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List of works by Ivonne Rietjens

19F NMR metabolomics for the elucidation of microbial degradation pathways of fluorophenols

article published in 2001

19F NMR study on the biodegradation of fluorophenols by various Rhodococcus species

scientific article published on 01 January 1998

19F NMR study on the biological Baeyer-Villiger oxidation of acetophenones.

scientific article

19F-NMR study on the pH-dependent regioselectivity and rate of the ortho-hydroxylation of 3-fluorophenol by phenol hydroxylase from Trichosporon cutaneum. Implications for the reaction mechanism

scientific article published on 01 December 1993

5-Fluorouracil in colorectal cancer: rationale and clinical results of frequently used schedules ⬇️

scientific article published on June 1, 1998

A comparative study on the effect of algal and fish oil on viability and cell proliferation of Caco-2 cells

scientific article published on 28 October 2006

A low-density DNA microchip for the detection of (anti-)estrogenic compounds and their relative potencies.

scientific article

A mechanism for oxygen exchange between ligated oxometalloporphinates and bulk water

scientific article published on 01 June 2000

A physiological threshold for protection against menadione toxicity by human NAD(P)H:quinone oxidoreductase (NQO1) in Chinese hamster ovary (CHO) cells.

scientific article

A physiologically based biokinetic (PBBK) model for estragole bioactivation and detoxification in rat.

scientific article published on 27 April 2008

A physiologically based in silico kinetic model predicting plasma cholesterol concentrations in humans ⬇️

scientific article published on September 29, 2012

A physiologically based in silico model for trans-2-hexenal detoxification and DNA adduct formation in human including interindividual variation indicates efficient detoxification and a negligible genotoxicity risk.

scientific article published on 18 July 2013

A physiologically based in silico model for trans-2-hexenal detoxification and DNA adduct formation in rat

scientific article published on 19 October 2012

A physiologically based kinetic (PBK) model describing plasma concentrations of quercetin and its metabolites in rats.

scientific article published on 19 February 2014

A physiologically-based kinetic model for the prediction of plasma cholesterol concentrations in the mouse

scientific article published on 12 February 2011

A specific interaction between NADPH-cytochrome reductase and phosphatidylserine and phosphatidylinositol.

scientific article published in December 1993

A spectrophotometric assay for the detection of 2-aminophenols in biological samples

scientific article published on 01 July 1994

A state-of-the-art overview of the effect of metabolic conjugation on the biological activity of flavonoids ⬇️

scientific article published on July 12, 2012

Alkaloids in the human food chain – Natural occurrence and possible adverse effects ⬇️

scientific article published on 08 August 2011

An in vitro and in silico study on the flavonoid-mediated modulation of the transport of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) through Caco-2 monolayers

scientific article published on 10 August 2006

An n-3 PUFA-rich microalgal oil diet protects to a similar extent as a fish oil-rich diet against AOM-induced colonic aberrant crypt foci in F344 rats

scientific article published on 18 November 2008

Application of a continuous bioreactor cascade to study the effect of linoleic acid on hybridoma cell physiology.

scientific article published in October 2006

Application of bioassays in toxicological hazard, risk and impact assessments of dredged sediments.

scientific article published on 17 September 2010

Assessment of an in vitro transport model using BeWo b30 cells to predict placental transfer of compounds.

scientific article published on 21 May 2013

Basil extract inhibits the sulfotransferase mediated formation of DNA adducts of the procarcinogen 1'-hydroxyestragole by rat and human liver S9 homogenates and in HepG2 human hepatoma cells.

scientific article

Bioavailability of genistein and its glycoside genistin as measured in the portal vein of freely moving unanesthetized rats

scientific article published on 01 October 2006

Biphasic modulation of cell proliferation by quercetin at concentrations physiologically relevant in humans.

scientific article published on October 2003

Bovine liver slices: A multifunctional in vitro model to study the prohormone dehydroepiandrosterone (DHEA) ⬇️

scientific article published on May 26, 2012

Calculated ionisation potentials determine the oxidation of vanillin precursors by lignin peroxidase

scientific article published on 01 July 1998

Cell proliferation and modulation of interaction of estrogen receptors with coregulators induced by ERα and ERβ agonists.

scientific article

Characterization of different commercial soybean peroxidase preparations and use of the enzyme for N-demethylation of methyl N-methylanthranilate To produce the food flavor methylanthranilate

scientific article published on 01 May 2000

Chemical analysis of estragole in fennel based teas and associated safety assessment using the Margin of Exposure (MOE) approach.

scientific article

Combined quantum mechanical and molecular mechanical reaction pathway calculation for aromatic hydroxylation by p-hydroxybenzoate-3-hydroxylase

scientific article published on 01 June 1999

Combining in vitro embryotoxicity data with physiologically based kinetic (PBK) modelling to define in vivo dose-response curves for developmental toxicity of phenol in rat and human.

scientific article

Comparative MO-QSAR studies in various species including man

scientific article published on 01 March 1996

Consequences of quercetin methylation for its covalent glutathione and DNA adduct formation.

scientific article published on 3 March 2006

Consumer and farmer safety evaluation of application of botanical pesticides in black pepper crop protection.

scientific article published on 30 January 2013

Conversion of 2-fluoromuconate to cis-dienelactone by purified enzymes of Rhodococcus opacus 1cp

scientific article

Conversion of major soy isoflavone glucosides and aglycones in in vitro intestinal models

scientific article published on 18 November 2013

Conversion of pentahalogenated phenols by microperoxidase-8/H2O2 to benzoquinone-type products

scientific article published on 01 November 1998

Conversion of phenol derivatives to hydroxylated products by phenol hydroxylase from Trichosporon cutaneum. A comparison of regioselectivity and rate of conversion with calculated molecular orbital substrate characteristics

scientific article published on 01 January 1995

Correlation between activation of PPARγ and resistin downregulation in a mouse adipocyte cell line by a series of thiazolidinediones.

scientific article published on 3 April 2013

Cytotoxicity and cellular uptake of tri-block copolymer nanoparticles with different size and surface characteristics

scientific article

Decrease of intracellular pH as possible mechanism of embryotoxicity of glycol ether alkoxyacetic acid metabolites.

scientific article published on 11 March 2010

Degradation of 3,4-dichloro- and 3,4-difluoroaniline by Pseudomonas fluorescens 26-K.

scientific article

Development of a 19F-n.m.r. method for studies on the in vivo and in vitro metabolism of 2-fluoroaniline

scientific article published on 01 July 1990

Development of an on-line high performance liquid chromatography detection system for human cytochrome P450 1A2 inhibitors in extracts of natural products

scientific article published on 20 December 2006

Developmental toxicity of thyroid-active compounds in a zebrafish embryotoxicity test.

scientific article published on 10 April 2014

Differences in simulated liver concentrations of toxic coumarin metabolites in rats and different human populations evaluated through physiologically based biokinetic (PBBK) modeling.

scientific article published on 18 September 2008

Differential induction of electrophile-responsive element-regulated genes by n-3 and n-6 polyunsaturated fatty acids.

scientific article published on 20 July 2006

Differential substrate behaviour of phenol and aniline derivatives during conversion by horseradish peroxidase

scientific article published on 01 November 1999

Effects of C 60 nanoparticle exposure on earthworms ( Lumbricus rubellus ) and implications for population dynamics

scientific article published on 06 October 2010

Effects of silver nanoparticles (NM-300K) on Lumbricus rubellus earthworms and particle characterization in relevant test matrices including soil.

scientific article published in April 2014

Estrogenicity of food-associated estrogenic compounds in the fetuses of female transgenic mice upon oral and IP maternal exposure.

scientific article published on 11 February 2009

Evaluation of research activities and research needs to increase the impact and applicability of alternative testing strategies in risk assessment practice.

scientific article published on 18 July 2011

Excretion and metabolism of desogestrel in healthy postmenopausal women.

scientific article published in November 2001

Excretion balance and metabolism of the progestagen Org 30659 in healthy postmenopausal women

scientific article published on 01 May 2000

Flavonoid-mediated inhibition of intestinal ABC transporters may affect the oral bioavailability of drugs, food-borne toxic compounds and bioactive ingredients.

scientific article published on September 2006

Flavonoids and alkenylbenzenes: New concepts in bioactivation studies ⬇️

scientific article published on September 21, 2010

Flavonoids and alkenylbenzenes: mechanisms of mutagenic action and carcinogenic risk.

scientific article

Food-associated estrogenic compounds induce estrogen receptor-mediated luciferase gene expression in transgenic male mice.

scientific article published on 10 April 2008

Frontier orbital study on the 4-hydroxybenzoate-3-hydroxylase-dependent activity with benzoate derivatives.

scientific article published on June 1992

Future of toxicology--low-dose toxicology and risk--benefit analysis.

scientific article published on August 2006

GRASr2 evaluation of aliphatic acyclic and alicyclic terpenoid tertiary alcohols and structurally related substances used as flavoring ingredients.

scientific article published in April 2014

GSTP1-1 stereospecifically catalyzes glutathione conjugation of ethacrynic acid.

scientific article published on December 1998

Glutathione S-transferase phenotypes in relation to genetic variation and fruit and vegetable consumption in an endoscopy-based population

scientific article published on 27 October 2006

Heme-(hydro)peroxide mediated O- and N-dealkylation. A study with microperoxidase

scientific article published on 01 November 2000

Human NAD(P)H:quinone oxidoreductase inhibition by flavonoids in living cells.

scientific article published on 6 April 2005

Human T47D-ERβ breast cancer cells with tetracycline-dependent ERβ expression reflect ERα/ERβ ratios in rat and human breast tissue.

scientific article published on 13 May 2013

Human cytochrome p450 enzyme specificity for the bioactivation of estragole and related alkenylbenzenes.

scientific article published on 4 April 2007

Human cytochrome p450 enzymes of importance for the bioactivation of methyleugenol to the proximate carcinogen 1'-hydroxymethyleugenol.

scientific article published on January 2006

Human glutathione S-transferase-mediated glutathione conjugation of curcumin and efflux of these conjugates in Caco-2 cells.

scientific article published in November 2007

Identification of 14 quercetin phase II mono- and mixed conjugates and their formation by rat and human phase II in vitro model systems.

scientific article

Identification of coregulators influenced by estrogen receptor subtype specific binding of the ER antagonists 4-hydroxytamoxifen and fulvestrant

scientific article

Identification of fluoropyrogallols as new intermediates in biotransformation of monofluorophenols in Rhodococcus opacus 1cp.

scientific article published on May 2000

Identification of o-quinone/quinone methide metabolites of quercetin in a cellular in vitro system.

scientific article

Identification of phosphodiesterase type-5 (PDE-5) inhibitors in herbal supplements using a tiered approach and associated consumer risk

scientific article published in 2022

Impact of structural and metabolic variations on the toxicity and carcinogenicity of hydroxy- and alkoxy-substituted allyl- and propenylbenzenes.

scientific article published on 11 June 2014

In vitro nanoparticle toxicity to rat alveolar cells and coelomocytes from the earthworm Lumbricus rubellus.

scientific article

In vitro-in silico-based analysis of the dose-dependent in vivo oestrogenicity of the soy phytoestrogen genistein in humans.

scientific article published on 05 June 2017

In vivo validation and physiologically based biokinetic modeling of the inhibition of SULT-mediated estragole DNA adduct formation in the liver of male Sprague-Dawley rats by the basil flavonoid nevadensin.

scientific article

In vivo validation of DNA adduct formation by estragole in rats predicted by physiologically based biodynamic modelling.

scientific article published on 27 July 2012

Induction of electrophile-responsive element (EpRE)-mediated gene expression by tomato extracts in vitro.

scientific article published on 26 May 2012

Induction of peroxisome proliferator-activated receptor γ (PPARγ)-mediated gene expression by tomato (Solanum lycopersicum L.) extracts.

scientific article published on 2 April 2013

Influence of cellular ERalpha/ERbeta ratio on the ERalpha-agonist induced proliferation of human T47D breast cancer cells

scientific article published on 21 July 2008

Influence of substituents in fluorobenzene derivatives on the cytochrome P450-catalyzed hydroxylation at the adjacent ortho aromatic carbon center

scientific article published on 01 March 1997

Influence of the halogen-substituent pattern of fluoronitrobenzenes on their biotransformation and capacity to induce methemoglobinemia

scientific article published on 01 July 1996

Influence of the type of halogen substituent on in vivo and in vitro phase II metabolism of 2-fluoro-4-halophenol metabolites formed from 3-halo-fluorobenzenes

scientific article published on 01 August 1994

Inhibition of cellular efflux pumps involved in multi xenobiotic resistance (MXR) in echinoid larvae as a possible mode of action for increased ecotoxicological risk of mixtures

scientific article published on 07 August 2012

Inhibition of methyleugenol bioactivation by the herb-based constituent nevadensin and prediction of possible in vivo consequences using physiologically based kinetic modeling.

scientific article published on 4 July 2013

Inhibition of multidrug resistance proteins MRP1 and MRP2 by a series of alpha,beta-unsaturated carbonyl compounds.

scientific article

Interaction of hesperetin glucuronide conjugates with human BCRP, MRP2 and MRP3 as detected in membrane vesicles of overexpressing baculovirus-infected Sf9 cells.

scientific article

Interference of flavonoids with enzymatic assays for the determination of free fatty acid and triglyceride levels.

scientific article published on 26 November 2011

Interlaboratory comparison of microsomal ethoxyresorufin and pentoxyresorufin O-dealkylation determinations: standardization of assay conditions

scientific article published on 01 January 1992

Interplay between MRP inhibition and metabolism of MRP inhibitors: the case of curcumin.

scientific article published on December 2003

Levels of lead, arsenic, mercury and cadmium in clays for oral use on the Dutch market and estimation of associated risks.

scientific article

MP8-dependent oxidative dehalogenation: evidence for the direct formation of 1,4-benzoquinone from 4-fluorophenol by a peroxidase-type of reaction pathway.

scientific article published on May 1997

Malabaricone C-containing mace extract inhibits safrole bioactivation and DNA adduct formation both in vitro and in vivo.

scientific article

Marine neurotoxins: state of the art, bottlenecks, and perspectives for mode of action based methods of detection in seafood.

scientific article published on 05 December 2013

Matrix Modulation of the Bioactivation of Estragole by Constituents of Different Alkenylbenzene-containing Herbs and Spices and Physiologically Based Biokinetic Modeling of Possible In Vivo Effects ⬇️

scientific article published on May 30, 2012

Mechanisms underlying the dualistic mode of action of major soy isoflavones in relation to cell proliferation and cancer risks.

scientific article

Metabolism of the insecticide teflubenzuron in rats.

scientific article published in August 1997

Methyl linoleate ozonide: a substrate for rat glutathione S-transferases

scientific article published on 01 October 1987

Microsomal metabolism of fluoroanilines

scientific article published on 01 November 1989

Modelling flavin and substrate substituent effects on the activation barrier and rate of oxygen transfer by p-hydroxybenzoate hydroxylase

scientific article published on 01 July 2000

Molecular determinants of xenobiotic metabolism: QM/MM simulation of the conversion of 1-chloro-2,4-dinitrobenzene catalyzed by M1-1 glutathione S-transferase

scientific article published on 05 May 2007

Molecular orbital study of porphyrin-substrate interactions in cytochrome P450 catalysed aromatic hydroxylation of substituted anilines

scientific article published on 01 July 1998

Monitoring of polycyclic aromatic hydrocarbons (PAH) in food supplements containing botanicals and other ingredients on the Dutch market.

scientific article published on 13 May 2011

Novel advances in biotransformation and bioactivation research-2019 year in review

scientific article published on 09 July 2020

Occurrence of the NIH shift upon the cytochrome P450-catalyzed in vivo and in vitro aromatic ring hydroxylation of fluorobenzenes

scientific article published on 01 May 1998

On the number of EINECS compounds that can be covered by (Q)SAR models for acute toxicity

scientific article published on 07 November 2008

Organophosphate and carbamate pesticide residues and accompanying risks in commonly consumed vegetables in Kenya

scientific article published on 22 December 2020

P-gp efflux pump inhibition potential of common environmental contaminants determined in vitro

scientific article published on 26 February 2014

Pathway and single gene analyses of inhibited Caco-2 differentiation by ascorbate-stabilized quercetin suggest enhancement of cellular processes associated with development of colon cancer.

scientific article published on August 2007

Peroxidase-catalyzed formation of quercetin quinone methide-glutathione adducts.

scientific article

Phase II metabolism of hesperetin by individual UDP-glucuronosyltransferases and sulfotransferases and rat and human tissue samples

scientific article

Physiologically based biokinetic (PBBK) model for safrole bioactivation and detoxification in rats.

scientific article published on 8 April 2011

Physiologically based biokinetic model of bioactivation and detoxification of the alkenylbenzene methyleugenol in rat.

scientific article published on 7 September 2010

Physiologically based kinetic modeling of bioactivation and detoxification of the alkenylbenzene methyleugenol in human as compared with rat.

scientific article published on 14 March 2012

Physiologically based kinetic models for the alkenylbenzene elemicin in rat and human and possible implications for risk assessment.

scientific article

Phytoestrogen-mediated inhibition of proliferation of the human T47D breast cancer cells depends on the ERalpha/ERbeta ratio.

scientific article published on 8 October 2008

Potency of isothiocyanates to induce luciferase reporter gene expression via the electrophile-responsive element from murine glutathione S-transferase Ya.

scientific article

Prediction of in vivo developmental toxicity of all-trans-retinoic acid based on in vitro toxicity data and in silico physiologically based kinetic modeling

scientific article

Presence and risks of polycyclic aromatic hydrocarbons, dioxins and dioxin-like PCBs in dietary plant supplements as elucidated by a combined DR CALUX<sup>®</sup> bioassay and GC-HRMS based approach

scientific article published in 2022

Proliferation assays for estrogenicity testing with high predictive value for the in vivo uterotrophic effect ⬇️

scientific article published on November 25, 2011

Promises and pitfalls of quantitative structure-activity relationship approaches for predicting metabolism and toxicity.

scientific article published on December 2008

Prooxidant toxicity of polyphenolic antioxidants to HL-60 cells: description of quantitative structure-activity relationships

scientific article published on 01 December 1999

Quantitative comparison between in vivo DNA adduct formation from exposure to selected DNA-reactive carcinogens, natural background levels of DNA adduct formation and tumour incidence in rodent bioassays.

scientific article

Quantitative structure activity relationship studies on the flavonoid mediated inhibition of multidrug resistance proteins 1 and 2.

scientific article published on 23 December 2004

Quantitative structure activity relationships for the conversion of nitrobenzimidazolones and nitrobenzimidazoles by DT-diaphorase: implications for the kinetic mechanism

scientific article published on 01 May 1998

Quantitative structure activity relationships for the electron transfer reactions of Anabaena PCC 7119 ferredoxin-NADP+ oxidoreductase with nitrobenzene and nitrobenzimidazolone derivatives: mechanistic implications

scientific article published on 01 April 1999

Quantitative structure-activity relationship modeling of the toxicity of organothiophosphate pesticides to Daphnia magna and Cyprinus carpio

scientific article published on 18 April 2009

Quantitative structure/activity relationship for the rate of conversion of C4-substituted catechols by catechol-1,2-dioxygenase from Pseudomonas putida (arvilla) C1.

scientific article published on October 1998

Quantum chemistry based quantitative structure-activity relationships for modeling the (sub)acute toxicity of substituted mononitrobenzenes in aquatic systems

scientific article published on 01 September 2006

Quercetin decreases high-fat diet induced body weight gain and accumulation of hepatic and circulating lipids in mice.

scientific article

Quercetin induces hepatic lipid omega-oxidation and lowers serum lipid levels in mice

scientific article published on 24 January 2013

Rapid yeast estrogen bioassays stably expressing human estrogen receptors alpha and beta, and green fluorescent protein: a comparison of different compounds with both receptor types.

scientific article

Rat liver microsomal metabolism of 2-halogenated 4-methylanilines

scientific article published on 01 December 1992

Regioselectivity and reversibility of the glutathione conjugation of quercetin quinone methide

scientific article

Regioselectivity of phase II metabolism of luteolin and quercetin by UDP-glucuronosyl transferases.

scientific article

Relationships between the regioselectivity of the hydroxylation of C4-substituted 2-fluoroaniline derivatives and their toxic endpoints

scientific article published on 01 December 1996

Relative developmental toxicity potencies of retinoids in the embryonic stem cell test compared with their relative potencies in in vivo and two other in vitro assays for developmental toxicity.

scientific article published on 26 February 2011

Relative embryotoxic potency of p-substituted phenols in the embryonic stem cell test (EST) and comparison to their toxic potency in vivo and in the whole embryo culture (WEC) assay.

scientific article published on 20 July 2012

Reversal of in vitro cellular MRP1 and MRP2 mediated vincristine resistance by the flavonoid myricetin.

scientific article

Risk assessment of combined exposure to alkenylbenzenes through consumption of plant food supplements containing parsley and dill.

scientific article published on 5 June 2017

Risk assessment of herbal supplements containing ingredients that are genotoxic and carcinogenic

scientific article published on 01 August 2019

Role of catechin quinones in the induction of EpRE-mediated gene expression.

scientific article

Role of surface charge and oxidative stress in cytotoxicity of organic monolayer-coated silicon nanoparticles towards macrophage NR8383 cells.

scientific article published on 11 September 2010

Safety evaluation of neem (Azadirachta indica) derived pesticides.

scientific article published in September 2004

Sildenafil and analogous phosphodiesterase type 5 (PDE-5) inhibitors in herbal food supplements sampled on the Dutch market

scientific article published in December 2013

Stable reporter cell lines for peroxisome proliferator-activated receptor γ (PPARγ)-mediated modulation of gene expression.

scientific article published on 24 February 2011

Stereoselective conjugation, transport and bioactivity of s- and R-hesperetin enantiomers in vitro.

scientific article

T-screen to quantify functional potentiating, antagonistic and thyroid hormone-like activities of poly halogenated aromatic hydrocarbons (PHAHs).

scientific article published on 10 October 2005

TEAC antioxidant activity of 4-hydroxybenzoates

scientific article published on 01 December 1999

Tandem mass spectrometry analysis of N2-(trans-Isoestragol-3'-yl)-2'-deoxyguanosine as a strategy to study species differences in sulfotransferase conversion of the proximate carcinogen 1'-hydroxyestragole.

scientific article

The FEMA GRAS assessment of aliphatic and aromatic terpene hydrocarbons used as flavor ingredients.

scientific article published on 02 July 2011

The Use of In Vitro Toxicity Data and Physiologically Based Kinetic Modeling to Predict Dose-Response Curves for In Vivo Developmental Toxicity of Glycol Ethers in Rat and Man ⬇️

scientific article published on September 10, 2010

The definition of hormesis and its implications for in vitro to in vivo extrapolation and risk assessment.

scientific article

The effect of age on inducibility of various types of rat liver cytochrome P-450

scientific article published on May 1, 1992

The effect of co-administered flavonoids on the metabolism of hesperetin and the disposition of its metabolites in Caco-2 cell monolayers.

scientific article published in June 2010

The effect of iron to manganese substitution on microperoxidase 8 catalysed peroxidase and cytochrome P450 type of catalysis

scientific article published on 01 June 1999

The mercapturic acid biotransformation pathway of hexachlorobenzene is not involved in the induction of splenomegaly, or skin and lung lesions in the Brown Norway rat.

scientific article

The natural basil flavonoid nevadensin protects against a methyleugenol-induced marker of hepatocarcinogenicity in male F344 rat.

scientific article published on 10 September 2014

The pro-oxidant chemistry of the natural antioxidants vitamin C, vitamin E, carotenoids and flavonoids

scientific article published on 01 July 2002

The stimulation of cell proliferation by quercetin is mediated by the estrogen receptor.

scientific article

Toward in vitro biomarkers for developmental toxicity and their extrapolation to the in vivo situation.

scientific article

Towards an integrated in vitro strategy for estrogenicity testing

scientific article published on 30 September 2013

Transformation of the insecticide teflubenzuron by microorganisms.

scientific article

Tutorial on physiologically based kinetic modeling in molecular nutrition and food research.

scientific article published on 26 April 2011

Update of risk assessments of main marine biotoxins in the European Union.

scientific article published on 14 July 2011

Use of physiologically based biokinetic (PBBK) modeling to study estragole bioactivation and detoxification in humans as compared with male rats.

scientific article published on 15 May 2009

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