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List of works by Guy Sauvageau

A Fanci knockout mouse model reveals common and distinct functions for FANCI and FANCD2

scientific article published on 01 August 2019

A functional screen to identify novel effectors of hematopoietic stem cell activity

scientific journal article

A key role for EZH2 and associated genes in mouse and human adult T-cell acute leukemia

scientific article published on 19 March 2012

A mutant allele of the Swi/Snf member BAF250a determines the pool size of fetal liver hemopoietic stem cell populations

scientific article

A retroviral strategy that efficiently creates chromosomal deletions in mammalian cells

scientific article published on 4 February 2007

A role for GPx3 in activity of normal and leukemia stem cells

scientific article

AML1-ETO requires enhanced C/D box snoRNA/RNP formation to induce self-renewal and leukaemia

scientific article published on 26 June 2017

Allodepleted T-cell immunotherapy after haploidentical haematopoietic stem cell transplantation without severe acute graft-versus-host disease (GVHD) in the absence of GVHD prophylaxis

scientific article published on 28 May 2019

An RNAi screen identifies Msi2 and Prox1 as having opposite roles in the regulation of hematopoietic stem cell activity

scientific article

An anticlastogenic function for the Polycomb Group gene Bmi1.

scientific article

An automated system for delivery of an unstable transcription factor to hematopoietic stem cell cultures

scientific article published in June 2009

Analysis of HSC activity and compensatory Hox gene expression profile in Hoxb cluster mutant fetal liver cells

scientific article published on 8 December 2005

Analysis of blood stem cell activity and cystatin gene expression in a mouse model presenting a chromosomal deletion encompassing Csta and Stfa2l1

scientific article

Are genetic determinants of asymmetric stem cell division active in hematopoietic stem cells?

scientific article published in September 2004

Asymmetric segregation and self-renewal of hematopoietic stem and progenitor cells with endocytic Ap2a2

scientific journal article

Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells ⬇️

scientific article (publication date: 15 May 2003)

Bringing a Leukemic Stem Cell Gene Signature into Clinics: Are We There Yet?

scientific article published in March 2017

C-terminal domain of MEIS1 converts PKNOX1 (PREP1) into a HOXA9-collaborating oncoprotein.

scientific article published on 7 September 2011

Cardiac tamponade potentially related to sirolimus following cord blood transplantation ⬇️

scientific article published on March 14, 2011

Cellular proliferation and transformation induced by HOXB4 and HOXB3 proteins involves cooperation with PBX1 ⬇️

scientific article published on July 2, 1998

Chemo-genomic interrogation of CEBPA mutated AML reveals recurrent CSF3R mutations and subgroup sensitivity to JAK inhibitors

scientific article published on 31 March 2016

Chemogenomic Landscape of RUNX1-mutated AML Reveals Importance of RUNX1 Allele Dosage in Genetics and Glucocorticoid Sensitivity

scientific article published on 30 August 2017

Complex karyotype AML displays G2/M signature and hypersensitivity to PLK1 inhibition

scientific article published on 01 February 2019

Cord blood expansion. Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal

scientific article

Correction: High expression of HMGA2 independently predicts poor clinical outcomes in acute myeloid leukemia

scientific article published on 28 February 2019

Cost-Effectiveness Analysis of a HMGA2 Prognostic Test for Acute Myeloid Leukemia in a Canadian Setting

scientific article published on 01 December 2019

Cut-like homeobox 1 (CUX1) tumor suppressor gene haploinsufficiency induces apoptosis evasion to sustain myeloid leukemia

scientific article published on 30 April 2021

Deregulated expression of HOXB4 enhances the primitive growth activity of human hematopoietic cells

scientific article (publication date: August 2002)

Distinct signaling programs control human hematopoietic stem cell survival and proliferation.

scientific article

E4F1 is a master regulator of CHK1-mediated functions

scientific article

E4F1: a novel candidate factor for mediating BMI1 function in primitive hematopoietic cells

scientific article published on August 2006

EN2 is a candidate oncogene in human breast cancer

scientific article published on October 2005

EPCR expression marks UM171-expanded CD34+ cord blood stem cells.

scientific article published on 13 April 2017

EVI1-rearranged acute myeloid leukemias are characterized by distinct molecular alterations

scientific article

Effect of Monoclonal Antibodies to Epstein-Barr Virus Envelope Glycoproteins on Epstein-Barr Virus Neutralization and Binding to Target Cell Receptors ⬇️

scientific article published on January 1, 1990

Entinostat prevents leukemia maintenance in a collaborating oncogene-dependent model of cytogenetically normal acute myeloid leukemia

scientific article published in July 2013

Essential role of BRG, the ATPase subunit of BAF chromatin remodeling complexes, in leukemia maintenance.

scientific article published on 29 January 2014

Evaluation of the Impact of Autologous Hematopoietic Stem Cell Transplantation on the Quality of Life of Older Patients with Lymphoma

scientific article published on 12 September 2019

Evidence that donor intrinsic response to G-CSF is the best predictor of acute graft-vs-host disease following allogeneic peripheral blood stem cell transplantation

scientific article published on January 2006

Expression of immunoproteasome genes is regulated by cell-intrinsic and -extrinsic factors in human cancers

scientific article published on 23 September 2016

GPR56 identifies primary human acute myeloid leukemia cells with high repopulating potential in vivo.

scientific article

Genetic Landscape of Electron Transport Chain Complex I Dependency in Acute Myeloid Leukemia

Genetic characterization of ABT-199 sensitivity in human AML

scientific article published on 12 July 2019

Genetic programs regulating HSC specification, maintenance and expansion

scientific article published in September 2004

Genome-wide interrogation of Mammalian stem cell fate determinants by nested chromosome deletions

scientific article

Gfi-1: another piece in the HSC puzzle

scientific article

Graft-versus-host disease prophylaxis with tacrolimus and mycophenolate mofetil in HLA-matched nonmyeloablative transplant recipients is associated with very low incidence of GVHD and nonrelapse mortality

scientific article

H3K27M/I mutations promote context-dependent transformation in acute myeloid leukemia with RUNX1 alterations

scientific article published on 30 August 2017

HOXB4-induced expansion of adult hematopoietic stem cells ex vivo

scientific article published in April 2002

Haploinsufficiency screen highlights two distinct groups of ribosomal protein genes essential for embryonic stem cell fate.

scientific article

Hematopoietic stem cell transplantation using single UM171-expanded cord blood: a single-arm, phase 1-2 safety and feasibility study

scientific article published on 06 November 2019

Hepatic leukemia factor is a novel leukemic stem cell regulator in DNMT3A, NPM1, and FLT3-ITD triple-mutated AML

scientific article published on 10 May 2019

High expression of HMGA2 independently predicts poor clinical outcomes in acute myeloid leukemia

scientific article published on 19 July 2018

High frequency of germline RUNX1 mutations in RUNX1 mutated AML patients

scientific article published on 13 February 2020

High incidence of invasive aspergillosis associated with intestinal graft-versus-host disease following nonmyeloablative transplantation

scientific article published on 3 August 2007

High incidence of proviral integrations in the Hoxa locus in a new model of E2a-PBX1-induced B-cell leukemia.

scientific article

High-throughput screening in niche-based assay identifies compounds to target preleukemic stem cells.

scientific article

HoxA cluster is haploinsufficient for activity of hematopoietic stem and progenitor cells

scientific article published on 23 July 2010

Hoxa cluster genes determine the proliferative activity of adult mouse hematopoietic stem and progenitor cells.

scientific article

Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b ⬇️

scientific article published on July 1, 1998

Human NUP98-HOXA9 promotes hyperplastic growth of hematopoietic tissues in Drosophila

scientific article published on 9 November 2016

Identification of cooperative genes for NUP98-HOXA9 in myeloid leukemogenesis using a mouse model

scientific article

Identification of non-cell-autonomous networks from engineered feeder cells that enhance murine hematopoietic stem cell activity

scientific article

Identification of small molecules that support human leukemia stem cell activity ex vivo.

scientific article published on 23 February 2014

In vitro and in vivo expansion of hematopoietic stem cells.

scientific article published in September 2004

In vitro expansion of hematopoietic stem cells by recombinant TAT-HOXB4 protein

scientific article

Incidence and prognostic value of eosinophilia in chronic graft-versus-host disease after nonmyeloablative hematopoietic cell transplantation

scientific article

Integrin-α3 Is a Functional Marker of Ex Vivo Expanded Human Long-Term Hematopoietic Stem Cells

scientific article published on 01 July 2019

Killer granzyme B linked to N-myc- and c-myc-dependent HSC survival: isn't that comyc?

scientific article published on December 2008

Legal and Ethical Considerations for the Design and Use of Web Portals for Researchers, Clinicians, and Patients: Scoping Literature Review

scientific article published on 05 August 2021

Loss of expression of the Hoxa-9 homeobox gene impairs the proliferation and repopulating ability of hematopoietic stem cells

scientific article

MEF2C phosphorylation is required for chemotherapy resistance in acute myeloid leukemia.

scientific article published on 5 February 2018

Medicine. The blood stem cell Holy Grail?

scientific article

MiSTIC, an integrated platform for the analysis of heterogeneity in large tumour transcriptome datasets

scientific article published on 4 May 2017

Molecular basis for stem-cell self-renewal

scientific article published on January 2004

Molecular dissection of Meis1 reveals 2 domains required for leukemia induction and a key role for Hoxa gene activation

scientific article published on 09 February 2006

Molecular interactions involved in HOXB4-induced activation of HSC self-renewal

scientific article published on 29 June 2004

Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of OXPHOS Dependency in Acute Myeloid Leukemia

scientific article published on 01 July 2019

Near-maximal expansions of hematopoietic stem cells in culture using NUP98-HOX fusions

scientific article published on May 2007

Newly diagnosed multiple myeloma patients treated with tandem auto-allogeneic stem cell transplant have better overall survival with similar outcomes at time of relapse compared to patients who received autologous transplant only

scientific article published on 27 September 2020

Oncogenic interaction between BCR-ABL and NUP98-HOXA9 demonstrated by the use of an in vitro purging culture system.

scientific article

Outcome of autologous hematopoietic stem cell transplant in older patients with B cell lymphoma when selected for fitness and chemosensitive disease

scientific article published on 06 January 2019

Overexpression of the myeloid leukemia-associated Hoxa9 gene in bone marrow cells induces stem cell expansion

scientific article

Pathways, Processes, and Candidate Drugs Associated with a Hoxa Cluster-Dependency Model of Leukemia

scientific article published on 17 December 2019

Polycomb group genes as epigenetic regulators of normal and leukemic hemopoiesis

scientific article

Polycomb group genes: keeping stem cell activity in balance

scientific article

Polycomb group proteins: multi-faceted regulators of somatic stem cells and cancer

scientific article

Posttranslational regulation of self-renewal capacity: insights from proteome and phosphoproteome analyses of stem cell leukemia

scientific article published on 16 July 2012

Quantitative expression profiling guided by common retroviral insertion sites reveals novel and cell type specific cancer genes in leukemia

scientific article published on 28 September 2007

RNA-Seq reveals spliceosome and proteasome genes as most consistent transcripts in human cancer cells

scientific article

RNA-seq analysis of 2 closely related leukemia clones that differ in their self-renewal capacity.

scientific article published on 27 October 2010

RNA-sequencing analysis of core binding factor AML identifies recurrent ZBTB7A mutations and defines RUNX1-CBFA2T3 fusion signature

scientific article published on 11 March 2016

RNAi screen identifies Jarid1b as a major regulator of mouse HSC activity

scientific article published on 18 June 2013

Roles for MSI2 and PROX1 in hematopoietic stem cell activity

scientific article published on July 2011

SCL, LMO1 and Notch1 reprogram thymocytes into self-renewing cells

scientific article

SMARCD2 subunit of SWI/SNF chromatin-remodeling complexes mediates granulopoiesis through a CEBPɛ dependent mechanism

scientific article published on 3 April 2017

Safety and cost-effectiveness of outpatient autologous stem cell transplantation in patients with multiple myeloma

scientific article

Scl regulates the quiescence and the long-term competence of hematopoietic stem cells

scientific journal article

Selectively weakened binding of methotrexate by human dihydrofolate reductase allows rapid ex vivo selection of mammalian cells

scientific article published on 01 March 2011

Single UM171-expanded cord blood transplant can cure severe idiopathic aplastic anemia in absence of suitable donors

scientific article published on 04 August 2020

Small molecule regulation of normal and leukemic stem cells

scientific article published on July 2015

Sustained in vitro trigger of self-renewal divisions in Hoxb4hiPbx1(10) hematopoietic stem cells.

scientific article

Tandem autologous-allogeneic nonmyeloablative sibling transplantation in relapsed follicular lymphoma leads to impressive progression-free survival with minimal toxicity

scientific article published on 07 December 2011

Targeted variant detection using unaligned RNA-Seq reads

scientific article published on 19 August 2019

The competitive nature of HOXB4-transduced HSC is limited by PBX1: the generation of ultra-competitive stem cells retaining full differentiation potential

scientific article published on 01 April 2003

The methyltransferase G9a regulates HoxA9-dependent transcription in AML.

scientific article published on February 2014

The neuropeptide receptor calcitonin receptor-like (CALCRL) is a potential therapeutic target in acute myeloid leukemia

scientific article published on 10 June 2019

The signaling protein Wnt4 enhances thymopoiesis and expands multipotent hematopoietic progenitors through beta-catenin-independent signaling

scientific journal article

The transcriptomic landscape and directed chemical interrogation of MLL-rearranged acute myeloid leukemias

scientific article

Transcriptomic landscape of acute promyelocytic leukemia reveals aberrant surface expression of the platelet aggregation agonist Podoplanin.

scientific article published on 23 February 2018

UBAP2L is a novel BMI1-interacting protein essential for hematopoietic stem cell activity

scientific article

UBAP2L is amplified in a large subset of human lung adenocarcinoma and is critical for epithelial lung cell identity and tumor metastasis.

scientific article

UM171 Enhances Lentiviral Gene Transfer and Recovery of Primitive Human Hematopoietic Cells

article

UM171 Preserves Epigenetic Marks that Are Reduced in Ex Vivo Culture of Human HSCs via Potentiation of the CLR3-KBTBD4 Complex

scientific article published on 01 January 2021

UM171 induces a homeostatic inflammatory-detoxification response supporting human HSC self-renewal

scientific article published on 08 November 2019

UM171-expanded cord blood transplants support robust T cell reconstitution with low rates of severe infections

scientific article published on 03 October 2020

Uncovering stemness

scientific article published on 01 October 2006

Zfx: at the crossroads of survival and self-renewal

scientific article published on 01 April 2007

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