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List of works by Kristel Van Laethem

A genotypic assay for the amplification and sequencing of gag and protease from diverse human immunodeficiency virus type 1 group M subtypes.

scientific article

A genotypic assay for the amplification and sequencing of integrase from diverse HIV-1 group M subtypes.

scientific article

A genotypic drug resistance interpretation algorithm that significantly predicts therapy response in HIV-1-infected patients.

scientific article

A genotypic resistance assay for the detection of drug resistance in the human immunodeficiency virus type 1 envelope gene

scientific article published in January 2005

A18 Random amplification with next-generation sequencing to cover HIV and HCV full-length genomes.

scientific article

A21 HIV-1 sub-subtype F1 outbreak among MSM in Belgium

scientific article published on 5 March 2017

Actinohivin, a broadly neutralizing prokaryotic lectin, inhibits HIV-1 infection by specifically targeting high-mannose-type glycans on the gp120 envelope

scientific article published on 24 May 2010

Activity of non-nucleoside reverse transcriptase inhibitors against HIV-2 and SIV

scientific article

African origin of human T-lymphotropic virus type 2 (HTLV-2) supported by a potential new HTLV-2d subtype in Congolese Bambuti Efe Pygmies.

scientific article published on May 1998

Analysis of HIV-1 pol sequences using Bayesian Networks: implications for drug resistance

scientific article published on 4 October 2006

Antiretroviral drug resistance in HIV-1 therapy-naive patients in Cuba

scientific article

Appearance of a single amino acid insertion at position 33 in HIV type 1 protease under a lopinavir-containing regimen, associated with reduced protease inhibitor susceptibility

scientific article published on 13 May 2011

Bayesian network analyses of resistance pathways against efavirenz and nevirapine

scientific article published on October 2008

Bayesian network analysis of resistance pathways against HIV-1 protease inhibitors

scientific article published on 28 November 2006

CRF19_cpx is an Evolutionary fit HIV-1 Variant Strongly Associated With Rapid Progression to AIDS in Cuba

scientific article published on 28 January 2015

Capture and transmission of HIV-1 by the C-type lectin L-SIGN (DC-SIGNR) is inhibited by carbohydrate-binding agents and polyanions

scientific article

Carbohydrate-binding Agents Cause Deletions of Highly Conserved Glycosylation Sites in HIV GP120

scientific article published in Journal of Biological Chemistry

Cellular HIV-1 DNA levels in drug sensitive strains are equivalent to those in drug resistant strains in newly-diagnosed patients in Europe

scientific article

Characterization of amino acids Arg, Ser and Thr at position 70 within HIV-1 reverse transcriptase.

scientific article published on 7 August 2014

Clinical evaluation of Rega 8: an updated genotypic interpretation system that significantly predicts HIV-therapy response

scientific article

Comparative performances of HIV-1 RNA load assays at low viral load levels: results of an international collaboration.

scientific article published on 04 December 2013

Comparison of HIV-1 genotypic resistance test interpretation systems in predicting virological outcomes over time

scientific article

Comparison of the LiPA HIV-1 RT test, selective PCR and direct solid phase sequencing for the detection of HIV-1 drug resistance mutations

scientific article

Complete genome sequence of Montana Myotis leukoencephalitis virus, phylogenetic analysis and comparative study of the 3' untranslated region of flaviviruses with no known vector

scientific article published in August 2002

Current levels of drug resistance among therapy-naive HIV-infected patients have significant impact on treatment response.

scientific article published in December 2004

Decision tree for accurate infection timing in individuals newly diagnosed with HIV-1 infection

scientific article published on 29 November 2017

Declining Prevalence of HIV-1 Drug Resistance in Antiretroviral Treatment-exposed Individuals in Western Europe ⬇️

scientific article published on January 11, 2013

Detection of drug resistance mutations at low plasma HIV-1 RNA load in a European multicentre cohort study ⬇️

scientific article published on May 30, 2011

Development of resistance of human immunodeficiency virus type 1 to dextran sulfate associated with the emergence of specific mutations in the envelope gp120 glycoprotein.

scientific article published on July 1997

Diagnosis of human immunodeficiency virus infection by a polymerase chain reaction assay evaluated in patients harbouring strains of diverse geographical origin

scientific article published in February 1998

Differences in the mannose oligomer specificities of the closely related lectins from Galanthus nivalis and Zea mays strongly determine their eventual anti-HIV activity

scientific article published on 11 February 2011

Different evolution of genotypic resistance profiles to emtricitabine versus lamivudine in tenofovir-containing regimens

scientific article published on November 2010

Discordances between interpretation algorithms for genotypic resistance to protease and reverse transcriptase inhibitors of human immunodeficiency virus are subtype dependent

scientific article

Discordant predictions of residual activity could impact dolutegravir prescription upon raltegravir failure

scientific article published on 29 July 2015

Discovery of TSAO derivatives with an unusual HIV-1 activity/resistance profile

scientific article published on 29 March 2006

Estimating the individualized HIV-1 genetic barrier to resistance using a nelfinavir fitness landscape

scientific article

Estimating the relative contribution of dNTP pool imbalance and APOBEC3G/3F editing to HIV evolution in vivo

scientific article published in October 2007

Estimation of an in vivo fitness landscape experienced by HIV-1 under drug selective pressure useful for prediction of drug resistance evolution during treatment

scientific article published on 17 November 2007

Evaluating Clinical Isolates for Their Phenotypic and Genotypic Resistance Against Anti-HIV Drugs.

scientific article

Evaluation of the automatic editing tool RECall for HIV-1 pol and V3 loop sequences

scientific article published on 5 June 2013

Evaluation of two commercial kits for the detection of genotypic drug resistance on a panel of HIV type 1 subtypes A through J.

scientific article

Evolution of genotypic resistance to enfuvirtide in HIV-1 isolates from different group M subtypes

scientific article published on 23 February 2009

Evolutionary rate and genetic heterogeneity of human T-cell lymphotropic virus type II (HTLV-II) using isolates from European injecting drug users

scientific article published in May 1998

Exploring resistance pathways for first-generation NS3/4A protease inhibitors boceprevir and telaprevir using Bayesian network learning

scientific article published on 09 May 2017

Failure to quantify viral load with two of the three commercial methods in a pregnant woman harboring an HIV type 1 subtype G strain.

scientific article published in March 1998

Fatal brain necrosis in primary HIV infection

scientific article

Full-length genomic sequence of an HIV type 1 subtype G from Kinshasa.

scientific article published in April 1999

Genotypic drug resistance interpretation algorithms display high levels of discordance when applied to non-B strains from HIV-1 naive and treated patients

scientific article

Glycan deletions in the HIV-1 gp120 V1/V2 domain compromise viral infectivity, sensitize the mutant virus strains to carbohydrate-binding agents and represent a specific target for therapeutic intervention

scientific article

HIV-1 Gag C-terminal amino acid substitutions emerging under selective pressure of protease inhibitors in patient populations infected with different HIV-1 subtypes

scientific article

HIV-1 fitness landscape models for indinavir treatment pressure using observed evolution in longitudinal sequence data are predictive for treatment failure

scientific article

HIV-1 genetic variation and drug resistance development.

scientific article

HIV-1 genotypic drug resistance testing: digging deep, reaching wide?

scientific article published on 23 June 2015

HIV-1 protease and reverse transcriptase mutation patterns responsible for discordances between genotypic drug resistance interpretation algorithms

scientific article published on May 2003

HIV-1 protease mutation 82M contributes to phenotypic resistance to protease inhibitors in subtype G

article

HIV-1 transmitted drug resistance in Latin America and the Caribbean: what do we know?

scientific article published on October 2012

High frequency of antiviral drug resistance and non-B subtypes in HIV-1 patients failing antiviral therapy in Cuba.

scientific article published on 13 September 2012

High frequency of antiviral drug resistance and non-b subtypes in HIV-1 patients failing antiviral therapy in Cuba

scientific article published on 2 November 2014

Horizontal gene transfer from human host to HIV-1 reverse transcriptase confers drug resistance and partly compensates for replication deficits

scientific article published on 25 April 2014

Human immunodeficiency virus type 1 escape from cyclotriazadisulfonamide-induced CD4-targeted entry inhibition is associated with increased neutralizing antibody susceptibility

scientific article

Impact of HCV genotype on treatment regimens and drug resistance: a snapshot in time

scientific article

Impact of HIV-1 protease mutations A71V/T and T74S on M89I/V-mediated protease inhibitor resistance in subtype G isolates

scientific article

Impact on replicative fitness of the G48E substitution in the protease of HIV-1: an in vitro and in silico evaluation

scientific article published in July 2008

Implications of hepatitis C virus subtype 1a migration patterns for virus genetic sequencing policies in Italy

scientific article

Increase in transmitted resistance to non-nucleoside reverse transcriptase inhibitors among newly diagnosed HIV-1 infections in Europe

scientific article

Initiation of HAART in drug-naive HIV type 1 patients prevents viral breakthrough for a median period of 35.5 months in 60% of the patients.

scientific article

Interpreting resistance data for HIV-1 therapy management--know the limitations

scientific article

Long-term stability of human immunodeficiency virus viral load and infectivity in whole blood.

scientific article published in May 1999

Managing resistance to anti-HIV drugs: an important consideration for effective disease management.

scientific article

Mapping the genomic diversity of HCV subtypes 1a and 1b: Implications of structural and immunological constraints for vaccine and drug development

scientific article published on July 2016

Marked depletion of glycosylation sites in HIV-1 gp120 under selection pressure by the mannose-specific plant lectins of Hippeastrum hybrid and Galanthus nivalis.

scientific article published on 17 February 2005

Modelled in vivo HIV fitness under drug selective pressure and estimated genetic barrier towards resistance are predictive for virological response.

scientific article published in January 2008

Molecular epidemiology of antiretroviral resistance in therapy-experienced HIV-1 patients in Cuba (2009).

scientific article published on 8 November 2010

Molecular footprint of drug-selective pressure in a human immunodeficiency virus transmission chain

scientific article published on September 2005

Molecular testing of multiple HIV-1 transmissions in a criminal case

scientific article published in October 2005

Multiple dideoxynucleoside analogue-resistant (MddNR) HIV-1 strains isolated from patients from different European countries

scientific article published on October 1998

Mutational pathways, resistance profile, and side effects of cyanovirin relative to human immunodeficiency virus type 1 strains with N-glycan deletions in their gp120 envelopes

scientific article

Mutations at 65 and 70 within the context of a Q151M cluster in human immunodeficiency virus type 1 reverse transcriptase impact the susceptibility to the different nucleoside reverse transcriptase inhibitors in distinct ways

scientific article

Mutations in the non-nucleoside binding-pocket interfere with the multi-nucleoside resistance phenotype

scientific article published in March 2001

Mutations selected in HIV-2-infected patients failing a regimen including atazanavir.

scientific article

No response to first-line tenofovir+lamivudine+efavirenz despite optimization according to baseline resistance testing: Impact of resistant minority variants on efficacy of low genetic barrier drugs

article

Novel recombinant virus assay for measuring susceptibility of human immunodeficiency virus type 1 group M subtypes to clinically approved drugs

scientific article published on 29 April 2009

Optimization of a genotypic assay applicable to all human immunodeficiency virus type 1 protease and reverse transcriptase subtypes

scientific article

Patient HIV-1 strains carrying the multiple nucleoside resistance mutations are cross-resistant to abacavir

article

Patterns of transmitted HIV drug resistance in Europe vary by risk group

scientific article (publication date: 2014)

Performance of ViroSeq HIV-1 Genotyping System in routine practice at a Belgian clinical laboratory

article

Performance of an in-house human immunodeficiency virus type 1 genotyping system for assessment of drug resistance in Cuba

scientific article

Performance of the VERSANT®HIV-1 Resistance Assays (LiPA) for detecting drug resistance in therapy-naive patients infected with different HIV-1 subtypes

article

Phylogenetic evidence for underreporting of male-to-male sex among human immunodeficiency virus-infected donors in the Netherlands and Flanders

scientific article published on 4 April 2017

Possible footprints of APOBEC3F and/or other APOBEC3 deaminases, but not APOBEC3G, on HIV-1 from patients with acute/early and chronic infections

scientific article published on 27 August 2014

Pradimicin A, a carbohydrate-binding nonpeptidic lead compound for treatment of infections with viruses with highly glycosylated envelopes, such as human immunodeficiency virus

scientific article published on 18 October 2006

Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use.

scientific article

Prediction of response to antiretroviral therapy by human experts and by the EuResist data-driven expert system (the EVE study).

scientific article

Predictive value of HIV-1 genotypic resistance test interpretation algorithms

scientific article published on August 2009

Presence of 2',5'-Bis-O-(tert-butyldimethylsilyl)-3'-spiro-5"-(4"-amino-1",2"-oxath iole-2",2"-dioxide) (TSAO)-resistant virus strains in TSAO-inexperienced HIV patients

scientific article published in June 2000

Prevalence and characteristics of multinucleoside-resistant human immunodeficiency virus type 1 among European patients receiving combinations of nucleoside analogues

scientific article published in August 2000

Prevalence and epidemiology of HIV type 1 drug resistance among newly diagnosed therapy-naive patients in Belgium from 2003 to 2006.

scientific article published in March 2008

Prevalence and origin of HIV-1 group M subtypes among patients attending a Belgian hospital in 1999.

scientific article

Prevalence of drug-resistant HIV-1 variants in untreated individuals in Europe: implications for clinical management

scientific article published on 15 August 2005

Profile of resistance of human immunodeficiency virus to mannose-specific plant lectins

scientific article published on October 2004

Pronounced in vitro and in vivo antiretroviral activity of 5-substituted 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy] pyrimidines

scientific article published on 22 November 2006

Quality Control of Next-Generation Sequencing-Based HIV-1 Drug Resistance Data in Clinical Laboratory Information Systems Framework

scientific article published on 14 June 2020

Quantifying Next Generation Sequencing Sample Pre-Processing Bias in HIV-1 Complete Genome Sequencing

scientific article published on 7 January 2016

RegaDB: community-driven data management and analysis for infectious diseases

scientific article

Resistance of HIV-1 to the broadly HIV-1-neutralizing, anti-carbohydrate antibody 2G12.

scientific article published on 21 November 2006

Resistance pathways of human immunodeficiency virus type 1 against the combination of zidovudine and lamivudine

scientific article published on 21 April 2010

Rising prevalence of HIV-1 non-B subtypes in Belgium: 1983-2001.

scientific article

Site-directed mutagenesis of human immunodeficiency virus type 1 reverse transcriptase at amino acid position 138.

scientific article

Sub-Epidemics Explain Localized High Prevalence of Reduced Susceptibility to Rilpivirine in Treatment-Naive HIV-1-Infected Patients: Subtype and Geographic Compartmentalization of Baseline Resistance Mutations

scientific article published on 13 December 2015

Superinfection with drug-resistant HIV is rare and does not contribute substantially to therapy failure in a large European cohort

scientific article

The Calculated Genetic Barrier for Antiretroviral Drug Resistance Substitutions Is Largely Similar for Different HIV-1 Subtypes

article

The genealogical population dynamics of HIV-1 in a large transmission chain: bridging within and among host evolutionary rates

scientific article (publication date: April 2014)

The rare HIV-1 gp41 mutations 43T and 50V elevate enfuvirtide resistance levels of common enfuvirtide resistance mutations that did not impact susceptibility to sifuvirtide

scientific article published on 21 March 2010

The three human T-lymphotropic virus type I subtypes arose from three geographically distinct simian reservoirs

scientific article published in February 1996

Tracing the HIV-1 subtype B mobility in Europe: a phylogeographic approach

scientific article published on 20 May 2009

Transmitted drug resistance, selection of resistance mutations and moderate antiretroviral efficacy in HIV-2: analysis of the HIV-2 Belgium and Luxembourg database

scientific article

Treatment-associated polymorphisms in protease are significantly associated with higher viral load and lower CD4 count in newly diagnosed drug-naive HIV-1 infected patients

scientific article

Trends and predictors of transmitted drug resistance (TDR) and clusters with TDR in a local Belgian HIV-1 epidemic

scientific article (publication date: 2014)

Use of a generic polymerase chain reaction assay detecting human T-lymphotropic virus (HTLV) types I, II and divergent simian strains in the evaluation of individuals with indeterminate HTLV serology

scientific article published in May 1997

Virologic therapy response significantly correlates with the number of active drugs as evaluated using a LiPA HIV-1 resistance scoring system

scientific article published in December 2004

env chimeric virus technology for evaluating human immunodeficiency virus susceptibility to entry inhibitors

scientific article

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