List of works - Christian Siebold

A Dual Binding Mode for RhoGTPases in Plexin Signalling

scientific article

A calcium-sensing receptor mutation causing hypocalcemia disrupts a transmembrane salt bridge to activate β-arrestin-biased signaling.

scientific article published on 20 February 2018

A mechanism of covalent substrate binding in the x-ray structure of subunit K of the Escherichia coli dihydroxyacetone kinase

scientific article

A tick protein with a modified Kunitz fold inhibits human tryptase

scientific article

An ion-channel modulator from the saliva of the brown ear tick has a highly modified Kunitz/BPTI structure

scientific article

Automation of large scale transient protein expression in mammalian cells

scientific article published on 6 May 2011

Biochemical and structural studies of ASPP proteins reveal differential binding to p53, p63, and p73

scientific article

Biochemical mechanisms of vertebrate hedgehog signaling

scientific article published on 15 May 2019

Calibration-free <em>In Vitro</em> Quantification of Protein Homo-oligomerization Using Commercial Instrumentation and Free, Open Source Brightness Analysis Software

scientific article published in 2018

Cholesterol access in cellular membranes controls Hedgehog signaling

scientific article published on 16 November 2020

Cholesterol accessibility at the ciliary membrane controls hedgehog signaling

scientific article published on 30 October 2019

Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling.

scientific article published on 05 October 2016

Crystal Structure of Enzyme I of the Phosphoenolpyruvate Sugar Phosphotransferase System in the Dephosphorylated State

scientific article

Crystal structure of HLA-DQ0602 that protects against type 1 diabetes and confers strong susceptibility to narcolepsy

scientific article

Crystal structure of the Citrobacter freundii dihydroxyacetone kinase reveals an eight-stranded alpha-helical barrel ATP-binding domain

scientific article

Crystal structure of the GluR2 amino-terminal domain provides insights into the architecture and assembly of ionotropic glutamate receptors

scientific article

Diversity of oligomerization in Drosophila semaphorins suggests a mechanism of functional fine-tuning

scientific article published on 15 August 2019

Glypicans shield the Wnt lipid moiety to enable signalling at a distance

scientific article published on 22 July 2020

Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling

scientific article published on 09 December 2021

Humidity control as a strategy for lattice optimization applied to crystals of HLA-A*1101 complexed with variant peptides from dengue virus

scientific article

Initiation of T cell signaling by CD45 segregation at 'close contacts'

scientific article (publication date: May 2016)

Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases

scientific journal article

Modular mechanism of Wnt signaling inhibition by Wnt inhibitory factor 1

scientific article

Molecular analysis of receptor protein tyrosine phosphatase mu-mediated cell adhesion

scientific article

Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex ⬇️

scientific article published on October 28, 2012

Patched 1 reduces the accessibility of cholesterol in the outer leaflet of membranes

scientific article published on 26 October 2021

Patched 1 regulates Smoothened by controlling sterol binding to its extracellular cysteine-rich domain

scientific article published on 03 June 2022

Proteoglycan-Specific Molecular Switch for RPTP Clustering and Neuronal Extension

scientific article

R-spondins engage heparan sulfate proteoglycans to potentiate WNT signaling

scientific article published on 20 May 2020

Receptor protein tyrosine phosphatase micro: measuring where to stick

scientific article

Recording information on protein complexes in an information management system

scientific article

Relative Affinities of Protein–Cholesterol Interactions from Equilibrium Molecular Dynamics Simulations

scientific article published on 15 September 2021

Repulsive guidance molecule is a structural bridge between neogenin and bone morphogenetic protein

scientific article published on 4 May 2015

Repulsive guidance molecules lock growth differentiation factor 5 in an inhibitory complex

scientific article published on 23 June 2020

Restoring p53 function in human melanoma cells by inhibiting MDM2 and cyclin B1/CDK1-phosphorylated nuclear iASPP

scientific article

Simultaneous binding of Guidance Cues NET1 and RGM blocks extracellular NEO1 signaling

scientific article published on 18 March 2021

Structural Plasticity of Eph Receptor A4 Facilitates Cross-Class Ephrin Signaling

scientific article

Structural Plasticity of Eph-Receptor A4 Facilitates Cross-Class Ephrin Signaling.

scientific article published on 8 December 2009

Structural and Functional Studies of LRP6 Ectodomain Reveal a Platform for Wnt Signaling

scientific article

Structural basis for integration of GluD receptors within synaptic organizer complexes

scientific article

Structural basis of Smoothened regulation by its extracellular domains

scientific article

Structural basis of semaphorin-plexin signalling

scientific article

Structural insights into hedgehog ligand sequestration by the human hedgehog-interacting protein HHIP

scientific article

Structural insights into proteoglycan-shaped Hedgehog signaling

scientific article

Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling

scientific article

Structure of HLA-A*0301 in complex with a peptide of proteolipid protein: insights into the role of HLA-A alleles in susceptibility to multiple sclerosis

scientific article

Structure of a tyrosine phosphatase adhesive interaction reveals a spacer-clamp mechanism

scientific article

Structure, mechanism, and inhibition of Hedgehog acyltransferase

scientific article published on 09 December 2021

The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism

scientific article published on 23 September 2019

iASPP mediates p53 selectivity through a modular mechanism fine-tuning DNA recognition

scientific article published on 08 August 2019

List of works by Christian Siebold

A Dual Binding Mode for RhoGTPases in Plexin Signalling

A calcium-sensing receptor mutation causing hypocalcemia disrupts a transmembrane salt bridge to activate β-arrestin-biased signaling.

A mechanism of covalent substrate binding in the x-ray structure of subunit K of the Escherichia coli dihydroxyacetone kinase

A tick protein with a modified Kunitz fold inhibits human tryptase

An ion-channel modulator from the saliva of the brown ear tick has a highly modified Kunitz/BPTI structure

Automation of large scale transient protein expression in mammalian cells

Biochemical and structural studies of ASPP proteins reveal differential binding to p53, p63, and p73

Biochemical mechanisms of vertebrate hedgehog signaling

Calibration-free &lt;em&gt;In Vitro&lt;/em&gt; Quantification of Protein Homo-oligomerization Using Commercial Instrumentation and Free, Open Source Brightness Analysis Software

Cholesterol access in cellular membranes controls Hedgehog signaling

Cholesterol accessibility at the ciliary membrane controls hedgehog signaling

Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling.

Crystal Structure of Enzyme I of the Phosphoenolpyruvate Sugar Phosphotransferase System in the Dephosphorylated State

Crystal structure of HLA-DQ0602 that protects against type 1 diabetes and confers strong susceptibility to narcolepsy

Crystal structure of the Citrobacter freundii dihydroxyacetone kinase reveals an eight-stranded alpha-helical barrel ATP-binding domain

Crystal structure of the GluR2 amino-terminal domain provides insights into the architecture and assembly of ionotropic glutamate receptors

Diversity of oligomerization in Drosophila semaphorins suggests a mechanism of functional fine-tuning

Glypicans shield the Wnt lipid moiety to enable signalling at a distance

Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling

Humidity control as a strategy for lattice optimization applied to crystals of HLA-A*1101 complexed with variant peptides from dengue virus

Initiation of T cell signaling by CD45 segregation at 'close contacts'

Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases

Modular mechanism of Wnt signaling inhibition by Wnt inhibitory factor 1

Molecular analysis of receptor protein tyrosine phosphatase mu-mediated cell adhesion

Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex ⬇️

Patched 1 reduces the accessibility of cholesterol in the outer leaflet of membranes

Patched 1 regulates Smoothened by controlling sterol binding to its extracellular cysteine-rich domain

Proteoglycan-Specific Molecular Switch for RPTP Clustering and Neuronal Extension

R-spondins engage heparan sulfate proteoglycans to potentiate WNT signaling

Receptor protein tyrosine phosphatase micro: measuring where to stick

Recording information on protein complexes in an information management system

Relative Affinities of Protein–Cholesterol Interactions from Equilibrium Molecular Dynamics Simulations

Repulsive guidance molecule is a structural bridge between neogenin and bone morphogenetic protein

Repulsive guidance molecules lock growth differentiation factor 5 in an inhibitory complex

Restoring p53 function in human melanoma cells by inhibiting MDM2 and cyclin B1/CDK1-phosphorylated nuclear iASPP

Simultaneous binding of Guidance Cues NET1 and RGM blocks extracellular NEO1 signaling

Structural Plasticity of Eph Receptor A4 Facilitates Cross-Class Ephrin Signaling

Structural Plasticity of Eph-Receptor A4 Facilitates Cross-Class Ephrin Signaling.

Structural and Functional Studies of LRP6 Ectodomain Reveal a Platform for Wnt Signaling

Structural basis for integration of GluD receptors within synaptic organizer complexes

Structural basis of Smoothened regulation by its extracellular domains

Structural basis of semaphorin-plexin signalling

Structural insights into hedgehog ligand sequestration by the human hedgehog-interacting protein HHIP

Structural insights into proteoglycan-shaped Hedgehog signaling

Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling

Structure of HLA-A*0301 in complex with a peptide of proteolipid protein: insights into the role of HLA-A alleles in susceptibility to multiple sclerosis

Structure of a tyrosine phosphatase adhesive interaction reveals a spacer-clamp mechanism

Structure, mechanism, and inhibition of Hedgehog acyltransferase

The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism

iASPP mediates p53 selectivity through a modular mechanism fine-tuning DNA recognition

Calibration-free <em>In Vitro</em> Quantification of Protein Homo-oligomerization Using Commercial Instrumentation and Free, Open Source Brightness Analysis Software