List of works - Carine Michiels

A Hybrid Assembly by Encapsulation of Human Cells within Mineralised Beads for Cell Therapy ⬇️

scientific article published on January 23, 2013

A p38(MAPK)/HIF-1 pathway initiated by UVB irradiation is required to induce Noxa and apoptosis of human keratinocytes

scientific article published on 15 April 2010

Activation of the oxidative stress pathway by HIV-1 Vpr leads to induction of hypoxia-inducible factor 1alpha expression

scientific article

Anti-apoptotic role of HIF-1 and AP-1 in paclitaxel exposed breast cancer cells under hypoxia

scientific article

Anti-cancer activities of pH- or heat-modified pectin

scientific article

Antibody-functionalized nanoparticles for imaging cancer: influence of conjugation to gold nanoparticles on the biodistribution of 89Zr-labeled cetuximab in mice

scientific article published on September 2013

Autophagy as a mediator of chemotherapy-induced cell death in cancer ⬇️

scientific article published on June 16, 2011

CoCl2, a chemical inducer of hypoxia-inducible factor-1, and hypoxia reduce apoptotic cell death in hepatoma cell line HepG2.

scientific article published on November 2002

Comparison of the clonogenic survival of A549 non-small cell lung adenocarcinoma cells after irradiation with low-dose-rate beta particles and high-dose-rate X-rays

scientific article

Cycling hypoxia induces a specific amplified inflammatory phenotype in endothelial cells and enhances tumor-promoting inflammation in vivo

scientific article

Cycling hypoxia: A key feature of the tumor microenvironment

scientific article published on 22 June 2016

Differential effect of hypoxia on etoposide-induced DNA damage response and p53 regulation in different cell types

scientific article published on December 2013

Differential effects of hypoxia on etoposide-induced apoptosis according to the cancer cell lines

scientific article

Differential influence of anticancer treatments and angiogenesis on the seric titer of autoantibody used as tumor and metastasis biomarker

scientific article

Effects of Alpha Particle and Proton Beam Irradiation as Putative Cross-Talk between A549 Cancer Cells and the Endothelial Cells in a Co-Culture System

scientific article

Effects of copper sulfate-oxidized or myeloperoxidase-modified LDL on lipid loading and programmed cell death in macrophages under hypoxia

scientific article published on 23 September 2014

Endothelial cell functions

scientific article

Glycogen synthase kinase 3 phosphorylates hypoxia-inducible factor 1alpha and mediates its destabilization in a VHL-independent manner

scientific article published on 26 February 2007

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

Heat-modified citrus pectin induces apoptosis-like cell death and autophagy in HepG2 and A549 cancer cells

scientific article published on 20 March 2015

Hybrid Shell Engineering of Animal Cells for Immune Protections and Regulation of Drug Delivery: Towards the Design of “Artificial Organs” ⬇️

scientific article published on June 22, 2011

Hypoxia and CoCl2 protect HepG2 cells against serum deprivation- and t-BHP-induced apoptosis: a possible anti-apoptotic role for HIF-1.

scientific article published on May 2004

Hypoxia induces protection against etoposide-induced apoptosis: molecular profiling of changes in gene expression and transcription factor activity

scientific article

Hypoxia regulates inflammatory gene expression in endothelial cells

scientific article

Hypoxia-Induced Modulation of Apoptosis and BCL-2 Family Proteins in Different Cancer Cell Types ⬇️

scientific article published on November 5, 2012

Hypoxia-induced decrease in p53 protein level and increase in c-jun DNA binding activity results in cancer cell resistance to etoposide

scientific article published on October 2009

Hypoxia-inducible factor-1-dependent overexpression of myeloid cell factor-1 protects hypoxic cells against tert-butyl hydroperoxide-induced apoptosis

scientific article

Identification of a cytotoxic molecule in heat-modified citrus pectin

scientific article published on 19 October 2015

Intermittent hypoxia changes HIF-1alpha phosphorylation pattern in endothelial cells: unravelling of a new PKA-dependent regulation of HIF-1alpha

scientific article

Is HIF-1alpha a pro- or an anti-apoptotic protein?

scientific article

Kinases as upstream regulators of the HIF system: their emerging potential as anti-cancer drug targets

scientific article published on January 2009

Lactate influx through the endothelial cell monocarboxylate transporter MCT1 supports an NF-κB/IL-8 pathway that drives tumor angiogenesis

scientific article published on 7 February 2011

Local mitochondrial-endolysosomal microfusion cleaves voltage-dependent anion channel 1 to promote survival in hypoxia

scientific article

Low-LET proton irradiation of A549 non-small cell lung adenocarcinoma cells: dose response and RBE determination

scientific article published on 21 January 2013

Low-dose hypersensitivity and bystander effect are not mutually exclusive in A549 lung carcinoma cells after irradiation with charged particles

scientific article published on 14 October 2013

M1 and M2 macrophages derived from THP-1 cells differentially modulate the response of cancer cells to etoposide

scientific article published on 8 August 2015

Meta-analysis and gene set analysis of archived microarrays suggest implication of the spliceosome in metastatic and hypoxic phenotypes

scientific article published on 31 January 2014

Meta-analysis of archived DNA microarrays identifies genes regulated by hypoxia and involved in a metastatic phenotype in cancer cells

scientific article

Metabolism and cancer: old and new players

scientific article published on 23 June 2013

Metallic nanoparticles irradiated by low-energy protons for radiation therapy: Are there significant physical effects to enhance the dose delivery?

scientific article

Mitochondria permeability transition-dependent tert-butyl hydroperoxide-induced apoptosis in hepatoma HepG2 cells

scientific article published on February 2004

Molecular aspects of cancer cell resistance to chemotherapy

scientific article published on 19 February 2013

NDRG1 and CRK-I/II are regulators of endothelial cell migration under Intermittent Hypoxia

scientific article published on 17 September 2009

Physiological and pathological responses to hypoxia

scientific article

Preconditioning of the tumor vasculature and tumor cells by intermittent hypoxia: implications for anticancer therapies

scientific article published on December 2006

Reactive oxygen species activate the HIF-1alpha promoter via a functional NFkappaB site

scientific article

Regulation of gene expression by oxygen: NF-kappaB and HIF-1, two extremes

scientific article

Reprogramming of Tumor-Associated Macrophages with Anticancer Therapies: Radiotherapy versus Chemo- and Immunotherapies

scientific article published on 14 July 2017

Role for casein kinase 2 in the regulation of HIF-1 activity

scientific article published on December 2005

TMEM45A Is Dispensable for Epidermal Morphogenesis, Keratinization and Barrier Formation

scientific article published on 19 January 2016

TMEM45A is essential for hypoxia-induced chemoresistance in breast and liver cancer cells ⬇️

scientific article published on September 6, 2012

Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis.

scientific article

The peroxynitrite donor 3-morpholinosydnonimine activates Nrf2 and the UPR leading to a cytoprotective response in endothelial cells

scientific article published on 14 September 2011

The role of hypoxia-inducible factor 1α in determining the properties of castrate-resistant prostate cancers

scientific article

Transcriptional regulation of hypoxia-inducible factor 1alpha by HIPK2 suggests a novel mechanism to restrain tumor growth

scientific article

Tumour hypoxia affects the responsiveness of cancer cells to chemotherapy and promotes cancer progression

scientific article published on October 2008

Up-regulation of 94-kDa glucose-regulated protein by hypoxia-inducible factor-1 in human endothelial cells in response to hypoxia

scientific article

miRNA-196b inhibits cell proliferation and induces apoptosis in HepG2 cells by targeting IGF2BP1

scientific article

List of works by Carine Michiels

A Hybrid Assembly by Encapsulation of Human Cells within Mineralised Beads for Cell Therapy ⬇️

A p38(MAPK)/HIF-1 pathway initiated by UVB irradiation is required to induce Noxa and apoptosis of human keratinocytes

Activation of the oxidative stress pathway by HIV-1 Vpr leads to induction of hypoxia-inducible factor 1alpha expression

Anti-apoptotic role of HIF-1 and AP-1 in paclitaxel exposed breast cancer cells under hypoxia

Anti-cancer activities of pH- or heat-modified pectin

Antibody-functionalized nanoparticles for imaging cancer: influence of conjugation to gold nanoparticles on the biodistribution of 89Zr-labeled cetuximab in mice

Autophagy as a mediator of chemotherapy-induced cell death in cancer ⬇️

CoCl2, a chemical inducer of hypoxia-inducible factor-1, and hypoxia reduce apoptotic cell death in hepatoma cell line HepG2.

Comparison of the clonogenic survival of A549 non-small cell lung adenocarcinoma cells after irradiation with low-dose-rate beta particles and high-dose-rate X-rays

Cycling hypoxia induces a specific amplified inflammatory phenotype in endothelial cells and enhances tumor-promoting inflammation in vivo

Cycling hypoxia: A key feature of the tumor microenvironment

Differential effect of hypoxia on etoposide-induced DNA damage response and p53 regulation in different cell types

Differential effects of hypoxia on etoposide-induced apoptosis according to the cancer cell lines

Differential influence of anticancer treatments and angiogenesis on the seric titer of autoantibody used as tumor and metastasis biomarker

Effects of Alpha Particle and Proton Beam Irradiation as Putative Cross-Talk between A549 Cancer Cells and the Endothelial Cells in a Co-Culture System

Effects of copper sulfate-oxidized or myeloperoxidase-modified LDL on lipid loading and programmed cell death in macrophages under hypoxia

Endothelial cell functions

Glycogen synthase kinase 3 phosphorylates hypoxia-inducible factor 1alpha and mediates its destabilization in a VHL-independent manner

Guidelines for the use and interpretation of assays for monitoring autophagy

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Heat-modified citrus pectin induces apoptosis-like cell death and autophagy in HepG2 and A549 cancer cells

Hybrid Shell Engineering of Animal Cells for Immune Protections and Regulation of Drug Delivery: Towards the Design of “Artificial Organs” ⬇️

Hypoxia and CoCl2 protect HepG2 cells against serum deprivation- and t-BHP-induced apoptosis: a possible anti-apoptotic role for HIF-1.

Hypoxia induces protection against etoposide-induced apoptosis: molecular profiling of changes in gene expression and transcription factor activity

Hypoxia regulates inflammatory gene expression in endothelial cells

Hypoxia-Induced Modulation of Apoptosis and BCL-2 Family Proteins in Different Cancer Cell Types ⬇️

Hypoxia-induced decrease in p53 protein level and increase in c-jun DNA binding activity results in cancer cell resistance to etoposide

Hypoxia-inducible factor-1-dependent overexpression of myeloid cell factor-1 protects hypoxic cells against tert-butyl hydroperoxide-induced apoptosis

Identification of a cytotoxic molecule in heat-modified citrus pectin

Intermittent hypoxia changes HIF-1alpha phosphorylation pattern in endothelial cells: unravelling of a new PKA-dependent regulation of HIF-1alpha

Is HIF-1alpha a pro- or an anti-apoptotic protein?

Kinases as upstream regulators of the HIF system: their emerging potential as anti-cancer drug targets

Lactate influx through the endothelial cell monocarboxylate transporter MCT1 supports an NF-κB/IL-8 pathway that drives tumor angiogenesis

Local mitochondrial-endolysosomal microfusion cleaves voltage-dependent anion channel 1 to promote survival in hypoxia

Low-LET proton irradiation of A549 non-small cell lung adenocarcinoma cells: dose response and RBE determination

Low-dose hypersensitivity and bystander effect are not mutually exclusive in A549 lung carcinoma cells after irradiation with charged particles

M1 and M2 macrophages derived from THP-1 cells differentially modulate the response of cancer cells to etoposide

Meta-analysis and gene set analysis of archived microarrays suggest implication of the spliceosome in metastatic and hypoxic phenotypes

Meta-analysis of archived DNA microarrays identifies genes regulated by hypoxia and involved in a metastatic phenotype in cancer cells

Metabolism and cancer: old and new players

Metallic nanoparticles irradiated by low-energy protons for radiation therapy: Are there significant physical effects to enhance the dose delivery?

Mitochondria permeability transition-dependent tert-butyl hydroperoxide-induced apoptosis in hepatoma HepG2 cells

Molecular aspects of cancer cell resistance to chemotherapy

NDRG1 and CRK-I/II are regulators of endothelial cell migration under Intermittent Hypoxia

Physiological and pathological responses to hypoxia

Preconditioning of the tumor vasculature and tumor cells by intermittent hypoxia: implications for anticancer therapies

Reactive oxygen species activate the HIF-1alpha promoter via a functional NFkappaB site

Regulation of gene expression by oxygen: NF-kappaB and HIF-1, two extremes

Reprogramming of Tumor-Associated Macrophages with Anticancer Therapies: Radiotherapy versus Chemo- and Immunotherapies

Role for casein kinase 2 in the regulation of HIF-1 activity

TMEM45A Is Dispensable for Epidermal Morphogenesis, Keratinization and Barrier Formation

TMEM45A is essential for hypoxia-induced chemoresistance in breast and liver cancer cells ⬇️

Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis.

The peroxynitrite donor 3-morpholinosydnonimine activates Nrf2 and the UPR leading to a cytoprotective response in endothelial cells

The role of hypoxia-inducible factor 1α in determining the properties of castrate-resistant prostate cancers

Transcriptional regulation of hypoxia-inducible factor 1alpha by HIPK2 suggests a novel mechanism to restrain tumor growth

Tumour hypoxia affects the responsiveness of cancer cells to chemotherapy and promotes cancer progression

Up-regulation of 94-kDa glucose-regulated protein by hypoxia-inducible factor-1 in human endothelial cells in response to hypoxia

miRNA-196b inhibits cell proliferation and induces apoptosis in HepG2 cells by targeting IGF2BP1