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List of works by Alexis Nzila

2,4-diaminopteridine-based compounds as precursors for de novo synthesis of antifolates: a novel class of antimalarials

scientific article

A genome wide association study of Plasmodium falciparum susceptibility to 22 antimalarial drugs in Kenya

scientific article (publication date: 2014)

A phase I trial to evaluate the safety and pharmacokinetics of low-dose methotrexate as an anti-malarial drug in Kenyan adult healthy volunteers ⬇️

scientific article published on March 16, 2011

An open dataset of Plasmodium falciparum genome variation in 7,000 worldwide samples

Analysis of Plasmodium falciparum diversity in natural infections by deep sequencing

scientific article (publication date: 19 July 2012)

Anticancer agents against malaria: time to revisit?

scientific article published on 6 January 2010

Antimalarial activity of isoquine against Kenyan Plasmodium falciparum clinical isolates and association with polymorphisms in pfcrt and pfmdr1 genes

scientific article published on 20 November 2012

Antimalarial chemotherapy: young guns or back to the future? ⬇️

scientific article published on November 1, 2003

Artemether/lumefantrine in the treatment of uncomplicated falciparum malaria

scientific article published on January 2007

Baseline In Vitro Activities of the Antimalarials Pyronaridine and Methylene Blue against Plasmodium falciparum Isolates from Kenya ⬇️

scientific article published on November 28, 2011

Bioaugmentation: An Emerging Strategy of Industrial Wastewater Treatment for Reuse and Discharge

scientific article

Biodegradation of high-molecular-weight polycyclic aromatic hydrocarbons under anaerobic conditions: Overview of studies, proposed pathways and future perspectives.

scientific article

Biogenic Synthesis and Characterization of Chitosan-CuO Nanocomposite and Evaluation of Antibacterial Activity against Gram-Positive and -Negative Bacteria

scientific article published on 29 April 2022

Biotransformation and biocatalysis: roles and applications in the discovery of antimalarials

scientific article published on December 2012

Characterisation and microbial community analysis of lipid utilising microorganisms for biogas formation

scientific article published on 08 November 2019

Characterisation of the bifunctional dihydrofolate synthase-folylpolyglutamate synthase from Plasmodium falciparum; a potential novel target for antimalarial antifolate inhibition

scientific article

Characteristics of Plasmodium falciparum dhfr haplotypes that confer pyrimethamine resistance, Kilifi, Kenya, 1987--2006

scientific article published on June 2008

Characterization of aerobic oil and grease-degrading bacteria in wastewater

scientific article

Chemosensitization of Plasmodium falciparum by probenecid in vitro

scientific article

Chloroquine resistance before and after its withdrawal in Kenya

scientific article published on 18 May 2009

Combination of probenecid-sulphadoxine-pyrimethamine for intermittent preventive treatment in pregnancy ⬇️

scientific article published on February 9, 2012

Comparative folate metabolism in humans and malaria parasites (part I): pointers for malaria treatment from cancer chemotherapy

scientific article

Comparative folate metabolism in humans and malaria parasites (part II): activities as yet untargeted or specific to Plasmodium

scientific article

Current Status of and Future Perspectives in Bacterial Degradation of Benzo[a]pyrene

scientific article published on 31 December 2020

Current Status of the Degradation of Aliphatic and Aromatic Petroleum Hydrocarbons by Thermophilic Microbes and Future Perspectives

scientific article published on 07 December 2018

Declining responsiveness of Plasmodium falciparum infections to artemisinin-based combination treatments on the Kenyan coast

scientific article

Degradation of benzo[a]pyrene by halophilic bacterial strain Staphylococcus haemoliticus strain 10SBZ1A

scientific article published on 25 February 2021

Drug Repositioning in the Treatment of Malaria and TB ⬇️

scientific article published on September 1, 2011

Drugs for the treatment of malaria in the Kingdom of Saudi Arabia

scientific article published on June 2013

Effect of folate derivatives on the activity of antifolate drugs used against malaria and cancer

scientific article

Genome wide adaptations of Plasmodium falciparum in response to lumefantrine selective drug pressure

scientific article

Genome-wide screen identifies new candidate genes associated with artemisinin susceptibility in Plasmodium falciparum in Kenya

scientific article

Genomic epidemiology of the current wave of artemisinin resistant malaria

scholarly article by Roberto Amato et al published 22 May 2015 in bioRxiv

Impact of folate supplementation on the efficacy of sulfadoxine/pyrimethamine in preventing malaria in pregnancy: the potential of 5-methyl-tetrahydrofolate

scientific article published on 14 October 2013

In vitro activities of 2,4-diaminoquinazoline and 2,4-diaminopteridine derivatives against Plasmodium falciparum

scientific article published on October 2004

In vitro activities of piperaquine, lumefantrine, and dihydroartemisinin in Kenyan Plasmodium falciparum isolates and polymorphisms in pfcrt and pfmdr1.

scientific article published on 21 September 2009

In vitro activities of quinine and other antimalarials and pfnhe polymorphisms in Plasmodium isolates from Kenya

scientific article published on June 2010

In vitro activity of antifolate and polymorphism in dihydrofolate reductase of Plasmodium falciparum isolates from the Kenyan coast: emergence of parasites with Ile-164-Leu mutation

scientific article published on 15 June 2009

In vitro chemosensitization of Plasmodium falciparum to antimalarials by verapamil and probenecid

scientific article published on 13 April 2009

In vitro selection of Plasmodium falciparum drug-resistant parasite lines

scientific article

In vivo and in vitro efficacy of amodiaquine against Plasmodium falciparum in an area of continued use of 4-aminoquinolines in East Africa

scientific article published in June 2009

Inhibitors of de novo folate enzymes in Plasmodium falciparum

scientific article

Malaria in the Era of Food Fortification With Folic Acid

scientific article published on 4 March 2016

Methotrexate and aminopterin lack in vivo antimalarial activity against murine malaria species

scientific article published on 13 June 2009

Methotrexate is highly potent against pyrimethamine-resistant Plasmodium vivax ⬇️

scientific article

Mini review: Update on bioaugmentation in anaerobic processes for biogas production

scientific article published on 22 November 2016

Modulators of the efficacy and toxicity of drugs in malaria treatment

scientific article published on 09 April 2010

Molecular monitoring of the Leu-164 mutation of dihydrofolate reductase in a highly sulfadoxine/pyrimethamine-resistant area in Africa

scientific article

Piperaquine and Lumefantrine resistance in Plasmodium berghei ANKA associated with increased expression of Ca2+/H+ antiporter and glutathione associated enzymes.

scientific article published on 18 October 2014

PlasmoView: a web-based resource to visualise global Plasmodium falciparum genomic variation

scientific article

Polymorphisms in Plasmodium falciparum chloroquine resistance transporter and multidrug resistance 1 genes: parasite risk factors that affect treatment outcomes for P. falciparum malaria after artemether-lumefantrine and artesunate-amodiaquine

scientific article

Population genetic analysis of Plasmodium falciparum parasites using a customized Illumina GoldenGate genotyping assay

scientific article

Preclinical Evaluation of the Antifolate QN254, 5-Chloro- N'6'-(2,5-Dimethoxy-Benzyl)-Quinazoline-2,4,6-Triamine, as an Antimalarial Drug Candidate

scientific article

Preparation of Silver/Chitosan Nanofluids Using Selected Plant Extracts: Characterization and Antimicrobial Studies Against Gram-Positive and Gram-Negative Bacteria

scientific article published on 01 April 2020

Repeat polymorphisms in the low-complexity regions of Plasmodium falciparum ABC transporters and associations with in vitro antimalarial responses.

scientific article published on 30 September 2013

Short report: association between chloroquine and amodiaquine resistance and allelic variation in the Plasmodium falciparum multiple drug resistance 1 gene and the chloroquine resistance transporter gene in isolates from the upper Nile in southern S

scientific article published on August 2003

The MSPDBL2 codon 591 polymorphism is associated with lumefantrine in vitro drug responses in Plasmodium falciparum isolates from Kilifi, Kenya

scientific article

The molecular basis of folate salvage in Plasmodium falciparum: characterization of two folate transporters

scientific article (publication date: 30 December 2011)

The past, present and future of antifolates in the treatment of Plasmodium falciparum infection

scientific article

Therapeutic potential of folate uptake inhibition in Plasmodium falciparum

scientific article

Update on genetic markers of quinine resistance in Plasmodium falciparum

scientific article published on February 2011

Update on the cometabolism of organic pollutants by bacteria ⬇️

scientific article published on 06 April 2013

Whole-genome scans provide evidence of adaptive evolution in Malawian Plasmodium falciparum isolates

scientific article

Why has the dihydrofolate reductase 164 mutation not consistently been found in Africa yet?

scientific article

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