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List of works by Marit Otterlei

"Two hits - one stone"; increased efficacy of cisplatin-based therapies by targeting PCNA's role in both DNA repair and cellular signaling

22 DNA repair and cancer

5-hydroxymethylcytosine Marks Mammalian Origins Acting as a Barrier to Replication

scientific article published on 30 July 2019

A new high resolution screening method for study of phenotype stress responses of Saccharomyces cerevisae mutants

scientific article

A rat model of intravesical delivery of small interfering RNA for studying urinary carcinoma

scientific article published on 8 April 2010

A sequence in the N-terminal region of human uracil-DNA glycosylase with homology to XPA interacts with the C-terminal part of the 34-kDa subunit of replication protein A

scientific article

APIM-Mediated REV3L⁻PCNA Interaction Important for Error Free TLS Over UV-Induced DNA Lesions in Human Cells ⬇️

journal article from 'International Journal of Molecular Sciences' published in 2019

APIM-peptide targeting PCNA improves the efficacy of docetaxel treatment in the TRAMP mouse model of prostate cancer

scientific article published on 27 January 2018

Alkyladenine DNA glycosylase associates with transcription elongation to coordinate DNA repair with gene expression

scientific article published on 29 November 2019

Alkylation damage in DNA and RNA--repair mechanisms and medical significance

scientific article published in November 2004

An in vivo analysis of the localisation and interactions of human p66 DNA polymerase delta subunit

scientific article

Analysis of uracil-DNA glycosylases from the murine Ung gene reveals differential expression in tissues and in embryonic development and a subcellular sorting pattern that differs from the human homologues

scientific journal article

B cells from hyper-IgM patients carrying UNG mutations lack ability to remove uracil from ssDNA and have elevated genomic uracil

scientific article

Base excision repair of DNA in mammalian cells

scientific article

Cell cycle-specific UNG2 phosphorylations regulate protein turnover, activity and association with RPA.

scientific article

Changes in cellular signaling proteins in extracts from A549, H460, and U2OS cells treated with cisplatin or docetaxel

scientific article published on 18 March 2017

Different organization of base excision repair of uracil in DNA in nuclei and mitochondria and selective upregulation of mitochondrial uracil-DNA glycosylase after oxidative stress

scientific article published on 13 November 2006

Direct interaction between XRCC1 and UNG2 facilitates rapid repair of uracil in DNA by XRCC1 complexes

scientific article

Dynamic relocalization of hOGG1 during the cell cycle is disrupted in cells harbouring the hOGG1-Cys326 polymorphic variant

scientific article

Enhanced efficacy of bleomycin in bladder cancer cells by photochemical internalization.

scientific article

Extracts of proliferating and non-proliferating human cells display different base excision pathways and repair fidelity

scientific article

Genomic uracil and human disease

scientific article

Human ALKBH4 interacts with proteins associated with transcription

scientific article

Human AlkB homolog 1 is a mitochondrial protein that demethylates 3-methylcytosine in DNA and RNA

scientific article

Human Uracil-DNA Glycosylase

Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA

scientific article (publication date: 20 February 2003)

Human immunodeficiency virus type 1 Vpr modulates cellular expression of UNG2 via a negative transcriptional effect

scientific article published on 22 July 2009

Human mitochondrial uracil-DNA glycosylase preform (UNG1) is processed to two forms one of which is resistant to inhibition by AP sites

scientific article published on November 1998

Identification of a novel, widespread, and functionally important PCNA-binding motif

scientific article

Increased Anticancer Efficacy of Intravesical Mitomycin C Therapy when Combined with a PCNA Targeting Peptide

scientific article

Mitochondrial base excision repair of uracil and AP sites takes place by single-nucleotide insertion and long-patch DNA synthesis

scientific article

Monitoring of the spatial and temporal dynamics of BER/SSBR pathway proteins, including MYH, UNG2, MPG, NTH1 and NEIL1-3, during DNA replication

scientific article published on 29 May 2017

Multiple microRNAs may regulate the DNA repair enzyme uracil-DNA glycosylase

scientific article published on 08 December 2012

Nuclear and mitochondrial splice forms of human uracil-DNA glycosylase contain a complex nuclear localisation signal and a strong classical mitochondrial localisation signal, respectively

scientific article published on October 1998

Nuclear and mitochondrial uracil-DNA glycosylases are generated by alternative splicing and transcription from different positions in the UNG gene

scientific article

Nucleotide excision repair is associated with the replisome and its efficiency depends on a direct interaction between XPA and PCNA

scientific article published in 2012

On-column trypsinization allows for re-use of matrix in modified multiplexed inhibitor beads assay

scientific article published on 3 February 2017

PCNA-interacting peptides reduce Akt phosphorylation and TLR-mediated cytokine secretion suggesting a role of PCNA in cellular signaling

scientific article

Peptides containing the PCNA interacting motif APIM bind to the β-clamp and inhibit bacterial growth and mutagenesis

scientific article published on 29 April 2020

Post-replicative base excision repair in replication foci

scientific article

Properties and functions of human uracil-DNA glycosylase from the UNG gene

scientific article

RNA base damage and repair

scientific article published on December 2007

Repair of U/G and U/A in DNA by UNG2-associated repair complexes takes place predominantly by short-patch repair both in proliferating and growth-arrested cells

scientific article published on 12 October 2004

Repair of chromosomal abasic sites in vivo involves at least three different repair pathways

scientific article

Targeting proliferating cell nuclear antigen and its protein interactions induces apoptosis in multiple myeloma cells

scientific article

Targeting the non-canonical roles of PCNA modifies and increases the response to targeted anti-cancer therapy

scientific article published on 31 December 2019

The Human RAD5 Homologs, HLTF and SHPRH, Have Separate Functions in DNA Damage Tolerance Dependent on The DNA Lesion Type

scientific article published on 17 March 2020

The PCNA interaction motifs revisited: thinking outside the PIP-box

scientific article published on 27 May 2019

The UNG2 Arg88Cys variant abrogates RPA-mediated recruitment of UNG2 to single-stranded DNA.

scientific article

The Werner syndrome helicase and exonuclease cooperate to resolve telomeric D loops in a manner regulated by TRF1 and TRF2

scientific journal article

The region of XRCC1 which harbours the three most common nonsynonymous polymorphic variants, is essential for the scaffolding function of XRCC1

scientific article published on 26 January 2012

The role of PCNA as a scaffold protein in cellular signaling is functionally conserved between yeast and humans.

scientific article published on 31 May 2018

Uracil in DNA and its processing by different DNA glycosylases

scientific article

Uracil in DNA--general mutagen, but normal intermediate in acquired immunity

scientific article

WRN helicase and FEN-1 form a complex upon replication arrest and together process branchmigrating DNA structures associated with the replication fork

scientific article

WRN interacts physically and functionally with the recombination mediator protein RAD52

scientific article

Werner syndrome protein participates in a complex with RAD51, RAD54, RAD54B and ATR in response to ICL-induced replication arrest

scientific article

X-ray repair cross complementing protein 1 in base excision repair

scientific article

XRCC1 co-localizes and physically interacts with PCNA

scientific article

XRCC1 coordinates disparate responses and multiprotein repair complexes depending on the nature and context of the DNA damage

scientific article

hUNG2 is the major repair enzyme for removal of uracil from U:A matches, U:G mismatches, and U in single-stranded DNA, with hSMUG1 as a broad specificity backup

scientific article

p38 MAPK signaling and phosphorylations in the BRCT1 domain regulate XRCC1 recruitment to sites of DNA damage

scientific article

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