List of works - Catherine Léon

Abnormal megakaryocyte morphology and proplatelet formation in mice with megakaryocyte-restricted MYH9 inactivation.

scientific article

Activation of ADP receptors and platelet function

scientific article published on 01 July 1997

Biogenesis of the demarcation membrane system (DMS) in megakaryocytes

scientific article

Blood platelet formation at a glance

scientific article published on 30 October 2020

Broader expression of the mouse platelet factor 4-cre transgene beyond the megakaryocyte lineage.

scientific article published on 17 December 2014

CYP2C19*2 polymorphism is not the sole determinant of the response to clopidogrel: implications for its monitoring.

scientific article published on 17 July 2009

Calmodulin interacts with the platelet ADP receptor P2Y1

scientific article published on September 2006

Cdc42-dependent F-actin dynamics drive structuration of the demarcation membrane system in megakaryocytes

scientific article

Characterization of megakaryocyte development in the native bone marrow environment

scientific article published on 01 January 2012

Clot Contraction Drives the Translocation of Procoagulant Platelets to Thrombus Surface

scientific article published on 01 January 2019

Combined deficiency of RAB32 and RAB38 in the mouse mimics Hermansky-Pudlak syndrome and critically impairs thrombosis

scientific article published on 01 August 2019

Contractile forces sustain and polarize hematopoiesis from stem and progenitor cells.

scientific article

Contribution of P2Y(1) receptors to ADP signalling in mouse spinal cord cultures.

scientific article published on 10 March 2008

Desensitization of the platelet aggregation response to ADP: differential down-regulation of the P2Y1 and P2cyc receptors

scientific article published on 01 September 2000

Differential regulation and relocalization of the platelet P2Y receptors after activation: a way to avoid loss of hemostatic properties?

scientific article

Distinct localizations and roles of non-muscle myosin II during proplatelet formation and platelet release

scientific article published on 01 April 2015

Evidence for P2Y1, P2Y2, P2Y6 and atypical UTP-sensitive receptors coupled to rises in intracellular calcium in mouse cultured superior cervical ganglion neurons and glia

scientific article

Expression of cell adhesion molecules and catecholamine synthesizing enzymes in the developing rat adrenal gland

scientific article published on November 20, 1992

Hirudin and heparin enable efficient megakaryocyte differentiation of mouse bone marrow progenitors

scientific article published on 08 October 2011

Importance of environmental stiffness for megakaryocyte differentiation and proplatelet formation.

scientific article published on 8 August 2016

Inhibition of localized thrombosis in P2Y1-deficient mice and rodents treated with MRS2179, a P2Y1 receptor antagonist.

scientific article published in June 2003

Integrin-Alpha IIb Identifies Murine Lymph Node Lymphatic Endothelial Cells Responsive to RANKL

scientific article

Interplay between P2Y(1), P2Y(12), and P2X(1) receptors in the activation of megakaryocyte cation influx currents by ADP: evidence that the primary megakaryocyte represents a fully functional model of platelet P2 receptor signaling

scientific journal article

Intrinsic impaired proplatelet formation and microtubule coil assembly of megakaryocytes in a mouse model of Bernard-Soulier syndrome.

scientific article

L1 Cell Adhesion Molecule is Expressed by Noradrenergic but not Adrenergic Chromaffin Cells: A Possible Major Role for L1 in Adrenal Medullary Design

scientific article published on 01 January 1992

Major contribution of the P2Y₁receptor in purinergic regulation of TNFα-induced vascular inflammation.

scientific article

Megakaryocyte-restricted MYH9 inactivation dramatically affects hemostasis while preserving platelet aggregation and secretion.

scientific article

Megakaryocytes assemble podosomes that degrade matrix and protrude through basement membrane

scientific article published on 10 January 2013

Myosin IIA is critical for organelle distribution and F-actin organization in megakaryocytes and platelets.

scientific article

P2Y1 gene deficiency protects from renal disease progression and capillary rarefaction during passive crescentic glomerulonephritis.

scientific article

Podocyte-specific deletion of Myh9 encoding nonmuscle myosin heavy chain 2A predisposes mice to glomerulopathy.

scientific article published on 14 March 2011

Possible involvement of P2Y2 metabotropic receptors in ATP-induced transient receptor potential vanilloid receptor 1-mediated thermal hypersensitivity.

scientific article

Presence of P2X1 purinoceptors in human platelets and megakaryoblastic cell lines

scientific article published on 01 December 1997

Proplatelet formation deficit and megakaryocyte death contribute to thrombocytopenia in Myh9 knockout mice.

scientific article

Purinergic receptors on blood platelets.

scientific article published on January 1996

RUNX1-induced silencing of non-muscle myosin heavy chain IIB contributes to megakaryocyte polyploidization

scientific article

Romiplostim administration shows reduced megakaryocyte response-capacity and increased myelofibrosis in a mouse model of MYH9-RD.

scientific article

The P2Y1 receptor is necessary for adenosine 5'-diphosphate-induced platelet aggregation.

scientific article published in July 1998

The P2Y1 receptor is normal in a patient presenting a severe deficiency of ADP-induced platelet aggregation

scientific article published on 01 May 1999

The contribution of mouse models to the understanding of constitutional thrombocytopenia

scientific article

The platelet P2 receptors in arterial thrombosis.

scientific article

The role of extracellular matrix stiffness in megakaryocyte and platelet development and function.

scientific article

Three-Dimensional Culture in a Methylcellulose-Based Hydrogel to Study the Impact of Stiffness on Megakaryocyte Differentiation

scientific article published on 01 January 2018

beta-Arrestin-2 interaction and internalization of the human P2Y1 receptor are dependent on C-terminal phosphorylation sites.

scientific article

List of works by Catherine Léon

Abnormal megakaryocyte morphology and proplatelet formation in mice with megakaryocyte-restricted MYH9 inactivation.

Activation of ADP receptors and platelet function

Biogenesis of the demarcation membrane system (DMS) in megakaryocytes

Blood platelet formation at a glance

Broader expression of the mouse platelet factor 4-cre transgene beyond the megakaryocyte lineage.

CYP2C19*2 polymorphism is not the sole determinant of the response to clopidogrel: implications for its monitoring.

Calmodulin interacts with the platelet ADP receptor P2Y1

Cdc42-dependent F-actin dynamics drive structuration of the demarcation membrane system in megakaryocytes

Characterization of megakaryocyte development in the native bone marrow environment

Clot Contraction Drives the Translocation of Procoagulant Platelets to Thrombus Surface

Combined deficiency of RAB32 and RAB38 in the mouse mimics Hermansky-Pudlak syndrome and critically impairs thrombosis

Contractile forces sustain and polarize hematopoiesis from stem and progenitor cells.

Contribution of P2Y(1) receptors to ADP signalling in mouse spinal cord cultures.

Desensitization of the platelet aggregation response to ADP: differential down-regulation of the P2Y1 and P2cyc receptors

Differential regulation and relocalization of the platelet P2Y receptors after activation: a way to avoid loss of hemostatic properties?

Distinct localizations and roles of non-muscle myosin II during proplatelet formation and platelet release

Evidence for P2Y1, P2Y2, P2Y6 and atypical UTP-sensitive receptors coupled to rises in intracellular calcium in mouse cultured superior cervical ganglion neurons and glia

Expression of cell adhesion molecules and catecholamine synthesizing enzymes in the developing rat adrenal gland

Hirudin and heparin enable efficient megakaryocyte differentiation of mouse bone marrow progenitors

Importance of environmental stiffness for megakaryocyte differentiation and proplatelet formation.

Inhibition of localized thrombosis in P2Y1-deficient mice and rodents treated with MRS2179, a P2Y1 receptor antagonist.

Integrin-Alpha IIb Identifies Murine Lymph Node Lymphatic Endothelial Cells Responsive to RANKL

Interplay between P2Y(1), P2Y(12), and P2X(1) receptors in the activation of megakaryocyte cation influx currents by ADP: evidence that the primary megakaryocyte represents a fully functional model of platelet P2 receptor signaling

Intrinsic impaired proplatelet formation and microtubule coil assembly of megakaryocytes in a mouse model of Bernard-Soulier syndrome.

L1 Cell Adhesion Molecule is Expressed by Noradrenergic but not Adrenergic Chromaffin Cells: A Possible Major Role for L1 in Adrenal Medullary Design

Major contribution of the P2Y₁receptor in purinergic regulation of TNFα-induced vascular inflammation.

Megakaryocyte-restricted MYH9 inactivation dramatically affects hemostasis while preserving platelet aggregation and secretion.

Megakaryocytes assemble podosomes that degrade matrix and protrude through basement membrane

Myosin IIA is critical for organelle distribution and F-actin organization in megakaryocytes and platelets.

P2Y1 gene deficiency protects from renal disease progression and capillary rarefaction during passive crescentic glomerulonephritis.

Podocyte-specific deletion of Myh9 encoding nonmuscle myosin heavy chain 2A predisposes mice to glomerulopathy.

Possible involvement of P2Y2 metabotropic receptors in ATP-induced transient receptor potential vanilloid receptor 1-mediated thermal hypersensitivity.

Presence of P2X1 purinoceptors in human platelets and megakaryoblastic cell lines

Proplatelet formation deficit and megakaryocyte death contribute to thrombocytopenia in Myh9 knockout mice.

Purinergic receptors on blood platelets.

RUNX1-induced silencing of non-muscle myosin heavy chain IIB contributes to megakaryocyte polyploidization

Romiplostim administration shows reduced megakaryocyte response-capacity and increased myelofibrosis in a mouse model of MYH9-RD.

The P2Y1 receptor is necessary for adenosine 5'-diphosphate-induced platelet aggregation.

The P2Y1 receptor is normal in a patient presenting a severe deficiency of ADP-induced platelet aggregation

The contribution of mouse models to the understanding of constitutional thrombocytopenia

The platelet P2 receptors in arterial thrombosis.

The role of extracellular matrix stiffness in megakaryocyte and platelet development and function.

Three-Dimensional Culture in a Methylcellulose-Based Hydrogel to Study the Impact of Stiffness on Megakaryocyte Differentiation

beta-Arrestin-2 interaction and internalization of the human P2Y1 receptor are dependent on C-terminal phosphorylation sites.