List of works - Anna Bielawska

1,2,4-Triazine Sulfonamides: Synthesis by Sulfenamide Intermediates, In Vitro Anticancer Screening, Structural Characterization, and Molecular Docking Study

scientific article published on 16 May 2020

A novel series of pyrazole-platinum(II) complexes as potential anti-cancer agents that induce cell cycle arrest and apoptosis in breast cancer cells.

scientific article

Acetylsalicylic acid as a potential regulator of prolidase-convertible pro-drugs in control and neoplastic cells

scientific article (publication date: September 2004)

Amidine analogue of chlorambucil is a stronger inhibitor of protein and DNA synthesis in breast cancer MCF-7 cells than is the parent drug.

scientific article

Amidine analogues of melphalan: synthesis, cytotoxic activity, and DNA binding properties

scientific article published on May 2007

Anticancer Effect of a Novel Octahydropyrazino[2,1-a:5,4-a']diisoquinoline Derivative and Its Synergistic Action with Nigella sativa in Human Gastric Cancer Cells.

scientific article published on 26 December 2017

Antioxidant and cytotoxic activity of new di- and polyamine caffeine analogues

scientific article published on 18 April 2018

Antiproliferative activity of derivatives of ouabain, digoxin and proscillaridin A in human MCF-7 and MDA-MB-231 breast cancer cells

scientific article

Apoptosis-mediated cytotoxicity of ouabain, digoxin and proscillaridin A in the estrogen independent MDA-MB-231 breast cancer cells.

scientific article published on October 2007

Aromatic analogues of DNA minor groove binders--synthesis and biological evaluation.

scientific article published on January 2004

Aromatic extended bisamidines: synthesis, inhibition of topoisomerases, and anticancer cytotoxicity in vitro.

scientific article published in July 2001

Biological evaluation of dimethylpyridine-platinum complexes with potent antiproliferative activity.

scientific article published on 4 August 2016

Biological evaluation of octahydropyrazin[2,1-a:5,4-a']diisoquinoline derivatives as potent anticancer agents.

scientific article published in June 2017

Carbocyclic analogues of netropsin and distamycin: DNA-binding properties and inhibition of DNA topoisomerases

scientific article

Cardiac glycosides in cancer research and cancer therapy.

scientific article published on March 2006

Chlorine substituents and linker topology as factors of 5-HT6R activity for novel highly active 1,3,5-triazine derivatives with procognitive properties in vivo

scientific article published on 06 July 2020

Cytotoxic activity of G3 PAMAM-NH₂ dendrimer-chlorambucil conjugate in human breast cancer cells.

scientific article published on 9 August 2011

Cytotoxic activity of octahydropyrazin[2,1-a:5,4-a']diisoquinoline derivatives in human breast cancer cells

scientific article published on 25 July 2014

Cytotoxic effect and molecular docking of 4-ethoxycarbonylmethyl-1-(piperidin-4-ylcarbonyl)-thiosemicarbazide--a novel topoisomerase II inhibitor.

scientific article published on 28 November 2012

Cytotoxic efficacy of a novel dinuclear platinum(II) complex in human breast cancer cells.

scientific article published on 21 June 2010

Cytotoxic efficacy of a novel dinuclear platinum(II) complex used with anti-MUC1 in human breast cancer cells.

scientific article

Cytotoxicity and effect on collagen biosynthesis of proline analogue of melphalan as a prolidase-convertible prodrug in cultured human skin fibroblasts.

scientific article published in September 2001

Cytotoxicity and induction of apoptosis of human breast cancer cells by novel platinum(II) complexes.

scientific article published on 30 December 2012

Cytotoxicity and topoisomerase I/II inhibition activity of novel 4-aryl/alkyl-1-(piperidin-4-yl)-carbonylthiosemicarbazides and 4-benzoylthiosemicarbazides.

scientific article published on 25 February 2013

Cytotoxicity evaluation of three light-cured dentin adhesive materials on human gingival fibroblasts, ex vivo.

scientific article

DNA topoisomerases as molecular targets for anticancer drugs

scientific article published on 01 December 2020

DNA-binding activity and cytotoxicity of Pt-berenil compounds in MDA-MB-231 and MCF-7 breast cancer cells.

scientific article

DNA-binding activity and cytotoxicity of the extended diphenylfuran bisamidines in breast cancer MCF-7 cells.

scientific article published in June 2001

Dual antibacterial and anticancer activity of 4-benzoyl-1-dichlorobenzoylthiosemicarbazide derivatives

scientific article

Dual effects of ouabain, digoxin and proscillaridin A on the regulation of apoptosis in human fibroblasts

scientific article published in February 2010

Effect of 2nd and 3rd generation PAMAM dendrimers on proliferation, differentiation, and pro-inflammatory cytokines in human keratinocytes and fibroblasts

scientific article published on 03 September 2019

Effect of novel dinuclear platinum(II) complexes on redox status of MOLT-4 leukemic cells.

scientific article published on 12 August 2013

Effects of dinuclear berenil-platinum(II) complexes on fibroblasts redox status.

scientific article published on January 2013

Effects of novel alkyl pyridine platinum complexes on apoptosis in Ishikawa endometrial cancer cells

scientific article published on 01 January 2015

Elongation factor 2 as a target for selective inhibition of protein synthesis in vitro by the novel aromatic bisamidine.

scientific article published in April 2002

Evaluation of the Anticancer Activities of Novel Transition Metal Complexes with Berenil and Nitroimidazole

scientific article published on 21 June 2020

Exploration of novel heterofused 1,2,4-triazine derivative in colorectal cancer

scientific article

Inhibition of DNA topoisomerase I and II, and growth inhibition of MDA-MB-231 human breast cancer cells by bis-benzimidazole derivatives with alkylating moiety

scientific article published on 01 May 2004

Inhibition of DNA topoisomerases I and II by G3 PAMAM-NH2 dendrimer-modified digoxin and proscillaridin A conjugates in a cell free system.

scientific article published on November 2010

Inhibition of DNA topoisomerases I and II, and growth inhibition of breast cancer MCF-7 cells by ouabain, digoxin and proscillaridin A.

scientific article published on July 2006

Inhibition of collagen and DNA biosynthesis by a novel amidine analogue of chlorambucil is accompanied by deregulation of β(1)-integrin and IGF-I receptor signaling in MDA-MB 231 cells

scientific article published on 30 December 2004

Inhibition of non-enzymatic lipid peroxidation by 'Essentiale' a drug enriched in phosphatidylcholine in ethanol-induced liver injury

scientific article published on 01 June 1993

Lotus tetragonolobus and Maackia amurensis lectins influence phospho-IκBα, IL-8, Lewis b and H type 1 glycoforms levels in H. pylori infected CRL-1739 gastric cancer cells.

scientific article published on 30 November 2017

Mechanism of anticancer action of novel berenil complex of platinum(II) combined with anti-MUC1 in MCF-7 breast cancer cells.

scientific article published on 14 December 2017

Monoclonal anti‑MUC1 antibody with novel octahydropyrazino[2,1‑a:5,4‑a']diisoquinoline derivative as a potential multi‑targeted strategy in MCF‑7 breast cancer cells

scientific article published on 02 August 2019

Mucin levels in saliva of adolescents with dental caries.

scientific article published on 18 January 2014

New carbocyclic analogues of netropsin: synthesis and inhibition of topoisomerases.

scientific article

New carbocyclic lexitropsins with dinitromustard as N-terminal fragment. Inhibition of topoisomerases

scientific article published on 01 March 2003

New pyrazolo[4,3-e][1,2,4]triazine sulfonamides as carbonic anhydrase inhibitors

scientific article published on 10 April 2015

Novel amidine analogue of melphalan as a specific multifunctional inhibitor of growth and metabolism of human breast cancer cells.

scientific article published on 4 May 2006

Novel dinuclear platinum(II) complexes targets NFkappaB signaling pathway to induce apoptosis and inhibit metabolism of MCF-7 breast cancer cells.

scientific article

Phytochemical Composition and Biological Activities of Scorzonera Species ⬇️

journal article from 'International Journal of Molecular Sciences' published in 2021

Piracetam--an old drug with novel properties?

scientific article

Pro-inflammatory cytokines in saliva of adolescents with dental caries disease

scientific article published on 01 January 2012

Prolidase-activated prodrug for cancer chemotherapy cytotoxic activity of proline analogue of chlorambucil in breast cancer MCF-7 cells

scientific article published on 01 November 2000

Proline analogue of melphalan as a prodrug susceptible to the action of prolidase in breast cancer MDA-MB 231 cells.

scientific article published on November 2003

Proline analogue of nitrosourea as a new cytotoxic prodrug.

scientific article published on November 2009

Proline-linked nitrosoureas as prolidase-convertible prodrugs in human breast cancer cells.

scientific article

Pyrazolo[4,3-e][1,2,4]triazine sulfonamides as carbonic anhydrase inhibitors with antitumor activity.

scientific article published on 27 March 2014

Rosmarinic acid influences collagen, MMPs, TIMPs, glycosylation and MUC1 in CRL-1739 gastric cancer cell line

scientific article published on 09 August 2018

Search for human DNA topoisomerase II poisons in the group of 2,5-disubstituted-1,3,4-thiadiazoles

scientific article published on 20 March 2015

Small-molecule based delivery systems for alkylating antineoplastic compounds.

scientific article

Spermine partially normalizes in vivo antioxidant defense potential in certain brain regions in transiently hypoperfused rat brain.

scientific article published in December 1996

Structure-activity studies of novel amidine analogues of chlorambucil: correlation of cytotoxic activity with DNA-binding affinity and topoisomerase II inhibition.

scientific article published on August 2003

Synergistic action of cisplatin and echistatin in MDA-MB-231 breast cancer cells

scientific article published on 19 December 2016

Synthesis and antimicrobial activity of chiral quaternary N-spiro ammonium bromides with 3',4'-dihydro-1'H-spiro[isoindoline-2,2'-isoquinoline] skeleton.

scientific article published on 5 July 2017

Synthesis and biological evaluation of new cyclic amidine analogs of chlorambucil

scientific article published on February 2004

Synthesis and cytotoxic activity of G3 PAMAM-NH(2) dendrimer-modified digoxin and proscillaridin A conjugates in breast cancer cells.

scientific article

Synthesis and cytotoxic activity of novel amidine analogues of bis(2-chloroethyl)amine.

scientific article

Synthesis and kinase inhibitory activity of new sulfonamide derivatives of pyrazolo[4,3-e][1,2,4]triazines

scientific article published on 18 March 2014

Synthesis of unsymmetrical disulfanes bearing 1,2,4-triazine scaffold and their in vitro screening towards anti-breast cancer activity.

scientific article published on 27 June 2018

Synthesis, DNA binding, topoisomerase inhibition and cytotoxic properties of 2-chloroethylnitrosourea derivatives of hoechst 33258.

scientific article published in June 2005

Synthesis, DNA-binding activity and cytotoxicity of carbamate derivatives of Hoechst 33258 in breast cancer MCF-7 cells

scientific article published in July 2002

Synthesis, DNA-binding affinity and cytotoxicity of the dinuclear platinum(II) complexes with berenil and amines ligands.

scientific article

Synthetic approaches for sulfur derivatives containing 1,2,4-triazine moiety: their activity for in vitro screening towards two human cancer cell lines

scientific article

The Effect of Novel 7-methyl-5-phenyl-pyrazolo[4,3-e]tetrazolo[4,5-b][1,2,4]triazine Sulfonamide Derivatives on Apoptosis and Autophagy in DLD-1 and HT-29 Colon Cancer Cells

scientific article published on 23 July 2020

The assessment of sIgA, histatin-5, and lactoperoxidase levels in saliva of adolescents with dental caries

scientific article published on 29 June 2014

The combined treatment with novel platinum(II) complex and anti-MUC1 increases apoptotic response in MDA-MB-231 breast cancer cells

scientific article published on 27 June 2015

The effect of a novel dinuclear platinum complex with berenil and 2-picoline ligands on growth of human breast cancer cells.

scientific article published on November 2010

The molecular mechanism of anticancer action of novel octahydropyrazino[2,1-a:5,4-a']diisoquinoline derivatives in human gastric cancer cells.

scientific article published on 17 March 2018

Which salivary components can differentiate metabolic obesity?

scientific article published on 29 June 2020

List of works by Anna Bielawska

1,2,4-Triazine Sulfonamides: Synthesis by Sulfenamide Intermediates, In Vitro Anticancer Screening, Structural Characterization, and Molecular Docking Study

A novel series of pyrazole-platinum(II) complexes as potential anti-cancer agents that induce cell cycle arrest and apoptosis in breast cancer cells.

Acetylsalicylic acid as a potential regulator of prolidase-convertible pro-drugs in control and neoplastic cells

Amidine analogue of chlorambucil is a stronger inhibitor of protein and DNA synthesis in breast cancer MCF-7 cells than is the parent drug.

Amidine analogues of melphalan: synthesis, cytotoxic activity, and DNA binding properties

Anticancer Effect of a Novel Octahydropyrazino[2,1-a:5,4-a']diisoquinoline Derivative and Its Synergistic Action with Nigella sativa in Human Gastric Cancer Cells.

Antioxidant and cytotoxic activity of new di- and polyamine caffeine analogues

Antiproliferative activity of derivatives of ouabain, digoxin and proscillaridin A in human MCF-7 and MDA-MB-231 breast cancer cells

Apoptosis-mediated cytotoxicity of ouabain, digoxin and proscillaridin A in the estrogen independent MDA-MB-231 breast cancer cells.

Aromatic analogues of DNA minor groove binders--synthesis and biological evaluation.

Aromatic extended bisamidines: synthesis, inhibition of topoisomerases, and anticancer cytotoxicity in vitro.

Biological evaluation of dimethylpyridine-platinum complexes with potent antiproliferative activity.

Biological evaluation of octahydropyrazin[2,1-a:5,4-a']diisoquinoline derivatives as potent anticancer agents.

Carbocyclic analogues of netropsin and distamycin: DNA-binding properties and inhibition of DNA topoisomerases

Cardiac glycosides in cancer research and cancer therapy.

Chlorine substituents and linker topology as factors of 5-HT6R activity for novel highly active 1,3,5-triazine derivatives with procognitive properties in vivo

Cytotoxic activity of G3 PAMAM-NH₂ dendrimer-chlorambucil conjugate in human breast cancer cells.

Cytotoxic activity of octahydropyrazin[2,1-a:5,4-a']diisoquinoline derivatives in human breast cancer cells

Cytotoxic effect and molecular docking of 4-ethoxycarbonylmethyl-1-(piperidin-4-ylcarbonyl)-thiosemicarbazide--a novel topoisomerase II inhibitor.

Cytotoxic efficacy of a novel dinuclear platinum(II) complex in human breast cancer cells.

Cytotoxic efficacy of a novel dinuclear platinum(II) complex used with anti-MUC1 in human breast cancer cells.

Cytotoxicity and effect on collagen biosynthesis of proline analogue of melphalan as a prolidase-convertible prodrug in cultured human skin fibroblasts.

Cytotoxicity and induction of apoptosis of human breast cancer cells by novel platinum(II) complexes.

Cytotoxicity and topoisomerase I/II inhibition activity of novel 4-aryl/alkyl-1-(piperidin-4-yl)-carbonylthiosemicarbazides and 4-benzoylthiosemicarbazides.

Cytotoxicity evaluation of three light-cured dentin adhesive materials on human gingival fibroblasts, ex vivo.

DNA topoisomerases as molecular targets for anticancer drugs

DNA-binding activity and cytotoxicity of Pt-berenil compounds in MDA-MB-231 and MCF-7 breast cancer cells.

DNA-binding activity and cytotoxicity of the extended diphenylfuran bisamidines in breast cancer MCF-7 cells.

Dual antibacterial and anticancer activity of 4-benzoyl-1-dichlorobenzoylthiosemicarbazide derivatives

Dual effects of ouabain, digoxin and proscillaridin A on the regulation of apoptosis in human fibroblasts

Effect of 2nd and 3rd generation PAMAM dendrimers on proliferation, differentiation, and pro-inflammatory cytokines in human keratinocytes and fibroblasts

Effect of novel dinuclear platinum(II) complexes on redox status of MOLT-4 leukemic cells.

Effects of dinuclear berenil-platinum(II) complexes on fibroblasts redox status.

Effects of novel alkyl pyridine platinum complexes on apoptosis in Ishikawa endometrial cancer cells

Elongation factor 2 as a target for selective inhibition of protein synthesis in vitro by the novel aromatic bisamidine.

Evaluation of the Anticancer Activities of Novel Transition Metal Complexes with Berenil and Nitroimidazole

Exploration of novel heterofused 1,2,4-triazine derivative in colorectal cancer

Inhibition of DNA topoisomerase I and II, and growth inhibition of MDA-MB-231 human breast cancer cells by bis-benzimidazole derivatives with alkylating moiety

Inhibition of DNA topoisomerases I and II by G3 PAMAM-NH2 dendrimer-modified digoxin and proscillaridin A conjugates in a cell free system.

Inhibition of DNA topoisomerases I and II, and growth inhibition of breast cancer MCF-7 cells by ouabain, digoxin and proscillaridin A.

Inhibition of collagen and DNA biosynthesis by a novel amidine analogue of chlorambucil is accompanied by deregulation of β(1)-integrin and IGF-I receptor signaling in MDA-MB 231 cells

Inhibition of non-enzymatic lipid peroxidation by 'Essentiale' a drug enriched in phosphatidylcholine in ethanol-induced liver injury

Lotus tetragonolobus and Maackia amurensis lectins influence phospho-IκBα, IL-8, Lewis b and H type 1 glycoforms levels in H. pylori infected CRL-1739 gastric cancer cells.

Mechanism of anticancer action of novel berenil complex of platinum(II) combined with anti-MUC1 in MCF-7 breast cancer cells.

Monoclonal anti‑MUC1 antibody with novel octahydropyrazino[2,1‑a:5,4‑a']diisoquinoline derivative as a potential multi‑targeted strategy in MCF‑7 breast cancer cells

Mucin levels in saliva of adolescents with dental caries.

New carbocyclic analogues of netropsin: synthesis and inhibition of topoisomerases.

New carbocyclic lexitropsins with dinitromustard as N-terminal fragment. Inhibition of topoisomerases

New pyrazolo[4,3-e][1,2,4]triazine sulfonamides as carbonic anhydrase inhibitors

Novel amidine analogue of melphalan as a specific multifunctional inhibitor of growth and metabolism of human breast cancer cells.

Novel dinuclear platinum(II) complexes targets NFkappaB signaling pathway to induce apoptosis and inhibit metabolism of MCF-7 breast cancer cells.

Phytochemical Composition and Biological Activities of Scorzonera Species ⬇️

Piracetam--an old drug with novel properties?

Pro-inflammatory cytokines in saliva of adolescents with dental caries disease

Prolidase-activated prodrug for cancer chemotherapy cytotoxic activity of proline analogue of chlorambucil in breast cancer MCF-7 cells

Proline analogue of melphalan as a prodrug susceptible to the action of prolidase in breast cancer MDA-MB 231 cells.

Proline analogue of nitrosourea as a new cytotoxic prodrug.

Proline-linked nitrosoureas as prolidase-convertible prodrugs in human breast cancer cells.

Pyrazolo[4,3-e][1,2,4]triazine sulfonamides as carbonic anhydrase inhibitors with antitumor activity.

Rosmarinic acid influences collagen, MMPs, TIMPs, glycosylation and MUC1 in CRL-1739 gastric cancer cell line

Search for human DNA topoisomerase II poisons in the group of 2,5-disubstituted-1,3,4-thiadiazoles

Small-molecule based delivery systems for alkylating antineoplastic compounds.

Spermine partially normalizes in vivo antioxidant defense potential in certain brain regions in transiently hypoperfused rat brain.

Structure-activity studies of novel amidine analogues of chlorambucil: correlation of cytotoxic activity with DNA-binding affinity and topoisomerase II inhibition.

Synergistic action of cisplatin and echistatin in MDA-MB-231 breast cancer cells

Synthesis and antimicrobial activity of chiral quaternary N-spiro ammonium bromides with 3',4'-dihydro-1'H-spiro[isoindoline-2,2'-isoquinoline] skeleton.

Synthesis and biological evaluation of new cyclic amidine analogs of chlorambucil

Synthesis and cytotoxic activity of G3 PAMAM-NH(2) dendrimer-modified digoxin and proscillaridin A conjugates in breast cancer cells.

Synthesis and cytotoxic activity of novel amidine analogues of bis(2-chloroethyl)amine.

Synthesis and kinase inhibitory activity of new sulfonamide derivatives of pyrazolo[4,3-e][1,2,4]triazines

Synthesis of unsymmetrical disulfanes bearing 1,2,4-triazine scaffold and their in vitro screening towards anti-breast cancer activity.

Synthesis, DNA binding, topoisomerase inhibition and cytotoxic properties of 2-chloroethylnitrosourea derivatives of hoechst 33258.

Synthesis, DNA-binding activity and cytotoxicity of carbamate derivatives of Hoechst 33258 in breast cancer MCF-7 cells

Synthesis, DNA-binding affinity and cytotoxicity of the dinuclear platinum(II) complexes with berenil and amines ligands.

Synthetic approaches for sulfur derivatives containing 1,2,4-triazine moiety: their activity for in vitro screening towards two human cancer cell lines

The Effect of Novel 7-methyl-5-phenyl-pyrazolo[4,3-e]tetrazolo[4,5-b][1,2,4]triazine Sulfonamide Derivatives on Apoptosis and Autophagy in DLD-1 and HT-29 Colon Cancer Cells

The assessment of sIgA, histatin-5, and lactoperoxidase levels in saliva of adolescents with dental caries

The combined treatment with novel platinum(II) complex and anti-MUC1 increases apoptotic response in MDA-MB-231 breast cancer cells

The effect of a novel dinuclear platinum complex with berenil and 2-picoline ligands on growth of human breast cancer cells.