List of works by Maria Elena Bottazzi

"Running the Gauntlet": Formidable challenges in advancing neglected tropical diseases vaccines from development through licensure, and a "Call to Action"

scientific article published on 10 July 2019

2257: Vaccine efficacy and immunogenicity of recombinant WAP and CAP-1 proteins in AKR mice

scientific article published in September 2017

A method to probe protein structure from UV absorbance spectra

scientific article published on 21 September 2019

A new patient registry for Chagas disease

scientific article published on 01 October 2020

A novel blood-feeding detoxification pathway in Nippostrongylus brasiliensis L3 reveals a potential checkpoint for arresting hookworm development.

scientific article published on 22 March 2018

A phase 1 study of the safety, reactogenicity, and immunogenicity of a Schistosoma mansoni vaccine with or without glucopyranosyl lipid A aqueous formulation (GLA-AF) in healthy adults from a non-endemic area

scientific article published on 09 September 2019

A research capacity strengthening project for infectious diseases in Honduras: experience and lessons learned

scientific article published on January 2012

A scalable and reproducible manufacturing process for Phlebotomus papatasi salivary protein PpSP15, a vaccine candidate for leishmaniasis

scientific article published on 10 September 2020

A scoping review and prevalence analysis of soil-transmitted helminth infections in Honduras

scientific article (publication date: 2014)

A simple fluorescence-based assay for quantification of the Toll-Like Receptor agonist E6020 in vaccine formulations

scientific article

A therapeutic nanoparticle vaccine against Trypanosoma cruzi in a BALB/c mouse model of Chagas disease

scientific article published on 18 February 2016

A therapeutic vaccine prototype induces protective immunity and reduces cardiac fibrosis in a mouse model of chronic Trypanosoma cruzi infection

scientific article published on 30 May 2019

Ac-AP-12, a novel factor Xa anticoagulant peptide from the esophageal glands of adult Ancylostoma caninum

scientific article

Accelerating the development of a therapeutic vaccine for human Chagas disease: rationale and prospects

scientific article published on September 2012

Advances in neglected tropical disease vaccines: Developing relative potency and functional assays for the Na-GST-1/Alhydrogel hookworm vaccine

scientific article

Advances in vaccines against neglected tropical diseases: enhancing physical stability of a recombinant hookworm vaccine through biophysical and formulation studies

scientific article

Advancing a multivalent 'Pan-anthelmintic' vaccine against soil-transmitted nematode infections

scientific article

Advancing a vaccine to prevent hookworm disease and anemia

scientific article published on 31 March 2016

Advancing a vaccine to prevent human schistosomiasis

scientific article

Advancing the Development of a Human Schistosomiasis Vaccine

scientific article published on 16 November 2018

Alpha5beta1 integrin controls cyclin D1 expression by sustaining mitogen-activated protein kinase activity in growth factor-treated cells

scientific article published on October 1999

An enzymatically inactivated hemoglobinase from Necator americanus induces neutralizing antibodies against multiple hookworm species and protects dogs against heterologous hookworm infection

scientific article published on 20 April 2009

An ounce of prevention on a budget: a nonprofit approach to developing vaccines against neglected diseases

scientific article

An unfolding tragedy of Chagas disease in North America

scientific article

Ancylostoma caninum MTP-1, an astacin-like metalloprotease secreted by infective hookworm larvae, is involved in tissue migration

scientific article

Antibodies against a secreted protein from hookworm larvae reduce the intensity of hookworm infection in humans and vaccinated laboratory animals

scientific article

Antibody responses against the vaccine antigens Ov-103 and Ov-RAL-2 are associated with protective immunity to Onchocerca volvulus infection in both mice and humans

scientific article published on 16 September 2019

Ascaris Larval Infection and Lung Invasion Directly Induce Severe Allergic Airway Disease in Mice

scientific article published on 20 November 2018

BM2L is a spontaneous leukemogenic variant of a non-leukemogenic v-myb-transformed myeloid cell line

scientific article published on March 1993

Biochemical Screening of Potent Zika Virus Protease Inhibitors

scientific article published in 2022

Biophysical and formulation studies of the Schistosoma mansoni TSP-2 extracellular domain recombinant protein, a lead vaccine candidate antigen for intestinal schistosomiasis

scientific article published on 23 July 2013

Biophysical and stabilization studies of the Chlamydia trachomatis mouse pneumonitis major outer membrane protein

scientific article published on September 2009

COVID-19 in the Americas and the erosion of human rights for the poor

scientific article published on 18 December 2020

COVID-19 vaccine design: the Janus face of immune enhancement

scientific article published on 28 April 2020

COVID-19 vaccines: neutralizing antibodies and the alum advantage

scientific article published on 04 June 2020

Calling for rapid development of a safe and effective MERS vaccine.

scientific article published on 12 June 2014

Central Latin America: Two decades of challenges in neglected tropical disease control

scientific article published on 26 March 2020

Chagas disease: "the new HIV/AIDS of the Americas"

scientific article

Characterization and stability of Trypanosoma cruzi 24-C4 (Tc24-C4), a candidate antigen for a therapeutic vaccine against Chagas disease

scientific article published on 21 December 2017

China's shifting neglected parasitic infections in an era of economic reform, urbanization, disease control, and the Belt and Road Initiative

article

Controlled Human Hookworm Infection: Accelerating Human Hookworm Vaccine Development.

scientific article published on 19 April 2018

Coronavirus Vaccine-Associated Lung Immunopathology-What Is The Significance?

scientific article published on 26 June 2020

Correction: Safety and immunogenicity of the Na-GST-1 hookworm vaccine in Brazilian and American adults

scientific article published on 17 August 2020

Covalent vaccination with Trypanosoma cruzi Tc24 induces catalytic antibody production

scientific article published on 24 September 2018

Cysteine mutagenesis improves the production without abrogating antigenicity of a recombinant protein vaccine candidate for human chagas disease

scientific article

Developing a low-cost and accessible COVID-19 vaccine for global health

scientific article published on 29 July 2020

Development of chagas cardiac manifestations among Texas blood donors

scientific article published on 14 October 2014

Disproportionate impact of the COVID-19 pandemic on immigrant communities in the United States

scientific article published on 13 July 2020

Distinct effects of mitogens and the actin cytoskeleton on CREB and pocket protein phosphorylation control the extent and timing of cyclin A promoter activity

scientific article

Ears of the Armadillo: Global Health Research and Neglected Diseases in Texas

scientific article (publication date: June 2013)

Economic value of a therapeutic Chagas vaccine for indeterminate and Chagasic cardiomyopathy patients

scientific article published on 16 May 2019

Engineering a stable CHO cell line for the expression of a MERS-coronavirus vaccine antigen.

scientific article published on 26 February 2018

Establishing Preferred Product Characterization for the Evaluation of RNA Vaccine Antigens

scientific article published on 27 September 2019

Expression and purification of an engineered, yeast-expressed Leishmania donovani nucleoside hydrolase with immunogenic properties

scientific article published on 02 February 2016

Expression at a 20L scale and purification of the extracellular domain of the Schistosoma mansoni TSP-2 recombinant protein: a vaccine candidate for human intestinal schistosomiasis

scientific article published on 30 July 2013

Expression of the Necator americanus hookworm larval antigen Na-ASP-2 in Pichia pastoris and purification of the recombinant protein for use in human clinical trials

scientific article

Expression of the c-ski proto-oncogene during cell cycle arrest and myogenic differentiation

scientific article published on August 1995

Expression, immunogenicity, histopathology, and potency of a mosquito-based malaria transmission-blocking recombinant vaccine.

scientific article published on 6 February 2012

Expression, purification, and characterization of the Necator americanus aspartic protease-1 (Na-APR-1 (M74)) antigen, a component of the bivalent human hookworm vaccine

scientific article published in June 2015

Expression, purification, and molecular analysis of the Necator americanus glutathione S-transferase 1 (Na-GST-1): a production process developed for a lead candidate recombinant hookworm vaccine antigen

scientific article published on 4 April 2012

Expression, purification, crystallization and preliminary X-ray analysis of a truncated soluble domain of human glioma pathogenesis-related protein 1.

scientific article

Expression, purification, immunogenicity and protective efficacy of a recombinant nucleoside hydrolase from Leishmania donovani, a vaccine candidate for preventing cutaneous leishmaniasis

scientific article published on 20 October 2016

Expression, purification, immunogenicity, and protective efficacy of a recombinant Tc24 antigen as a vaccine against Trypanosoma cruzi infection in mice

scientific article

Functional consequences of cyclin D1/BRCA1 interaction in breast cancer cells

scientific article

Fusion of Na-ASP-2 with human immunoglobulin Fcγ abrogates histamine release from basophils sensitized with anti-Na-ASP-2 IgE.

scientific article published on August 2012

Genetic Adjuvantation of a Cell-Based Therapeutic Vaccine for Amelioration of Chagasic Cardiomyopathy

scientific article

Global COVID-19 Efforts as the Platform to Achieving the Sustainable Development Goals

scientific article published on 20 August 2020

Global economic burden of Chagas disease: a computational simulation model

scientific article published on 08 February 2013

Helminth infections of children: prospects for control

scientific article published on January 2005

Hookworm Infection

scientific article (publication date: 19 August 2004)

Hookworm: "the great infection of mankind".

scientific article published on 29 March 2005

Host Immunity and Inflammation to Pulmonary Helminth Infections

scientific article published on 20 October 2020

Human Intestinal Parasite Burden and Poor Sanitation in Rural Alabama

scientific article published on 5 September 2017

Human anthelminthic vaccines: Rationale and challenges

scientific article published on 9 May 2016

I Never Thought I Had "Moral Courage," until COVID-19 Happened

scientific article published on 24 June 2020

Identification and Characterization of the Trypanosoma cruzi B-cell Superantigen Tc24

scientific article

Identification of immunodominant antigens for the laboratory diagnosis of toxocariasis

scientific article published on October 2015

Identification, Characterization, and Structure of Tm16 from Trichuris muris

scientific article published on 14 August 2017

IgG Induced by Vaccination With Extracts Is Protective Against Infection

scientific article published on 09 November 2018

Immunogenicity of the hookworm Na-ASP-2 vaccine candidate: characterization of humoral and cellular responses after vaccination in the Sprague Dawley rat.

scientific article

Improved Biomarker and Imaging Analysis for Characterizing Progressive Cardiac Fibrosis in a Mouse Model of Chronic Chagasic Cardiomyopathy

scientific article published on 13 November 2019

In vitro cultured peripheral blood mononuclear cells from patients with chronic schistosomiasis mansoni show immunomodulation of cyclin D1,2,3 in the presence of soluble egg antigens.

scientific article

Innovation for the 'bottom 100 million': eliminating neglected tropical diseases in the Americas

scientific article published on January 2013

Inspiring women scientists in Honduras

scientific article published on 18 October 2019

Lessons along the Critical Path: Developing Vaccines against Human Helminths

scientific article published on 28 July 2018

Ligand binding properties of two Brugia malayi fatty acid and retinol (FAR) binding proteins and their vaccine efficacies against challenge infection in gerbils

scientific article published on 08 October 2018

Limited antigenic variation in the Trypanosoma cruzi candidate vaccine antigen TSA-1.

scientific article published on December 2014

Mechanisms of HTLV-1 transformation

scientific article published in September 2004

Mining the Metabolome for New and Innovative Chagas Disease Treatments

scientific article published on 25 November 2020

Model for product development of vaccines against neglected tropical diseases: a vaccine against human hookworm

scientific article

Modeling the economic and epidemiologic impact of hookworm vaccine and mass drug administration (MDA) in Brazil, a high transmission setting

scientific article

Modeling the economic value of a Chagas' disease therapeutic vaccine

scientific article published on 16 August 2012

Molecular cloning, biochemical characterization, and partial protective immunity of the heme-binding glutathione S-transferases from the human hookworm Necator americanus

scientific article

Mutations to Cysteine Residues in the Trypanosoma cruzi B-Cell Superantigen Tc24 Diminish Susceptibility to IgM-Mediated Hydrolysis

scientific article published on 05 June 2017

Neglected tropical diseases among the Association of Southeast Asian Nations (ASEAN): overview and update

scientific article

Neglected tropical diseases in Central America and Panama: review of their prevalence, populations at risk and impact on regional development

scientific article published on 15 May 2014

New Vaccines for the World's Poorest People

scientific article published on 03 September 2015

New technologies for the control of human hookworm infection

scientific article

New tools for NTD vaccines: A case study of quality control assays for product development of the human hookworm vaccine Na-APR-1M74

scientific article published in January 2015

New vaccines for neglected parasitic diseases and dengue

scientific article published on 08 April 2013

Onchocerca volvulus: The Road from Basic Biology to a Vaccine

scientific article

Optimization and revision of the production process of the Necator americanus glutathione S-transferase 1 (Na-GST-1), the lead hookworm vaccine recombinant protein candidate

scientific article

Optimization of the Production Process and Characterization of the Yeast-Expressed SARS-CoV Recombinant Receptor-Binding Domain (RBD219-N1), a SARS Vaccine Candidate

scientific article

Potency testing for the experimental Na-GST-1 hookworm vaccine

scientific article published on October 2010

Potential for developing a SARS-CoV receptor-binding domain (RBD) recombinant protein as a heterologous human vaccine against coronavirus infectious disease (COVID)-19

scientific article published on 16 April 2020

Preparing for SARS-CoV-2 Vaccines in US Immigrant Communities: Strategies for Allocation, Distribution, and Communication

scientific article published on 22 December 2020

Process Characterization and Biophysical Analysis for a Yeast-Expressed Phlebotomus papatasi Salivary Protein (PpSP15) as a Leishmania Vaccine Candidate

scientific article published on 15 February 2020

Production of recombinant TSA-1 and evaluation of its potential for the immuno-therapeutic control of Trypanosoma cruzi infection in mice

scientific article published on 21 September 2018

Progress in the development of a recombinant vaccine for human hookworm disease: the Human Hookworm Vaccine Initiative

scientific article

Protective immunity elicited by the nematode-conserved As37 recombinant protein against Ascaris suum infection

scientific article published on 13 February 2020

Protein profile of tax-associated complexes

scientific article (publication date: 2 January 2004)

Reduction of worm fecundity and canine host blood loss mediates protection against hookworm infection elicited by vaccination with recombinant Ac-16.

scientific article published on 31 January 2007

Regulation of p21(cip1) expression by growth factors and the extracellular matrix reveals a role for transient ERK activity in G1 phase

scientific article

Repeat-driven generation of antigenic diversity in a major human pathogen, Trypanosoma cruzi

Reproductive Outcomes in Rhesus Macaques (Macaca mulatta) with Naturally-acquired Trypanosoma cruzi Infection

scientific article published on 17 March 2020

Response to `letter to the editor: 'Strategies to enhance access to diagnosis and treatment for Chagas disease patients in Latin America'´

scientific article published on 06 August 2019

Roadmap to developing a recombinant coronavirus S protein receptor-binding domain vaccine for severe acute respiratory syndrome

scientific article published on December 2012

Role of viral regulatory and accessory proteins in HIV-1 replication

scientific article

SARS-CoV-2 RBD219-N1C1: A Yeast-Expressed SARS-CoV-2 Recombinant Receptor-Binding Domain Candidate Vaccine Stimulates Virus Neutralizing Antibodies and T-cell Immunity in Mice

scientific article published on 05 November 2020

SARS‑CoV-2 RBD219-N1C1: A yeast-expressed SARS-CoV-2 recombinant receptor-binding domain candidate vaccine stimulates virus neutralizing antibodies and T-cell immunity in mice

scientific article

Safety and immunogenicity of a recombinant vaccine against Trypanosoma cruzi in Rhesus macaques

scientific article published on 13 May 2020

Safety and immunogenicity of co-administered hookworm vaccine candidates Na-GST-1 and Na-APR-1 in Gabonese adults: a randomised, controlled, double-blind, phase 1 dose-escalation trial

scientific article published on 11 September 2020

Safety and immunogenicity of the Na-GST-1 hookworm vaccine in Brazilian and American adults

scientific article

Schistosoma haematobium Extracellular Vesicle Proteins Confer Protection in a Heterologous Model of Schistosomiasis

scientific article published on 24 July 2020

Status of vaccine research and development of vaccines for Chagas disease

scientific article

Status of vaccine research and development of vaccines for leishmaniasis

scientific article published on 10 March 2016

Strategies to enhance access to diagnosis and treatment for Chagas disease patients in Latin America

scientific article published on 13 February 2019

Structure of SALO, a leishmaniasis vaccine candidate from the sand fly Lutzomyia longipalpis

scientific article (publication date: 9 March 2017)

TLR4 agonist protects against Trypanosoma cruzi acute lethal infection by decreasing cardiac parasite burdens

scientific article published on 26 June 2020

Texas and Mexico: sharing a legacy of poverty and neglected tropical diseases

scientific article (publication date: 2012)

The BENEFIT Trial: Where Do We Go from Here?

scientific article published on 25 February 2016

The Factor H-binding site of CspZ as a protective target against multi-strain, tick-transmitted Lyme disease

scientific article published on 02 March 2020

The Global Economic and Health Burden of Human Hookworm Infection

scientific article

The Gulf of Mexico: a "hot zone" for neglected tropical diseases?

scientific article

The HTLV-I Tax oncoprotein targets the retinoblastoma protein for proteasomal degradation

scientific article

The Human Hookworm Vaccine

scientific article published on April 2013

The Immunomodulatory Role of Adjuvants in Vaccines Formulated with the Recombinant Antigens Ov-103 and Ov-RAL-2 against Onchocerca volvulus in Mice

scientific article

The Onchocerciasis Vaccine for Africa--TOVA--Initiative

scientific article

The Potential Economic Value of a Zika Vaccine for a Woman of Childbearing Age

scientific article published on 21 January 2020

The Potential Role of Th17 Immune Responses in Coronavirus Immunopathology and Vaccine-induced Immune Enhancement

scientific article published on 16 April 2020

The SARS-CoV-2 Vaccine Pipeline: an Overview

scientific article published on 03 March 2020

The extracellular matrix and mitogenic growth factors control G1 phase cyclins and cyclin-dependent kinase inhibitors.

scientific article published in September 1997

The hookworm Ancylostoma ceylanicum intestinal transcriptome provides a platform for selecting drug and vaccine candidates

scientific article published on 27 September 2016

The impact of concurrent and treated Ancylostoma ceylanicum hookworm infections on the immunogenicity of a recombinant hookworm vaccine in hamsters

scientific article published on 29 November 2005

The neglected tropical diseases of Latin America and the Caribbean: a review of disease burden and distribution and a roadmap for control and elimination

scientific article

The parasite-derived rOv-ASP-1 is an effective antigen-sparing CD4 T cell-dependent adjuvant for the trivalent inactivated influenza vaccine, and functions in the absence of MyD88 pathway

scientific article published on 01 June 2018

The potential economic value of a cutaneous leishmaniasis vaccine in seven endemic countries in the Americas

scientific article

The potential economic value of a therapeutic Chagas disease vaccine for pregnant women to prevent congenital transmission

scientific article published on 12 March 2020

The role of cyclin D2 and p21/waf1 in human T-cell leukemia virus type 1 infected cells

scientific article

The unfinished public health agenda of chagas disease in the era of globalization

scientific article

Toxocariasis in North America: a systematic review

scientific article

Trichuris muris whey acidic protein induces type 2 protective immunity against whipworm

scientific article published on 28 August 2018

Trypanosoma cruzi screening in Texas blood donors, 2008-2012.

scientific article published on 29 August 2014

Trypanosoma cruzi vaccine candidate antigens Tc24 and TSA-1 recall memory immune response associated with HLA-A and -B supertypes in Chagasic chronic patients from Mexico

scientific article

Use of Multi-Parallel Real-Time Quantitative PCR to Determine Blastocystis Prevalence and Association with Other Gastrointestinal Parasite Infection in a Rural Honduran Location

scientific article published on 16 March 2020

Vaccination of Gerbils with Bm-103 and Bm-RAL-2 Concurrently or as a Fusion Protein Confers Consistent and Improved Protection against Brugia malayi Infection

scientific article (publication date: April 2016)

Vaccination of dogs with a recombinant cysteine protease from the intestine of canine hookworms diminishes the fecundity and growth of worms

scientific article

Vaccination with chimeric protein induces protection in murine model against ascariasis

scientific article published on 26 November 2020

Vaccination with irradiated Ancylostoma caninum third stage larvae induces a Th2 protective response in dogs

scientific article published on 15 August 2005

Vaccination with recombinant aspartic hemoglobinase reduces parasite load and blood loss after hookworm infection in dogs

scientific article

Vaccine Efficacy Needed for a COVID-19 Coronavirus Vaccine to Prevent or Stop an Epidemic as the Sole Intervention

scientific article published on 15 July 2020

Vaccine-linked chemotherapy improves benznidazole efficacy for acute Chagas disease

scientific article published on 8 January 2018

Vaccines against neglected tropical diseases: promising interventions to rescue the poorest populations in the Americas

scientific article published on 01 January 2014

Vaccines to combat river blindness: expression, selection and formulation of vaccines against infection with Onchocerca volvulus in a mouse model

scientific article

Will COVID-19 become the next neglected tropical disease?

scientific article published on 10 April 2020

Yeast-Expressed SARS-CoV Recombinant Receptor-Binding Domain (RBD219-N1) Formulated with Alum Induces Protective Immunity and Reduces Immune Enhancement

scientific article published on 16 May 2020

Yeast-expressed SARS-CoV recombinant receptor-binding domain (RBD219-N1) formulated with aluminum hydroxide induces protective immunity and reduces immune enhancement

scientific article published on 22 September 2020

Yeast-expressed recombinant As16 protects mice against Ascaris suum infection through induction of a Th2-skewed immune response

scientific article published on 14 July 2017

Yeast-expressed recombinant protein of the receptor-binding domain in SARS-CoV spike protein with deglycosylated forms as a SARS vaccine candidate

scientific article

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