List of works by Clemens Kocken

A Continuous, Long-Term Plasmodium vivax In Vitro Blood-Stage Culture: What Are We Missing?

scientific article

A comparative transcriptomic analysis of replicating and dormant liver stages of the relapsing malaria parasite Plasmodium cynomolgi.

scientific article published on 7 December 2017

A diversity-covering approach to immunization with Plasmodium falciparum apical membrane antigen 1 induces broader allelic recognition and growth inhibition responses in rabbits

scientific article published on 31 March 2008

A dual fluorescent Plasmodium cynomolgi reporter line reveals in vitro malaria hypnozoite reactivation

scientific article published on 03 January 2020

A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria

scientific article

A novel live-dead staining methodology to study malaria parasite viability.

scientific article published on 7 June 2013

A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance

scientific article published on 24 May 2017

A triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor (DSM421) with improved drug-like properties for treatment and prevention of malaria

scientific article (publication date: 9 December 2016)

Accelerated phase Ia/b evaluation of the malaria vaccine candidate PfAMA1 DiCo demonstrates broadening of humoral immune responses

scientific article published on 14 April 2021

Admixture in Humans of Two Divergent Plasmodium knowlesi Populations Associated with Different Macaque Host Species

scientific article published on 28 May 2015

Antibody response of naturally infected individuals to recombinant Plasmodium vivax apical membrane antigen-1.

scientific article published on 19 December 2004

Antibody responses to a novel Plasmodium falciparum merozoite surface protein vaccine correlate with protection against experimental malaria infection in Aotus monkeys

scientific article published on 08 January 2014

Antigen-stimulated PBMC transcriptional protective signatures for malaria immunization

scientific article published on 01 May 2020

Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase.

scientific article

Apical membrane antigen 1: a malaria vaccine candidate in review

scientific article published on 15 January 2008

Biochemical characterization of Plasmodium falciparum CTP:phosphoethanolamine cytidylyltransferase shows that only one of the two cytidylyltransferase domains is active

scientific article (publication date: 15 February 2013)

Comparative characterization of hexose transporters of Plasmodium knowlesi, Plasmodium yoelii and Toxoplasma gondii highlights functional differences within the apicomplexan family

scientific article (publication date: 15 December 2002)

Correction: Variant Exported Blood-Stage Proteins Encoded by Plasmodium Multigene Families Are Expressed in Liver Stages Where They Are Exported into the Parasitophorous Vacuole

scientific article published on 17 January 2017

Correction: Variant Exported Blood-Stage Proteins Encoded by Plasmodium Multigene Families Are Expressed in Liver Stages Where They Are Exported into the Parasitophorous Vacuole

scientific article published on 14 December 2016

Cross-reactivity studies of an anti-Plasmodium vivax apical membrane antigen 1 monoclonal antibody: binding and structural characterisation

scientific article

Crystal structure of Plasmodium knowlesi apical membrane antigen 1 and its complex with an invasion-inhibitory monoclonal antibody ⬇️

scientific article published on 17 April 2015

Crystal structure of the malaria vaccine candidate apical membrane antigen 1.

scientific article published on 24 February 2005

Detection of new Babesia microti-like parasites in a rhesus monkey (Macaca mulatta) with a suppressed Plasmodium cynomolgi infection.

scientific article published in April 2008

Diversity covering AMA1-MSP119 fusion proteins as malaria vaccines

scientific article published on 19 February 2013

Diversity-oriented synthesis yields novel multistage antimalarial inhibitors

scientific article (publication date: 7 September 2016)

Down selecting adjuvanted vaccine formulations: a comparative method for harmonized evaluation

scientific article published on 31 January 2018

Dual-Luciferase-Based Fast and Sensitive Detection of Malaria Hypnozoites for the Discovery of Antirelapse Compounds

scientific article published on 08 April 2020

Evaluation of Chimpanzee Adenovirus and MVA Expressing TRAP and CSP from Plasmodium cynomolgi to Prevent Malaria Relapse in Nonhuman Primates

scientific article published on 06 July 2020

Ex vivo culture of Plasmodium vivax and Plasmodium cynomolgi and in vitro culture of Plasmodium knowlesi blood stages

article

Expression, crystallization and preliminary structural analysis of the ectoplasmic region of apical membrane antigen 1 from Plasmodium vivax, a malaria-vaccine candidate

scientific article published on 20 October 2004

From marginal to essential: the golden thread between nutrient sensing, medium composition and Plasmodium vivax maturation in in vitro culture

scientific article published on 10 October 2019

Generation of humoral immune responses to multi-allele PfAMA1 vaccines; effect of adjuvant and number of component alleles on the breadth of response

scientific article (publication date: 3 November 2010)

Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria

scientific article

Heterologous promoter activity in stable and transient Plasmodium knowlesi transgenes

scientific article published on 01 August 2003

High-Level Expression of the Malaria Blood-Stage Vaccine Candidate Plasmodium falciparum Apical Membrane Antigen 1 and Induction of Antibodies That Inhibit Erythrocyte Invasion.

scientific article published in October 2002

High-Throughput Luciferase-Based Assay for the Discovery of Therapeutics That Prevent Malaria

scientific article

High-level expression of Plasmodium vivax apical membrane antigen 1 (AMA-1) in Pichia pastoris: strong immunogenicity in Macaca mulatta immunized with P. vivax AMA-1 and adjuvant SBAS2.

scientific article published on January 1999

High-level expression of the malaria blood-stage vaccine candidate Plasmodium falciparum apical membrane antigen 1 and induction of antibodies that inhibit erythrocyte invasion ⬇️

scientific article

Human Plasmodium knowlesi infection detected by rapid diagnostic tests for malaria.

scientific article published on September 2009

Human antibodies to recombinant protein constructs of Plasmodium falciparum Apical Membrane Antigen 1 (AMA1) and their associations with protection from malaria

scientific article

Humoral immune responses to a single allele PfAMA1 vaccine in healthy malaria-naïve adults

scientific article (publication date: 2012)

Identification of adjuvants for clinical trials performed with Plasmodium falciparum AMA1 in rabbits

scientific article published on 30 July 2019

Immunization with different PfAMA1 alleles in sequence induces clonal imprint humoral responses that are similar to responses induced by the same alleles as a vaccine cocktail in rabbits

scientific article (publication date: 14 February 2011)

Immunological properties of recombinant proteins of the transmission blocking vaccine candidate, Pfs48/45, of the human malaria parasite Plasmodium falciparum produced in Escherichia coli.

scientific article published in August 1998

Insights into an Optimization of Plasmodium vivax Sal-1 In Vitro Culture: The Aotus Primate Model

scientific article

K562 erythroleukemia line as a possible reticulocyte source to culture Plasmodium vivax and its surrogates

scientific article published on 30 January 2020

KAI407, a potent non-8-aminoquinoline compound that kills Plasmodium cynomolgi early dormant liver stage parasites in vitro

scientific article published on 23 December 2013

Lead optimization of imidazopyrazines: a new class of antimalarial with activity on Plasmodium liver stages

scientific article published on 6 July 2014

Low levels of polymorphisms and no evidence for diversifying selection on the Plasmodium knowlesi Apical Membrane Antigen 1 gene

scientific article published on 16 April 2015

Malaria infection by sporozoite challenge induces high functional antibody titres against blood stage antigens after a DNA prime, poxvirus boost vaccination strategy in Rhesus macaques

scientific article

Malaria vaccine-related benefits of a single protein comprising Plasmodium falciparum apical membrane antigen 1 domains I and II fused to a modified form of the 19-kilodalton C-terminal fragment of merozoite surface protein 1

scientific article

Measurement of the plasma levels of antibodies against the polymorphic vaccine candidate apical membrane antigen 1 in a malaria-exposed population.

scientific article (publication date: 2 February 2012)

Metabolic, Pharmacokinetic, and Activity Profile of the Liver Stage Antimalarial (RC-12)

scientific article published on 30 March 2022

Minimal variation in the transmission-blocking vaccine candidate Pfs48/45 of the human malaria parasite Plasmodium falciparum.

scientific article published in January 1995

Molecular characterisation of Plasmodium reichenowi apical membrane antigen-1 (AMA-1), comparison with P. falciparum AMA-1, and antibody-mediated inhibition of red cell invasion.

scientific article published on July 2000

Multi-plasmid DNA vaccination avoids antigenic competition and enhances immunogenicity of a poorly immunogenic plasmid

article

Natural human antibody responses to Plasmodium vivax apical membrane antigen 1 under low transmission and unstable malaria conditions in Sri Lanka.

scientific article

New selectable markers and single crossover integration for the highly versatile Plasmodium knowlesi transfection system

scientific article published in March 2004

PI4 Kinase Is a Prophylactic but Not Radical Curative Target in Plasmodium vivax-Type Malaria Parasites

scientific article published on 29 February 2016

Persistence and activation of malaria hypnozoites in long-term primary hepatocyte cultures

scientific article published on 9 February 2014

Plasmodium CDP-DAG synthase: an atypical gene with an essential N-terminal extension

scientific article published on 10 April 2010

Plasmodium cynomolgi: transfection of blood-stage parasites using heterologous DNA constructs.

scientific article published in September 1999

Plasmodium falciparum apical membrane antigen 1 (PfAMA-1) is translocated within micronemes along subpellicular microtubules during merozoite development

scientific article published on 05 August 2003

Plasmodium falciparum-activated chloride channels are defective in erythrocytes from cystic fibrosis patients.

scientific article published on 16 December 2003

Plasmodium knowlesi provides a rapid in vitro and in vivo transfection system that enables double-crossover gene knockout studies

scientific article

Plasmodium knowlesi: a relevant, versatile experimental malaria model

scientific article published on 12 December 2016

Plasmodium reichenowi: deduced amino acid sequence of sexual stage-specific surface antigen Prs48/45 and comparison with its homologue in Plasmodium falciparum.

scientific article published in October 1997

Plasmodium vivax: in vitro susceptibility of blood stages to synthetic trioxolane compounds and the diamidine DB75.

scientific article published on 3 February 2006

Prevention of tuberculosis infection and disease by local BCG in repeatedly exposed rhesus macaques

scientific article published on 21 January 2019

Prodrugs of bisthiazolium salts are orally potent antimalarials

scholarly article

Production, Quality Control, Stability and Pharmacotoxicity of a Malaria Vaccine Comprising Three Highly Similar PfAMA1 Protein Molecules to Overcome Antigenic Variation

scientific article

Production, quality control, stability and pharmacotoxicity of cGMP-produced Plasmodium falciparum AMA1 FVO strain ectodomain expressed in Pichia pastoris

scientific article published on 17 September 2008

Proteolytic processing and primary structure of Plasmodium falciparum apical membrane antigen-1.

scientific article published on 8 June 2001

Proteomic and genetic analyses demonstrate that Plasmodium berghei blood stages export a large and diverse repertoire of proteins

scientific article published on 28 November 2012

Purification of fusion proteins expressed by pEX3 and a truncated pEX3 derivative

scientific article published on 01 August 1988

Quinolone-3-diarylethers: a new class of antimalarial drug.

scientific article published in March 2013

Reduced CD36-dependent tissue sequestration of Plasmodium-infected erythrocytes is detrimental to malaria parasite growth in vivo

scientific article published on 19 December 2011

Robust continuous in vitro culture of the Plasmodium cynomolgi erythrocytic stages

scientific article published on 12 August 2019

Safety and immunogenicity of a recombinant Plasmodium falciparum AMA1 malaria vaccine adjuvanted with Alhydrogel, Montanide ISA 720 or AS02.

scientific article

Safety and immunogenicity of multi-antigen AMA1-based vaccines formulated with CoVaccine HTTM and Montanide ISA 51 in rhesus macaques

scientific article (publication date: 4 July 2011)

Signalling in malaria parasites. The MALSIG consortium

scientific article published on September 2009

Statistical model to evaluate in vivo activities of antimalarial drugs in a Plasmodium cynomolgi-macaque model for Plasmodium vivax malaria

scientific article

Stronger induction of trained immunity by mucosal BCG or MTBVAC vaccination compared to standard intradermal vaccination

scientific article published on 19 January 2021

Structural comparison of apical membrane antigen 1 orthologues and paralogues in apicomplexan parasites

scientific article published in 2005

Suppression of Plasmodium cynomolgi in rhesus macaques by coinfection with Babesia microti

scientific article

Susceptibility of human Plasmodium knowlesi infections to anti-malarials.

scientific article published on 19 November 2013

Targeted deletion of Plasmodium knowlesi Duffy binding protein confirms its role in junction formation during invasion

scientific article published in March 2005

Targeting Plasmodium PI(4)K to eliminate malaria

scientific article (publication date: 12 December 2013)

The RON2-AMA1 interaction is a critical step in moving junction-dependent invasion by apicomplexan parasites

scientific article (publication date: 10 February 2011)

The genome of the simian and human malaria parasite Plasmodium knowlesi

scientific article

The translational value of non-human primates in preclinical research on infection and immunopathology.

scientific article published on 23 March 2015

Towards an in vitro model of Plasmodium hypnozoites suitable for drug discovery

scientific article

Transcriptomic analysis reveals reduced transcriptional activity in the malaria parasite during progression into dormancy

scientific article published on 27 December 2018

Transfected Plasmodium knowlesi produces bioactive host gamma interferon: a new perspective for modulating immune responses to malaria parasites

scientific article

Transgenic Plasmodium knowlesi: relieving a bottleneck in malaria research?

scientific article published on 25 July 2009

Transgenic fluorescent Plasmodium cynomolgi liver stages enable live imaging and purification of Malaria hypnozoite-forms

scientific article

Vaccination with Plasmodium knowlesi AMA1 formulated in the novel adjuvant co-vaccine HT™ protects against blood-stage challenge in rhesus macaques

scientific article (publication date: 2011)

Variable BCG efficacy in rhesus populations: Pulmonary BCG provides protection where standard intra-dermal vaccination fails.

scientific article

Variant Exported Blood-Stage Proteins Encoded by Plasmodium Multigene Families Are Expressed in Liver Stages Where They Are Exported into the Parasitophorous Vacuole

scientific article (publication date: November 2016)

Variations in the quality of malaria-specific antibodies with transmission intensity in a seasonal malaria transmission area of Northern Ghana

scientific article published on 25 September 2017

Workshop report: Malaria vaccine development in Europe--preparing for the future.

scientific article published on 30 September 2015

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