List of works - Ed Hurt

60S pre-ribosome formation viewed from assembly in the nucleolus until export to the cytoplasm

scientific article

60S ribosome biogenesis requires rotation of the 5S ribonucleoprotein particle

scientific article

90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, and 40S subunit processing factors but predominantly lack 60S synthesis factors

scientific article

A Noc complex specifically involved in the formation and nuclear export of ribosomal 40 S subunits

scientific article

A network of assembly factors is involved in remodeling rRNA elements during preribosome maturation

scientific article

A versatile interaction platform on the Mex67-Mtr2 receptor creates an overlap between mRNA and ribosome export

scientific article

ATPase-dependent role of the atypical kinase Rio2 on the evolving pre-40S ribosomal subunit

scientific article

Adaptor Aly and co-adaptor Thoc5 function in the Tap-p15-mediated nuclear export of HSP70 mRNA

scientific article

An endoribonuclease functionally linked to perinuclear mRNP quality control associates with the nuclear pore complexes

scientific article

Architecture of the 90S Pre-ribosome: A Structural View on the Birth of the Eukaryotic Ribosome

scientific article

Architecture of the Rix1-Rea1 checkpoint machinery during pre-60S-ribosome remodeling

scientific article

Arx1 functions as an unorthodox nuclear export receptor for the 60S preribosomal subunit

scientific article published on 7 September 2007

Co-translational capturing of nascent ribosomal proteins by their dedicated chaperones

scientific article

Consistent mutational paths predict eukaryotic thermostability

scientific article

Coordinated Ribosomal ITS2 RNA Processing by the Las1 Complex Integrating Endonuclease, Polynucleotide Kinase, and Exonuclease Activities

scientific article published on 3 December 2015

Coordinated Ribosomal L4 Protein Assembly into the Pre-Ribosome Is Regulated by Its Eukaryote-Specific Extension

scientific article

Cotranscriptional recruitment of the serine-arginine-rich (SR)-like proteins Gbp2 and Hrb1 to nascent mRNA via the TREX complex

scientific article

Coupled GTPase and remodelling ATPase activities form a checkpoint for ribosome export

scientific article

Dominant Rio1 kinase/ATPase catalytic mutant induces trapping of late pre-40S biogenesis factors in 80S-like ribosomes

scientific article

Evidence for an evolutionary relationship between the large adaptor nucleoporin Nup192 and karyopherins

scientific article

Exporting RNA from the nucleus to the cytoplasm

scientific article (publication date: October 2007)

Formation and nuclear export of tRNA, rRNA and mRNA is regulated by the ubiquitin ligase Rsp5p

scientific article

Functional and structural characterization of the mammalian TREX-2 complex that links transcription with nuclear messenger RNA export

scientific article

Functional reconstitution of mitochondrial Fe/S cluster synthesis on Isu1 reveals the involvement of ferredoxin

scientific article

Hrr25-dependent phosphorylation state regulates organization of the pre-40S subunit

scientific article

Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile

scientific article

Mechanochemical removal of ribosome biogenesis factors from nascent 60S ribosomal subunits

scientific article

Modular self-assembly of a Y-shaped multiprotein complex from seven nucleoporins

scientific article

Molecular architecture of the inner ring scaffold of the human nuclear pore complex

scientific article

Molecular basis for the functional interaction of dynein light chain with the nuclear-pore complex

scientific article

Mutational uncoupling of the role of Sus1 in nuclear pore complex targeting of an mRNA export complex and histone H2B deubiquitination

scientific article

Nuclear export of ribosomal 60S subunits by the general mRNA export receptor Mex67-Mtr2.

scientific article

RNA helicase Prp43 and its co-factor Pfa1 promote 20 to 18 S rRNA processing catalyzed by the endonuclease Nob1.

scientific article

Rea1, a dynein-related nuclear AAA-ATPase, is involved in late rRNA processing and nuclear export of 60 S subunits

scientific article

Recruitment of the human TREX complex to mRNA during splicing

scientific article

Structural Basis for Assembly and Activation of the Heterotetrameric SAGA Histone H2B Deubiquitinase Module

scientific article

Structural basis for cooperativity of CRM1 export complex formation

scientific article

Structural basis for the assembly and nucleic acid binding of the TREX-2 transcription-export complex ⬇️

scientific article published on February 19, 2012

Structural basis for the interaction between yeast Spt-Ada-Gcn5 acetyltransferase (SAGA) complex components Sgf11 and Sus1.

scientific article

Structural basis for the molecular evolution of SRP-GTPase activation by protein

scientific article

Structural basis of histone H2A-H2B recognition by the essential chaperone FACT

scientific article

Structural basis of the nic96 subcomplex organization in the nuclear pore channel

scientific article

Structural characterization of a eukaryotic chaperone--the ribosome-associated complex

scientific article

Structural insights into tail-anchored protein binding and membrane insertion by Get3

scientific article

Structure of the C-terminal FG-nucleoporin binding domain of Tap/NXF1

scientific article

Structure of the pre-60S ribosomal subunit with nuclear export factor Arx1 bound at the exit tunnel

scientific article

Sus1, Cdc31, and the Sac3 CID Region Form a Conserved Interaction Platform that Promotes Nuclear Pore Association and mRNA Export

scientific article

Sus1, a functional component of the SAGA histone acetylase complex and the nuclear pore-associated mRNA export machinery

scientific article

Synchronizing nuclear import of ribosomal proteins with ribosome assembly

scientific article

TOR regulates late steps of ribosome maturation in the nucleoplasm via Nog1 in response to nutrients

scientific article

TREX is a conserved complex coupling transcription with messenger RNA export

scientific article

The AAA ATPase Rix7 powers progression of ribosome biogenesis by stripping Nsa1 from pre-60S particles

scientific article

The NUG1 GTPase reveals and N-terminal RNA-binding domain that is essential for association with 60 S pre-ribosomal particles

scientific article

The conserved Bud20 zinc finger protein is a new component of the ribosomal 60S subunit export machinery

scientific article

The crystal structure of Ebp1 reveals a methionine aminopeptidase fold as binding platform for multiple interactions

scientific article

The inner nuclear membrane protein Src1 associates with subtelomeric genes and alters their regulated gene expression

scientific article

The mRNA export factor Sus1 is involved in Spt/Ada/Gcn5 acetyltransferase-mediated H2B deubiquitinylation through its interaction with Ubp8 and Sgf11.

scientific article

The mRNA export machinery requires the novel Sac3p-Thp1p complex to dock at the nucleoplasmic entrance of the nuclear pores

scientific article

The path from nucleolar 90S to cytoplasmic 40S pre-ribosomes

scientific article

The structure of Get4 reveals an alpha-solenoid fold adapted for multiple interactions in tail-anchored protein biogenesis

scientific article

The tRNA aminoacylation co-factor Arc1p is excluded from the nucleus by an Xpo1p-dependent mechanism

scientific article

The yeast kinase Swe1 is required for proper entry into cell cycle after arrest due to ribosome biogenesis and protein synthesis defects

scientific article

Two structurally distinct domains of the nucleoporin Nup170 cooperate to tether a subset of nucleoporins to nuclear pores

scientific article

List of works by Ed Hurt

60S pre-ribosome formation viewed from assembly in the nucleolus until export to the cytoplasm

60S ribosome biogenesis requires rotation of the 5S ribonucleoprotein particle

90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, and 40S subunit processing factors but predominantly lack 60S synthesis factors

A Noc complex specifically involved in the formation and nuclear export of ribosomal 40 S subunits

A network of assembly factors is involved in remodeling rRNA elements during preribosome maturation

A versatile interaction platform on the Mex67-Mtr2 receptor creates an overlap between mRNA and ribosome export

ATPase-dependent role of the atypical kinase Rio2 on the evolving pre-40S ribosomal subunit

Adaptor Aly and co-adaptor Thoc5 function in the Tap-p15-mediated nuclear export of HSP70 mRNA

An endoribonuclease functionally linked to perinuclear mRNP quality control associates with the nuclear pore complexes

Architecture of the 90S Pre-ribosome: A Structural View on the Birth of the Eukaryotic Ribosome

Architecture of the Rix1-Rea1 checkpoint machinery during pre-60S-ribosome remodeling

Arx1 functions as an unorthodox nuclear export receptor for the 60S preribosomal subunit

Co-translational capturing of nascent ribosomal proteins by their dedicated chaperones

Consistent mutational paths predict eukaryotic thermostability

Coordinated Ribosomal ITS2 RNA Processing by the Las1 Complex Integrating Endonuclease, Polynucleotide Kinase, and Exonuclease Activities

Coordinated Ribosomal L4 Protein Assembly into the Pre-Ribosome Is Regulated by Its Eukaryote-Specific Extension

Cotranscriptional recruitment of the serine-arginine-rich (SR)-like proteins Gbp2 and Hrb1 to nascent mRNA via the TREX complex

Coupled GTPase and remodelling ATPase activities form a checkpoint for ribosome export

Dominant Rio1 kinase/ATPase catalytic mutant induces trapping of late pre-40S biogenesis factors in 80S-like ribosomes

Evidence for an evolutionary relationship between the large adaptor nucleoporin Nup192 and karyopherins

Exporting RNA from the nucleus to the cytoplasm

Formation and nuclear export of tRNA, rRNA and mRNA is regulated by the ubiquitin ligase Rsp5p

Functional and structural characterization of the mammalian TREX-2 complex that links transcription with nuclear messenger RNA export

Functional reconstitution of mitochondrial Fe/S cluster synthesis on Isu1 reveals the involvement of ferredoxin

Hrr25-dependent phosphorylation state regulates organization of the pre-40S subunit

Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile

Mechanochemical removal of ribosome biogenesis factors from nascent 60S ribosomal subunits

Modular self-assembly of a Y-shaped multiprotein complex from seven nucleoporins

Molecular architecture of the inner ring scaffold of the human nuclear pore complex

Molecular basis for the functional interaction of dynein light chain with the nuclear-pore complex

Mutational uncoupling of the role of Sus1 in nuclear pore complex targeting of an mRNA export complex and histone H2B deubiquitination

Nuclear export of ribosomal 60S subunits by the general mRNA export receptor Mex67-Mtr2.

RNA helicase Prp43 and its co-factor Pfa1 promote 20 to 18 S rRNA processing catalyzed by the endonuclease Nob1.

Rea1, a dynein-related nuclear AAA-ATPase, is involved in late rRNA processing and nuclear export of 60 S subunits

Recruitment of the human TREX complex to mRNA during splicing

Structural Basis for Assembly and Activation of the Heterotetrameric SAGA Histone H2B Deubiquitinase Module

Structural basis for cooperativity of CRM1 export complex formation

Structural basis for the assembly and nucleic acid binding of the TREX-2 transcription-export complex ⬇️

Structural basis for the interaction between yeast Spt-Ada-Gcn5 acetyltransferase (SAGA) complex components Sgf11 and Sus1.

Structural basis for the molecular evolution of SRP-GTPase activation by protein

Structural basis of histone H2A-H2B recognition by the essential chaperone FACT

Structural basis of the nic96 subcomplex organization in the nuclear pore channel

Structural characterization of a eukaryotic chaperone--the ribosome-associated complex

Structural insights into tail-anchored protein binding and membrane insertion by Get3

Structure of the C-terminal FG-nucleoporin binding domain of Tap/NXF1

Structure of the pre-60S ribosomal subunit with nuclear export factor Arx1 bound at the exit tunnel

Sus1, Cdc31, and the Sac3 CID Region Form a Conserved Interaction Platform that Promotes Nuclear Pore Association and mRNA Export

Sus1, a functional component of the SAGA histone acetylase complex and the nuclear pore-associated mRNA export machinery

Synchronizing nuclear import of ribosomal proteins with ribosome assembly

TOR regulates late steps of ribosome maturation in the nucleoplasm via Nog1 in response to nutrients

TREX is a conserved complex coupling transcription with messenger RNA export

The AAA ATPase Rix7 powers progression of ribosome biogenesis by stripping Nsa1 from pre-60S particles

The NUG1 GTPase reveals and N-terminal RNA-binding domain that is essential for association with 60 S pre-ribosomal particles

The conserved Bud20 zinc finger protein is a new component of the ribosomal 60S subunit export machinery

The crystal structure of Ebp1 reveals a methionine aminopeptidase fold as binding platform for multiple interactions

The inner nuclear membrane protein Src1 associates with subtelomeric genes and alters their regulated gene expression

The mRNA export factor Sus1 is involved in Spt/Ada/Gcn5 acetyltransferase-mediated H2B deubiquitinylation through its interaction with Ubp8 and Sgf11.

The mRNA export machinery requires the novel Sac3p-Thp1p complex to dock at the nucleoplasmic entrance of the nuclear pores

The path from nucleolar 90S to cytoplasmic 40S pre-ribosomes

The structure of Get4 reveals an alpha-solenoid fold adapted for multiple interactions in tail-anchored protein biogenesis

The tRNA aminoacylation co-factor Arc1p is excluded from the nucleus by an Xpo1p-dependent mechanism

The yeast kinase Swe1 is required for proper entry into cell cycle after arrest due to ribosome biogenesis and protein synthesis defects

Two structurally distinct domains of the nucleoporin Nup170 cooperate to tether a subset of nucleoporins to nuclear pores

Unconventional tethering of Ulp1 to the transport channel of the nuclear pore complex by karyopherins

Yeast Ataxin-7 links histone deubiquitination with gene gating and mRNA export

Yeast centrin Cdc31 is linked to the nuclear mRNA export machinery