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List of works by Silvia Soddu

A mutated p53 status did not prevent the induction of apoptosis by sulforaphane, a promising anti-cancer drug

scientific article

ATM is activated by default in mitosis, localizes at centrosomes and monitors mitotic spindle integrity.

scientific article

ATM-depletion in breast cancer cells confers sensitivity to PARP inhibition

scientific article

Abscopal effect of radiation therapy: Interplay between radiation dose and p53 status

scientific article published on 6 February 2014

Abstract P3-06-01: ATM Heterozygosity as a Breast Cancer-Susceptibility Factor in the General Population

Activation of p53 function in carcinoma cells by the alpha6beta4 integrin

scientific article published on 01 July 1999

Adenovirus infection induces reentry into the cell cycle of terminally differentiated skeletal muscle cells.

scientific article published on March 1995

An Alternative Splice Variant of HIPK2 with Intron Retention Contributes to Cytokinesis

scientific article published on 20 February 2020

Apoptosis induced by a HIPK2 full-length-specific siRNA is due to off-target effects rather than prevalence of HIPK2-Δe8 isoform.

scientific article published on 28 November 2015

CDKL5 localizes at the centrosome and midbody and is required for faithful cell division

scientific article published on 24 July 2017

Che-1 affects cell growth by interfering with the recruitment of HDAC1 by Rb

scientific article (publication date: November 2002)

Che-1 phosphorylation by ATM/ATR and Chk2 kinases activates p53 transcription and the G2/M checkpoint

scientific article

Corrigendum

correction published 2015-02-04

Detection of ATM germline variants by the p53 mitotic centrosomal localization test in BRCA1/2-negative patients with early-onset breast cancer

scientific article published on 06 September 2016

Dual targeting of HER3 and MEK may overcome HER3-dependent drug-resistance of colon cancers.

scientific article published on 19 August 2016

Effects of Y361-auto-phosphorylation on structural plasticity of the HIPK2 kinase domain

scientific article

Epitelial-to-mesenchimal transition and invasion are upmodulated by tumor-expressed granzyme B and inhibited by docosahexaenoic acid in human colorectal cancer cells.

scientific article published on 2 February 2016

Erratum to: Detection of ATM germline variants by the p53 mitotic centrosomal localization test in BRCA1/2-negative patients with early-onset breast cancer

scientific article published on 28 November 2016

Evaluation of the molecular mechanisms involved in the gain of function of a Li-Fraumeni TP53 mutation

scientific article published on August 2005

Expression of exogenous wt-p53 does not affect normal hematopoiesis: implications for bone marrow purging.

scientific article

Extrachromosomal Histone H2B Contributes to the Formation of the Abscission Site for Cell Division

scientific article published on 05 November 2019

From p63 to p53 across p73.

scientific article

Functional Classification of the ATM Variant c.7157C>A and <i>In Vitro</i> Effects of Dexamethasone

scientific article published on 25 October 2021

Gal-3 is stimulated by gain-of-function p53 mutations and modulates chemoresistance in anaplastic thyroid carcinomas.

scientific article

Growth and differentiation signals by the insulin-like growth factor 1 receptor in hemopoietic cells are mediated through different pathways

scientific article published on 01 April 1999

HIPK2 Phosphorylates the Microtubule-Severing Enzyme Spastin at S268 for Abscission

scientific article published on 05 July 2019

HIPK2 and extrachromosomal histone H2B are separately recruited by Aurora-B for cytokinesis.

scientific article published on 22 March 2018

HIPK2 catalytic activity and subcellular localization are regulated by activation-loop Y354 autophosphorylation.

scientific article published on 26 February 2013

HIPK2 deficiency causes chromosomal instability by cytokinesis failure and increases tumorigenicity

scientific article published in April 2015

HIPK2 is involved in cell proliferation and its suppression promotes growth arrest independently of DNA damage.

scientific article

HIPK2 neutralizes MDM2 inhibition rescuing p53 transcriptional activity and apoptotic function

scientific article

HIPK2 phosphorylates ΔNp63α and promotes its degradation in response to DNA damage.

scientific article

HIPK2 sustains apoptotic response by phosphorylating Che-1/AATF and promoting its degradation

scientific article

HIPK2-T566 autophosphorylation diversely contributes to UV- and doxorubicin-induced HIPK2 activation

scientific article published on 02 January 2017

HIPK2: a multitalented partner for transcription factors in DNA damage response and development.

scientific article

HIPKs: Jack of all trades in basic nuclear activities.

scientific article published on 18 June 2008

HOPS/TMUB1 retains p53 in the cytoplasm and sustains p53-dependent mitochondrial apoptosis

scientific article published on 23 December 2019

High Mobility Group A1 (HMGA1) proteins interact with p53 and inhibit its apoptotic activity.

scientific article published on 9 December 2005

High-mobility group A1 inhibits p53 by cytoplasmic relocalization of its proapoptotic activator HIPK2.

scientific article published on 8 February 2007

Homeodomain interacting protein kinase 2 activation compromises endothelial cell response to laminar flow: protective role of p21(waf1,cip1,sdi1)

scientific article

Homeodomain-interacting Protein Kinase-2 Stabilizes p27kip1 by Its Phosphorylation at Serine 10 and Contributes to Cell Motility ⬇️

scientific article published on June 29, 2011

Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.

scientific article

Homeodomain-interacting protein kinase-2 stabilizes p27kip1 by its phosphorylation at serine 10 and contributes to cell motility.

scientific article

Identification of an aberrantly spliced form of HDMX in human tumors: a new mechanism for HDM2 stabilization

scientific article published on November 2005

Immune response to cytomegalovirus in patients with acquired-immunodeficiency syndrome related complex (ARC) and AIDS.

scientific article published in December 1987

Increase of BCNU sensitivity by wt-p53 gene therapy in glioblastoma lines depends on the administration schedule

scientific article

Investigation into the reactivity of the coordinatively unsaturated phosphonodithioato [Ni(MeOpdt)2] towards 2,4,6-tris(2-pyridyl)-1,3,5-triazine: goals and achievements

scientific article published on 02 April 2007

Lonidamine induces apoptosis in drug-resistant cells independently of the p53 gene.

scientific article published on September 1996

MDM2-regulated degradation of HIPK2 prevents p53Ser46 phosphorylation and DNA damage-induced apoptosis.

scientific article

MDM4 (MDMX) localizes at the mitochondria and facilitates the p53-mediated intrinsic-apoptotic pathway

scientific article

MDM4/HIPK2/p53 cytoplasmic assembly uncovers coordinated repression of molecules with anti-apoptotic activity during early DNA damage response

scientific article

MRE11 inhibition highlights a replication stress-dependent vulnerability of MYCN-driven tumors

scientific article published on 30 August 2018

MYCN sensitizes human neuroblastoma to apoptosis by HIPK2 activation through a DNA damage response.

scientific article published on 20 December 2010

Methyl-CpG-binding protein 2 is phosphorylated by homeodomain-interacting protein kinase 2 and contributes to apoptosis

scientific article

Mice with reduced expression of the telomere-associated protein Ft1 develop p53-sensitive progeroid traits

scientific article published on 10 April 2018

Mutant cohesin drives chromosomal instability in early colorectal adenomas

scientific article published on 30 July 2014

Mutant p53 gains new function in promoting inflammatory signals by repression of the secreted interleukin-1 receptor antagonist.

scientific article

NF-Y mediates the transcriptional inhibition of the cyclin B1, cyclin B2, and cdc25C promoters upon induced G2 arrest

scientific article published in Journal of Biological Chemistry

Oncogenes belonging to the CSF-1 transduction pathway direct p53 tumor suppressor effects to monocytic differentiation in 32D cells ⬇️

scientific article published on July 31, 1997

Overexpression of the cohesin-core subunit SMC1A contributes to colorectal cancer development

scientific article published on 01 March 2019

P53 detection by fluorescence lifetime on a hybrid fluorescein isothiocyanate gold nanosensor.

scientific article published in December 2009

PKC theta ablation improves healing in a mouse model of muscular dystrophy

scientific article

Pax8 has a critical role in epithelial cell survival and proliferation ⬇️

scientific article published on July 18, 2013

Prognostic role of serum p53 antibodies in lung cancer

scientific article

Repression of the antiapoptotic molecule galectin-3 by homeodomain-interacting protein kinase 2-activated p53 is required for p53-induced apoptosis.

scientific article published on June 2006

Retinoic acid and cAMP differentially regulate human chromogranin A promoter activity during differentiation of neuroblastoma cells.

scientific article published on January 1995

Ser58 of mouse p53 is the homologue of human Ser46 and is phosphorylated by HIPK2 in apoptosis

scientific article published on 26 May 2006

Serum p53 antibody detection in patients with impaired lung function.

scientific article

Sgk1 activates MDM2-dependent p53 degradation and affects cell proliferation, survival, and differentiation.

scientific article published on 11 September 2009

TP53INP1s and homeodomain-interacting protein kinase-2 (HIPK2) are partners in regulating p53 activity.

scientific article

TRIM8 interacts with KIF11 and KIFC1 and controls bipolar spindle formation and chromosomal stability

scientific article published on 02 January 2020

The Cockayne syndrome group A and B proteins are part of a ubiquitin-proteasome degradation complex regulating cell division

scientific article published on 16 November 2020

The Loss of the p53 Activator HIPK2 Is Responsible for Galectin-3 Overexpression in Well Differentiated Thyroid Carcinomas ⬇️

scientific article published on June 17, 2011

The beta 4 integrin subunit is expressed in mouse fibroblasts and modulated by transforming growth factor-beta 1.

scientific article published on September 1996

The effects of end point overdispersions on the validity of single-dose tumorigenicity assays.

scientific article published on July 1995

Updates on HIPK2: a resourceful oncosuppressor for clearing cancer ⬇️

scientific article published on August 13, 2012

Wt-p53 action in human leukaemia cell lines corresponding to different stages of differentiation.

scientific article published on May 1998

hMENA(11a) contributes to HER3-mediated resistance to PI3K inhibitors in HER2-overexpressing breast cancer cells.

scientific article published on 11 May 2015

p53 displacement from centrosomes and p53-mediated G1 arrest following transient inhibition of the mitotic spindle.

scientific article published on 28 February 2001

p53 is involved in the differentiation but not in the differentiation-associated apoptosis of myoblasts

scientific article published on 01 May 2000

p53 localization at centrosomes during mitosis and postmitotic checkpoint are ATM-dependent and require serine 15 phosphorylation.

scientific article published on 4 June 2004

p53 mitotic centrosome localization preserves centrosome integrity and works as sensor for the mitotic surveillance pathway

scientific article published on 07 November 2019

p53 re-expression inhibits proliferation and restores differentiation of human thyroid anaplastic carcinoma cells.

scientific article published on February 1997

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