List of works - Joshua Rokach

12-Oxo-LTB4, a Key Pivotal Intermediate in LTB4 Metabolism

article

5-oxo-6,8,11,14-eicosatetraenoic acid induces the infiltration of granulocytes into human skin

scientific article

5-oxo-ETE is a major oxidative stress-induced arachidonate metabolite in B lymphocytes

scientific article published on 18 February 2011

A convenient strategy for the synthesis of β,γ-unsaturated aldehydes and acids. A construction of skipped dienes

article published in 1999

A new method for the preparation of olefins from vicinal diols

article published in 1999

A new synthetic approach for 4(S)-hydroxycyclopent-2-enone: a precursor to prostanoid synthesis

article

A photoaffinity probe for 5-hydroxyeicosanoid dehydrogenase suitable for radioiodination

Airway epithelial cells synthesize the lipid mediator 5-oxo-ETE in response to oxidative stress

scientific article published on 14 December 2006

An efficient approach to the synthesis of LTB4 and ω-substituted LTB4 metabolites

An efficient preparation of stereospecific β-hydroxy nitriles

Biochemistry, biology and chemistry of the 5-lipoxygenase product 5-oxo-ETE

scientific article

Biosynthesis, biological effects, and receptors of hydroxyeicosatetraenoic acids (HETEs) and oxoeicosatetraenoic acids (oxo-ETEs) derived from arachidonic acid

scientific article

Corrigendum to "In vivo α-hydroxylation of a 2-alkylindole antagonist of the OXE receptor for the eosinophil chemoattractant 5-oxo-6,8,11,14-eicosatetraenoic acid in monkeys" [Biochem. Pharmacol. 138 (2017) 107-118]

scientific article published on 10 May 2018

Effects of prostaglandin D2, 15-deoxy-Delta12,14-prostaglandin J2, and selective DP1 and DP2 receptor agonists on pulmonary infiltration of eosinophils in Brown Norway rats

scientific article published on 8 December 2004

Enhanced formation of 5-oxo-6,8,11,14-eicosatetraenoic acid by cancer cells in response to oxidative stress, docosahexaenoic acid and neutrophil-derived 5-hydroxy-6,8,11,14-eicosatetraenoic acid

scientific article

High-Pressure Liquid Chromatography of Oxo-Eicosanoids Derived from Arachidonic Acid

scientific article published in 1997

Human neutrophils convert the sebum-derived polyunsaturated fatty acid Sebaleic acid to a potent granulocyte chemoattractant ⬇️

scientific article

In vivo α-hydroxylation of a 2-alkylindole antagonist of the OXE receptor for the eosinophil chemoattractant 5-oxo-6,8,11,14-eicosatetraenoic acid in monkeys.

scientific article published on 2 May 2017

Inhibition of allergen-induced dermal eosinophilia by an oxoeicosanoid receptor antagonist in non-human primates

scientific article published on 17 January 2020

Interactions between 5-oxo-ETE and chemokines in stimulating eosinophils

scientific article

Intramolecular sulfur-assisted NaBH4 reduction of esters synthesis of 5-oxo-ETE and 5-oxo-12-HETE

Metabolism and pharmacokinetics of a potent N-acylindole antagonist of the OXE receptor for the eosinophil chemoattractant 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE) in rats and monkeys

scientific article published on 12 January 2018

Quantification of lipid mediator metabolites in human urine from asthma patients by electrospray ionization mass spectrometry: controlling matrix effects

scientific article

Reductive Deprotection of Silyl Groups with Wilkinson's Catalyst/Catechol Borane

scientific article

Regulation of 5-hydroxyeicosanoid dehydrogenase activity in monocytic cells

scientific article published on April 2007

Silyl group deprotection by Pd/C/H2. A facile and selective method

Stereoselective synthesis of two highly potent 5-oxo-ETE receptor antagonists

Structure-activity relationship study of β-oxidation resistant indole-based 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE) receptor antagonists

scientific article

Synthesis of 12-KETE and its 8,9-trans-isomer

Targeting the OXE receptor as a potential novel therapy for asthma

scientific article published on 30 March 2020

The Total Synthesis of 5-Oxo-12(S)-hydroxy-6(E),8(Z),10(E),14(Z)-eicosatetraenoic Acid and Its 8,9-trans-Isomer and Their Identification in Human Platelets

The Total Synthesis of Tritiated and Deuterated 5-Oxo-ETE, a Novel Inflammatory Mediator

article published in 1998

The design and synthesis of a 5-HETE affinity chromatography ligand for 5-hydroxyeicosanoid dehydrogenase

The eosinophil chemoattractant 5-oxo-ETE and the OXE receptor

scientific article

The synthesis of a 5-HETE photoaffinity ligand

Total Synthesis of a Potent Proinflammatory 5-Oxo-ETE and Its 6,7-Dihydro Biotransformation Product

article

List of works by Joshua Rokach

12-Oxo-LTB4, a Key Pivotal Intermediate in LTB4 Metabolism

5-oxo-6,8,11,14-eicosatetraenoic acid induces the infiltration of granulocytes into human skin

5-oxo-ETE is a major oxidative stress-induced arachidonate metabolite in B lymphocytes

A convenient strategy for the synthesis of β,γ-unsaturated aldehydes and acids. A construction of skipped dienes

A new method for the preparation of olefins from vicinal diols

A new synthetic approach for 4(S)-hydroxycyclopent-2-enone: a precursor to prostanoid synthesis

A photoaffinity probe for 5-hydroxyeicosanoid dehydrogenase suitable for radioiodination

Airway epithelial cells synthesize the lipid mediator 5-oxo-ETE in response to oxidative stress

An efficient approach to the synthesis of LTB4 and ω-substituted LTB4 metabolites

An efficient preparation of stereospecific β-hydroxy nitriles

Biochemistry, biology and chemistry of the 5-lipoxygenase product 5-oxo-ETE

Biosynthesis, biological effects, and receptors of hydroxyeicosatetraenoic acids (HETEs) and oxoeicosatetraenoic acids (oxo-ETEs) derived from arachidonic acid

Corrigendum to "In vivo α-hydroxylation of a 2-alkylindole antagonist of the OXE receptor for the eosinophil chemoattractant 5-oxo-6,8,11,14-eicosatetraenoic acid in monkeys" [Biochem. Pharmacol. 138 (2017) 107-118]

Effects of prostaglandin D2, 15-deoxy-Delta12,14-prostaglandin J2, and selective DP1 and DP2 receptor agonists on pulmonary infiltration of eosinophils in Brown Norway rats

Enhanced formation of 5-oxo-6,8,11,14-eicosatetraenoic acid by cancer cells in response to oxidative stress, docosahexaenoic acid and neutrophil-derived 5-hydroxy-6,8,11,14-eicosatetraenoic acid

High-Pressure Liquid Chromatography of Oxo-Eicosanoids Derived from Arachidonic Acid

Human neutrophils convert the sebum-derived polyunsaturated fatty acid Sebaleic acid to a potent granulocyte chemoattractant ⬇️

In vivo α-hydroxylation of a 2-alkylindole antagonist of the OXE receptor for the eosinophil chemoattractant 5-oxo-6,8,11,14-eicosatetraenoic acid in monkeys.

Inhibition of allergen-induced dermal eosinophilia by an oxoeicosanoid receptor antagonist in non-human primates

Interactions between 5-oxo-ETE and chemokines in stimulating eosinophils

Intramolecular sulfur-assisted NaBH4 reduction of esters synthesis of 5-oxo-ETE and 5-oxo-12-HETE

Metabolism and pharmacokinetics of a potent N-acylindole antagonist of the OXE receptor for the eosinophil chemoattractant 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE) in rats and monkeys

Quantification of lipid mediator metabolites in human urine from asthma patients by electrospray ionization mass spectrometry: controlling matrix effects

Reductive Deprotection of Silyl Groups with Wilkinson's Catalyst/Catechol Borane

Regulation of 5-hydroxyeicosanoid dehydrogenase activity in monocytic cells

Silyl group deprotection by Pd/C/H2. A facile and selective method

Stereoselective synthesis of two highly potent 5-oxo-ETE receptor antagonists

Structure-activity relationship study of β-oxidation resistant indole-based 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE) receptor antagonists

Synthesis of 12-KETE and its 8,9-trans-isomer

Targeting the OXE receptor as a potential novel therapy for asthma

The Total Synthesis of 5-Oxo-12(S)-hydroxy-6(E),8(Z),10(E),14(Z)-eicosatetraenoic Acid and Its 8,9-trans-Isomer and Their Identification in Human Platelets

The Total Synthesis of Tritiated and Deuterated 5-Oxo-ETE, a Novel Inflammatory Mediator

The design and synthesis of a 5-HETE affinity chromatography ligand for 5-hydroxyeicosanoid dehydrogenase

The eosinophil chemoattractant 5-oxo-ETE and the OXE receptor

The synthesis of a 5-HETE photoaffinity ligand

Total Synthesis of a Potent Proinflammatory 5-Oxo-ETE and Its 6,7-Dihydro Biotransformation Product

Total synthesis of proinflammatory dihydro-12-KETE metabolites