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List of works by Gerd Pluschke

A Ring‐Closing Metathesis (RCM)‐Based Approach to Mycolactones A/B ⬇️

scientific article published on 04 October 2011

A Sero-epidemiological Approach to Explore Transmission of Mycobacterium ulcerans

scientific article published on 25 January 2016

A Synthetic Virus-Like Particle Streptococcal Vaccine Candidate Using B-Cell Epitopes from the Proline-Rich Region of Pneumococcal Surface Protein A.

scientific article

A broadly-protective vaccine against meningococcal disease in sub-Saharan Africa based on generalized modules for membrane antigens (GMMA).

scientific article published on 3 April 2014

A case of cutaneous tuberculosis in a Buruli ulcer-endemic area

scientific article

A randomized placebo-controlled phase Ia malaria vaccine trial of two virosome-formulated synthetic peptides in healthy adult volunteers

scientific article

A role for apical membrane antigen 1 during invasion of hepatocytes by Plasmodium falciparum sporozoites

scientific article (publication date: 5 March 2004)

A virosomal malaria peptide vaccine elicits a long-lasting sporozoite-inhibitory antibody response in a phase 1a clinical trial

scientific article

A virosome-mimotope approach to synthetic vaccine design and optimization: synthesis, conformation, and immune recognition of a potential malaria-vaccine candidate

scientific article published in May 2003

Amino acid dimorphism and parasite immune evasion: cellular immune responses to a promiscuous epitope of Plasmodium falciparum merozoite surface protein 1 displaying dimorphic amino acid polymorphism are highly constrained

scientific article published on December 2002

An efficient system to generate monoclonal antibodies against membrane-associated proteins by immunisation with antigen-expressing mammalian cells

scientific article

An outbreak of serotype 1 Streptococcus pneumoniae meningitis in northern Ghana with features that are characteristic of Neisseria meningitidis meningitis epidemics

scientific article published on 10 June 2005

Analysis of the Mycobacterium ulcerans genome sequence reveals new loci for variable number tandem repeats (VNTR) typing

scientific article published on May 2007

Anthrax spore detection by a luminex assay based on monoclonal antibodies that recognize anthrose-containing oligosaccharides

scientific article published on 21 July 2010

Anti-carbohydrate antibodies for the detection of anthrax spores

scientific article published on October 2006

Antibodies elicited by a virosomally formulated Plasmodium falciparum serine repeat antigen-5 derived peptide detect the processed 47 kDa fragment both in sporozoites and merozoites

scientific article

Antibody and T-cell responses associated with experimental human malaria infection or vaccination show limited relationships

scientific article

Antibody-Mediated Neutralization of the Exotoxin Mycolactone, the Main Virulence Factor Produced by Mycobacterium ulcerans

scientific article

Assessing and managing wounds of Buruli ulcer patients at the primary and secondary health care levels in Ghana

scientific article

Burden and Historical Trend of Buruli Ulcer Prevalence in Selected Communities along the Offin River of Ghana

scientific article

Buruli Ulcer in Cameroon: The Development and Impact of the National Control Programme

scientific article published on 13 January 2016

Buruli ulcer (M. ulcerans infection): new insights, new hope for disease control

scientific article

Buruli ulcer disease in Cameroon rediscovered.

scientific article published in May 2004

Buruli ulcer disease: prospects for a vaccine

scientific article published on 07 February 2009

Buruli ulcer: The Efficacy of Innate Immune Defense May Be a Key Determinant for the Outcome of Infection With Mycobacterium ulcerans

scientific article published on 25 May 2020

Challenges associated with management of buruli ulcer/human immunodeficiency virus coinfection in a treatment center in Ghana: A case series study

scholarly article

Characteristics and epidemiological profile of Buruli ulcer in the district of Tiassalé, south Côte d'Ivoire

scientific article published on 26 December 2016

Characterization of a reduced peptide bond analogue of a promiscuous CD4 T cell epitope derived from the Plasmodium falciparum malaria vaccine candidate merozoite surface protein 1.

scientific article

Characterization of vaccine antigens of meningococcal serogroup W isolates from Ghana and Burkina Faso from 2003 to 2009.

scientific article

Chemotherapy-associated changes of histopathological features of Mycobacterium ulcerans lesions in a Buruli ulcer mouse model

scientific article published on 5 December 2011

Clonal groupings in serogroup X Neisseria meningitidis

scientific article published on May 2002

Clonal waves of Neisseria colonisation and disease in the African meningitis belt: eight- year longitudinal study in northern Ghana

scientific article

Combining PCR with microscopy to reduce costs of laboratory diagnosis of buruli ulcer

scientific article

Community knowledge, perceptions and attitudes regarding leprosy in rural Cameroon: The case of Ekondotiti and Mbonge health districts in the South-west Region

scientific article published on 12 February 2018

Comparative Study of Activities of a Diverse Set of Antimycobacterial Agents against Mycobacterium tuberculosis and Mycobacterium ulcerans

scientific article (publication date: May 2016)

Complete Healing of a Laboratory-Confirmed Buruli Ulcer Lesion after Receiving Only Herbal Household Remedies

scientific article published on 25 November 2015

Configurationally Stabilized Analogs of M. ulcerans Exotoxins Mycolactones A and B Reveal the Importance of Side Chain Geometry for Mycolactone Virulence

scientific article published on 11 July 2019

Contiguous spread of Mycobacterium ulcerans in Buruli ulcer lesions analysed by histopathology and real-time PCR quantification of mycobacterial DNA.

scientific article published on January 2006

Contribution of influenza immunity and virosomal-formulated synthetic peptide to cellular immune responses in a phase I subunit malaria vaccine trial

scientific article published on 11 March 2008

Correction: Buruli Ulcer (M. ulcerans Infection): New Insights, New Hope for Disease Control

scientific article

Correction: Clonal Waves of Neisseria Colonisation and Disease in the African Meningitis Belt: Eight-Year Longitudinal Study in Northern Ghana.

scientific article published on 29 May 2007

Correction: Evidence of Blood Stage Efficacy with a Virosomal Malaria Vaccine in a Phase IIa Clinical Trial.

scientific article published on 26 February 2011

Correction: The Burden of Leprosy in Cameroon: Fifteen Years into the Post-elimination Era.

scientific article published on 18 January 2017

Cysteine-Rich Protective Antigen (CyRPA) as promising blood-stage candidate protein for inclusion in a malaria subunit vaccine

scholarly article by Paola Favuzza et al published 2012 in Malaria Journal

DNA Methylation Assessed by SMRT Sequencing Is Linked to Mutations in Neisseria meningitidis Isolates.

scientific article published on 11 December 2015

Design and pre-clinical profiling of a Plasmodium falciparum MSP-3 derived component for a multi-valent virosomal malaria vaccine

scientific article published on 30 December 2009

Development of Dengue Virus Serotype-Specific NS1 Capture Assays for the Rapid and Highly Sensitive Identification of the Infecting Serotype in Human Sera.

scientific article published on 16 April 2018

Development of a bead-based Luminex assay using lipopolysaccharide specific monoclonal antibodies to detect biological threats from Brucella species

scientific article published on 5 October 2015

Development of a glycoconjugate vaccine to prevent meningitis in Africa caused by meningococcal serogroup X.

scientific article

Development of a temperature-switch PCR-based SNP typing method for mycobacterium ulcerans

scientific article

Development of an ELISA for the quantification of mycolactone, the cytotoxic macrolide toxin of Mycobacterium ulcerans

scientific article published on 26 June 2020

Development of highly organized lymphoid structures in Buruli ulcer lesions after treatment with rifampicin and streptomycin

scientific article

Development of influenza virosome-based synthetic malaria vaccines ⬇️

scientific article published on April 1, 2008

Diagnosis of mycobacterium ulcerans infection (buruli ulcer) at a treatment centre in Ghana: A retrospective analysis of laboratory results of clinically diagnosed cases

scientific article published in February 2008

Diagnostic accuracy of loop-mediated isothermal amplification (LAMP) for detection of Leishmania DNA in buffy coat from visceral leishmaniasis patients

scientific article published on 3 December 2012

Differential gene repertoire in Mycobacterium ulcerans identifies candidate genes for patho-adaptation

scientific article

Emergence and genomic diversification of a virulent serogroup W:ST-2881(CC175) Neisseria meningitidis clone in the African meningitis belt

scientific article published on 21 June 2017

Emergence of W135 meningococcal meningitis in Ghana

scientific article published in December 2005

Emergence of a new epidemic Neisseria meningitidis serogroup A Clone in the African meningitis belt: high-resolution picture of genomic changes that mediate immune evasion.

scientific article

Engineered synthetic virus-like particles and their use in vaccine delivery

scientific article published in January 2011

Enhancement of the immunogenicity of synthetic carbohydrates by conjugation to virosomes: a leishmaniasis vaccine candidate

scientific article published on 01 April 2006

Evaluating decontamination protocols for the isolation of Mycobacterium ulcerans from swabs

scientific article (publication date: 5 January 2017)

Evaluation of decontamination methods and growth media for primary isolation of mycobacterium ulcerans from surgical specimens

scientific article published on December 2004

Evidence of blood stage efficacy with a virosomal malaria vaccine in a phase IIa clinical trial

scientific article

Evolution of two distinct phylogenetic lineages of the emerging human pathogen Mycobacterium ulcerans

scientific article

Experimental infection of the pig with Mycobacterium ulcerans: a novel model for studying the pathogenesis of Buruli ulcer disease

scientific article

Exudate collection using wound sponges-An easy, non-invasive and reliable method to explore protease activities in ulcers

scientific article published on April 2017

Flow cytometric analysis on cross-reactivity of human-specific CD monoclonal antibodies with splenocytes of Aotus nancymaae, a non-human primate model for biomedical research

scientific article published on 20 June 2007

Generation of Plasmodium falciparum parasite-inhibitory antibodies by immunization with recombinantly-expressed CyRPA

scientific article published on 15 March 2016

Generation of monoclonal antibodies against native viral proteins using antigen-expressing mammalian cells for mouse immunization

scientific article (publication date: 22 November 2016)

Genetic diversification of Neisseria meningitidis during waves of colonization and disease in the meningitis belt of sub-Saharan Africa.

scientific article

Genetic diversity in mycobacterium ulcerans isolates from Ghana revealed by a newly identified locus containing a variable number of tandem repeats

scientific article

Genomic analysis of ST88 community-acquired methicillin resistant Staphylococcus aureus in Ghana

scientific article published on 28 February 2017

Genomic diversity and evolution of mycobacterium ulcerans revealed by next-generation sequencing

scientific article (publication date: September 2009)

Genotypic diversity and drug susceptibility patterns among M. tuberculosis complex isolates from South-Western Ghana

scientific article

Geographic Distribution, Age Pattern and Sites of Lesions in a Cohort of Buruli Ulcer Patients from the Mapé Basin of Cameroon ⬇️

scientific article published on June 13, 2013

Global phylogenomic analysis of nonencapsulated Streptococcus pneumoniae reveals a deep-branching classic lineage that is distinct from multiple sporadic lineages

scientific article published on 04 December 2014

Histopathological changes and clinical responses of Buruli ulcer plaque lesions during chemotherapy: a role for surgical removal of necrotic tissue?

scientific article published on 27 September 2011

Identification and characterization of a conserved, stage-specific gene product of Plasmodium falciparum recognized by parasite growth inhibitory antibodies

scientific article

Identification and quantification of a new family of peptide endocannabinoids (Pepcans) showing negative allosteric modulation at CB1 receptors

scientific article

Identification of an African Bacillus anthracis lineage that lacks expression of the spore surface-associated anthrose-containing oligosaccharide

scientific article published on 13 May 2011

Identification of the Mycobacterium ulcerans protein MUL_3720 as a promising target for the development of a diagnostic test for Buruli ulcer

scientific article

Immunogenicity of a virosomally-formulated Plasmodium falciparum GLURP-MSP3 chimeric protein-based malaria vaccine candidate in comparison to adjuvanted formulations

scientific article published on 13 December 2011

Immunohistochemical monitoring of wound healing in antibiotic treated Buruli ulcer patients

scientific article published on 24 April 2014

Immunosuppression and treatment-associated inflammatory response in patients with Mycobacterium ulcerans infection (Buruli ulcer)

scientific article published on 01 February 2009

Improved protective efficacy of a species-specific DNA vaccine encoding mycolyl-transferase Ag85A from Mycobacterium ulcerans by homologous protein boosting

scientific article

Independent loss of immunogenic proteins in Mycobacterium ulcerans suggests immune evasion.

scientific article published on 6 February 2008

Induction of parasite growth-inhibitory antibodies by a virosomal formulation of a peptidomimetic of loop I from domain III of Plasmodium falciparum apical membrane antigen 1

scientific article

Infiltrating leukocytes surround early Buruli ulcer lesions, but are unable to reach the mycolactone producing mycobacteria

scientific article published on 5 September 2017

Interferon-γ Is a Crucial Activator of Early Host Immune Defense against Mycobacterium ulcerans Infection in Mice

scientific article published on 10 February 2016

Isolation of mycobacterium ulcerans from swab and fine-needle-aspiration specimens

scientific article published on 16 March 2011

Lack of antigenic diversification of major outer membrane proteins during clonal waves of Neisseria meningitidis serogroup A colonization and disease

scientific article published on 28 November 2012

Lack of insertional-deletional polymorphism in a collection of mycobacterium ulcerans isolates from Ghanaian buruli ulcer patients

scientific article published on 02 September 2009

Large sequence polymorphisms unveil the phylogenetic relationship of environmental and pathogenic mycobacteria related to Mycobacterium ulcerans

scientific article

Late Onset of the Serological Response against the 18 kDa Small Heat Shock Protein of Mycobacterium ulcerans in Children

scientific article

Limited Genetic Diversity of Hepatitis B Virus in the General Population of the Offin River Valley in Ghana

scientific article

Local Cellular Immune Responses and Pathogenesis of Buruli Ulcer Lesions in the Experimental Mycobacterium Ulcerans Pig Infection Model

scientific article

Local Heat Application for the Treatment of Buruli Ulcer: Results of a Phase II Open Label Single Center Non Comparative Clinical Trial

scientific article

Local activation of the innate immune system in Buruli ulcer lesions

scientific article published on 19 October 2006

Locally Confined Clonal Complexes of Mycobacterium ulcerans in Two Buruli Ulcer Endemic Regions of Cameroon

scientific article

Loss of Genomic Diversity in a Neisseria meningitidis Clone Through a Colonization Bottleneck

scientific article published on 01 August 2018

Maximizing microscopy as a diagnostic tool in peripheral health centres of BU endemic areas in Ghana

scientific article

Molecular analysis of carbohydrate-antibody interactions: case study using a Bacillus anthracis tetrasaccharide.

scientific article

Molecular epidemiology of pneumococci obtained from Gambian children aged 2-29 months with invasive pneumococcal disease during a trial of a 9-valent pneumococcal conjugate vaccine

scientific article

Mycobacterium ulcerans DNA in Bandicoot Excreta in Buruli Ulcer-Endemic Area, Northern Queensland, Australia

scientific article published in December 2017

Mycobacterium ulcerans Mouse Model Refinement for Pre-Clinical Profiling of Vaccine Candidates.

scientific article

Mycobacterium ulcerans persistence at a village water source of Buruli ulcer patients

scientific article

Mycolactone-Dependent Depletion of Endothelial Cell Thrombomodulin Is Strongly Associated with Fibrin Deposition in Buruli Ulcer Lesions

scientific article (publication date: July 2015)

On the origin of mycobacterium ulcerans, the causative agent of buruli ulcer

scientific article

Ongoing genome reduction in Mycobacterium ulcerans

scientific article

Optimized DNA preparation from mycobacteria

scientific article published in April 2010

Optimized Malaria-antigens delivered by immunostimulating reconstituted influenza virosomes

scientific article published on January 2006

Optimized method for preparation of DNA from pathogenic and environmental mycobacteria

scientific article published on December 2008

Oral Treatment for Mycobacterium ulcerans Infection: Results From a Pilot Study in Benin

scientific article published on 01 January 2011

Passive immunoprotection of Plasmodium falciparum-infected mice designates the CyRPA as candidate malaria vaccine antigen

scientific article (publication date: 15 June 2012)

Phase change material for thermotherapy of Buruli ulcer: a prospective observational single centre proof-of-principle trial

scientific article

Possible healthcare-associated transmission as a cause of secondary infection and population structure of Staphylococcus aureus isolates from two wound treatment centres in Ghana

scientific article published on 12 July 2016

Preclinical profiling of the immunogenicity of a two-component subunit malaria vaccine candidate based on virosome technology

scientific article

Presence of nonhemolytic pneumolysin in serotypes of Streptococcus pneumoniae associated with disease outbreaks

scientific article published on 6 August 2007

Primary cultivation: Factors affecting contamination and Mycobacterium ulcerans growth after long turnover time of clinical specimens

scientific article

Prospective study of a serogroup X Neisseria meningitidis outbreak in northern Ghana

scientific article published on 14 February 2002

Region-specific diversification of the highly virulent serotype 1 Streptococcus pneumoniae

scientific article published on 11 August 2015

Research priorities for neglected infectious diseases in Latin America and the Caribbean region

scientific article

Safety, tolerability and immunogenicity of new formulations of the Plasmodium falciparum malaria peptide vaccine SPf66 combined with the immunological adjuvant QS-21.

scientific article published in May 2002

Screening of Antifungal Azole Drugs and Agrochemicals with an Adapted alamarBlue-Based Assay Demonstrates Antibacterial Activity of Croconazole against Mycobacterium ulcerans ⬇️

scientific article published on September 24, 2012

Secondary Bacterial Infections of Buruli Ulcer Lesions Before and After Chemotherapy with Streptomycin and Rifampicin

scientific article

Secondary Buruli Ulcer Skin Lesions Emerging Several Months after Completion of Chemotherapy: Paradoxical Reaction or Evidence for Immune Protection? ⬇️

scientific article published on August 2, 2011

Selamectin Is the Avermectin with the Best Potential for Buruli Ulcer Treatment

scientific article (publication date: August 2015)

Sero-epidemiology as a tool to screen populations for exposure to mycobacterium ulcerans

scientific article

Serological evaluation of Mycobacterium ulcerans antigens identified by comparative genomics

scientific article

Single nucleotide polymorphism typing of mycobacterium ulcerans reveals focal transmission of buruli ulcer in a highly endemic region of Ghana

scientific article

Single nucleotide polymorphisms on the road to strain differentiation in Mycobacterium ulcerans

scientific article published on 2 September 2009

Socio-Environmental Factors Associated with the Risk of Contracting Buruli Ulcer in Tiassalé, South Côte d'Ivoire: A Case-Control Study

scientific article published on 8 January 2016

Spatial Distribution of Mycobacterium ulcerans in Buruli Ulcer Lesions: Implications for Laboratory Diagnosis

scientific article

Spatiotemporal Co-existence of Two Mycobacterium ulcerans Clonal Complexes in the Offin River Valley of Ghana

scientific article

Spontaneous point mutations in the capsule synthesis locus leading to structural and functional changes of the capsule in serogroup A meningococcal populations

scientific article published on 01 January 2018

Staphylococcal disease in Africa: another neglected 'tropical' disease

scientific article published on January 2013

Structural and functional characterisation of the Toll like receptor 9 of Aotus nancymaae, a non-human primate model for malaria vaccine development

scientific article

Structure of the malaria vaccine candidate antigen CyRPA and its complex with a parasite invasion inhibitory antibody

scientific article published on 14 February 2017

Structure-Activity Relationship Studies on the Macrolide Exotoxin Mycolactone of Mycobacterium ulcerans ⬇️

scientific article published on March 28, 2013

Structure-activity-based design of a synthetic malaria peptide eliciting sporozoite inhibitory antibodies in a virosomal formulation

scientific article

Susceptibility to Mycobacterium ulcerans Disease (Buruli ulcer) Is Associated with IFNG and iNOS Gene Polymorphisms

scientific article published on 4 October 2017

Synthesis, Biological, and Immunological Properties of Cyclic Peptides from Plasmodium Falciparum Merozoite Surface Protein-1

scientific article published on 01 July 2001

Synthesis, solution structure and immune recognition of an epidermal growth factor-like domain from Plasmodium falciparum merozoite surface protein-1.

scientific article published in December 2006

Synthetic GPI array to study antitoxic malaria response

scientific article published on 2 March 2008

Synthetic glycosylphosphatidylinositol microarray reveals differential antibody levels and fine specificities in children with mild and severe malaria

scientific article published on 24 April 2010

Systemic suppression of interferon-gamma responses in Buruli ulcer patients resolves after surgical excision of the lesions caused by the extracellular pathogen Mycobacterium ulcerans

scientific article published on 10 March 2006

Targeting the Mycobacterium ulcerans cytochrome bc:aa for the treatment of Buruli ulcer

scientific article published in Nature Communications

The Macrolide Toxin Mycolactone Promotes Bim-Dependent Apoptosis in Buruli Ulcer through Inhibition of mTOR.

scientific article

The N'-terminal domain of glyceraldehyde-3-phosphate dehydrogenase of the apicomplexan Plasmodium falciparum mediates GTPase Rab2-dependent recruitment to membranes

scientific article (publication date: August 2003)

The causative pathogen determines the inflammatory profile in cerebrospinal fluid and outcome in patients with bacterial meningitis

scientific article published on 20 June 2013

The genome, evolution and diversity of Mycobacterium ulcerans

scientific article published on 28 January 2012

The global distribution and diversity of protein vaccine candidate antigens in the highly virulent Streptococcus pnuemoniae serotype 1.

scientific article published on 09 January 2017

The immunology of other mycobacteria: M. ulcerans, M. leprae

scientific article published on 25 February 2020

Thermal field formation during wIRA-hyperthermia: temperature measurements in skin and subcutis of piglets as a basis for thermotherapy of superficial tumors and local skin infections caused by thermosensitive microbial pathogens

scientific article published on 01 January 2019

Toward a single dose cure for Buruli ulcer

scientific article published on 06 July 2020

Transmission of Hepatitis B and D Viruses in an African Rural Community

article

Understanding pneumococcal serotype 1 biology through population genomic analysis

scientific article published on 8 November 2016

Use of Recombinant Virus Replicon Particles for Vaccination against Mycobacterium ulcerans Disease.

scientific article published on 14 August 2015

Use of diagnostic microarrays for determination of virulence gene patterns of Escherichia coli K1, a major cause of neonatal meningitis

scientific article

Use of the immunodominant 18-kilodalton small heat shock protein as a serological marker for exposure to mycobacterium ulcerans

scientific article

Vaccination with the Surface Proteins MUL_2232 and MUL_3720 of Mycobacterium ulcerans Induces Antibodies but Fails to Provide Protection against Buruli Ulcer.

scientific article published on 5 February 2016

Vaccination with virosomally formulated recombinant CyRPA elicits protective antibodies against Plasmodium falciparum parasites in preclinical in vitro and in vivo models

scientific article published on 31 January 2020

Virosome-formulated Plasmodium falciparum AMA-1 & CSP derived peptides as malaria vaccine: randomized phase 1b trial in semi-immune adults & children

scientific article (publication date: 2011)

What does detection of Mycobacterium ulcerans DNA in the margin of an excised Buruli ulcer lesion tell us?

scientific article published on 23 August 2006

wIRA: hyperthermia as a treatment option for intracellular bacteria, with special focus on Chlamydiae and Mycobacteria

scientific article published on 01 January 2020

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