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List of works by Mitsuhiko Ikura

A Ca2+-dependent mechanism of neuronal survival mediated by the microtubule-associated protein p600

scientific article published on 16 July 2013

A coiled-coil clamp controls both conformation and clustering of stromal interaction molecule 1 (STIM1).

scientific article published on 23 October 2014

A comparative CEST NMR study of slow conformational dynamics of small GTPases complexed with GTP and GTP analogues

scientific article published on 22 August 2013

A fluorescent cassette-based strategy for engineering multiple domain fusion proteins

scientific article

A monomeric histidine kinase derived from EnvZ, an Escherichia coli osmosensor

scientific article published on 01 April 2000

Alternate routes to conformational specificity in a Greek key beta barrel protein

scientific article

An Autoinhibited Structure of  -Catenin and Its Implications for Vinculin Recruitment to Adherens Junctions

scientific article

An Optical Method for Evaluating Ion Selectivity for Calcium Signaling Pathways in the Cell

scientific article published on 01 August 1997

An autoinhibited noncanonical mechanism of GTP hydrolysis by Rheb maintains mTORC1 homeostasis

scientific article

An efficient 3D NMR technique for correlating the proton and 15N backbone amide resonances with the alpha-carbon of the preceding residue in uniformly 15N/13C enriched proteins

scientific article (publication date: May 1991)

An interaction between Scribble and the NADPH oxidase complex controls M1 macrophage polarization and function

scientific article

Application of two-dimensional NMR spectroscopy to the complete analysis of the1H and13C NMR spectra ofd-biotin in aqueous solution

article published in 1982

Auto-inhibitory role of the EF-SAM domain of STIM proteins in store-operated calcium entry

scientific article

Backbone dynamics of calmodulin studied by 15N relaxation using inverse detected two-dimensional NMR spectroscopy: the central helix is flexible.

scientific article published in June 1992

Backbone resonance assignments of the F-actin binding domain of mouse αN-catenin.

scientific article published in November 2016

Bacterial histidine kinase as signal sensor and transducer.

scientific article

Biophysical characterization of the EF-hand and SAM domain containing Ca2+ sensory region of STIM1 and STIM2

scientific article

CLIP170 autoinhibition mimics intermolecular interactions with p150Glued or EB1

scientific article

CaBP1, a neuronal Ca2+ sensor protein, inhibits inositol trisphosphate receptors by clamping intersubunit interactions.

scientific article published on 6 May 2013

Calcium Binding and Conformation of Regulatory Light Chains of Smooth Muscle Myosin of Scallop1

scientific article published in 1985

Calcium-induced conformational transition revealed by the solution structure of apo calmodulin

scientific article

Calcium-regulated DNA binding and oligomerization of the neuronal calcium-sensing protein, calsenilin/DREAM/KChIP3

scientific article (publication date: 2 November 2001)

Calexcitin B is a new member of the sarcoplasmic calcium-binding protein family.

scientific article published on 16 April 2001

Calmodulin disrupts plasma membrane localization of farnesylated KRAS4b by sequestering its lipid moiety

scientific article published on 31 March 2020

Calmodulin in action: diversity in target recognition and activation mechanisms.

scientific article

Calmodulin target database

scientific article published on 01 January 2000

Characterization of a conserved "threonine clasp" in CAP-Gly domains: role of a functionally critical OH/pi interaction in protein recognition.

scientific article

Characterization of novel calmodulin-binding peptides with distinct inhibitory effects on calmodulin-dependent enzymes

scientific article published on January 1997

Characterization of the ATP-binding domain of the sarco(endo)plasmic reticulum Ca(2+)-ATPase: probing nucleotide binding by multidimensional NMR.

scientific article published in January 2002

Characterization of the intrinsic and TSC2-GAP-regulated GTPase activity of Rheb by real-time NMR.

scientific article published on 27 January 2009

Cholesterol modulates Orai1 channel function

scientific article published on 26 January 2016

Complete structural analysis of globoseries glycolipids by two-dimensional nuclear magnetic resonance

article

Conformational coupling of Mg2+ and Ca2+ on the three-state folding of calexcitin B.

scientific article published in May 2003

Conformational states of syntaxin-1 govern the necessity of N-peptide binding in exocytosis of PC12 cells and Caenorhabditis elegans

scientific article (publication date: 23 December 2015)

Crystal structure of the amino-terminal microtubule-binding domain of end-binding protein 1 (EB1)

scientific article

Crystal structure of the ligand binding suppressor domain of type 1 inositol 1,4,5-trisphosphate receptor.

scientific article

Crystal structure of type I ryanodine receptor amino-terminal  -trefoil domain reveals a disease-associated mutation"hot spot"loop

scientific article

Crystal structure of venus, a yellow fluorescent protein with improved maturation and reduced environmental sensitivity

scientific article

Crystallographic evidence for water-assisted photo-induced peptide cleavage in the stony coral fluorescent protein Kaede

scientific article

DREAM is a critical transcriptional repressor for pain modulation

scientific article (publication date: 11 January 2002)

Detecting protein kinase recognition modes of calmodulin by residual dipolar couplings in solution NMR.

scientific article published in October 2002

Detection of nuclear Overhauser effects between degenerate amide proton resonances by heteronuclear three-dimensional NMR spectroscopy

scientific article published in 1990

Domain fusion analysis by applying relational algebra to protein sequence and domain databases

scientific article

Dynamic and static interactions between p120 catenin and E-cadherin regulate the stability of cell-cell adhesion

scientific article

Equilibrium folding intermediates of a Greek key beta-barrel protein.

scientific article

Evolution of AF6-RAS association and its implications in mixed-lineage leukemia.

scientific article

FRET evidence for a conformational change in TFIIB upon TBP-DNA binding.

scientific article published on February 2004

Fluorescent indicators for Ca2+ based on green fluorescent proteins and calmodulin

scientific article (publication date: 28 August 1997)

Four-dimensional heteronuclear triple-resonance NMR of isotopically enriched proteins for sequential assignment of backbone atoms

Functional silencing of TATA-binding protein (TBP) by a covalent linkage of the N-terminal domain of TBP-associated factor 1.

scientific article published on 6 June 2007

High-resolution structure of TBP with TAF1 reveals anchoring patterns in transcriptional regulation

scientific article

How calpain is activated by calcium

scientific article published on 01 April 2002

Human general transcription factor TFIIB: conformational variability and interaction with VP16 activation domain

scientific article

Identification and characterization of subfamily-specific signatures in a large protein superfamily by a hidden Markov model approach

scientific article

Improved three-dimensional1H−13C−1H correlation spectroscopy of a13C-labeled protein using constant-time evolution ⬇️

scientific article published on September 1, 1991

Inhibition of RAS function through targeting an allosteric regulatory site.

scientific article published on 7 November 2016

Inhibitory Mechanism of Escherichia coli RelE-RelB Toxin-Antitoxin Module Involves a Helix Displacement Near an mRNA Interferase Active Site

scientific article

Initial activation of STIM1, the regulator of store-operated calcium entry

scientific article

Insights into a Single Rod-like Helix in Activated Radixin Required for Membrane−Cytoskeletal Cross-Linking ⬇️

scientific article published on October 14, 2003

Interaction domains of Sos1/Grb2 are finely tuned for cooperative control of embryonic stem cell fate

scientific journal article

Largen: a molecular regulator of mammalian cell size control

scientific article

Lateral self-assembly of E-cadherin directed by cooperative calcium binding

scientific article published on 01 November 1997

Ligand-induced conformational changes via flexible linkers in the amino-terminal region of the inositol 1,4,5-trisphosphate receptor.

scientific article published on 29 August 2007

Light-dependent regulation of structural flexibility in a photochromic fluorescent protein

scientific article

MARK3-mediated phosphorylation of ARHGEF2 couples microtubules to the actin cytoskeleton to establish cell polarity.

scientific article published on 31 October 2017

Measurement of the exchange rates of rapidly exchanging amide protons: Application to the study of calmodulin and its complex with a myosin light chain kinase fragment ⬇️

scientific article published on July 1, 1991

Mechanistic Insight into the Microtubule and Actin Cytoskeleton Coupling through Dynein-Dependent RhoGEF Inhibition

article published in 2012

Membrane-dependent modulation of the mTOR activator Rheb: NMR observations of a GTPase tethered to a lipid-bilayer nanodisc

scientific article

Mg2+ and Ca2+ differentially regulate DNA binding and dimerization of DREAM

scientific journal article

Missense mutation in immunodeficient patients shows the multifunctional roles of coiled-coil domain 3 (CC3) in STIM1 activation

scientific article published on 27 April 2015

Molecular and structural basis of target recognition by calmodulin.

scientific article

Molecular basis for E-cadherin recognition by killer cell lectin-like receptor G1 (KLRG1).

scientific article

Molecular basis of the isoform-specific ligand-binding affinity of inositol 1,4,5-trisphosphate receptors

scientific journal article

Molecular mechanics of calcium-myristoyl switches

scientific article

Molecular structure and target recognition of neuronal calcium sensor proteins.

scientific article

Multiple Calmodulin-Binding Sites Positively and Negatively Regulate Arabidopsis CYCLIC NUCLEOTIDE-GATED CHANNEL12.

scientific article published on 22 June 2016

Multiplexed Real-Time NMR GTPase Assay for Simultaneous Monitoring of Multiple Guanine Nucleotide Exchange Factor Activities from Human Cancer Cells and Organoids

scientific article published on 15 March 2018

Multivalent assembly of KRAS with the RAS-binding and cysteine-rich domains of CRAF on the membrane

scientific article published on 15 May 2020

N-terminal region (domain 1) of calmodulin is the low affinity site for Ca2+. A 13C NMR study of S-cyanocalmodulin.

scientific article published in February 1984

NMR in integrated biophysical drug discovery for RAS: past, present, and future

scientific article published on 17 August 2020

NMR structure of the histidine kinase domain of the E. coli osmosensor EnvZ

scientific article

NMR-based functional profiling of RASopathies and oncogenic RAS mutations.

scientific article published on 4 March 2013

Nuclear magnetic resonance evidence for Ca(2+)-induced extrusion of the myristoyl group of recoverin.

scientific article

Nuclear magnetic resonance studies on calmodulin: calcium-induced conformational change

article

Nuclear magnetic resonance studies on calmodulin: spectral assignments in the calcium-free state

scientific article published on 01 May 1983

Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site

scientific article published on 4 May 2015

Point mutations of the mTOR-RHEB pathway in renal cell carcinoma

scientific article published on July 2015

Practical aspects of proton-carbon-carbon-proton three-dimensional correlation spectroscopy of 13C-labeled proteins

Probing Zn2+-binding effects on the zinc-ribbon domain of human general transcription factor TFIIB

scientific article

Probing catalytically essential domain orientation in histidine kinase EnvZ by targeted disulfide crosslinking.

scientific article published in April 2003

Probing nucleotide-binding effects on backbone dynamics and folding of the nucleotide-binding domain of the sarcoplasmic/endoplasmic-reticulum Ca2+-ATPase.

scientific article published on April 2004

Proton-proton correlation via carbon-carbon couplings: a three-dimensional NMR approach for the assignment of aliphatic resonances in proteins labeled with carbon-13

scientific article published in 1990

Purification and spectroscopic characterization of a recombinant amino-terminal polypeptide fragment of mouse epithelial cadherin

scientific article published on 01 October 1994

Radixin: cytoskeletal adopter and signaling protein

scientific article

Real-time NMR study of guanine nucleotide exchange and activation of RhoA by PDZ-RhoGEF.

scientific article published on 17 December 2009

Real-time NMR study of three small GTPases reveals that fluorescent 2'(3')-O-(N-methylanthraniloyl)-tagged nucleotides alter hydrolysis and exchange kinetics.

scientific article published on 14 December 2009

Resonance Assignments of 30 kDa Complexes of TFIID Subunit TAF1 with TATA-binding Protein

scientific article published on 01 September 2005

Ryanodine receptor calcium release channels: lessons from structure-function studies.

scientific article published on 18 March 2013

STIM1 couples to ORAI1 via an intramolecular transition into an extended conformation

scientific article

Secretion of human superoxide dismutase in Escherichia coli using the condensed single-protein-production system

scientific article

Sequestration of the membrane-targeting myristoyl group of recoverin in the calcium-free state

scientific article

Solution structure of a calmodulin-target peptide complex by multidimensional NMR

scientific article published on May 1, 1992

Solution structure of the C-terminal core domain of human TFIIB: similarity to cyclin A and interaction with TATA-binding protein

scientific journal article

Solution structure of the epithelial cadherin domain responsible for selective cell adhesion.

scientific article

Spectroscopic Characterization of a High-Affinity Calmodulin−Target Peptide Hybrid Molecule†

scientific article published in 1996

Stored Ca2+ depletion-induced oligomerization of stromal interaction molecule 1 (STIM1) via the EF-SAM region: An initiation mechanism for capacitive Ca2+ entry

scientific article

Stromal interaction molecule (STIM) 1 and STIM2 calcium sensing regions exhibit distinct unfolding and oligomerization kinetics

scientific article

Structural Determinants of the Mechanical Stability of α-Catenin

scientific article published on 12 June 2015

Structural and functional conservation of key domains in InsP3 and ryanodine receptors

scientific article

Structural and mechanistic insights into STIM1-mediated initiation of store-operated calcium entry

scientific article

Structural aspects of calcium-release activated calcium channel function

scientific article

Structural basis for simultaneous binding of two carboxy-terminal peptides of plant glutamate decarboxylase to calmodulin

scientific article (publication date: 18 April 2003)

Structural basis for the activation of microtubule assembly by the EB1 and p150Glued complex.

scientific article published in August 2005

Structural basis of CBP/p300 recruitment in leukemia induction by E2A-PBX1.

scientific article published on 12 September 2012

Structural basis of calcium-induced E-cadherin rigidification and dimerization

scientific article

Structural characterization of Escherichia coli sensor histidine kinase EnvZ: the periplasmic C-terminal core domain is critical for homodimerization.

scientific article published on January 2005

Structural characterization of a blue chromoprotein and its yellow mutant from the sea anemone Cnidopus japonicus.

scientific article published on 6 October 2006

Structural determination of the phosphorylation domain of the ryanodine receptor

scientific article

Structural insights into the regulatory mechanism of IP3 receptor.

scientific article

Structural mechanism of transcriptional autorepression of the Escherichia coli RelB/RelE antitoxin/toxin module

scientific article

Structural similarity of a developmentally regulated bacterial spore coat protein to beta gamma-crystallins of the vertebrate eye lens.

scientific article

Structurally delineating stromal interaction molecules as the endoplasmic reticulum calcium sensors and regulators of calcium release-activated calcium entry.

scientific article published on September 2009

Structure of calmodulin-target peptide complexes

Structure of the inositol 1,4,5-trisphosphate receptor binding core in complex with its ligand

scientific article

Structure-guided Mutation of the Conserved G3-box Glycine in Rheb Generates a Constitutively Activated Regulator of Mammalian Target of Rapamycin (mTOR)

scientific article

Structures of KIX domain of CBP in complex with two FOXO3a transactivation domains reveal promiscuity and plasticity in coactivator recruitment

scientific article

TFIIA-TAF regulatory interplay: NMR evidence for overlapping binding sites on TBP.

scientific article published in February 2000

The ATCUN Domain as a Probe of Intermolecular Interactions: Application to Calmodulin−Peptide Complexes

scientific article published on 01 November 2002

The Histone Folds in Transcription Factor TFIID

scientific article published in Journal of Biological Chemistry

The LxxLL motif: a multifunctional binding sequence in transcriptional regulation

scientific article published on 01 February 2005

The PTB domain of ShcA couples receptor activation to the cytoskeletal regulator IQGAP1

scientific journal article

The RhoGEF GEF-H1 is required for oncogenic RAS signaling via KSR-1

scientific article

The acute myeloid leukemia fusion protein AML1-ETO targets E proteins via a paired amphipathic helix-like TBP-associated factor homology domain

scholarly article

The cadherin-catenin complex as a focal point of cell adhesion and signalling: new insights from three-dimensional structures.

scientific article published on May 2004

The design and optimization of complex NMR experiments. Application to a triple-resonance pulse scheme correlating Hα, NH, and 15N chemical shifts in 15N13C-labeled proteins

The signaling adaptor GAB1 regulates cell polarity by acting as a PAR protein scaffold.

scientific article

Themes and Variations in ER/SR Calcium Release Channels: Structure and Function ⬇️

scientific article published on December 1, 2012

Three-dimensional NOESY-HMQC spectroscopy of a 13C-labeled protein

Three-dimensional structure of guanylyl cyclase activating protein-2, a calcium-sensitive modulator of photoreceptor guanylyl cyclases

scientific article

Transcriptional/epigenetic regulator CBP/p300 in tumorigenesis: structural and functional versatility in target recognition.

scientific article

Type 2 ryanodine receptor domain A contains a unique and dynamic α-helix that transitions to a β-strand in a mutant linked with a heritable cardiomyopathy

scientific article

Tyr-167/Trp-168 in type 1/3 inositol 1,4,5-trisphosphate receptor mediates functional coupling between ligand binding and channel opening

scientific journal article

Unusual helix-containing greek keys in development-specific Ca(2+)-binding protein S. 1H, 15N, and 13C assignments and secondary structure determined with the use of multidimensional double and triple resonance heteronuclear NMR spectroscopy.

scientific article

Where cancer meets calcium--p53 crosstalk with EF-hands

scientific article published on 01 July 2000

p120-catenin binding masks an endocytic signal conserved in classical cadherins.

scientific article

p120RasGAP is a mediator of rho pathway activation and tumorigenicity in the DLD1 colorectal cancer cell line

scientific article

α-Catenin homodimers are recruited to phosphoinositide-activated membranes to promote adhesion.

scientific article

α-Catenin phosphorylation promotes intercellular adhesion through a dual-kinase mechanism.

scientific article

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