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List of works by Domenico Regoli

A new ligand for the urotensin II receptor

scientific article published on October 2002

Altered anxiety-related behavior in nociceptin/orphanin FQ receptor gene knockout mice

article

Angiotensin II induced increase in frequency of cytosolic and nuclear calcium waves of heart cells via activation of AT1 and AT2 receptors

scientific article published in August 2005

Angiotensin II-induced increase of T-type Ca2+ current and decrease of L-type Ca2+ current in heart cells.

scientific article published on 8 April 2005

Angiotensin, high blood pressure and glomerular autoregulation

scientific article published in April 2004

Anxiolytic- and antidepressant-like activities of H-Dmt-Tic-NH-CH(CH2-COOH)-Bid (UFP-512), a novel selective delta opioid receptor agonist.

scientific article

Autoradiographic analysis of rat brain kinin B1 and B2 receptors: normal distribution and alterations induced by epilepsy

scientific article published in July 2003

Biological markers to predict cardiac resynchronization therapy effect

scientific article published on 06 August 2014

Bradykinin B2 type receptor activation regulates fluid and electrolyte transport in the rabbit kidney.

scientific article published on 13 April 2005

Bradykinin induced a positive chronotropic effect via stimulation of T- and L-type calcium currents in heart cells.

scientific article published in March 2003

Bradykinin receptor ligands: therapeutic perspectives

scientific article published in October 2004

Characterization and localization of Ac-SDKP receptor binding sites using 125I-labeled Hpp-Aca-SDKP in rat cardiac fibroblasts

scientific article published on 6 October 2006

Chronic effects of angiotensin-converting enzyme inhibition on kinin receptor binding sites in the rat spinal cord.

scientific article published on 13 February 2003

Conformation-activity relationship of neuropeptide S and some structural mutants: helicity affects their interaction with the receptor

scientific article published on 15 August 2007

Contractile responses of aortae from WKY and SHR to vasoconstrictors

scientific journal article

Critical insights into the beneficial and protective actions of the kallikrein-kinin system

scientific article published on 09 January 2015

Daily Intravesical Instillation of 1 mg Nociceptin/Orphanin FQ for the Control of Neurogenic Detrusor Overactivity: A Multicenter, Placebo Controlled, Randomized Exploratory Study

article by Massimo Lazzeri et al published November 2006 in Journal of Urology

Dmt-Tic-NH-CH2-Bid (UFP-502), a potent DOP receptor agonist: in vitro and in vivo studies.

scientific article published on 11 September 2006

Do angiotensin-converting enzyme inhibitors directly stimulate the kinin B1 receptor?

scientific article published on 20 March 2003

Effects of human urotensin II in isolated vessels of various species; comparison with other vasoactive agents

scientific article published on 20 November 2001

Endogenous nociceptin/orphanin FQ signalling produces opposite spinal antinociceptive and supraspinal pronociceptive effects in the mouse formalin test: Pharmacological and genetic evidences

article

Further studies at neuropeptide s position 5: discovery of novel neuropeptide S receptor antagonists

scientific article published on July 2009

Human urotensin-II enhances plasma extravasation in specific vascular districts in Wistar rats

scientific article published in January 2004

Hypotensive effects of hemopressin and bradykinin in rabbits, rats and mice. A comparative study

scientific article

Identification of an achiral analogue of J-113397 as potent nociceptin/orphanin FQ receptor antagonist.

scientific article published on 3 October 2005

Impact of kinins in the treatment of cardiovascular diseases

scientific article published on 17 April 2012

In vitro and in vivo pharmacological characterization of the neuropeptide s receptor antagonist [D-Cys(tBu)5]neuropeptide S

scientific article

In vitro and in vivo pharmacological characterization of the novel NK₁ receptor selective antagonist Netupitant

scientific article

In vitro and in vivo pharmacological characterization of the novel UT receptor ligand [Pen5,DTrp7,Dab8]urotensin II(4-11) (UFP-803)

scientific article

In vitro and in vivo studies on UFP-112, a novel potent and long lasting agonist selective for the nociceptin/orphanin FQ receptor

scientific article

Inhibition of prostaglandin G/H synthase unveils a potent effect of platelet activating factor on the permeability of bovine aortic endothelial cells to albumin

scientific article published on December 2002

Kallikrein-kinin system as the dominant mechanism to counteract hyperactive renin-angiotensin system

scientific article published on 6 April 2017

Kinin B1 receptor antagonists with multi-enzymatic resistance properties

scientific article published on 01 April 2002

Kinins and peptide receptors

scientific article published on 25 September 2015

N- and C-terminal modifications of nociceptin/orphanin FQ generate highly potent NOP receptor ligands.

scientific article published in March 2005

Neurobiology, pharmacology, and medicinal chemistry of neuropeptide S and its receptor

scientific article published on September 2010

Nociceptin receptor antagonists display antidepressant-like properties in the mouse forced swimming test

scientific article (publication date: February 2002)

Nociceptin/Orphanin FQ(1-13)NH2 analogues modified in the Phe1-Gly2 peptide bond

scientific article

Nociceptin/orphanin FQ inhibits electrically induced contractions of the human bronchus via NOP receptor activation

scientific article published on 18 April 2005

Novel pathogenic mechanism and therapeutic approaches to angioedema associated with C1 inhibitor deficiency

scientific article

Pharmacological characterisation of [(pX)Phe 4 ]nociceptin(1-13)NH 2 analogues

scholarly article by Anna Rizzi et al published 1 June 2002 in Naunyn-Schmiedeberg's Archives of Pharmacology

Pharmacological characterisation of [(pX)Phe4]nociceptin(1-13)amide analogues. 1. In vitro studies.

scientific article

Pharmacological characterization of the nociceptin/orphanin FQ receptor antagonist SB-612111 [(-)-cis-1-methyl-7-[[4-(2,6-dichlorophenyl)piperidin-1-yl]methyl]-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol]: in vitro studies.

scientific article published on 28 February 2007

Pharmacological characterization of the nociceptin/orphanin FQ receptor antagonist SB-612111 [(-)-cis-1-methyl-7-[[4-(2,6-dichlorophenyl)piperidin-1-yl]methyl]-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol]: in vivo studies.

scientific article published on 28 February 2007

Pharmacological characterization of the nociceptin/orphanin FQ receptor non peptide antagonist Compound 24.

scientific article published on 12 May 2009

Pharmacological characterization of the novel nociceptin/orphanin FQ receptor ligand, ZP120: in vitro and in vivo studies in mice

scientific article

Pharmacological profile of NOP receptors coupled with calcium signaling via the chimeric protein G alpha qi5.

scientific article published on 28 January 2009

Pharmacological profile of nociceptin/orphanin FQ receptors

scientific article

Platelet-activating factor and kinin-dependent vascular leakage as a novel functional activity of the soluble terminal complement complex

scientific article

Preclinical pharmacology, metabolic stability, pharmacokinetics and toxicology of the peptidic kinin B1 receptor antagonist R-954

scholarly article by Fernand Gobeil et al published February 2014 in Peptides

Safety and pharmacokinetics of a kinin B1 receptor peptide agonist produced with different counter-ions.

scientific article published on 13 November 2015

Structure-activity relationship study of position 4 in the urotensin-II receptor ligand U-II(4-11).

scientific article published on 31 July 2007

Structure-activity relationship study on Tyr9 of urotensin-II(4-11): identification of a partial agonist of the UT receptor

scientific article

Structure-activity relationship study on human urotensin II

scholarly article by Remo Guerrini published in January 2005

Structure-activity studies on neuropeptide S: identification of the amino acid residues crucial for receptor activation

scientific article

Structure-activity studies on the nociceptin/orphanin FQ receptor antagonist 1-benzyl-N-{3-[spiroisobenzofuran-1(3H),4'-piperidin-1-yl]propyl} pyrrolidine-2-carboxamide.

scientific article published on 2 June 2009

Structure-activity study at positions 3 and 4 of human neuropeptide S.

scientific article

Structure−Activity Study of the Nociceptin(1−13)-NH2N-Terminal Tetrapeptide and Discovery of a Nociceptin Receptor Antagonist

Studies on the angiotensin-converting enzyme and the kinin B2 receptor in the rabbit jugular vein: modulation of contractile response to bradykinin

scientific article

Synthesis and biological activity of human neuropeptide S analogues modified in position 2.

scientific article

Synthesis and biological activity of human neuropeptide S analogues modified in position 5: identification of potent and pure neuropeptide S receptor antagonists

scientific article

Synthesis and biological activity of nociceptin/orphanin FQ analogues substituted in position 7 or 11 with Calpha,alpha-dialkylated amino acids.

scientific article published on 24 April 2007

Targeting kinin B(1) receptor for therapeutic neovascularization

scientific article

The interaction of highly helical structural mutants with the NOP receptor discloses the role of the address domain of nociceptin/orphanin FQ.

scientific article

The non-peptide kinin receptor antagonists FR 173657 and SSR 240612: preclinical evidence for the treatment of skin inflammation

scientific article

UFP-101 antagonizes the spinal antinociceptive effects of nociceptin/orphanin FQ: Behavioral and electrophysiological studies in mice

scientific article published on 11 December 2006

UFP-101, a peptide antagonist selective for the nociceptin/orphanin FQ receptor.

scientific article

UFP-112 a potent and long-lasting agonist selective for the Nociceptin/Orphanin FQ receptor

scientific article published on 18 May 2010

Up-regulation of kinin B1 receptor in the lung of streptozotocin-diabetic rat: autoradiographic and functional evidence

scientific journal article

Urantide mimics urotensin-II induced calcium release in cells expressing recombinant UT receptors.

scientific article published in September 2004

Urodynamic effects of intravesical nociceptin/orphanin FQ in neurogenic detrusor overactivity: a randomized, placebo-controlled, double-blind study

scientific article published in May 2003

Urotensin II stimulates plasma extravasation in mice via UT receptor activation.

scientific article

Urotensin II-induced hypotensive responses in Wistar-Kyoto (Wky) and spontaneously hypertensive (Shr) rats

scientific article published in August 2005

[(pF)Phe4,Arg14,Lys15]N/OFQ-NH2 (UFP-102), a highly potent and selective agonist of the nociceptin/orphanin FQ receptor.

scientific article published on 27 October 2004

[Arg(14),Lys(15)]nociceptin, a highly potent agonist of the nociceptin/orphanin FQ receptor: in vitro and in vivo studies

scientific article published in January 2002

[Nphe1,Arg14,Lys15]nociceptin-NH2, a novel potent and selective antagonist of the nociceptin/orphanin FQ receptor.

scientific article

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