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List of works by Cynthia J. Burrows

4n-1 Is a "Sweet Spot" in DNA i-Motif Folding of 2'-Deoxycytidine Homopolymers.

scientific article published on 14 March 2017

5-Carboxamido-5-formamido-2-iminohydantoin, in Addition to 8-oxo-7,8-Dihydroguanine, Is the Major Product of the Iron-Fenton or X-ray Radiation-Induced Oxidation of Guanine under Aerobic Reducing Conditions in Nucleoside and DNA Contexts

scientific article published in July 2015

50 Years of Accounts.

scientific article published in January 2017

8-Oxo-7,8-dihydro-2'-deoxyguanosine and abasic site tandem lesions are oxidation prone yielding hydantoin products that strongly destabilize duplex DNA.

scientific article

8-Oxo-7,8-dihydroguanine in the Context of a Gene Promoter G-Quadruplex Is an On-Off Switch for Transcription

scientific article published on 22 August 2017

8-Oxo-7,8-dihydroguanine, friend and foe: Epigenetic-like regulator versus initiator of mutagenesis

scientific article

8-Oxoguanosine Switches Modulate the Activity of Alkylated siRNAs by Controlling Steric Effects in the Major versus Minor Grooves ⬇️

scientific article published on March 31, 2011

A Prebiotic Role for 8-Oxoguanosine as a Flavin Mimic in Pyrimidine Dimer Photorepair ⬇️

scientific article published on August 30, 2011

A Role for the Fifth G-Track in G-Quadruplex Forming Oncogene Promoter Sequences during Oxidative Stress: Do These "Spare Tires" Have an Evolved Function?

scientific article

Accounts: 50 Years of a Great Idea.

scientific article published in January 2018

An exploration of mechanisms for the transformation of 8-oxoguanine to guanidinohydantoin and spiroiminodihydantoin by density functional theory

scientific article

Base Flipping within the α-Hemolysin Latch Allows Single-Molecule Identification of Mismatches in DNA.

scientific article

Base-excision repair activity of uracil-DNA glycosylase monitored using the latch zone of α-hemolysin

scientific article published on 11 December 2013

Case studies on potential G-quadruplex-forming sequences from the bacterial orders Deinococcales and Thermales derived from a survey of published genomes

scientific article published in Scientific Reports

Changes afoot!

scientific article published on 01 February 2015

Characterization of 2′-deoxyguanosine oxidation products observed in the Fenton-like system Cu(ii)/H2O2/reductant in nucleoside and oligodeoxynucleotide contexts ⬇️

scientific article published on March 29, 2011

Characterization of G-quadruplexes in Chlamydomonas reinhardtii and the effects of polyamine and magnesium cations on structure and stability

scientific article published on 15 November 2018

Chemical modification of siRNA bases to probe and enhance RNA interference

scientific article published on 17 August 2011

Colocalization of mA and G-Quadruplex-Forming Sequences in Viral RNA (HIV, Zika, Hepatitis B, and SV40) Suggests Topological Control of Adenosine -Methylation

article

Comparison of transition metal-mediated oxidation reactions of guanine in nucleoside and single-stranded oligodeoxynucleotide contexts ⬇️

scientific article published on April 15, 2011

Computational Study of Oxidation of Guanine by Singlet Oxygen (1 Δg ) and Formation of Guanine:Lysine Cross-Links

scientific article

Computational Study of the Formation of C8, C5, and C4 Guanine:Lysine Adducts via Oxidation of Guanine by Sulfate Radical Anion

scientific article published on 06 June 2019

Computational Study of the Radical Mediated Mechanism of the Formation of C8, C5, and C4 Guanine:Lysine Adducts in the Presence of the Benzophenone Photosensitizer.

scientific article published on 29 August 2016

Computational studies of electronic circular dichroism spectra predict absolute configuration assignments for the guanine oxidation product 5-carboxamido-5-formamido-2-iminohydantoin

scientific article published on June 2015

Confronting Racism in Chemistry Journals

scientific article published on 19 June 2020

Confronting Racism in Chemistry Journals

Copper/H2O2-mediated oxidation of 2'-deoxyguanosine in the presence of 2-naphthol leads to the formation of two distinct isomeric adducts

scientific article published on August 25, 2011

Crown ether–electrolyte interactions permit nanopore detection of individual DNA abasic sites in single molecules ⬇️

scientific article published on June 18, 2012

Cruciform DNA sequences in gene promoters can impact transcription upon oxidative modification of 2'-deoxyguanosine

scientific article published on 22 June 2020

Crystal Structure of DNA Polymerase β with DNA Containing the Base Lesion Spiroiminodihydantoin in a Templating Position

scientific article

Crystal Structure of a Replicative DNA Polymerase Bound to the Oxidized Guanine Lesion Guanidinohydantoin ,

scientific article

DNA-protein cross-links between guanine and lysine depend on the mechanism of oxidation for formation of C5 vs C8 guanosine adducts

scientific article

Detection of benzo[a]pyrene-guanine adducts in single-stranded DNA using the α-hemolysin nanopore

scientific article (publication date: 20 February 2015)

Differentiation of G:C vs A:T and G:C vs G:mC Base Pairs in the Latch Zone of α-Hemolysin

scientific article published on 27 October 2015

Dynamics of a DNA Mismatch Site Held in Confinement Discriminate Epigenetic Modifications of Cytosine.

scientific article

Editorial

Effect of Oxidative Damage on Charge and Spin Transport in DNA

scientific article published on 17 December 2018

Effect of an Electrolyte Cation on Detecting DNA Damage with the Latch Constriction of α-Hemolysin.

scientific article

Effect of the Oxidized Guanosine Lesions Spiroiminodihydantoin and Guanidinohydantoin on Proofreading by Escherichia coli DNA Polymerase I (Klenow Fragment) in Different Sequence Contexts ⬇️

scientific article published on November 11, 2003

Efficient UV-induced charge separation and recombination in an 8-oxoguanine-containing dinucleotide

scientific article

Electrical Current Signatures of DNA Base Modifications in Single Molecules Immobilized in the α-Hemolysin Ion Channel

scientific article published on June 2013

Electronic structure of DNA--unique properties of 8-oxoguanosine

scientific article

Endonuclease VIII-like 3 (Neil3) DNA glycosylase promotes neurogenesis induced by hypoxia-ischemia

scientific article published on 7 November 2011

Endonuclease and Exonuclease Activities on Oligodeoxynucleotides Containing Spiroiminodihydantoin Depend on the Sequence Context and the Lesion Stereochemistry

scientific article

Energetics of base flipping at a DNA mismatch site confined at the latch constriction of α-hemolysin

scientific article published on 20 September 2016

Evolution of Accounts

scientific article published on 01 January 2016

Exploration of mechanisms for the transformation of 8-hydroxy guanine radical to FAPyG by density functional theory

scientific article

Finding needles in DNA stacks

scientific article published on 15 September 2009

First Accounts: The Capstone of a Tenure Tour

scientific article published on 29 April 2020

Formation and processing of DNA damage substrates for the hNEIL enzymes

scientific article published on 20 November 2016

Formation of 13C-, 15N-, and 18O-Labeled Guanidinohydantoin from Guanosine Oxidation with Singlet Oxygen. Implications for Structure and Mechanism ⬇️

scientific article published on November 19, 2003

Formation of tricyclic [4.3.3.0] adducts between 8-oxoguanosine and tyrosine under conditions of oxidative DNA-protein cross-linking

scientific article

G-quadruplex folds of the human telomere sequence alter the site reactivity and reaction pathway of guanine oxidation compared to duplex DNA.

scientific article published on 13 March 2013

Guanine oxidation product 5-carboxamido-5-formamido-2-iminohydantoin induces mutations when bypassed by DNA polymerases and is a substrate for base excision repair

scientific article published on 27 August 2015

Holy Grails in Chemistry, Part II.

scientific article

Human DNA Repair Genes Possess Potential G-Quadruplex Sequences in Their Promoters and 5'-Untranslated Regions.

scientific article published on 10 January 2018

Human NEIL3 Gene Expression Regulated by Epigenetic-Like Oxidative DNA Modification

scientific article published on 08 July 2019

Human NEIL3 is mainly a monofunctional DNA glycosylase removing spiroimindiohydantoin and guanidinohydantoin

scientific article

Human Telomere G-Quadruplexes with Five Repeats Accommodate 8-Oxo-7,8-dihydroguanine by Looping out the DNA Damage

scientific article

Human endonuclease VIII-like (NEIL) proteins in the giant DNA Mimivirus

scientific article

Hysteresis in poly-2'-deoxycytidine i-motif folding is impacted by the method of analysis as well as loop and stem lengths

scientific article published on 18 July 2020

Identification of DNA lesions using a third base pair for amplification and nanopore sequencing

scientific article

Impact of DNA Oxidation on Toxicology: From Quantification to Genomics

scientific article published on 26 February 2019

In vitro ligation of oligodeoxynucleotides containing C8-oxidized purine lesions using bacteriophage T4 DNA ligase

scientific article published on 27 February 2007

In vitro nucleotide misinsertion opposite the oxidized guanosine lesions spiroiminodihydantoin and guanidinohydantoin and DNA synthesis past the lesions using Escherichia coli DNA polymerase I (Klenow fragment).

scientific article

Interactions of the human telomere sequence with the nanocavity of the α-hemolysin ion channel reveal structure-dependent electrical signatures for hybrid folds

scientific article published on 29 May 2013

Internal vs fishhook hairpin DNA: unzipping locations and mechanisms in the α-hemolysin nanopore

scientific article

Interplay of Guanine Oxidation and G-Quadruplex Folding in Gene Promoters

scientific article published on 09 January 2020

Interrogation of Base Pairing of the Spiroiminodihydantoin Diastereomers Using the α-Hemolysin Latch

scientific article published on 23 February 2017

Iron Fenton oxidation of 2'-deoxyguanosine in physiological bicarbonate buffer yields products consistent with the reactive oxygen species carbonate radical anion not the hydroxyl radical

scientific article published on 27 July 2020

Key References: A New Feature of Accounts

scientific article published on 29 May 2020

Kinetics of T3-DNA Ligase-Catalyzed Phosphodiester Bond Formation Measured Using the α-Hemolysin Nanopore

scientific article published on 2 December 2016

Location dependence of the transcriptional response of a potential G-quadruplex in gene promoters under oxidative stress

scientific article published on 01 June 2019

Mechanism of two-electron oxidation of deoxyguanosine 5'-monophosphate by a platinum(IV) complex

scientific article

Mechanistic Information on the Redox Cycling of Nickel(II/III) Complexes in the Presence of Sulfur Oxides and Oxygen. Correlation with DNA Damage Experiments

scientific article published on 01 July 1999

Mechanistic aspects of the formation of guanidinohydantoin from spiroiminodihydantoin under acidic conditions

scientific article

Modulation of the current signatures of DNA abasic site adducts in the α-hemolysin ion channel ⬇️

scientific article published on October 17, 2012

Mutation versus repair: NEIL1 removal of hydantoin lesions in single-stranded, bulge, bubble, and duplex DNA contexts

scientific article

Nanopore Analysis of the 5-Guanidinohydantoin to Iminoallantoin Isomerization in Duplex DNA

scientific article published on 08 March 2018

Nanopore Dwell Time Analysis Permits Sequencing and Conformational Assignment of Pseudouridine in SARS-CoV-2

scientific article published on 15 September 2021

Nanopore detection of 8-oxo-7,8-dihydro-2'-deoxyguanosine in immobilized single-stranded DNA via adduct formation to the DNA damage site

scientific article published on 7 December 2010

Nanopore detection of 8-oxoguanine in the human telomere repeat sequence

scientific article

Neil3 and NEIL1 DNA glycosylases remove oxidative damages from quadruplex DNA and exhibit preferences for lesions in the telomeric sequence context

scientific article

Nickel Complexes as Antioxidants. Inhibition of Aldehyde Autoxidation by Nickel(II) Tetraazamacrocycles

scientific article

On the irrelevancy of hydroxyl radical to DNA damage from oxidative stress and implications for epigenetics

scientific article published on 12 August 2020

Origins of Chemical Evolution

scientific article published on 01 December 2012

Oxidative DNA damage is epigenetic by regulating gene transcription via base excision repair

scientific article published on 31 January 2017

Oxidative DNA damage is epigenetic by regulating gene transcription via base excision repair

article

Oxidative Modification of Guanine in a Potential Z-DNA-Forming Sequence of a Gene Promoter Impacts Gene Expression

scientific article published on 07 March 2019

Oxidative Modification of the Potential G-Quadruplex Sequence in the PCNA Gene Promoter Can Turn on Transcription

scientific article published on 14 January 2019

Oxidative Nucleobase Modifications Leading to Strand Scission

scientific article published on 01 May 1998

Oxidatively induced DNA-protein cross-linking between single-stranded binding protein and oligodeoxynucleotides containing 8-oxo-7,8-dihydro-2'-deoxyguanosine

scientific article

Photoinduced Electron Transfer in DNA: Charge Shift Dynamics Between 8-Oxo-Guanine Anion and Adenine

scientific article

Plant and fungal Fpg homologs are formamidopyrimidine DNA glycosylases but not 8-oxoguanine DNA glycosylases.

scientific article published on 12 February 2009

Potential G-quadruplex forming sequences and N6-methyladenosine colocalize at human pre-mRNA intron splice sites

scientific article published on 12 May 2020

Prebiotic chemistry: Ribozyme takes its vitamins

scientific article published in November 2013

Promiscuous 8-Alkoxyadenosines in the Guide Strand of an SiRNA: Modulation of Silencing Efficacy and Off-Pathway Protein Binding ⬇️

scientific article published on October 11, 2012

QnAs with Cynthia J. Burrows

scientific article published on 27 October 2014

RNA polymerase II stalls on oxidative DNA damage via a torsion-latch mechanism involving lone pair-π and CH-π interactions

scientific article published on 13 April 2020

Rapid Screen of Potential i-Motif Forming Sequences in DNA Repair Gene Promoters

article

Rates of chemical cleavage of DNA and RNA oligomers containing guanine oxidation products

scientific article published on 22 April 2015

Recognition and removal of oxidized guanines in duplex DNA by the base excision repair enzymes hOGG1, yOGG1, and yOGG2.

scientific article published in September 2003

Reconciliation of chemical, enzymatic, spectroscopic and computational data to assign the absolute configuration of the DNA base lesion spiroiminodihydantoin

scientific article

Repair of hydantoin lesions and their amine adducts in DNA by base and nucleotide excision repair

scientific article published on 05 September 2013

Reverse Transcription Past Products of Guanine Oxidation in RNA Leads to Insertion of A and C opposite 8-Oxo-7,8-dihydroguanine and A and G opposite 5-Guanidinohydantoin and Spiroiminodihydantoin Diastereomers.

scientific article published on 28 August 2017

Sequence-Specific Single-Molecule Analysis of 8-Oxo-7,8-dihydroguanine Lesions in DNA Based on Unzipping Kinetics of Complementary Probes in Ion Channel Recordings ⬇️

scientific article published on August 29, 2011

Sequencing DNA for the Oxidatively Modified Base 8-Oxo-7,8-Dihydroguanine.

scientific article published on 7 April 2017

Sequencing of DNA Lesions Facilitated by Site-Specific Excision via Base Excision Repair DNA Glycosylases Yielding Ligatable Gaps

scientific article published on 7 January 2016

Sequencing the Mouse Genome for the Oxidatively Modified Base 8-Oxo-7,8-dihydroguanine by OG-Seq.

scientific article published on 2 February 2017

Single-Molecule Titration in a Protein Nanoreactor Reveals the Protonation/Deprotonation Mechanism of a C:C Mismatch in DNA

scientific article published on 03 April 2018

Single-molecule analysis of thymine dimer-containing G-quadruplexes formed from the human telomere sequence

scientific article

Single-molecule detection of a guanine(C8) - thymine(N3) cross-link using ion channel recording

scientific article

Single-molecule investigation of G-quadruplex folds of the human telomere sequence in a protein nanocavity

scientific article

Solving 21st Century Problems in Biological Inorganic Chemistry Using Synthetic Models

scientific article published in October 2015

Spermine participates in oxidative damage of guanosine and 8-oxoguanosine leading to deoxyribosylurea formation

scientific article

Spirodi(iminohydantoin) products from oxidation of 2'-deoxyguanosine in the presence of NH4Cl in nucleoside and oligodeoxynucleotide contexts

scientific article

Structural Context Effects in the Oxidation of 8-Oxo-7,8-dihydro-2′-deoxyguanosine to Hydantoin Products: Electrostatics, Base Stacking, and Base Pairing ⬇️

scientific article published on August 29, 2012

Structural Elucidation of Bisulfite Adducts to Pseudouridine That Result in Deletion Signatures during Reverse Transcription of RNA

scientific article published on 02 October 2019

Structural destabilization of DNA duplexes containing single-base lesions investigated by nanopore measurements

scientific article published on 31 October 2013

Structure and potential mutagenicity of new hydantoin products from guanosine and 8-oxo-7,8-dihydroguanine oxidation by transition metals.

scientific article

Substituent effects on the aliphatic Claisen rearrangement. 1. Synthesis and rearrangement of cyano-substituted allyl vinyl ethers

scientific article published in 1981

Superior removal of hydantoin lesions relative to other oxidized bases by the human DNA glycosylase hNEIL1

scientific article published on 11 June 2008

Surviving an Oxygen Atmosphere: DNA Damage and Repair

scientific article (publication date: 20 December 2009)

Synthesis and characterization of the oxidized dGTP lesions spiroiminodihydantoin-2'-deoxynucleoside-5'- triphosphate and guanidinohydantoin-2'-deoxynucleoside-5'- triphosphate

scientific article published on March 2006

Synthesis of N2-Alkyl-8-oxo-7,8-dihydro-2′-deoxyguanosine Derivatives and Effects of These Modifications on RNA Duplex Stability ⬇️

scientific article published on December 30, 2010

Synthesis of Site-Specific Crown Ether Adducts to DNA Abasic Sites: 8-Oxo-7,8-Dihydro-2'-Deoxyguanosine and 2'-Deoxycytidine

scientific article published on 01 January 2019

Synthesis of a metallopeptide-PNA conjugate and its oxidative cross-linking to a DNA target

scientific article published in January 2005

Temperature and electrolyte optimization of the α-hemolysin latch sensing zone for detection of base modification in double-stranded DNA.

scientific article

The Cys-Xaa-His metal-binding motif: [N] versus [S] coordination and nickel-mediated formation of cysteinyl sulfinic acid

scientific article

The Fifth Domain in the G-Quadruplex-Forming Sequence of the Human NEIL3 Promoter Locks DNA Folding in Response to Oxidative Damage

scientific article published on 10 May 2018

The NEIL glycosylases remove oxidized guanine lesions from telomeric and promoter quadruplex DNA structures

scientific article published on 26 March 2015

The NEIL glycosylases remove oxidized guanine lesions from telomeric and promoter quadruplex DNA structures

scientific article published on 27 June 2015

The RAD17 Promoter Sequence Contains a Potential Tail-Dependent G-Quadruplex That Downregulates Gene Expression upon Oxidative Modification

scientific article published on 15 August 2018

The hydantoin lesions formed from oxidation of 7,8-dihydro-8-oxoguanine are potent sources of replication errors in vivo

scientific article published in August 2003

The mouse ortholog of NEIL3 is a functional DNA glycosylase in vitro and in vivo

scientific journal article

The oxidative DNA glycosylases of Mycobacterium tuberculosis exhibit different substrate preferences from their Escherichia coli counterparts

scientific journal article

Transcriptome-wide profiling of multiple RNA modifications simultaneously at single-base resolution

scientific article published on 14 March 2019

UV-Induced Proton-Coupled Electron Transfer in Cyclic DNA Miniduplexes

scientific article published on 03 June 2016

Ultrafast excited-state dynamics and vibrational cooling of 8-oxo-7,8-dihydro-2'-deoxyguanosine in D2O.

scientific article published on 20 November 2013

Unfolding Kinetics of the Human Telomere i-Motif Under a 10 pN Force Imposed by the α-Hemolysin Nanopore Identify Transient Folded-State Lifetimes at Physiological pH.

scientific article published on 9 July 2015

Unraveling the 4n - 1 rule for DNA i-motif stability: base pairs vs. loop lengths

scientific article published on 01 June 2018

Unusual Isothermal Hysteresis in DNA i-Motif pH Transitions: A Study of the RAD17 Promoter Sequence

scientific article published on 01 April 2018

Unusual structural features of hydantoin lesions translate into efficient recognition by Escherichia coli Fpg

scientific article published on 27 July 2007

Unzipping Kinetics of Duplex DNA Containing Oxidized Lesions in an α-Hemolysin Nanopore ⬇️

scientific article published on June 25, 2012

Unzipping of A-Form DNA-RNA, A-Form DNA-PNA, and B-Form DNA-DNA in the α-Hemolysin Nanopore

scientific article

Update to Our Reader, Reviewer, and Author Communities-April 2020

scientific article published on 22 April 2020

Update to Our Reader, Reviewer, and Author Communities-April 2020

scientific article published on 23 April 2020

Welcoming Our New Sister Journal, Accounts of Materials Research

scientific article published on 03 November 2020

Whence Flavins? Redox-Active Ribonucleotides Link Metabolism and Genome Repair to the RNA World ⬇️

scientific article published on October 10, 2012

Zika Virus Genomic RNA Possesses Conserved G-Quadruplexes Characteristic of the Flaviviridae Family

scientific article

pH-Dependent Equilibrium between 5-Guanidinohydantoin and Iminoallantoin Affects Nucleotide Insertion Opposite the DNA Lesion

scientific article published on 19 November 2015

α-Hemolysin nanopore studies reveal strong interactions between biogenic polyamines and DNA hairpins

scientific article published on 10 May 2015

γ-Hemolysin Nanopore is Sensitive to Guanine-to-Inosine Substitutions in Double-Stranded DNA at the Single-Molecule Level

scientific article published on 16 October 2018

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