List of works - Matthew Sigman

A Cancer-Selective Zinc Ionophore Inspired by the Natural Product Naamidine A

scientific article published on 08 January 2019

A Physical Organic Approach to Tuning Reagents for Selective and Stable Methionine Bioconjugation

scientific article published on 30 July 2019

A synthetic chemist's guide to electroanalytical tools for studying reaction mechanisms

scientific article published on 23 May 2019

Carbon Atom Insertion into Pyrroles and Indoles Promoted by Chlorodiazirines

scientific article published on 21 July 2021

Catalytic Carbonyl-Olefin Metathesis of Aliphatic Ketones: Iron(III) Homo-Dimers as Lewis Acidic Superelectrophiles

scientific article published on 16 January 2019

Catalytic asymmetric C–H insertion reactions of vinyl carbocations

scientific article published on 9 December 2022

Combining traditional 2D and modern physical organic-derived descriptors to predict enhanced enantioselectivity for the key aza-Michael conjugate addition in the synthesis of Prevymis™ (letermovir)

scientific article published on 18 July 2018

Correction to "Enantioselective N-Alkylation of Indoles via an Intermolecular Aza-Wacker-Type Reaction"

scientific article published on 26 July 2019

Correction to "Exploiting and Understanding the Selectivity of Ru-N-Heterocyclic Carbene Metathesis Catalysts for the Ethenolysis of Cyclic Olefins to α,ω-Dienes"

scientific article published on 13 December 2018

Correction to "Investigating the Role of Ligand Electronics on Stabilizing Electrocatalytically Relevant Low-Valent Co(I) Intermediates"

scientific article published on 17 September 2019

Correction to "Nickel-Catalyzed Enantioselective Reductive Cross-Coupling of Styrenyl Aziridines"

scientific article published on 11 June 2018

Developing a Predictive Solubility Model for Monomeric and Oligomeric Cyclopropenium-Based Flow Battery Catholytes

scientific article published on 20 June 2019

Disparate Catalytic Scaffolds for Atroposelective Cyclodehydration

scientific article published on 10 April 2019

Electrochemical Ruthenium-Catalyzed C-H Hydroxylation of Amine Derivatives in Aqueous Acid

scientific article published on 18 May 2020

Enantiodivergent Pd-catalyzed C-C bond formation enabled through ligand parameterization

scientific article published on 20 September 2018

Enantioselective Allenoate-Claisen Rearrangement Using Chiral Phosphate Catalysts

scientific article published on 23 March 2020

Enantioselective C2-alkylation of indoles via a redox-relay Heck reaction of 2-indole triflates

scientific article published on 11 December 2018

Enantioselective Markovnikov Addition of Carbamates to Allylic Alcohols for the Construction of α-Secondary and α-Tertiary Amines.

scientific article published on 24 May 2019

Enantioselective N-Alkylation of Indoles via an Intermolecular Aza-Wacker-Type Reaction

scientific article published on 24 May 2019

Enantioselective Synthesis of N,S-Acetals by an Oxidative Pummerer-Type Transformation using Phase-Transfer Catalysis.

scientific article published on 23 November 2017

Enantioselective construction of remote tertiary carbon-fluorine bonds

scientific article published on 15 July 2019

Enantioselective fluorination of homoallylic alcohols enabled by the tuning of non-covalent interactions

scientific article published on 03 August 2018

Exploiting and Understanding the Selectivity of Ru-N-Heterocyclic Carbene Metathesis Catalysts for the Ethenolysis of Cyclic Olefins to α,ω-Dienes.

scientific article published on 18 August 2017

Formation of Chiral Allylic Ethers via an Enantioselective Palladium-Catalyzed Alkenylation of Acyclic Enol Ethers.

scientific article published on 27 April 2018

Generality-oriented optimization of enantioselective aminoxyl radical catalysis

scientific article published on 18 May 2023

Integrating Electrochemical and Statistical Analysis Tools for Molecular Design and Mechanistic Understanding

scientific article published on 10 January 2020

Interrogation of 2,2'-Bipyrimidines as Low-Potential Two-Electron Electrolytes

scientific article published on 07 January 2021

Inverting Conventional Chemoselectivity in Pd-Catalyzed Amine Arylations with Multiply Halogenated Pyridines.

scientific article

Investigating the Role of Ligand Electronics on Stabilizing Electrocatalytically Relevant Low-Valent Co(I) Intermediates

scientific article published on 11 January 2019

Mechanism-Based Design of a High-Potential Catholyte Enables a 3.2 V All-Organic Nonaqueous Redox Flow Battery

scientific article published on 10 September 2019

Mechanistic Investigations of the Pd(0)-Catalyzed Enantioselective 1,1-Diarylation of Benzyl Acrylates.

scientific article

Mechanistic Studies Inform Design of Improved Ti(salen) Catalysts for Enantioselective [3 + 2] Cycloaddition

scientific article published on 16 October 2020

Mechanistic Studies into the Oxidative Addition of Co(I) Complexes: Combining Electroanalytical Techniques with Parameterization

scientific article published on 15 November 2019

Mechanistic Study of Ruthenium-Catalyzed C–H Hydroxylation Reveals an Unexpected Pathway for Catalyst Arrest

scientific article published on 02 January 2019

Mechanistically Guided Workflow for Relating Complex Reactive Site Topologies to Catalyst Performance in C–H Functionalization Reactions

scientific article published in 2022

Multidimensional Correlations in Asymmetric Catalysis through Parameterization of Uncatalyzed Transition States.

scientific article

Nickel-Catalyzed Enantioselective Reductive Cross-Coupling of Styrenyl Aziridines.

scientific article published on 13 April 2017

Noncovalent Interactions Drive the Efficiency of Molybdenum Imido Alkylidene Catalysts for Olefin Metathesis

scientific article published on 27 June 2019

Organic Chemistry: A Call to Action for Diversity and Inclusion

scientific article published on 10 August 2020

Palladium-Catalyzed Enantioselective Alkenylation of Enelactams Using a Relay Heck Strategy

scientific article published on 26 July 2019

Palladium-Catalyzed Enantioselective Redox-Relay Heck Alkynylation of Alkenols To Access Propargylic Stereocenters.

scientific article published on 3 May 2017

Palladium-Catalyzed Enantioselective Relay Heck Arylation of Enelactams: Accessing α,β-Unsaturated δ-Lactams.

scientific article published on 16 May 2018

Palladium-catalyzed enantioselective alkenylation of alkenylbenzene derivatives

scientific article published on 17 June 2019

Parameterization and Analysis of Peptide-Based Catalysts for the Atroposelective Bromination of 3-Arylquinazolin-4(3H)-ones

scientific article

Parameterization of Acyclic Diaminocarbene Ligands Applied to a Gold(I)-Catalyzed Enantioselective Tandem Rearrangement/Cyclization.

scientific article published on 8 September 2017

Parametrization of Non-covalent Interactions for Transition State Interrogation Applied to Asymmetric Catalysis.

scientific article published on 5 May 2017

Physical Organic Approach to Persistent, Cyclable, Low-Potential Electrolytes for Flow Battery Applications.

scientific article published on 21 February 2017

Predictive Multivariate Linear Regression Analysis Guides Successful Catalytic Enantioselective Minisci Reactions of Diazines

scientific article published on 21 November 2019

Predictive and mechanistic multivariate linear regression models for reaction development.

scientific article published on 23 January 2018

Pursuit of Noncovalent Interactions for Strategic Site-Selective Catalysis

scientific article published on March 2017

Quantitative Modeling of Bis(pyridine)silver(I) Permanganate Oxidation of Hydantoin Derivatives: Guidelines for Predicting the Site of Oxidation in Complex Substrates

scientific article

Ruthenium-Catalyzed C-H Hydroxylation in Aqueous Acid Enables Selective Functionalization of Amine Derivatives

scientific article

Site-selective acylation of natural products with BINOL-derived phosphoric acids

scientific article published on 01 October 2019

The development and mechanistic investigation of a palladium-catalyzed 1,3-arylfluorination of chromenes.

scientific article published on 9 February 2017

List of works by Matthew Sigman

A Cancer-Selective Zinc Ionophore Inspired by the Natural Product Naamidine A

A Physical Organic Approach to Tuning Reagents for Selective and Stable Methionine Bioconjugation

A synthetic chemist's guide to electroanalytical tools for studying reaction mechanisms

Carbon Atom Insertion into Pyrroles and Indoles Promoted by Chlorodiazirines

Catalytic Carbonyl-Olefin Metathesis of Aliphatic Ketones: Iron(III) Homo-Dimers as Lewis Acidic Superelectrophiles

Catalytic asymmetric C–H insertion reactions of vinyl carbocations

Combining traditional 2D and modern physical organic-derived descriptors to predict enhanced enantioselectivity for the key aza-Michael conjugate addition in the synthesis of Prevymis™ (letermovir)

Correction to "Enantioselective N-Alkylation of Indoles via an Intermolecular Aza-Wacker-Type Reaction"

Correction to "Exploiting and Understanding the Selectivity of Ru-N-Heterocyclic Carbene Metathesis Catalysts for the Ethenolysis of Cyclic Olefins to α,ω-Dienes"

Correction to "Investigating the Role of Ligand Electronics on Stabilizing Electrocatalytically Relevant Low-Valent Co(I) Intermediates"

Correction to "Nickel-Catalyzed Enantioselective Reductive Cross-Coupling of Styrenyl Aziridines"

Developing a Predictive Solubility Model for Monomeric and Oligomeric Cyclopropenium-Based Flow Battery Catholytes

Disparate Catalytic Scaffolds for Atroposelective Cyclodehydration

Electrochemical Ruthenium-Catalyzed C-H Hydroxylation of Amine Derivatives in Aqueous Acid

Enantiodivergent Pd-catalyzed C-C bond formation enabled through ligand parameterization

Enantioselective Allenoate-Claisen Rearrangement Using Chiral Phosphate Catalysts

Enantioselective C2-alkylation of indoles via a redox-relay Heck reaction of 2-indole triflates

Enantioselective Markovnikov Addition of Carbamates to Allylic Alcohols for the Construction of α-Secondary and α-Tertiary Amines.

Enantioselective N-Alkylation of Indoles via an Intermolecular Aza-Wacker-Type Reaction

Enantioselective Synthesis of N,S-Acetals by an Oxidative Pummerer-Type Transformation using Phase-Transfer Catalysis.

Enantioselective construction of remote tertiary carbon-fluorine bonds

Enantioselective fluorination of homoallylic alcohols enabled by the tuning of non-covalent interactions

Exploiting and Understanding the Selectivity of Ru-N-Heterocyclic Carbene Metathesis Catalysts for the Ethenolysis of Cyclic Olefins to α,ω-Dienes.

Formation of Chiral Allylic Ethers via an Enantioselective Palladium-Catalyzed Alkenylation of Acyclic Enol Ethers.

Generality-oriented optimization of enantioselective aminoxyl radical catalysis

Integrating Electrochemical and Statistical Analysis Tools for Molecular Design and Mechanistic Understanding

Interrogation of 2,2'-Bipyrimidines as Low-Potential Two-Electron Electrolytes

Inverting Conventional Chemoselectivity in Pd-Catalyzed Amine Arylations with Multiply Halogenated Pyridines.

Investigating the Role of Ligand Electronics on Stabilizing Electrocatalytically Relevant Low-Valent Co(I) Intermediates

Mechanism-Based Design of a High-Potential Catholyte Enables a 3.2 V All-Organic Nonaqueous Redox Flow Battery

Mechanistic Investigations of the Pd(0)-Catalyzed Enantioselective 1,1-Diarylation of Benzyl Acrylates.

Mechanistic Studies Inform Design of Improved Ti(salen) Catalysts for Enantioselective [3 + 2] Cycloaddition

Mechanistic Studies into the Oxidative Addition of Co(I) Complexes: Combining Electroanalytical Techniques with Parameterization

Mechanistic Study of Ruthenium-Catalyzed C–H Hydroxylation Reveals an Unexpected Pathway for Catalyst Arrest

Mechanistically Guided Workflow for Relating Complex Reactive Site Topologies to Catalyst Performance in C–H Functionalization Reactions

Multidimensional Correlations in Asymmetric Catalysis through Parameterization of Uncatalyzed Transition States.

Nickel-Catalyzed Enantioselective Reductive Cross-Coupling of Styrenyl Aziridines.

Noncovalent Interactions Drive the Efficiency of Molybdenum Imido Alkylidene Catalysts for Olefin Metathesis

Organic Chemistry: A Call to Action for Diversity and Inclusion

Palladium-Catalyzed Enantioselective Alkenylation of Enelactams Using a Relay Heck Strategy

Palladium-Catalyzed Enantioselective Redox-Relay Heck Alkynylation of Alkenols To Access Propargylic Stereocenters.

Palladium-Catalyzed Enantioselective Relay Heck Arylation of Enelactams: Accessing α,β-Unsaturated δ-Lactams.

Palladium-catalyzed enantioselective alkenylation of alkenylbenzene derivatives

Parameterization and Analysis of Peptide-Based Catalysts for the Atroposelective Bromination of 3-Arylquinazolin-4(3H)-ones

Parameterization of Acyclic Diaminocarbene Ligands Applied to a Gold(I)-Catalyzed Enantioselective Tandem Rearrangement/Cyclization.

Parametrization of Non-covalent Interactions for Transition State Interrogation Applied to Asymmetric Catalysis.

Physical Organic Approach to Persistent, Cyclable, Low-Potential Electrolytes for Flow Battery Applications.

Predictive Multivariate Linear Regression Analysis Guides Successful Catalytic Enantioselective Minisci Reactions of Diazines

Predictive and mechanistic multivariate linear regression models for reaction development.

Pursuit of Noncovalent Interactions for Strategic Site-Selective Catalysis

Quantitative Modeling of Bis(pyridine)silver(I) Permanganate Oxidation of Hydantoin Derivatives: Guidelines for Predicting the Site of Oxidation in Complex Substrates

Ruthenium-Catalyzed C-H Hydroxylation in Aqueous Acid Enables Selective Functionalization of Amine Derivatives

Site-selective acylation of natural products with BINOL-derived phosphoric acids

The development and mechanistic investigation of a palladium-catalyzed 1,3-arylfluorination of chromenes.