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List of works by Joke Bouwstra

A new method to determine the distribution of a fluorophore in scalp skin with focus on hair follicles

scientific article published on 01 March 2002

A novel in vitro percutaneous penetration model: evaluation of barrier properties with p-aminobenzoic acid and two of its derivatives

scientific article published on 4 May 2006

A theoretical compartment model for antigen kinetics in the skin

scientific article

Acylceramide head group architecture affects lipid organization in synthetic ceramide mixtures

scientific article published in November 2004

Advances in transcutaneous vaccine delivery: Do all ways lead to Rome? ⬇️

scientific article published on September 24, 2010

Altered expression of epidermal lipid bio-synthesis enzymes in atopic dermatitis skin is accompanied by changes in stratum corneum lipid composition

article

Altered lipid properties of the stratum corneum in Canine Atopic Dermatitis

scientific article published on 22 November 2017

Animal models for cutaneous vaccine delivery.

scientific article

Arrangement of Ceramides in the Skin: Sphingosine Chains Localize at a Single Position in Stratum Corneum Lipid Matrix Models

scientific article published on 20 August 2020

Barrier Capability of Skin Lipid Models: Effect of Ceramides and Free Fatty Acid Composition

scientific article published on 12 November 2019

Barrier properties of an N/TERT-based human skin equivalent.

scientific article published on 4 August 2014

Cationic liposomes loaded with a synthetic long peptide and poly(I:C): a defined adjuvanted vaccine for induction of antigen-specific T cell cytotoxicity.

scientific article

Ceramides in the Skin Lipid Membranes: Length Matters

scientific article published on 06 December 2013

Characterization and skin permeation of ketoprofen-loaded vesicular systems

scientific article published on 14 March 2013

Characterization of stratum corneum molecular dynamics by natural-abundance ¹³C solid-state NMR

scientific article

Co-encapsulation of antigen and Toll-like receptor ligand in cationic liposomes affects the quality of the immune response in mice after intradermal vaccination

scientific article published on December 2010

Coated and Hollow Microneedle-Mediated Intradermal Immunization in Mice with Diphtheria Toxoid Loaded Mesoporous Silica Nanoparticles

scientific article published on 13 August 2018

Combined LC/MS-platform for analysis of all major stratum corneum lipids, and the profiling of skin substitutes.

scientific article

Complement Receptor Targeted Liposomes Encapsulating the Liver X Receptor Agonist GW3965 Accumulate in and Stabilize Atherosclerotic Plaques

scientific article published on 24 April 2020

Comprehensive evaluation of microneedle-based intradermal adalimumab delivery versus subcutaneous administration: results of a randomized controlled trial

scientific article published on 05 January 2021

Contribution of Palmitic Acid to Epidermal Morphogenesis and Lipid Barrier Formation in Human Skin Equivalents

scientific article published on 02 December 2019

Degree of Skin Barrier Disruption Affects Lipid Organization in Regenerated Stratum Corneum

scientific article published on 15 December 2017

Determination of Depth-Dependent Intradermal Immunogenicity of Adjuvanted Inactivated Polio Vaccine Delivered by Microinjections via Hollow Microneedles.

scientific article published on 17 June 2016

Determination of the influence of C24 D/(2R)- and L/(2S)-isomers of the CER[AP] on the lamellar structure of stratum corneum model systems using neutron diffraction

scientific article published on 2 November 2017

Diverse regulation of claudin-1 and claudin-4 in atopic dermatitis.

scientific article published on 26 August 2015

Effect of the ω-acylceramides on the lipid organization of stratum corneum model membranes evaluated by X-ray diffraction and FTIR studies (Part I) ⬇️

scientific article published on January 14, 2011

Efficient induction of immune responses through intradermal vaccination with N-trimethyl chitosan containing antigen formulations.

scientific article published on 22 November 2009

Evidence of hydrocarbon nanodrops in highly ordered stratum corneum model membranes.

scientific article

Exploring the potentials of nurture: 2(nd) and 3(rd) generation explant human skin equivalents.

scientific article

FTIR studies show lipophilic moisturizers to interact with stratum corneum lipids, rendering the more densely packed

scientific article published on 18 March 2008

Fluorescent nanoparticle adhesion assay: a novel method for surface pKa determination of self-assembled monolayers on silicon surfaces

scientific article published on 7 February 2012

Focus on skin as a possible port of entry for solid nanoparticles and the toxicological impact

scientific article published on October 1, 2010

Free fatty acids chain length distribution affects the permeability of skin lipid model membranes.

scientific article

Glucocerebrosidase: Functions in and Beyond the Lysosome

scientific article published on 09 March 2020

Glucosylated cholesterol in skin: synthetic role of extracellular glucocerebrosidase

scientific article published on 15 September 2020

Hollow microneedle-mediated intradermal delivery of model vaccine antigen-loaded PLGA nanoparticles elicits protective T cell-mediated immunity to an intracellular bacterium.

scientific article published on 13 September 2017

Hollow microneedle-mediated micro-injections of a liposomal HPV E743-63 synthetic long peptide vaccine for efficient induction of cytotoxic and T-helper responses

scientific article

Human skin equivalents cultured under hypoxia display enhanced epidermal morphogenesis and lipid barrier formation.

scientific article

Hydrophilic and lipophilic moisturizers have similar penetration profiles but different effects on SC water distribution in vivo

scientific article published on 25 June 2009

Hyperalphalipoproteinemic scavenger receptor BI knockout mice exhibit a disrupted epidermal lipid barrier

scientific article published on 19 December 2019

Hypercholesterolemia in young adult APOE-/- mice alters epidermal lipid composition and impairs barrier function

scientific article published on 21 March 2019

Impact-insertion applicator improves reliability of skin penetration by solid microneedle arrays.

scientific article

Improved epidermal barrier formation in human skin models by chitosan modulated dermal matrices

scientific article

In situ visualization of glucocerebrosidase in human skin tissue: zymography versus activity-based probe labeling.

scientific article

In vitro model systems for studying the impact of organic chemicals on the skin barrier lipids.

scientific article

In vivo assessment of safety of microneedle arrays in human skin

scientific article

Increase in short-chain ceramides correlates with an altered lipid organization and decreased barrier function in atopic eczema patients

scientific article

Influence of microneedle shape on the transport of a fluorescent dye into human skin in vivo.

scientific article

Intercellular skin barrier lipid composition and organization in Netherton syndrome patients.

scientific article

Investigating the barrier function of skin lipid models with varying compositions ⬇️

scientific article published on May 30, 2011

Is an orthorhombic lateral packing and a proper lamellar organization important for the skin barrier function? ⬇️

scientific article published on October 28, 2010

LC/MS analysis of stratum corneum lipids: ceramide profiling and discovery

scientific article

Lamellar Lipid Organization and Ceramide Composition in the Stratum Corneum of Patients with Atopic Eczema

article

Layer-by-Layer Assembly of Inactivated Poliovirus and N-Trimethyl Chitosan on pH-Sensitive Microneedles for Dermal Vaccination

scientific article published on 5 July 2015

Lipid mixtures prepared with well-defined synthetic ceramides closely mimic the unique stratum corneum lipid phase behavior

scientific article

Lipid organization in human and porcine stratum corneum differs widely, while lipid mixtures with porcine ceramides model human stratum corneum lipid organization very closely

scientific article published on 12 March 2008

Lipophilic and hydrophilic moisturizers show different actions on human skin as revealed by cryo scanning electron microscopy

scientific article

Long periodicity phase in extracted lipids of vernix caseosa obtained with equilibration at physiological temperature

scientific article

Mesoporous Silica Nanoparticle-Coated Microneedle Arrays for Intradermal Antigen Delivery

scientific article published on 23 May 2017

Microneedle technologies for (trans)dermal drug and vaccine delivery

scientific article published on 04 February 2012

Microneedle-based drug and vaccine delivery via nanoporous microneedle arrays

scientific article

Microneedle-based transcutaneous immunisation in mice with N-trimethyl chitosan adjuvanted diphtheria toxoid formulations

scientific article

Mimicking vernix caseosa--preparation and characterization of synthetic biofilms

scientific article

Model membranes prepared with ceramide EOS, cholesterol and free fatty acids form a unique lamellar phase

scientific article published in March 2010

Modelling the stratum corneum lipid organisation with synthetic lipid mixtures: the importance of synthetic ceramide composition

scientific article

Modulation of stratum corneum lipid composition and organization of human skin equivalents by specific medium supplements.

scientific article published on 14 July 2015

Monounsaturated fatty acids reduce the barrier of stratum corneum lipid membranes by enhancing the formation of a hexagonal lateral packing

scientific article published on 27 May 2014

Nanolayered chemical modification of silicon surfaces with ionizable surface groups for pH-triggered protein adsorption and release: application to microneedles

scientific article published on 29 July 2013

Non-animal models of epithelial barriers (skin, intestine and lung) in research, industrial applications and regulatory toxicology.

scientific article

Novel hollow microneedle technology for depth-controlled microinjection-mediated dermal vaccination: a study with polio vaccine in rats

scientific article published on 28 January 2014

Novel lipid mixtures based on synthetic ceramides reproduce the unique stratum corneum lipid organization

scientific article published on 16 February 2004

On-line diffusion profile of a lipophilic model dye in different depths of a hair follicle in human scalp skin

scientific article published in October 2005

On-line visualization of dye diffusion in fresh unfixed human skin

scientific article published in May 2004

Penetration and distribution of three lipophilic probes in vitro in human skin focusing on the hair follicle

scientific article

Permeant lipophilicity and vehicle composition influence accumulation of dyes in hair follicles of human skin ⬇️

scientific article published on April 1, 2003

Phase behavior of stratum corneum lipid mixtures based on human ceramides: the role of natural and synthetic ceramide 1.

scientific article published in April 2002

Physicochemical characterization of drug-loaded rigid and elastic vesicles ⬇️

scientific article published on April 16, 2011

Preclinical studies with 5,10,15-Tris(4-methylpyridinium)-20-phenyl-[21H,23H]-porphine trichloride for the photodynamic treatment of superficial mycoses caused by Trichophyton rubrum

scientific article published on 19 November 2008

Preferential arrangement of lipids in the long periodicity phase of a stratum corneum matrix model

scientific article published on 17 October 2018

Preparation and characterization of a stratum corneum substitute for in vitro percutaneous penetration studies

scientific article published on 19 April 2006

Preparation and characterization of diphtheria toxoid-loaded elastic vesicles for transcutaneous immunization

scientific article published on August 2008

Psoriasis-Associated Late Cornified Envelope (LCE) Proteins Have Antibacterial Activity.

scientific article published on 17 June 2017

Quantitative analysis of ceramides using a novel lipidomics approach with three dimensional response modelling.

scientific article published on 12 July 2016

Quantitative assessment of the transport of elastic and rigid vesicle components and a model drug from these vesicle formulations into human skin in vivo

scientific article published in November 2004

Selectivity in cornified envelop binding of ceramides in human skin and the role of LXR inactivation on ceramide binding

scientific article published on 18 May 2019

Shedding light on the effects of 1,25-dihydroxyvitamin D3 on epidermal lipid barrier formation in three-dimensional human skin equivalents

scientific article published on 31 January 2019

Skin barrier lipid enzyme activity in Netherton patients is associated with protease activity and ceramide abnormalities

scientific article published on 07 April 2020

Skin lipids: localization of ceramide and fatty acid in the unit cell of the long periodicity phase

scientific article published on June 2015

Skin of atopic dermatitis patients shows disturbed β-glucocerebrosidase and acid sphingomyelinase activity that relates to changes in stratum corneum lipid composition

scientific article published on 21 February 2020

Solid and fluid segments within the same molecule of stratum corneum ceramide lipid

scientific article published on 01 January 2018

Stratum Corneum Lipids: Their Role for the Skin Barrier Function in Healthy Subjects and Atopic Dermatitis Patients.

scientific article published on 4 February 2016

Structure of the skin barrier and its modulation by vesicular formulations

scientific article

Synthesis and characterization of hyperbranched polyglycerol hydrogels

scientific article

Temperature-induced changes in structural and physicochemical properties of vernix caseosa

scientific article published on 02 August 2007

The Cornified Envelope-Bound Ceramide Fraction Is Altered in Patients with Atopic Dermatitis

scientific article published on 17 October 2019

The effect of the chain length distribution of free fatty acids on the mixing properties of stratum corneum model membranes

article

The pharmacokinetics and pharmacological effect of (S)-5-OH-DPAT following controlled delivery with transdermal iontophoresis

scientific article

The skin barrier in healthy and diseased state

scientific article

Time and depth resolved visualisation of the diffusion of a lipophilic dye into the hair follicle of fresh unfixed human scalp skin

scientific article

Topically Applied Ceramides Interact with the Stratum Corneum Lipid Matrix in Compromised Ex Vivo Skin

scientific article published on 6 February 2018

Topically applied fatty acids are elongated before incorporation in the stratum corneum lipid matrix in compromised skin

scientific article published on 16 June 2016

Towards tailored vaccine delivery: needs, challenges and perspectives.

scientific article published on 05 January 2012

Transcutaneous immunization studies in mice using diphtheria toxoid-loaded vesicle formulations and a microneedle array

scientific article

Two new methods for preparing a unique stratum corneum substitute

scientific article published in July 2008

Unravelling effects of relative humidity on lipid barrier formation in human skin equivalents

scientific article published on 18 July 2019

Water Distribution and Related Morphology in Human Stratum Corneum at Different Hydration Levels ⬇️

scientific article published on May 1, 2003

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