List of works by Dafna Bar-Sagi

A Ras-induced conformational switch in the Ras activator Son of sevenless

scientific article (publication date: 7 November 2006)

A mouse model of hereditary pancreatitis generated by transgenic expression of R122H trypsinogen.

scientific article

Allosteric gating of Son of sevenless activity by the histone domain

scientific article

An orthosteric inhibitor of the RAS-SOS interaction.

scientific article published on 7 November 2013

An orthosteric inhibitor of the Ras-Sos interaction

scientific article published on 17 July 2011

Analysis of Ras:RasGEF interactions by phage display and static multi-angle light scattering

scientific article

Autoinhibition of Sos by intramolecular interactions

scientific article

Characterization of a Ras mutant with identical GDP- and GTP-bound structures

scientific article

Chronic pancreatitis, pancreatic adenocarcinoma and the black box in-between

scientific article

Clinical and therapeutic implications of Sprouty2 feedback dysregulation in BRAF V600E-mutation-positive papillary thyroid cancer

scientific article

Computational docking and solution x-ray scattering predict a membrane-interacting role for the histone domain of the Ras activator son of sevenless

scientific article

Crosstalk between Regulatory T Cells and Tumor-Associated Dendritic Cells Negates Anti-tumor Immunity in Pancreatic Cancer

scientific article published on July 2017

Design, synthesis, and biological evaluation of new-generation taxoids

scientific article published on 09 May 2008

Determining the macropinocytic index of cells through a quantitative image-based assay

scientific article

Differential modification of Ras proteins by ubiquitination

scientific article published in March 2006

Direct coupling of the cell cycle and cell death machinery by E2F.

scientific article published on November 2002

Distinct populations of metastases-enabling myeloid cells expand in the liver of mice harboring invasive and preinvasive intra-abdominal tumor

scientific article

E-cadherin-mediated cell coupling is required for apoptotic cell extrusion

scientific article

EZH2 couples pancreatic regeneration to neoplastic progression

scientific article

Erratum: Corrigendum: Gain-of-function SOS1 mutations cause a distinctive form of Noonan syndrome

scholarly article published in Nature Genetics

Escorting Ras.

scientific article published on 27 June 2012

Expression of sprouty2 inhibits B-cell proliferation and is epigenetically silenced in mouse and human B-cell lymphomas

scientific article

Feedback regulation of Ras signaling by Rabex-5-mediated ubiquitination

scientific article

Gain-of-function SOS1 mutations cause a distinctive form of Noonan syndrome.

scientific article published on 13 December 2006

High-content, full genome siRNA screen for regulators of oncogenic HRAS-driven macropinocytosis

scientific article published on 12 August 2015

Histological Image Processing Features Induce a Quantitative Characterization of Chronic Tumor Hypoxia

scientific article

Honokiol suppresses survival signals mediated by Ras-dependent phospholipase D activity in human cancer cells

scientific article published on July 2008

Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular protein

scientific article

IL35-Producing B Cells Promote the Development of Pancreatic Neoplasia

scientific article published on 29 December 2015

In liver fibrosis, dendritic cells govern hepatic inflammation in mice via TNF-alpha

scientific article published on 12 October 2009

Macropinocytosis of Nab-paclitaxel Drives Macrophage Activation in Pancreatic Cancer

scientific article published on 20 January 2017

Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

scientific article published on 12 May 2013

Membrane-dependent signal integration by the Ras activator Son of sevenless

scientific article published on 4 May 2008

Microdissection and culture of murine pancreatic ductal epithelial cells.

scientific article published in January 2013

Modulation of signalling by Sprouty: a developing story

scientific article published on June 2004

Mutant KRAS Enhances Tumor Cell Fitness by Upregulating Stress Granules

scientific article published on December 2016

Oncogenic KRas Suppresses Inflammation-Associated Senescence of Pancreatic Ductal Cells ⬇️

scientific article published on November 16, 2010

Oncogenic Kras-induced GM-CSF production promotes the development of pancreatic neoplasia

scientific article published on June 2012

Perturbation of cytoskeleton dynamics by the opposing effects of Rac1 and Rac1b

scientific article

Phospholipase D2-generated phosphatidic acid couples EGFR stimulation to Ras activation by Sos.

scientific article published on 7 May 2007

RAS oncogenes: weaving a tumorigenic web

scientific article

Ras/MAPK signaling from endomembranes

scientific article

Redox-dependent downregulation of Rho by Rac.

scientific article published in March 2003

Regulating the regulator: post-translational modification of RAS

scientific article published on 22 December 2011

Regulation of RAS oncogenicity by acetylation

scientific article

Regulation of sprouty stability by Mnk1-dependent phosphorylation

scientific article

Rewiring cellular morphology pathways with synthetic guanine nucleotide exchange factors

scientific article published on 21 May 2007

Role of boundary conditions in an experimental model of epithelial wound healing

scientific article published on 22 February 2006

Role of the histone domain in the autoinhibition and activation of the Ras activator Son of Sevenless

scientific article

Signaling endosomes: seeing is believing

scientific article

Simulating Heterogeneous Tumor Cell Populations

scientific article

Sos-mediated cross-activation of wild-type Ras by oncogenic Ras is essential for tumorigenesis

scientific article published on January 2012

Spatial regulation of EGFR signaling by Sprouty2.

scientific article published on 22 February 2007

Spry2 expression correlates with BRAF mutation in thyroid cancer

scientific article published on December 2010

Structural analysis of autoinhibition in the Ras activator Son of sevenless

scientific article

Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS

scientific article

Structure of the G60A mutant of Ras: implications for the dominant negative effect

scientific article published on 5 May 2005

Suppression of Ras-stimulated transformation by the JNK signal transduction pathway

scientific article

Tandem histone folds in the structure of the N-terminal segment of the ras activator Son of Sevenless

scientific article

The Bax subfamily of Bcl2-related proteins is essential for apoptotic signal transduction by c-Jun NH(2)-terminal kinase

scientific article

The bimodal regulation of epidermal growth factor signaling by human Sprouty proteins

scientific article

The pleckstrin homology (PH) domain-interacting protein couples the insulin receptor substrate 1 PH domain to insulin signaling pathways leading to mitogenesis and GLUT4 translocation

scientific article

The structural basis for the transition from Ras-GTP to Ras-GDP

scientific article

The two hats of SOS

scientific article (publication date: 13 August 2002)

The ubiquitin ligase Siah2 regulates tumorigenesis and metastasis by HIF-dependent and -independent pathways

scholarly article

VEGF exerts an angiogenesis-independent function in cancer cells to promote their malignant progression

scientific article

Wild-type H- and N-Ras promote mutant K-Ras-driven tumorigenesis by modulating the DNA damage response

scientific article

hSpry2 is targeted to the ubiquitin-dependent proteasome pathway by c-Cbl

scientific journal article

γδ T Cells Support Pancreatic Oncogenesis by Restraining αβ T Cell Activation

scientific article

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