List of works - Gabriella D'Orazi

A fluorescent curcumin-based Zn(II)-complex reactivates mutant (R175H and R273H) p53 in cancer cells

scientific article published on 07 October 2013

A ruthenium(II)-curcumin compound modulates NRF2 expression balancing the cancer cell death/survival outcome according to p53 status

scientific article published on 30 June 2020

Activation of p53/p21waf1 pathway is associated with senescence during v-Ha-ras transformation of immortal C2C12 myoblasts

scientific article

Apigenin, by activating p53 and inhibiting STAT3, modulates the balance between pro-apoptotic and pro-survival pathways to induce PEL cell death

scientific article published on 28 November 2017

Apoptosis as anticancer mechanism: function and dysfunction of its modulators and targeted therapeutic strategies

scientific article

Autophagy manipulation as a strategy for efficient anticancer therapies: possible consequences

scientific article published on 14 June 2019

Azurin modulates the association of Mdm2 with p53: SPR evidence from interaction of the full-length proteins

scientific article published on 01 July 2011

Chloroquine supplementation increases the cytotoxic effect of curcumin against Her2/neu overexpressing breast cancer cells in vitro and in vivo in nude mice while counteracts it in immune competent mice.

scientific article published on 31 July 2017

Concomitant reduction of c-Myc expression and PI3K/AKT/mTOR signaling by quercetin induces a strong cytotoxic effect against Burkitt's Lymphoma.

scientific article published on 9 September 2016

Counteracting MDM2-induced HIPK2 downregulation restores HIPK2/p53 apoptotic signaling in cancer cells

scientific article published on 16 September 2010

Cytotoxic Drugs Activate KSHV Lytic Cycle in Latently Infected PEL Cells by Inducing a Moderate ROS Increase Controlled by HSF1, NRF2 and p62/SQSTM1

scientific article published on 24 December 2018

Degradation of mutant p53H175 protein by Zn(II) through autophagy.

scientific article

Exogenous wt-p53 protein is active in transformed cells but not in their non-transformed counterparts: implications for cancer gene therapy without tumor targeting

scientific article

Expression and synthesis of fibronectin and laminin by an intestinal epithelial cell line

scientific article published on 01 January 1988

Genome-wide analysis discloses reversal of the hypoxia-induced changes of gene expression in colon cancer cells by zinc supplementation

scientific article published on December 2011

Gentian violet induces wtp53 transactivation in cancer cells

scientific article published on 14 February 2014

Glucose restriction induces cell death in parental but not in homeodomain-interacting protein kinase 2-depleted RKO colon cancer cells: molecular mechanisms and implications for tumor therapy

scientific article published on 23 May 2013

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

HHV-6A infection dysregulates autophagy/UPR interplay increasing beta amyloid production and tau phosphorylation in astrocytoma cells as well as in primary neurons, possible molecular mechanisms linking viral infection to Alzheimer's disease

scientific article published on 19 December 2019

HIF-1α antagonizes p53-mediated apoptosis by triggering HIPK2 degradation.

scientific article

HIPK2 contributes to PCAF-mediated p53 acetylation and selective transactivation of p21Waf1 after nonapoptotic DNA damage

scientific article

HIPK2 downregulates vimentin and inhibits breast cancer cell invasion.

scientific article published on 15 February 2012

HIPK2 inhibits both MDM2 gene and protein by, respectively, p53-dependent and independent regulations.

scientific article

HIPK2 knock-down compromises tumor cell efficiency to repair damaged DNA.

scientific article

HIPK2 modulates p53 activity towards pro-apoptotic transcription

scientific article published on 14 October 2009

HIPK2 neutralizes MDM2 inhibition rescuing p53 transcriptional activity and apoptotic function

scientific article

HIPK2 role in the tumor-host interaction: Impact on fibroblasts transdifferentiation CAF-like

scientific article published on 15 August 2019

HIPK2-a therapeutical target to be (re)activated for tumor suppression: role in p53 activation and HIF-1α inhibition.

scientific article published on April 2010

HIPK2-induced p53Ser46 phosphorylation activates the KILLER/DR5-mediated caspase-8 extrinsic apoptotic pathway

scientific article published on 13 July 2007

HSP70 inhibition by 2-phenylethynesulfonamide induces lysosomal cathepsin D release and immunogenic cell death in primary effusion lymphoma.

scientific article published on 18 July 2013

HSP70 inhibition by 2-phenylethynesulfonamide induces lysosomal cathepsin D release and immunogenic cell death in primary effusion lymphoma.

scientific article published on 22 May 2014

High glucose and hyperglycemic sera from type 2 diabetic patients impair DC differentiation by inducing ROS and activating Wnt/β-catenin and p38 MAPK.

scientific article

High glucose dephosphorylates serine 46 and inhibits p53 apoptotic activity

scientific article

Histone deacetylase inhibitors VPA and TSA induce apoptosis and autophagy in pancreatic cancer cells.

scientific article published on 3 February 2017

Homeodomain interacting protein kinase 2: a target for Alzheimer's beta amyloid leading to misfolded p53 and inappropriate cell survival

scientific article

Homeodomain-interacting protein kinase-2 activity and p53 phosphorylation are critical events for cisplatin-mediated apoptosis

scientific article published on February 2004

Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.

scientific article

Homeodomain-interacting protein kinase-2 restrains cytosolic phospholipase A2-dependent prostaglandin E2 generation in human colorectal cancer cells.

scientific article published on February 2006

Hyperglycemia triggers HIPK2 protein degradation.

scientific article

Increase of BCNU sensitivity by wt-p53 gene therapy in glioblastoma lines depends on the administration schedule

scientific article

Inhibition of HIF-1alpha activity by homeodomain-interacting protein kinase-2 correlates with sensitization of chemoresistant cells to undergo apoptosis.

scientific article

Interaction of p53 with Mdm2 and azurin as studied by atomic force spectroscopy

scientific article published on 01 July 2010

Interplay between Endoplasmic Reticulum (ER) Stress and Autophagy Induces Mutant p53H273 Degradation

scientific article published on 03 March 2020

JNK and macroautophagy activation by bortezomib has a pro-survival effect in primary effusion lymphoma cells.

scientific article

KSHV infection skews macrophage polarisation towards M2-like/TAM and activates Ire1 α-XBP1 axis up-regulating pro-tumorigenic cytokine release and PD-L1 expression

scientific article published on 18 May 2020

Kaposi sarcoma associated herpesvirus (KSHV) induces AKT hyperphosphorylation, bortezomib-resistance and GLUT-1 plasma membrane exposure in THP-1 monocytic cell line

scientific article published on 23 October 2013

Metformin triggers apoptosis in PEL cells and alters bortezomib-induced Unfolded Protein Response increasing its cytotoxicity and inhibiting KSHV lytic cycle activation

scientific article published on 27 September 2017

Modulation of laminin synthesis in human neuroblastoma cells during retinoic acid induced differentiation

scientific article published on May 30, 1992

Mutant p53 and Cellular Stress Pathways: A Criminal Alliance That Promotes Cancer Progression.

scientific article published on 2 May 2019

Mutant p53 proteins alter cancer cell secretome and tumour microenvironment: Involvement in cancer invasion and metastasis

scientific article published on April 2016

Mutant p53, Stabilized by Its Interplay with HSP90, Activates a Positive Feed-Back Loop Between NRF2 and p62 that Induces Chemo-Resistance to Apigenin in Pancreatic Cancer Cells

scientific article published on 22 May 2019

N(6)-Methyldeoxyadenosine, a nucleoside commonly found in prokaryotes, induces C2C12 myogenic differentiation.

scientific article published on February 2004

Negative regulation of beta4 integrin transcription by homeodomain-interacting protein kinase 2 and p53 impairs tumor progression

scientific article

Nobel committee honors tumor immunologists

scientific article published on 30 October 2018

Nox1 is involved in p53 deacetylation and suppression of its transcriptional activity and apoptosis.

scientific article

Nuclear factor erythroid 2 (NF-E2) p45-related factor 2 interferes with homeodomain-interacting protein kinase 2/p53 activity to impair solid tumors chemosensitivity

scientific article published on 27 June 2020

Oncogenic pathways activated by pro-inflammatory cytokines promote mutant p53 stability: clue for novel anticancer therapies

scientific article published on 17 October 2020

Overexpression of HIPK2 circumvents the blockade of apoptosis in chemoresistant ovarian cancer cells

scientific article

Oxidant species are involved in T/B-mediated ERK1/2 phosphorylation that activates p53-p21 axis to promote KSHV lytic cycle in PEL cells.

scientific article published on 8 August 2017

PBA Preferentially Impairs Cell Survival of Glioblastomas Carrying mutp53 by Reducing Its Expression Level, Stabilizing wtp53, Downregulating the Mevalonate Kinase and Dysregulating UPR

scientific article published on 10 April 2020

Quercetin Interrupts the Positive Feedback Loop Between STAT3 and IL-6, Promotes Autophagy, and Reduces ROS, Preventing EBV-Driven B Cell Immortalization

scientific article published on 12 September 2019

Quercetin induces apoptosis and autophagy in primary effusion lymphoma cells by inhibiting PI3K/AKT/mTOR and STAT3 signaling pathways

scientific article published on 5 January 2017

Reactivation of mutant p53 by capsaicin, the major constituent of peppers

scientific article published on 06 September 2016

Reduced chemotherapeutic sensitivity in high glucose condition: implication of antioxidant response

scientific article published on 23 July 2019

Regulation of p53 activity by HIPK2: molecular mechanisms and therapeutical implications in human cancer cells.

scientific article published on 31 May 2010

Regulation of vascular endothelial growth factor expression by homeodomain-interacting protein kinase-2.

scientific article

Restoring p53 active conformation by zinc increases the response of mutant p53 tumor cells to anticancer drugs.

scientific article published on 15 May 2011

Restoring wtp53 activity in HIPK2 depleted MCF7 cells by modulating metallothionein and zinc.

scientific article

Reversible dysfunction of wild-type p53 following homeodomain-interacting protein kinase-2 knockdown

scientific article

SLC25A1, or CIC, is a novel transcriptional target of mutant p53 and a negative tumor prognostic marker

scientific article

STAT3 and mutp53 Engage a Positive Feedback Loop Involving HSP90 and the Mevalonate Pathway

scientific article published on 10 July 2020

STAT3 phosphorylation affects p53/p21 axis and KSHV lytic cycle activation

scientific article published on 05 January 2019

Targeting COX-2/PGE(2) pathway in HIPK2 knockdown cancer cells: impact on dendritic cell maturation.

scientific article

Targeting MKK3 as a novel anticancer strategy: molecular mechanisms and therapeutical implications.

scientific article

Targeting hypoxia in cancer cells by restoring homeodomain interacting protein-kinase 2 and p53 activity and suppressing HIF-1alpha

scientific article

Targeting hypoxia in tumor: a new promising therapeutic strategy

scientific article published on 10 January 2020

Targeting mutant p53 in cancer: the latest insights

scientific article published on 05 July 2019

The 72-kDa and the 92-kDa gelatinases, but not their inhibitors TIMP-1 and TIMP-2, are expressed in early psoriatic lesions.

scientific article published in December 1997

The beneficial effect of Zinc(II) on low-dose chemotherapeutic sensitivity involves p53 activation in wild-type p53-carrying colorectal cancer cells

scientific article

Tp53-gene transfer induces hypersensitivity to low doses of X-rays in glioblastoma cells: a strategy to convert a radio-resistant phenotype into a radiosensitive one.

scientific article published in January 2006

Transcriptional regulation of hypoxia-inducible factor 1alpha by HIPK2 suggests a novel mechanism to restrain tumor growth

scientific article

Type IV collagenase(s) and TIMPs modulate endothelial cell morphogenesis in vitro.

scientific article published in August 1993

Unfolded p53 in the pathogenesis of Alzheimer's disease: is HIPK2 the link?

scientific article

Updates on HIPK2: a resourceful oncosuppressor for clearing cancer ⬇️

scientific article published on August 13, 2012

Wild-type p53-mediated down-modulation of interleukin 15 and interleukin 15 receptors in human rhabdomyosarcoma cells

scientific article

Zinc downregulates HIF-1α and inhibits its activity in tumor cells in vitro and in vivo

scientific article

Zinc supplementation augments in vivo antitumor effect of chemotherapy by restoring p53 function.

scientific article

Zinc supplementation is required for the cytotoxic and immunogenic effects of chemotherapy in chemoresistant p53-functionally deficient cells

scientific article published on 12 September 2013

Zn(II)-curc targets p53 in thyroid cancer cells

scientific article

ZnCl2 sustains the adriamycin-induced cell death inhibited by high glucose.

scientific article published on 30 June 2016

p53 can inhibit cell proliferation through caspase-mediated cleavage of ERK2/MAPK.

scientific article published on June 2004

p53 reactivation: the link to zinc

scientific article published on 15 July 2012

p53-Dependent PUMA to DRAM antagonistic interplay as a key molecular switch in cell-fate decision in normal/high glucose conditions

scientific article published on 11 September 2017

List of works by Gabriella D'Orazi

A fluorescent curcumin-based Zn(II)-complex reactivates mutant (R175H and R273H) p53 in cancer cells

A ruthenium(II)-curcumin compound modulates NRF2 expression balancing the cancer cell death/survival outcome according to p53 status

Activation of p53/p21waf1 pathway is associated with senescence during v-Ha-ras transformation of immortal C2C12 myoblasts

Apigenin, by activating p53 and inhibiting STAT3, modulates the balance between pro-apoptotic and pro-survival pathways to induce PEL cell death

Apoptosis as anticancer mechanism: function and dysfunction of its modulators and targeted therapeutic strategies

Autophagy manipulation as a strategy for efficient anticancer therapies: possible consequences

Azurin modulates the association of Mdm2 with p53: SPR evidence from interaction of the full-length proteins

Chloroquine supplementation increases the cytotoxic effect of curcumin against Her2/neu overexpressing breast cancer cells in vitro and in vivo in nude mice while counteracts it in immune competent mice.

Concomitant reduction of c-Myc expression and PI3K/AKT/mTOR signaling by quercetin induces a strong cytotoxic effect against Burkitt's Lymphoma.

Counteracting MDM2-induced HIPK2 downregulation restores HIPK2/p53 apoptotic signaling in cancer cells

Cytotoxic Drugs Activate KSHV Lytic Cycle in Latently Infected PEL Cells by Inducing a Moderate ROS Increase Controlled by HSF1, NRF2 and p62/SQSTM1

Degradation of mutant p53H175 protein by Zn(II) through autophagy.

Exogenous wt-p53 protein is active in transformed cells but not in their non-transformed counterparts: implications for cancer gene therapy without tumor targeting

Expression and synthesis of fibronectin and laminin by an intestinal epithelial cell line

Genome-wide analysis discloses reversal of the hypoxia-induced changes of gene expression in colon cancer cells by zinc supplementation

Gentian violet induces wtp53 transactivation in cancer cells

Glucose restriction induces cell death in parental but not in homeodomain-interacting protein kinase 2-depleted RKO colon cancer cells: molecular mechanisms and implications for tumor therapy

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

HHV-6A infection dysregulates autophagy/UPR interplay increasing beta amyloid production and tau phosphorylation in astrocytoma cells as well as in primary neurons, possible molecular mechanisms linking viral infection to Alzheimer's disease

HIF-1α antagonizes p53-mediated apoptosis by triggering HIPK2 degradation.

HIPK2 contributes to PCAF-mediated p53 acetylation and selective transactivation of p21Waf1 after nonapoptotic DNA damage

HIPK2 downregulates vimentin and inhibits breast cancer cell invasion.

HIPK2 inhibits both MDM2 gene and protein by, respectively, p53-dependent and independent regulations.

HIPK2 knock-down compromises tumor cell efficiency to repair damaged DNA.

HIPK2 modulates p53 activity towards pro-apoptotic transcription

HIPK2 neutralizes MDM2 inhibition rescuing p53 transcriptional activity and apoptotic function

HIPK2 role in the tumor-host interaction: Impact on fibroblasts transdifferentiation CAF-like

HIPK2-a therapeutical target to be (re)activated for tumor suppression: role in p53 activation and HIF-1α inhibition.

HIPK2-induced p53Ser46 phosphorylation activates the KILLER/DR5-mediated caspase-8 extrinsic apoptotic pathway

HSP70 inhibition by 2-phenylethynesulfonamide induces lysosomal cathepsin D release and immunogenic cell death in primary effusion lymphoma.

HSP70 inhibition by 2-phenylethynesulfonamide induces lysosomal cathepsin D release and immunogenic cell death in primary effusion lymphoma.

High glucose and hyperglycemic sera from type 2 diabetic patients impair DC differentiation by inducing ROS and activating Wnt/β-catenin and p38 MAPK.

High glucose dephosphorylates serine 46 and inhibits p53 apoptotic activity

Histone deacetylase inhibitors VPA and TSA induce apoptosis and autophagy in pancreatic cancer cells.

Homeodomain interacting protein kinase 2: a target for Alzheimer's beta amyloid leading to misfolded p53 and inappropriate cell survival

Homeodomain-interacting protein kinase-2 activity and p53 phosphorylation are critical events for cisplatin-mediated apoptosis

Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.

Homeodomain-interacting protein kinase-2 restrains cytosolic phospholipase A2-dependent prostaglandin E2 generation in human colorectal cancer cells.

Hyperglycemia triggers HIPK2 protein degradation.

Increase of BCNU sensitivity by wt-p53 gene therapy in glioblastoma lines depends on the administration schedule

Inhibition of HIF-1alpha activity by homeodomain-interacting protein kinase-2 correlates with sensitization of chemoresistant cells to undergo apoptosis.

Interaction of p53 with Mdm2 and azurin as studied by atomic force spectroscopy

Interplay between Endoplasmic Reticulum (ER) Stress and Autophagy Induces Mutant p53H273 Degradation

JNK and macroautophagy activation by bortezomib has a pro-survival effect in primary effusion lymphoma cells.

KSHV infection skews macrophage polarisation towards M2-like/TAM and activates Ire1 α-XBP1 axis up-regulating pro-tumorigenic cytokine release and PD-L1 expression

Kaposi sarcoma associated herpesvirus (KSHV) induces AKT hyperphosphorylation, bortezomib-resistance and GLUT-1 plasma membrane exposure in THP-1 monocytic cell line

Metformin triggers apoptosis in PEL cells and alters bortezomib-induced Unfolded Protein Response increasing its cytotoxicity and inhibiting KSHV lytic cycle activation

Modulation of laminin synthesis in human neuroblastoma cells during retinoic acid induced differentiation

Mutant p53 and Cellular Stress Pathways: A Criminal Alliance That Promotes Cancer Progression.

Mutant p53 proteins alter cancer cell secretome and tumour microenvironment: Involvement in cancer invasion and metastasis

Mutant p53, Stabilized by Its Interplay with HSP90, Activates a Positive Feed-Back Loop Between NRF2 and p62 that Induces Chemo-Resistance to Apigenin in Pancreatic Cancer Cells

N(6)-Methyldeoxyadenosine, a nucleoside commonly found in prokaryotes, induces C2C12 myogenic differentiation.

Negative regulation of beta4 integrin transcription by homeodomain-interacting protein kinase 2 and p53 impairs tumor progression

Nobel committee honors tumor immunologists

Nox1 is involved in p53 deacetylation and suppression of its transcriptional activity and apoptosis.

Nuclear factor erythroid 2 (NF-E2) p45-related factor 2 interferes with homeodomain-interacting protein kinase 2/p53 activity to impair solid tumors chemosensitivity

Oncogenic pathways activated by pro-inflammatory cytokines promote mutant p53 stability: clue for novel anticancer therapies

Overexpression of HIPK2 circumvents the blockade of apoptosis in chemoresistant ovarian cancer cells

Oxidant species are involved in T/B-mediated ERK1/2 phosphorylation that activates p53-p21 axis to promote KSHV lytic cycle in PEL cells.

PBA Preferentially Impairs Cell Survival of Glioblastomas Carrying mutp53 by Reducing Its Expression Level, Stabilizing wtp53, Downregulating the Mevalonate Kinase and Dysregulating UPR

Quercetin Interrupts the Positive Feedback Loop Between STAT3 and IL-6, Promotes Autophagy, and Reduces ROS, Preventing EBV-Driven B Cell Immortalization

Quercetin induces apoptosis and autophagy in primary effusion lymphoma cells by inhibiting PI3K/AKT/mTOR and STAT3 signaling pathways

Reactivation of mutant p53 by capsaicin, the major constituent of peppers

Reduced chemotherapeutic sensitivity in high glucose condition: implication of antioxidant response

Regulation of p53 activity by HIPK2: molecular mechanisms and therapeutical implications in human cancer cells.

Regulation of vascular endothelial growth factor expression by homeodomain-interacting protein kinase-2.

Restoring p53 active conformation by zinc increases the response of mutant p53 tumor cells to anticancer drugs.

Restoring wtp53 activity in HIPK2 depleted MCF7 cells by modulating metallothionein and zinc.

Reversible dysfunction of wild-type p53 following homeodomain-interacting protein kinase-2 knockdown

SLC25A1, or CIC, is a novel transcriptional target of mutant p53 and a negative tumor prognostic marker

STAT3 and mutp53 Engage a Positive Feedback Loop Involving HSP90 and the Mevalonate Pathway

STAT3 phosphorylation affects p53/p21 axis and KSHV lytic cycle activation

Targeting COX-2/PGE(2) pathway in HIPK2 knockdown cancer cells: impact on dendritic cell maturation.

Targeting MKK3 as a novel anticancer strategy: molecular mechanisms and therapeutical implications.

Targeting hypoxia in cancer cells by restoring homeodomain interacting protein-kinase 2 and p53 activity and suppressing HIF-1alpha

Targeting hypoxia in tumor: a new promising therapeutic strategy

Targeting mutant p53 in cancer: the latest insights

The 72-kDa and the 92-kDa gelatinases, but not their inhibitors TIMP-1 and TIMP-2, are expressed in early psoriatic lesions.

The beneficial effect of Zinc(II) on low-dose chemotherapeutic sensitivity involves p53 activation in wild-type p53-carrying colorectal cancer cells