List of works - Gerard Manning

A comprehensive transcriptional portrait of human cancer cell lines

scientific article published on 08 December 2014

A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties

scientific article

Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2

scientific article

Amphioxus encodes the largest known family of green fluorescent proteins, which have diversified into distinct functional classes

scientific article

Assessment of computational methods for predicting the effects of missense mutations in human cancers

scientific article

Bioinformatics analysis of thousands of TCGA tumors to determine the involvement of epigenetic regulators in human cancer

scientific article published on 18 June 2015

Comparative analysis of Histophilus somni immunoglobulin-binding protein A (IbpA) with other fic domain-containing enzymes reveals differences in substrate and nucleotide specificities

scientific article

Creating a specialist protein resource network: a meeting report for the protein bioinformatics and community resources retreat

scientific article

Cyclin-dependent kinases: a family portrait.

scientific article

Development of the Drosophila tracheal system occurs by a series of morphologically distinct but genetically coupled branching events

scientific article published in May 1996

Discovery of a metabolic alternative to the classical mevalonate pathway

scientific article published on 10 December 2013

Distinct structural and functional roles of conserved residues in the first extracellular domain of receptors for corticotropin-releasing factor and related G-protein-coupled receptors

scientific article published on 16 October 2007

Evolution of protein kinase signaling from yeast to man

scientific article (publication date: October 2002)

Evolution of the chalcone-isomerase fold from fatty-acid binding to stereospecific catalysis

scientific article

From Plk1 to Plk5: functional evolution of polo-like kinases

scientific article published on 15 July 2011

Genetic control of epithelial tube fusion during Drosophila tracheal development.

scientific article published in November 1996

Genomic Minimalism in the Early Diverging Intestinal Parasite Giardia lamblia

scientific article

Genomic overview of protein kinases

scientific article published on 13 December 2005

Genomic survey of premetazoans shows deep conservation of cytoplasmic tyrosine kinases and multiple radiations of receptor tyrosine kinases.

scientific article published in May 2012

Genomics and evolution of protein phosphatases

scientific article

Genomics, evolution, and crystal structure of a new family of bacterial spore kinases

scientific article

HER2 is not a cancer subtype but rather a pan-cancer event and is highly enriched in AR-driven breast tumors.

scientific article

HSF-1-mediated cytoskeletal integrity determines thermotolerance and life span

scientific article

How the vertebrates were made: selective pruning of a double-duplicated genome

scientific article published on 13 December 2010

Identification of a mammalian-type phosphatidylglycerophosphate phosphatase in the Eubacterium Rhodopirellula baltica

scientific article published on 4 January 2013

Insights into evolution of multicellular fungi from the assembled chromosomes of the mushroom Coprinopsis cinerea (Coprinus cinereus)

scientific article

Insulin biosynthetic interaction network component, TMEM24, facilitates insulin reserve pool release

scientific journal article

Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer

scientific article published on 8 May 2014

Key challenges for the creation and maintenance of specialist protein resources

scientific article

Leveraging the Pre-DFG Residue Thr-406 To Obtain High Kinase Selectivity in an Aminopyrazole-Type PAK1 Inhibitor Series

scientific article published on 20 May 2015

Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB

scientific article

Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a model eukaryote

scientific article

Members of the NIMA-related kinase family promote disassembly of cilia by multiple mechanisms

scientific article

Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors

scientific article

Mutational alteration of human immunodeficiency virus type 1 Vif allows for functional interaction with nonhuman primate APOBEC3G.

scientific article

Necroptosis and Inflammation

scientific article published on 08 February 2016

Nitrosopumilus maritimus genome reveals unique mechanisms for nitrification and autotrophy in globally distributed marine crenarchaea

scientific article

Plk5, a polo box domain-only protein with specific roles in neuron differentiation and glioblastoma suppression

scientific article

Premetazoan genome evolution and the regulation of cell differentiation in the choanoflagellate Salpingoeca rosetta

scientific article

Programmed ribosomal frameshifting in the expression of the regulator of intestinal stem cell proliferation, adenomatous polyposis coli (APC).

scientific article

Quantitative exploration of the catalytic landscape separating divergent plant sesquiterpene synthases

scientific article

RPN-6 determines C. elegans longevity under proteotoxic stress conditions

scientific article published in September 2012

Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis

scientific article

Short Promoters in Viral Vectors Drive Selective Expression in Mammalian Inhibitory Neurons, but do not Restrict Activity to Specific Inhibitory Cell-Types

scientific article published on 9 November 2009

Structural and functional analysis of PTPMT1, a phosphatase required for cardiolipin synthesis

scientific article

Structural and functional diversity of the microbial kinome

scientific article

Structure of the Pseudokinase VRK3 Reveals a Degraded Catalytic Site, a Highly Conserved Kinase Fold, and a Putative Regulatory Binding Site

scientific article

TORC-specific phosphorylation of mammalian target of rapamycin (mTOR): phospho-Ser2481 is a marker for intact mTOR signaling complex 2.

scientific article published on 24 February 2009

The Amphimedon queenslandica genome and the evolution of animal complexity ⬇️

scientific article

The Capsaspora genome reveals a complex unicellular prehistory of animals

scientific article

The F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stress

scientific article

The Raine syndrome protein FAM20C is a Golgi kinase that phosphorylates bio-mineralization proteins

scientific article

The STE20 kinase HGK is broadly expressed in human tumor cells and can modulate cellular transformation, invasion, and adhesion

scientific article

The Selaginella genome identifies genetic changes associated with the evolution of vascular plants

scientific article

The Sorcerer II Global Ocean Sampling expedition: expanding the universe of protein families

scientific article published in March 2007

The dictyostelium kinome--analysis of the protein kinases from a simple model organism.

scientific article

The first myriapod genome sequence reveals conservative arthropod gene content and genome organisation in the centipede Strigamia maritima ⬇️

scientific article

The fold of alpha-synuclein fibrils

scholarly article

The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans

scientific article

The genome of the sea urchin Strongylocentrotus purpuratus

scientific article

The minimal kinome of Giardia lamblia illuminates early kinase evolution and unique parasite biology.

scientific article published on 25 July 2011

The mouse kinome: discovery and comparative genomics of all mouse protein kinases

scientific journal article

The protein kinase complement of the human genome

scientific article

The protist, Monosiga brevicollis, has a tyrosine kinase signaling network more elaborate and diverse than found in any known metazoan

scholarly article

The sea urchin kinome: a first look

scientific article

Viral MLKL Homologs Subvert Necroptotic Cell Death by Sequestering Cellular RIPK3

scientific article published on 01 September 2019

Whole animal cell sorting of Drosophila embryos.

scientific article

List of works by Gerard Manning

A comprehensive transcriptional portrait of human cancer cell lines

A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties

Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2

Amphioxus encodes the largest known family of green fluorescent proteins, which have diversified into distinct functional classes

Assessment of computational methods for predicting the effects of missense mutations in human cancers

Bioinformatics analysis of thousands of TCGA tumors to determine the involvement of epigenetic regulators in human cancer

Comparative analysis of Histophilus somni immunoglobulin-binding protein A (IbpA) with other fic domain-containing enzymes reveals differences in substrate and nucleotide specificities

Creating a specialist protein resource network: a meeting report for the protein bioinformatics and community resources retreat

Cyclin-dependent kinases: a family portrait.

Development of the Drosophila tracheal system occurs by a series of morphologically distinct but genetically coupled branching events

Discovery of a metabolic alternative to the classical mevalonate pathway

Distinct structural and functional roles of conserved residues in the first extracellular domain of receptors for corticotropin-releasing factor and related G-protein-coupled receptors

Evolution of protein kinase signaling from yeast to man

Evolution of the chalcone-isomerase fold from fatty-acid binding to stereospecific catalysis

From Plk1 to Plk5: functional evolution of polo-like kinases

Genetic control of epithelial tube fusion during Drosophila tracheal development.

Genomic Minimalism in the Early Diverging Intestinal Parasite Giardia lamblia

Genomic overview of protein kinases

Genomic survey of premetazoans shows deep conservation of cytoplasmic tyrosine kinases and multiple radiations of receptor tyrosine kinases.

Genomics and evolution of protein phosphatases

Genomics, evolution, and crystal structure of a new family of bacterial spore kinases

HER2 is not a cancer subtype but rather a pan-cancer event and is highly enriched in AR-driven breast tumors.

HSF-1-mediated cytoskeletal integrity determines thermotolerance and life span

How the vertebrates were made: selective pruning of a double-duplicated genome

Identification of a mammalian-type phosphatidylglycerophosphate phosphatase in the Eubacterium Rhodopirellula baltica

Insights into evolution of multicellular fungi from the assembled chromosomes of the mushroom Coprinopsis cinerea (Coprinus cinereus)

Insulin biosynthetic interaction network component, TMEM24, facilitates insulin reserve pool release

Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer

Key challenges for the creation and maintenance of specialist protein resources

Leveraging the Pre-DFG Residue Thr-406 To Obtain High Kinase Selectivity in an Aminopyrazole-Type PAK1 Inhibitor Series

Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB

Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a model eukaryote

Members of the NIMA-related kinase family promote disassembly of cilia by multiple mechanisms

Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors

Mutational alteration of human immunodeficiency virus type 1 Vif allows for functional interaction with nonhuman primate APOBEC3G.

Necroptosis and Inflammation

Nitrosopumilus maritimus genome reveals unique mechanisms for nitrification and autotrophy in globally distributed marine crenarchaea

Plk5, a polo box domain-only protein with specific roles in neuron differentiation and glioblastoma suppression

Premetazoan genome evolution and the regulation of cell differentiation in the choanoflagellate Salpingoeca rosetta

Programmed ribosomal frameshifting in the expression of the regulator of intestinal stem cell proliferation, adenomatous polyposis coli (APC).

Quantitative exploration of the catalytic landscape separating divergent plant sesquiterpene synthases

RPN-6 determines C. elegans longevity under proteotoxic stress conditions

Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis

Short Promoters in Viral Vectors Drive Selective Expression in Mammalian Inhibitory Neurons, but do not Restrict Activity to Specific Inhibitory Cell-Types

Structural and functional analysis of PTPMT1, a phosphatase required for cardiolipin synthesis

Structural and functional diversity of the microbial kinome

Structure of the Pseudokinase VRK3 Reveals a Degraded Catalytic Site, a Highly Conserved Kinase Fold, and a Putative Regulatory Binding Site

TORC-specific phosphorylation of mammalian target of rapamycin (mTOR): phospho-Ser2481 is a marker for intact mTOR signaling complex 2.

The Amphimedon queenslandica genome and the evolution of animal complexity ⬇️

The Capsaspora genome reveals a complex unicellular prehistory of animals

The F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stress

The Raine syndrome protein FAM20C is a Golgi kinase that phosphorylates bio-mineralization proteins

The STE20 kinase HGK is broadly expressed in human tumor cells and can modulate cellular transformation, invasion, and adhesion

The Selaginella genome identifies genetic changes associated with the evolution of vascular plants

The Sorcerer II Global Ocean Sampling expedition: expanding the universe of protein families

The dictyostelium kinome--analysis of the protein kinases from a simple model organism.

The first myriapod genome sequence reveals conservative arthropod gene content and genome organisation in the centipede Strigamia maritima ⬇️

The fold of alpha-synuclein fibrils

The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans

The genome of the sea urchin Strongylocentrotus purpuratus

The minimal kinome of Giardia lamblia illuminates early kinase evolution and unique parasite biology.

The mouse kinome: discovery and comparative genomics of all mouse protein kinases

The protein kinase complement of the human genome

The protist, Monosiga brevicollis, has a tyrosine kinase signaling network more elaborate and diverse than found in any known metazoan

The sea urchin kinome: a first look

Viral MLKL Homologs Subvert Necroptotic Cell Death by Sequestering Cellular RIPK3

Whole animal cell sorting of Drosophila embryos.