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List of works by David Mangelsdorf

1,25-Dihydroxyvitamin D3-induced differentiation in a human promyelocytic leukemia cell line (HL-60): receptor-mediated maturation to macrophage-like cells

scientific article

9-cis retinoic acid is a high affinity ligand for the retinoid X receptor

scientific article published on January 24, 1992

A Dozen Years of Discovery: Insights into the Physiology and Pharmacology of FGF21

scientific article published on 01 February 2019

A Nuclear Receptor Atlas: 3T3-L1 adipogenesis.

scientific article published on 28 July 2005

A direct repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR and RAR

scientific article

Activation of LXRs prevents bile acid toxicity and cholestasis in female mice.

scientific article published in February 2007

Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue

scientific article

Activation of mammalian retinoid X receptors by the insect growth regulator methoprene

scientific article

Activation of the orphan nuclear receptor steroidogenic factor 1 by oxysterols

scientific article

Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network

scientific article

Bile Acids as Hormones: The FXR-FGF15/19 Pathway ⬇️

scientific article published on 27 May 2015

Cardiac peroxisome proliferator-activated receptor γ is essential in protecting cardiomyocytes from oxidative damage

scientific article published on 04 July 2007

Characterization of DNA binding and retinoic acid binding properties of retinoic acid receptor ⬇️

scientific article published on May 1, 1991

Characterization of a region upstream of exon I.1 of the human CYP19 (aromatase) gene that mediates regulation by retinoids in human choriocarcinoma cells.

scientific article published on April 1998

Cholesterol and Bile Acid Metabolism Are Impaired in Mice Lacking the Nuclear Oxysterol Receptor LXRα ⬇️

scientific article published on May 29, 1998

Chromosomal localization of the human retinoid X receptors

scientific journal article

Circulating FGF21 is liver derived and enhances glucose uptake during refeeding and overfeeding.

scientific article

Cloning and expression of full-length cDNA encoding human vitamin D receptor

scientific article

Colesevelam suppresses hepatic glycogenolysis by TGR5-mediated induction of GLP-1 action in DIO mice.

scientific article published on 20 December 2012

Commentary: the year in nuclear receptor control of metabolism

scientific article

De-orphanization of cytochrome P450 2R1: a microsomal vitamin D 25-hydroxilase

scientific journal article

Detection of FGF15 in plasma by stable isotope standards and capture by anti-peptide antibodies and targeted mass spectrometry

scientific article published on June 2015

Differential expression and activation of a family of murine peroxisome proliferator-activated receptors

scientific journal article

Endocrine fibroblast growth factors 15/19 and 21: from feast to famine

scientific article

Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21

scientific article (publication date: June 2007)

Engineering novel specificities for ligand-activated transcription in the nuclear hormone receptor RXR

scientific article published on 01 January 1998

Engineering orthogonal ligand-receptor pairs from "near drugs".

scientific article

Enzymatic reduction of oxysterols impairs LXR signaling in cultured cells and the livers of mice.

scientific article published on January 2007

Evidence for in vivo upregulation of the intestinal vitamin D receptor during dietary calcium restriction in the rat.

scientific article

Expression of ABCG5 and ABCG8 is required for regulation of biliary cholesterol secretion

scientific article

FGF15/19 Regulates Hepatic Glucose Metabolism by Inhibiting the CREB-PGC-1α Pathway ⬇️

scientific article published on June 8, 2011

FGF19 as a postprandial, insulin-independent activator of hepatic protein and glycogen synthesis

scientific article

FGF19, FGF21, and an FGFR1/β-Klotho-Activating Antibody Act on the Nervous System to Regulate Body Weight and Glycemia

scientific article published on 5 October 2017

FGF21 Is an Exocrine Pancreas Secretagogue

scientific article published on 27 December 2016

FGF21 Regulates Sweet and Alcohol Preference.

scientific article published on 23 December 2015

FGF21 acts centrally to induce sympathetic nerve activity, energy expenditure, and weight loss.

scientific article

FGF21 induces PGC-1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response

scientific article

FGF21 regulates metabolism and circadian behavior by acting on the nervous system

scientific article published on 11 August 2013

Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor γ.

scientific article published on 6 February 2012

Fibroblast growth factor 21: from pharmacology to physiology

scientific article

Fibroblast growth factor-21 regulates PPARγ activity and the antidiabetic actions of thiazolidinediones.

scientific article

Functional interactions between the Moses corepressor and DHR78 nuclear receptor regulate growth in Drosophila. ⬇️

scientific article published on February 2007

Genetic evidence that the human CYP2R1 enzyme is a key vitamin D 25-hydroxylase

scientific article

Glucocorticoids regulate the metabolic hormone FGF21 in a feed-forward loop.

scientific article

Hepatocyte-specific mutation establishes retinoid X receptor alpha as a heterodimeric integrator of multiple physiological processes in the liver.

scientific article

Hormonal control of C. elegans dauer formation and life span by a Rieske-like oxygenase.

scientific article published on 23 March 2006

Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor.

scientific article published on 31 May 2001

Human white/murine ABC8 mRNA levels are highly induced in lipid-loaded macrophages. A transcriptional role for specific oxysterols

scientific article (publication date: 12 May 2000)

Identification and quantitation of intracellular retinol and retinoic acid binding proteins in cultured cells ⬇️

scientific article published on February 17, 1984

Identification of a hormonal basis for gallbladder filling.

scientific article

Identification of a liver-specific uridine phosphorylase that is regulated by multiple lipid-sensing nuclear receptors.

scientific article

Identification of ligands for DAF-12 that govern dauer formation and reproduction in C. elegans.

scientific article published on 9 March 2006

Impaired 17,20-Lyase Activity in Male Mice Lacking Cytochrome b5 in Leydig Cells

scientific article published on 14 March 2016

In VivoImaging of Farnesoid X Receptor Activity Reveals the Ileum as the Primary Bile Acid Signaling Tissue

scientific article published on 10 April 2007

Inhibition of growth hormone signaling by the fasting-induced hormone FGF21.

scientific article published on July 2008

Interaction between vitamin D receptor and vitamin D ligands: two-dimensional alanine scanning mutational analysis.

scientific article published in March 2003

Interleukin-1beta suppresses retinoid transactivation of two hepatic transporter genes involved in bile formation

scientific article published on 01 March 2000

International Union of Pharmacology. LXII. The NR1H and NR1I receptors: constitutive androstane receptor, pregnene X receptor, farnesoid X receptor alpha, farnesoid X receptor beta, liver X receptor alpha, liver X receptor beta, and vitamin D recept

scientific article

Interview: Interview with David Mangelsdorf for Personalized Medicine

scientific article published on 01 September 2011

Isolation of a functional ecdysteroid receptor homologue from the ixodid tick Amblyomma americanum (L.).

scientific article published on November 1997

Isolation of two functional retinoid X receptor subtypes from the Ixodid tick, Amblyomma americanum (L.) ⬇️

scientific article published on April 30, 1998

LRH-1 and PTF1-L coregulate an exocrine pancreas-specific transcriptional network for digestive function.

scientific article

LXR, a nuclear receptor that defines a distinct retinoid response pathway

scientific article

LXRS and FXR: the yin and yang of cholesterol and fat metabolism

scientific article

LXRs regulate the balance between fat storage and oxidation.

scientific article published in April 2005

LXRβ is required for glucocorticoid-induced hyperglycemia and hepatosteatosis in mice.

scientific article

Liver LXRα expression is crucial for whole body cholesterol homeostasis and reverse cholesterol transport in mice

scientific article

Liver X Receptor Signaling Pathways in Cardiovascular Disease ⬇️

scientific article published on April 10, 2003

Liver X receptor activators display anti-inflammatory activity in irritant and allergic contact dermatitis models: liver-X-receptor-specific inhibition of inflammation and primary cytokine production.

scientific article published in February 2003

Liver X receptor alpha is a transcriptional repressor of the uncoupling protein 1 gene and the brown fat phenotype.

scientific article

Liver X receptors and cholesterol homoeostasis: spotlight on the adrenal gland.

scientific article published on December 2006

Liver receptor homolog-1 regulates bile acid homeostasis but is not essential for feedback regulation of bile acid synthesis.

scientific article published on 6 March 2008

Loss of the liver X receptor LXRα/β in peripheral sensory neurons modifies energy expenditure.

scientific article published on 15 June 2015

Methylprednisolone acetate induces, and Δ7-dafachronic acid suppresses, Strongyloides stercoralis hyperinfection in NSG mice

scientific article

MicroRNA let-7 regulates 3T3-L1 adipogenesis

scientific article

Multiple retinoid-responsive receptors in a single cell: families of retinoid "X" receptors and retinoic acid receptors in the Xenopus egg ⬇️

scientific article (publication date: 15 March 1992)

Nuclear Receptor Expression Defines a Set of Prognostic Biomarkers for Lung Cancer ⬇️

scientific article (publication date: 14 December 2010)

Nuclear Receptors HNF4α and LRH-1 Cooperate in Regulating Cyp7a1 in Vivo ⬇️

scientific article published on October 4, 2012

Nuclear Receptors and Lipid Physiology: Opening the X-Files ⬇️

scientific article (publication date: 30 November 2001)

Nuclear Receptors, RXR, and the Big Bang

scientific article

Nuclear hormone receptor regulation of microRNAs controls developmental progression.

scientific article published on April 2009

Nuclear oxysterol receptors, LXRs, are involved in the maintenance of mouse caput epididymidis structure and functions.

scientific article published in October 2004

Nuclear receptor LRH-1 induces the reproductive neuropeptide kisspeptin in the hypothalamus.

scientific article

Nuclear receptor regulation of cholesterol and bile acid metabolism.

scientific article

Nuclear receptor regulation of stemness and stem cell differentiation.

scientific article published on August 2009

Nuclear receptors: emerging drug targets for parasitic diseases.

scientific article published on 6 February 2017

Orphan nuclear receptors as eLiXiRs and FiXeRs of sterol metabolism.

scientific article

Overexpression of leptin receptors in pancreatic islets of Zucker diabetic fatty rats restores GLUT-2, glucokinase, and glucose-stimulated insulin secretion

scientific article

Oxysterol stimulation of epidermal differentiation is mediated by liver X receptor-beta in murine epidermis.

scientific article published in January 2002

Oxysterols induce differentiation in human keratinocytes and increase Ap-1-dependent involucrin transcription

scientific article

PPARγ in vagal neurons regulates high-fat diet induced thermogenesis

scientific journal article

PPARγ-K107 SUMOylation regulates insulin sensitivity but not adiposity in mice

article published in the Proceedings of the National Academy of Sciences of the United States of America

Pancreatitis is an FGF21-deficient state that is corrected by replacement therapy

scientific article published on 01 January 2020

Partial resistance to peroxisome proliferator-activated receptor-alpha agonists in ZDF rats is associated with defective hepatic mitochondrial metabolism.

scientific article published on 9 May 2008

Placental expression of the nuclear receptors for oxysterols LXRalpha and LXRbeta during mouse and human development.

scientific article published on March 2005

Pregnane X receptor is a target of farnesoid X receptor

scientific article published on 08 May 2006

Prevention of cholesterol gallstone disease by FXR agonists in a mouse model.

scientific article

Prolongevity hormone FGF21 protects against immune senescence by delaying age-related thymic involution

scientific article

Reduction of atherosclerosis in apolipoprotein E knockout mice by activation of the retinoid X receptor.

scholarly article

Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and beta

scientific article (publication date: 30 August 2002)

Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors alpha and beta.

scientific article published on 18 March 2002

Regulation of Life Cycle Checkpoints and Developmental Activation of Infective Larvae in Strongyloides stercoralis by Dafachronic Acid

scientific article published on 4 January 2016

Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers

scientific article published on 01 September 2000

Regulation of lipoprotein lipase by the oxysterol receptors, LXRalpha and LXRbeta.

scientific article

Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta

scientific article

Regulation of the aldo-keto reductase gene akr1b7 by the nuclear oxysterol receptor LXRalpha (liver X receptor-alpha) in the mouse intestine: putative role of LXRs in lipid detoxification processes

scientific journal article

Research resource: Comprehensive expression atlas of the fibroblast growth factor system in adult mouse.

scientific article

Retinoic acid receptor expression abnormalities in lung cancer: important clues or major obstacles?

scientific article published on 01 May 1997

Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling ⬇️

scientific article (publication date: 30 January 1992)

Retinoid X receptor-COUP-TF interactions modulate retinoic acid signaling ⬇️

scientific article published on February 15, 1992

Role of LXRs in control of lipogenesis

scientific article

Roles of FGF19 in liver metabolism.

scientific article published on 03 August 2011

SnapShot: Hormones of the gastrointestinal tract.

scientific article published in December 2014

Stress pathway activation induces phosphorylation of retinoid X receptor

scientific article published on 01 October 2000

Structural Conservation of Ligand Binding Reveals a Bile Acid-like Signaling Pathway in Nematodes

scientific article

Structural determinants for vitamin D receptor response to endocrine and xenobiotic signals.

scientific article published on 2 October 2003

Structural determinants of allosteric ligand activation in RXR heterodimers.

scientific article published in February 2004

Structural insights into gene repression by the orphan nuclear receptor SHP

scientific article

The Drosophila orphan nuclear receptor DHR38 mediates an atypical ecdysteroid signaling pathway

scientific article

The G Protein-Coupled Bile Acid Receptor, TGR5, Stimulates Gallbladder Filling ⬇️

scientific article published on March 31, 2011

The Hormone FGF21 Stimulates Water Drinking in Response to Ketogenic Diet and Alcohol

scientific article published on 12 April 2018

The LXRs: a new class of oxysterol receptors

scientific article published on 01 October 1998

The RXR heterodimers and orphan receptors

scientific article (publication date: 15 December 1995)

The Rieske oxygenase DAF-36 functions as a cholesterol 7-desaturase in steroidogenic pathways governing longevity.

scientific article published on 7 August 2011

The nuclear receptor DAF-12 regulates nutrient metabolism and reproductive growth in nematodes

scientific article

The nuclear receptor superfamily: the second decade

scientific article (publication date: 15 December 1995)

The orphan nuclear receptor SHP regulates ER stress response by inhibiting XBP1s degradation

scientific article published on 11 July 2019

The starvation hormone, fibroblast growth factor-21, extends lifespan in mice.

scientific article

The Schistosoma mansoni nuclear receptor FTZ-F1 maintains esophageal gland function via transcriptional regulation of meg-8.3.

scientific article published on 15 December 2021

Tissue-specific actions of the metabolic hormones FGF15/19 and FGF21.

scientific article

Transcriptional activation of the Drosophila ecdysone receptor by insect and plant ecdysteroids.

scientific article published in November 2000

Trypanosoma brucei:Effects of Methoprene and Other Isoprenoid Compounds on Procyclic and Bloodstream Formsin Vitroand in Mice ⬇️

scientific article published on November 1, 1997

Unique requirements for retinoid-dependent transcriptional activation by the orphan receptor LXR.

scientific article published on February 1997

Vitamin A receptors.

scientific article

βKlotho Is Required for Fibroblast Growth Factor 21 Effects on Growth and Metabolism ⬇️

scientific article published on September 5, 2012

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