

scientific article

ClpB N-terminal domain plays a regulatory role in protein disaggregation

scientific article

Complementarity of ensemble and single-molecule measures of protein motion: a relaxation dispersion NMR study of an enzyme complex

scholarly article

Conformational heterogeneity in the Hsp70 chaperone-substrate ensemble: identified from analysis of NMR-detected titration data

scientific article

Conformational instability of the MARK3 UBA domain compromises ubiquitin recognition and promotes interaction with the adjacent kinase domain

scientific article

Confronting the Invisible: Assignment of Protein 1HN Chemical Shifts in Cases of Extreme Broadening

scientific article published on 14 April 2020

Conserved conformational selection mechanism of Hsp70 chaperone-substrate interactions.

scientific article published on 20 February 2018

Correlation between 2H NMR side-chain order parameters and sequence conservation in globular proteins

scientific article

Cross-Validation of the Structure of a Transiently Formed and Low Populated FF Domain Folding Intermediate Determined by Relaxation Dispersion NMR and CS-Rosetta ⬇️

scientific article published on December 23, 2011

Cross-correlated relaxation enhanced 1H[bond]13C NMR spectroscopy of methyl groups in very high molecular weight proteins and protein complexes

scientific article published in August 2003

Cross-correlated spin relaxation effects in methyl 1H CPMG-based relaxation dispersion experiments: complications and a simple solution

scientific article

Defining a length scale for millisecond-timescale protein conformational exchange

scientific article

Detecting protein kinase recognition modes of calmodulin by residual dipolar couplings in solution NMR.

scientific article published in October 2002

Determination of Leu side-chain conformations in excited protein states by NMR relaxation dispersion.

scientific article

Determination of isoleucine side-chain conformations in ground and excited states of proteins from chemical shifts

scientific article

Determining Valine Side-Chain Rotamer Conformations in Proteins from Methyl 13C Chemical Shifts: Application to the 360 kDa Half-Proteasome ⬇️

scientific article published on May 5, 2011

Deuterium spin probes of side-chain dynamics in proteins. 1. Measurement of five relaxation rates per deuteron in (13)C-labeled and fractionally (2)H-enriched proteins in solution

scientific article

Deviations from the simple two-parameter model-free approach to the interpretation of nitrogen-15 nuclear magnetic relaxation of proteins

article

Distribution of molecular size within an unfolded state ensemble using small-angle X-ray scattering and pulse field gradient NMR techniques

scientific article

Divided-evolution-based pulse scheme for quantifying exchange processes in proteins: powerful complement to relaxation dispersion experiments

scientific article published on 18 January 2011

Double- and zero-quantum NMR relaxation dispersion experiments sampling millisecond time scale dynamics in proteins

scientific article

Dramatic Decrease in CEST Measurement Times Using Multi-Site Excitation

Dramatic acceleration of protein folding by stabilization of a nonnative backbone conformation

scientific article

Dynamic equilibrium engagement of a polyvalent ligand with a single-site receptor

scholarly article

Dynamic regulation of archaeal proteasome gate opening as studied by TROSY NMR

scientific article

Effect of deuteration on some structural parameters of methyl groups in proteins as evaluated by residual dipolar couplings

scientific article published in May 2002

Effect of noncompetitive proteasome inhibition on bortezomib resistance

scientific article

Enhancing the Sensitivity of CPMG Relaxation Dispersion to Conformational Exchange Processes by Multiple-Quantum Spectroscopy

scientific article

Enhancing the Sensitivity of CPMG Relaxation Dispersion to Conformational Exchange Processes by Multiple-Quantum Spectroscopy

article published in 2016

Estimates of methyl 13C and 1H CSA values (Deltasigma) in proteins from cross-correlated spin relaxation

scientific article

Estimating side-chain order in [U-2H;13CH3]-labeled high molecular weight proteins from analysis of HMQC/HSQC spectra

scientific article published on 25 March 2013

Evaluating the influence of initial magnetization conditions on extracted exchange parameters in NMR relaxation experiments: applications to CPMG and CEST.

scientific article published on 29 July 2016

Evolution of magnetization due to asymmetric dimerization: theoretical considerations and application to aberrant oligomers formed by apoSOD1(2SH).

scientific article published on 9 July 2015

Exploiting conformational plasticity in the AAA+ protein VCP/p97 to modify function

scientific article published on 31 July 2017

Exploring methods to expedite the recording of CEST datasets using selective pulse excitation

Folding of an intrinsically disordered protein by phosphorylation as a regulatory switch

scientific article

Folding of the four-helix bundle FF domain from a compact on-pathway intermediate state is governed predominantly by water motion ⬇️

scientific article published on November 5, 2012

Four-dimensional NMR spectroscopy of a 723-residue protein: chemical shift assignments and secondary structure of malate synthase g.

scientific article published in August 2002

Four-dimensional heteronuclear triple-resonance NMR of isotopically enriched proteins for sequential assignment of backbone atoms

Fractional 13C enrichment of isolated carbons using [1-13C]- or [2-13C]-glucose facilitates the accurate measurement of dynamics at backbone Cα and side-chain methyl positions in proteins

article

Fractional enrichment of proteins using [2-(13)C]-glycerol as the carbon source facilitates measurement of excited state 13Cα chemical shifts with improved sensitivity

scientific article published on 20 May 2015

Functional dynamics of human FKBP12 revealed by methyl 13C rotating frame relaxation dispersion NMR spectroscopy

scientific article published on 01 May 2006

Global Folds of Highly Deuterated, Methyl-Protonated Proteins by Multidimensional NMR†

scientific article published in 1997

High-resolution four-dimensional 1H-13C NOE spectroscopy using methyl-TROSY, sparse data acquisition, and multidimensional decomposition

scientific article

Hsp70 biases the folding pathways of client proteins

scientific article published on 02 May 2016

Hydration and packing along the folding pathway of SH3 domains by pressure-dependent NMR.

scientific article

Identification of a collapsed intermediate with non-native long-range interactions on the folding pathway of a pair of Fyn SH3 domain mutants by NMR relaxation dispersion spectroscopy

scientific article

Ile, Leu, and Val Methyl Assignments of the 723-Residue Malate Synthase G Using a New Labeling Strategy and Novel NMR Methods ⬇️

scientific article published on November 12, 2003

Improved magnetization alignment schemes for spin-lock relaxation experiments

scientific article published on 20 February 2007

In support of the BMRB.

scientific article published in September 2012

Increasing the exchange time-scale that can be probed by CPMG relaxation dispersion NMR

scientific article published on 11 November 2011

Interplay of buried histidine protonation and protein stability in prion misfolding

scientific article published on 13 April 2017

Investigating the Dynamics of Destabilized Nucleosomes Using Methyl-TROSY NMR

article published in 2018

Is buffer a good proxy for a crowded cell-like environment? A comparative NMR study of calmodulin side-chain dynamics in buffer and E. coli lysate

scientific article

Isotope labeling methods for studies of excited protein states by relaxation dispersion NMR spectroscopy

scientific article

Isotope labeling strategies for the study of high-molecular-weight proteins by solution NMR spectroscopy.

scientific article

Line narrowing in methyl-TROSY using zero-quantum 1H-13C NMR spectroscopy

scientific article published in April 2004

Longitudinal relaxation optimized amide 1H-CEST experiments for studying slow chemical exchange processes in fully protonated proteins

scientific article published on 29 March 2017

Low-populated folding intermediates of Fyn SH3 characterized by relaxation dispersion NMR.

scientific article

Magnetic resonance realization of decoherence-free quantum computation

scientific article published on 21 November 2003

Mapping the conformation of a client protein through the Hsp70 functional cycle

scientific article

Measurement of bond vector orientations in invisible excited states of proteins

scholarly article

Measurement of carbonyl chemical shifts of excited protein states by relaxation dispersion NMR spectroscopy: comparison between uniformly and selectively (13)C labeled samples

scientific article published on 2 September 2008

Measurement of histidine pKa values and tautomer populations in invisible protein states

scientific article

Measurement of methyl axis orientations in invisible, excited states of proteins by relaxation dispersion NMR spectroscopy

scientific article published in August 2009

Measurement of methyl group motional parameters of invisible, excited protein states by NMR spectroscopy

scientific article

Measurement of proton chemical shifts in invisible states of slowly exchanging protein systems by chemical exchange saturation transfer

scientific article published on 29 November 2012

Measurement of side-chain carboxyl pK(a) values of glutamate and aspartate residues in an unfolded protein by multinuclear NMR spectroscopy

scientific article

Measurement of signs of chemical shift differences between ground and excited protein states: a comparison between H(S/M)QC and R1rho methods

scientific article

Measurement of the signs of methyl 13C chemical shift differences between interconverting ground and excited protein states by R 1ρ : an application to αB-crystallin ⬇️

scientific article published on 05 April 2012

Measuring 13Cbeta chemical shifts of invisible excited states in proteins by relaxation dispersion NMR spectroscopy.

scientific article published on 16 May 2009

Measuring 1HN temperature coefficients in invisible protein states by relaxation dispersion NMR spectroscopy

scientific article published on 18 March 2011

Measuring Diffusion Constants of Invisible Protein Conformers by Triple-Quantum 1 H CPMG Relaxation Dispersion

Measuring Diffusion Constants of Invisible Protein Conformers by Triple-Quantum ¹H CPMG Relaxation Dispersion

article published in 2018

Measuring Diffusion Constants of Invisible Protein Conformers by Triple‐Quantum 1 H CPMG Relaxation Dispersion

Measuring Solvent Hydrogen Exchange Rates by Multifrequency Excitation 15N CEST: Application to Protein Phase Separation

Measuring hydrogen exchange rates in invisible protein excited states

scientific article published on 2 June 2014

Measuring pK(a) values in protein folding transition state ensembles by NMR spectroscopy

scientific article

Measuring the signs of 1H(alpha) chemical shift differences between ground and excited protein states by off-resonance spin-lock R(1rho) NMR spectroscopy

scientific article

Mechanism of Amyloidogenesis of a Bacterial AAA+ Chaperone

scientific article published on 31 May 2016

Membrane-dependent modulation of the mTOR activator Rheb: NMR observations of a GTPase tethered to a lipid-bilayer nanodisc

scientific article

Methyl groups as probes of structure and dynamics in NMR studies of high-molecular-weight proteins

scientific article

Methyl groups as probes of supra-molecular structure, dynamics and function

scientific article published on 27 September 2009

Multiple-quantum relaxation dispersion NMR spectroscopy probing millisecond time-scale dynamics in proteins: theory and application

scientific article

Multiple-site exchange in proteins studied with a suite of six NMR relaxation dispersion experiments: an application to the folding of a Fyn SH3 domain mutant

scientific article

NMR Experiments for Studies of Dilute and Condensed Protein Phases: Application to the Phase-Separating Protein CAPRIN1

scientific article published on 21 January 2020

NMR dynamics-derived insights into the binding properties of a peptide interacting with an SH2 domain

scientific article

NMR paves the way for atomic level descriptions of sparsely populated, transiently formed biomolecular conformers

scientific article published on 18 July 2013

NMR spectroscopy brings invisible protein states into focus

scientific article

NMR spectroscopy of soluble protein complexes at one mega-dalton and beyond

scientific article

NMR structure of chaperone Chz1 complexed with histones H2A.Z-H2B

scientific article

NMR studies of protein structure and dynamics

scientific article

NMR studies of protein structure and dynamics - a look backwards and forwards

scientific article

NMR studies of protein structure and dynamics. 2005.

scientific article

New RNA labeling methods offer dramatic sensitivity enhancements in 2H NMR relaxation spectra

scientific article published on 01 July 2006

New Views of Functionally Dynamic Proteins by Solution NMR Spectroscopy

scientific article published on 18 December 2015

New tools provide new insights in NMR studies of protein dynamics

scientific article

Nonnative Interactions in the FF Domain Folding Pathway from an Atomic Resolution Structure of a Sparsely Populated Intermediate: An NMR Relaxation Dispersion Study

scientific article

Novel proteasome inhibitors to overcome bortezomib resistance

scientific article published on 23 May 2011

Nuclear magnetic resonance spectroscopy of high-molecular-weight proteins.

scientific article

Observing biological dynamics at atomic resolution using NMR.

scientific article published on 19 October 2009

Off-resonance R(1rho) NMR studies of exchange dynamics in proteins with low spin-lock fields: an application to a Fyn SH3 domain

scientific article

Off-resonance R1rho relaxation outside of the fast exchange limit: an experimental study of a cavity mutant of T4 lysozyme

scientific article published in May 2003

Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site

scientific article published on 4 May 2015

Optimal methyl labeling for studies of supra-molecular systems

scientific article published on 27 April 2010

Parallel acquisition of multi-dimensional spectra in protein NMR ⬇️

scientific article published on July 17, 2012

Phi-value analysis of a three-state protein folding pathway by NMR relaxation dispersion spectroscopy

scientific article

Polyubiquitin-Photoactivatable Crosslinking Reagents for Mapping Ubiquitin Interactome Identify Rpn1 as a Proteasome Ubiquitin-Associating Subunit

scientific article published on 16 March 2017

Practical aspects of proton-carbon-carbon-proton three-dimensional correlation spectroscopy of 13C-labeled proteins

Probing Chemical Shifts of Invisible States of Proteins with Relaxation Dispersion NMR Spectroscopy: How Well Can We Do?

scientific article published on 01 February 2008

Probing Invisible, Excited Protein States by Non-Uniformly Sampled Pseudo-4D CEST Spectroscopy

scientific article

Probing Residual Interactions in Unfolded Protein States Using NMR Spin Relaxation Techniques: An Application to Δ131Δ ⬇️

scientific article published on October 1, 2003

Probing conformational dynamics in biomolecules via chemical exchange saturation transfer: a primer

scientific article published on 19 March 2017

Probing conformational exchange in weakly interacting, slowly exchanging protein systems via off-resonance R1ρ experiments: Application to studies of protein phase separation

scientific article published on 5 January 2018

Probing dynamic conformations of the high-molecular-weight αB-crystallin heat shock protein ensemble by NMR spectroscopy.

scientific article

Probing invisible, low-populated States of protein molecules by relaxation dispersion NMR spectroscopy: an application to protein folding

scientific article published on 15 February 2008

Probing non-specific interactions of Ca²⁺-calmodulin in E. coli lysate

scientific article published on 17 January 2013

Probing side-chain dynamics in high molecular weight proteins by deuterium NMR spin relaxation: an application to an 82-kDa enzyme

scientific article published in June 2005

Probing slow chemical exchange at carbonyl sites in proteins by chemical exchange saturation transfer NMR spectroscopy

scientific article published on 28 February 2013

Probing slow dynamics in high molecular weight proteins by methyl-TROSY NMR spectroscopy: application to a 723-residue enzyme

scientific article published in March 2004

Probing slow timescale dynamics in proteins using methyl 1H CEST.

scientific article published on 24 June 2017

Probing slowly exchanging protein systems via ¹³Cα-CEST: monitoring folding of the Im7 protein

scientific article published on 6 February 2013

Probing structure in invisible protein states with anisotropic NMR chemical shifts

scientific article published on 08 February 2008

Probing supramolecular structure from measurement of methyl (1)H-(13)C residual dipolar couplings

scientific article published on 2 October 2007

Probing the cooperativity of Thermoplasma acidophilum proteasome core particle gating by NMR spectroscopy

scientific article published on 30 October 2017

Probing the free energy landscapes of ALS disease mutants of SOD1 by NMR spectroscopy

scientific article published on 24 October 2016

Probing the transition state ensemble of a protein folding reaction by pressure-dependent NMR relaxation dispersion

scientific article published in April 2006

Production and Incorporation of15N,13C,2H (1H-δ1 Methyl) Isoleucine into Proteins for Multidimensional NMR Studies

article

Promiscuous binding by Hsp70 results in conformational heterogeneity and fuzzy chaperone-substrate ensembles

scientific article published on 14 July 2017

Proteasome allostery as a population shift between interchanging conformers ⬇️

scientific article published on November 12, 2012

Protein dynamics and conformational disorder in molecular recognition

scientific article published on March 2010

Protein stabilization by specific binding of guanidinium to a functional arginine-binding surface on an SH3 domain

scientific article

Proton-proton correlation via carbon-carbon couplings: a three-dimensional NMR approach for the assignment of aliphatic resonances in proteins labeled with carbon-13

scientific article published in 1990

Pulsed-field gradient-enhanced three-dimensional NMR experiment for correlating 13C.alpha./.beta., 13C', and 1H.alpha. chemical shifts in uniformly carbon-13-labeled proteins dissolved in water

article by Lewis E. Kay published March 1993 in Journal of the American Chemical Society

Quantifying millisecond exchange dynamics in proteins by CPMG relaxation dispersion NMR using side-chain 1H probes

scientific article

Quantifying two-bond 1HN-13CO and one-bond 1H(alpha)-13C(alpha) dipolar couplings of invisible protein states by spin-state selective relaxation dispersion NMR spectroscopy

scientific article published on 03 June 2008

Quantitative 13C and 2H NMR relaxation studies of the 723-residue enzyme malate synthase G reveal a dynamic binding interface

scientific article

Quantitative NMR spectroscopy of supramolecular complexes: dynamic side pores in ClpP are important for product release

scientific article

Quantitative NMR studies of high molecular weight proteins: application to domain orientation and ligand binding in the 723 residue enzyme malate synthase G.

scientific article published in April 2003

Quantitative dynamics and binding studies of the 20S proteasome by NMR

scientific article published in Nature

Quantitative measurement of exchange dynamics in proteins via (13)C relaxation dispersion of (13)CHD2-labeled samples

scientific article published in June 2016

Quaternary Dynamics of αB-Crystallin as a Direct Consequence of Localised Tertiary Fluctuations in the C-Terminus ⬇️

scientific article published on August 3, 2011

Quaternary dynamics and plasticity underlie small heat shock protein chaperone function

scientific article

Reconstructing NMR spectra of "invisible" excited protein states using HSQC and HMQC experiments

scientific article published in October 2002

Refined solution structure of the 82-kDa enzyme malate synthase G from joint NMR and synchrotron SAXS restraints

scientific article

Relaxation dispersion NMR spectroscopy as a tool for detailed studies of protein folding

scientific article

Requirement for kinase-induced conformational change in eukaryotic initiation factor 2alpha (eIF2alpha) restricts phosphorylation of Ser51.

scientific article

Reversible inhibition of the ClpP protease via an N-terminal conformational switch

article published in the Proceedings of the National Academy of Sciences of the United States of America

Revisiting 1HN CPMG relaxation dispersion experiments: a simple modification can eliminate large artifacts

scientific article published on 23 October 2019

Selected topics in solution-phase biomolecular NMR spectroscopy

scientific article published on 17 March 2017

Selective Methyl Group Protonation of Perdeuterated Proteins

Selective characterization of microsecond motions in proteins by NMR relaxation

scientific article published in November 2009

Self-Assembly of Human Profilin-1 Detected by Carr-Purcell-Meiboom-Gill Nuclear Magnetic Resonance (CPMG NMR) Spectroscopy.

scientific article published on 4 January 2017

Separating Dipolar and Chemical Exchange Magnetization Transfer Processes in 1 H-CEST

Separating Dipolar and Chemical Exchange Magnetization Transfer Processes in 1 H-CEST.

scientific article

Separating degenerate (1)H transitions in methyl group probes for single-quantum (1)H-CPMG relaxation dispersion NMR spectroscopy

scientific article

Side Chain Assignments of Ile δ1 Methyl Groups in High Molecular Weight Proteins: an Application to a 46 ns Tumbling Molecule ⬇️

scientific article published on May 14, 2003

Side-chain interactions in the folding pathway of a Fyn SH3 domain mutant studied by relaxation dispersion NMR spectroscopy

scientific article

Significantly Improved Resolution for NOE Correlations from Valine and Isoleucine (Cγ2) Methyl Groups in15N,13C- and15N,13C,2H-Labeled Proteins

scientific article published in 1998

Simultaneous NMR characterisation of multiple minima in the free energy landscape of an RNA UUCG tetraloop

scientific article published on 9 January 2017

Site-directed methyl group labeling as an NMR probe of structure and dynamics in supramolecular protein systems: applications to the proteasome and to the ClpP protease.

scientific article

Site-specific contributions to the pH dependence of protein stability

scientific article

Slow internal dynamics in proteins: application of NMR relaxation dispersion spectroscopy to methyl groups in a cavity mutant of T4 lysozyme

scientific article

Solution NMR Studies of a 42 KDaEscherichiaColiMaltose Binding Protein/β-Cyclodextrin Complex: Chemical Shift Assignments and Analysis

article

Solution NMR spectroscopy of supra-molecular systems, why bother? A methyl-TROSY view ⬇️

scientific article published on March 8, 2011

Solution NMR-derived global fold of a monomeric 82-kDa enzyme

scientific article

Solution structure and dynamics of integral membrane proteins by NMR: a case study involving the enzyme PagP.

scientific article

Solution structure and dynamics of the outer membrane enzyme PagP by NMR.

scientific article

Solution structure of a minor and transiently formed state of a T4 lysozyme mutant

scientific article

Sparsely populated folding intermediates of the Fyn SH3 domain: matching native-centric essential dynamics and experiment

scientific article

Stereospecific NMR assignments of prochiral methyls, rotameric states and dynamics of valine residues in malate synthase G.

scientific article

Strong coupling effects during X-pulse CPMG experiments recorded on heteronuclear ABX spin systems: artifacts and a simple solution

scientific article published on 03 March 2007

Structural coupling of SH2-kinase domains links Fes and Abl substrate recognition and kinase activation

scientific article

Structural studies of FF domains of the transcription factor CA150 provide insights into the organization of FF domain tandem arrays

scientific article

Structure of a AAA+ unfoldase in the process of unfolding substrate

Structure of a AAA+ unfoldase in the process of unfolding substrate.

scientific article published on 8 April 2017

Structure of a regulatory complex involving the Abl SH3 domain, the Crk SH2 domain, and a Crk-derived phosphopeptide

scientific article

Structure of an intermediate state in protein folding and aggregation

scientific article

Structures of invisible, excited protein states by relaxation dispersion NMR spectroscopy

scientific article

Studying "invisible" excited protein states in slow exchange with a major state conformation

scientific article published on 3 May 2012

Studying Protein-Excited States by Nmr.

scientific article

TROSY-based NMR evidence for a novel class of 20S proteasome inhibitors

scientific article

The RNF168 paralog RNF169 defines a new class of ubiquitylated histone reader involved in the response to DNA damage.

scientific article published on 13 April 2017

The Role of Protein Thermodynamics and Primary Structure in Fibrillogenesis of Variable Domains from Immunoglobulin Light Chains

scientific article published on 14 August 2019

The ZIP5 ectodomain co-localizes with PrP and may acquire a PrP-like fold that assembles into a dimer

scientific article

The design and optimization of complex NMR experiments. Application to a triple-resonance pulse scheme correlating Hα, NH, and 15N chemical shifts in 15N13C-labeled proteins

The energetic cost of domain reorientation in maltose-binding protein as studied by NMR and fluorescence spectroscopy

scientific article published on 6 October 2003

The folding pathway of an FF domain: characterization of an on-pathway intermediate state under folding conditions by (15)N, (13)C(alpha) and (13)C-methyl relaxation dispersion and (1)H/(2)H-exchange NMR spectroscopy

scientific article published on 09 June 2007

The integral membrane enzyme PagP alternates between two dynamically distinct states

scientific article

The linker between the dimerization and catalytic domains of the CheA histidine kinase propagates changes in structure and dynamics that are important for enzymatic activity

scientific article published on 28 January 2014

The polydispersity of αB-crystallin is rationalized by an interconverting polyhedral architecture

scientific article

The proteasome antechamber maintains substrates in an unfolded state ⬇️

scientific article published on October 14, 2010

The response of internal dynamics to hydrophobic core mutations in the SH3 domain from the Fyn tyrosine kinase

scientific article

Thermal fluctuations of immature SOD1 lead to separate folding and misfolding pathways

scientific article published on 23 June 2015

Three-dimensional NOESY-HMQC spectroscopy of a 13C-labeled protein

Three-dimensional triple-resonance NMR Spectroscopy of isotopically enriched proteins ⬇️

scientific article published on December 1, 2011

Three-dimensional triple-resonance NMR spectroscopy of isotopically enriched proteins

article

Topology of an outer-membrane enzyme: Measuring oxygen and water contacts in solution NMR studies of PagP.

scientific article

Toward the solution structure of large (>30 kDa) proteins and macromolecular complexes

scholarly article published 1995

Tracing an allosteric pathway regulating the activity of the HslV protease

scientific article published on 27 January 2014

Transiently populated intermediate functions as a branching point of the FF domain folding pathway ⬇️

scientific article published on May 30, 2012

Triple resonance-based ¹³C(α) and ¹³C(β) CEST experiments for studies of ms timescale dynamics in proteins

scientific article published on 28 October 2014

Understanding the mechanism of proteasome 20S core particle gating

scientific article

Unfolding the mechanism of the AAA+ unfoldase VAT by a combined cryo-EM, solution NMR study

scientific article

Unraveling the mechanism of protein disaggregation through a ClpB-DnaK interaction.

scientific article

Using relaxation dispersion NMR spectroscopy to determine structures of excited, invisible protein states

scientific article published on 24 June 2008

Variable control of Ets-1 DNA binding by multiple phosphates in an unstructured region

scientific article

Visualizing side chains of invisible protein conformers by solution NMR.

scientific article published on 8 November 2013

αB-crystallin polydispersity is a consequence of unbiased quaternary dynamics.

scientific article

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