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List of works by Hanneke Schuitemaker

2775. Safety and Immunogenicity of a Seasonal Influenza Vaccine and Ad26.RSV.preF Vaccine With and Without Co-Administration: A Randomized, Double-Blind, Placebo-Controlled Phase 2a Study in Adults Aged ≥ 60 Years

902. A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy of a Single Immunization of Ad26.RSV.preF against RSV Infection in a Viral Challenge Model in Healthy Adults

A Universal Approach to Optimize the Folding and Stability of Prefusion-Closed HIV-1 Envelope Trimers

scientific article

A comparative study between outbred and inbred rat strains for the use in in vivo IPV potency testing

scientific article

A highly stable prefusion RSV F vaccine derived from structural analysis of the fusion mechanism

scientific article

A nonprogressive clinical course in HIV-infected individuals expressing human leukocyte antigen B57/5801 is associated with preserved CD8+ T lymphocyte responsiveness to the HW9 epitope in Nef

scientific article published on 01 March 2008

A sweet surprise for HIV broadly neutralizing antibodies ⬇️

scientific article published on 01 November 2012

Absence of HIV-1 superinfection 1 year after infection between 1985 and 1997 coincides with a reduction in sexual risk behavior in the seroincident Amsterdam cohort of homosexual men.

scientific article published in May 2010

Activity of broadly neutralizing antibodies, including PG9, PG16, and VRC01, against recently transmitted subtype B HIV-1 variants from early and late in the epidemic

scientific article

Ad26 vaccine protects against SARS-CoV-2 severe clinical disease in hamsters

scientific article published on 03 September 2020

Ad26-vector based COVID-19 vaccine encoding a prefusion stabilized SARS-CoV-2 Spike immunogen induces potent humoral and cellular immune responses

preprint

Ad26/MVA therapeutic vaccination with TLR7 stimulation in SIV-infected rhesus monkeys

scientific article

Ad35 and Ad26 Vaccine Vectors Induce Potent and Cross-Reactive Antibody and T-Cell Responses to Multiple Filovirus Species ⬇️

scientific article published on December 6, 2012

Adaptation of HIV-1 envelope gp120 to humoral immunity at a population level

article

Adenoviral type 35 and 26 vectors with a bidirectional expression cassette in the E1 region show an improved genetic stability profile and potent transgene-specific immune response

scientific article published on 17 August 2017

Adenoviral vector type 26 encoding Zika virus (ZIKV) M-Env antigen induces humoral and cellular immune responses and protects mice and nonhuman primates against ZIKV challenge

scientific article published in PLoS ONE

Adenovirus based HPV L2 vaccine induces broad cross-reactive humoral immune responses

article

An HIV-1 antibody from an elite neutralizer implicates the fusion peptide as a site of vulnerability

scientific article

An inactivated poliovirus vaccine using Sabin strains produced on the serum-free PER.C6® cell culture platform is immunogenic and safe in a non-human primate model

article

Antigen capsid-display on human adenovirus 35 via pIX fusion is a potent vaccine platform

scientific article

Antigen-Specific Antibody Glycosylation Is Regulated via Vaccination

scientific article

Antiviral activity of HIV type 1 protease inhibitors nelfinavir and indinavir in vivo is not influenced by P-glycoprotein activity on CD4+ T cells.

scientific article published in January 2007

Association between an interleukin-4 promoter polymorphism and the acquisition of CXCR4 using HIV-1 variants ⬇️

scientific article published on May 2, 2003

Association of HLA-C and HCP5 gene regions with the clinical course of HIV-1 infection

scientific article published on 01 January 2009

Association study of common genetic variants and HIV-1 acquisition in 6,300 infected cases and 7,200 controls

scientific article

Autologous neutralizing humoral immunity and evolution of the viral envelope in the course of subtype B human immunodeficiency virus type 1 infection

scientific article published on 4 June 2008

Both R5 and X4 human immunodeficiency virus type 1 variants persist during prolonged therapy with five antiretroviral drugs

scientific article

CC chemokine receptor 5 delta32 and CC chemokine receptor 2 64I polymorphisms do not influence the virologic and immunologic response to antiretroviral combination therapy in human immunodeficiency virus type 1-infected patients

scientific article published on 22 November 2002

CD39/adenosine pathway is involved in AIDS progression

scientific article

CTL escape and increased viremia irrespective of HIV-specific CD4+ T-helper responses in two HIV-infected individuals

article

Causal pathways of the effects of age and the CCR5-Delta32, CCR2-64I, and SDF-1 3'A alleles on AIDS development

scientific article published on 01 July 2005

Cell turnover and cell tropism in HIV-1 infection.

scientific article published on June 2002

Changing sensitivity to broadly neutralizing antibodies b12, 2G12, 2F5, and 4E10 of primary subtype B human immunodeficiency virus type 1 variants in the natural course of infection

scientific article published on 17 June 2009

Characterisation of long-term non-progression of HIV-1 infection after seroconversion: a cohort study

scientific article published on 18 September 2014

Comparison of in vivo and in vitro evolution of CCR5 to CXCR4 coreceptor use of primary human immunodeficiency virus type 1 variants

scientific article published on 4 February 2011

Comparison of multiple adjuvants on the stability and immunogenicity of a clade C HIV-1 gp140 trimer

scientific article published on 18 February 2014

Comparison of shortened mosaic HIV-1 vaccine schedules: a randomised, double-blind, placebo-controlled phase 1 trial (IPCAVD010/HPX1002) and a preclinical study in rhesus monkeys (NHP 17-22)

scientific article published on 17 February 2020

Complex-type N-glycan recognition by potent broadly neutralizing HIV antibodies

scientific article

Contribution of genetic background, traditional risk factors, and HIV-related factors to coronary artery disease events in HIV-positive persons

scientific article published on 26 March 2013

Correction: Antigen-Specific Antibody Glycosylation Is Regulated via Vaccination

scientific article published on 2 June 2016

Correlates of resistance to HIV-1 infection in homosexual men with high-risk sexual behaviour

scientific article published in May 2004

Correlations between HIV-1 clades and HIV-1 antibody neutralization sensitivity: significant for vaccine development?

scientific article published on December 2010

Cross‐Reactive Neutralizing Humoral Immunity Does Not Protect from HIV Type 1 Disease Progression

article

Decreasing sensitivity to RANTES (regulated on activation, normally T cell-expressed and -secreted) neutralization of CC chemokine receptor 5-using, non-syncytium-inducing virus variants in the course of human immunodeficiency virus type 1 infection

scientific article published on 4 September 2003

Depletion of naive CD4 T cells by CXCR4-using HIV-1 variants occurs mainly through increased T-cell death and activation

scientific article

Detection of inferred CCR5- and CXCR4-using HIV-1 variants and evolutionary intermediates using ultra-deep pyrosequencing

scientific article

Determination of cell tropism of HIV-1.

scientific article

Determination of co-receptor usage of HIV-1.

scientific article

Development of a replication-deficient adenoviral vector-based vaccine candidate for the interception of HPV16- and HPV18-induced infections and disease

scientific article published on 6 March 2017

Differential characteristics of cytotoxic T lymphocytes restricted by the protective HLA alleles B*27 and B*57 in HIV-1 infection

scientific article published on November 2014

Dissecting Polyclonal Vaccine-Induced Humoral Immunity against HIV Using Systems Serology

scientific article

Donor variation in in vitro HIV-1 susceptibility of monocyte-derived macrophages

scientific article published on 16 June 2009

Durable Humoral and Cellular Immune Responses 8 Months after Ad26.COV2.S Vaccination

scientific article

Dynamics of the pool of infected resting CD4 HLA-DR- T lymphocytes in patients who started a triple class five-drug antiretroviral regimen during primary HIV-1 infection

scientific article published on April 1, 2003

Early development of broadly reactive HIV-1 neutralizing activity in elite neutralizers

scientific article published in May 2014

Early viral load and CD4+ T cell count, but not percentage of CCR5+ or CXCR4+ CD4+ T cells, are associated with R5-to-X4 HIV type 1 virus evolution

scientific article published in May 2003

Effects of CCR5-Delta32 and CCR2-64I alleles on HIV-1 disease progression: the protection varies with duration of infection

scientific article published in February 2003

Emergence of monoclonal antibody b12-resistant human immunodeficiency virus type 1 variants during natural infection in the absence of humoral or cellular immune pressure

scientific article

Escape from autologous humoral immunity of HIV-1 is not associated with a decrease in replicative capacity.

scientific article published on 27 November 2009

Escape of human immunodeficiency virus type 1 from broadly neutralizing antibodies is not associated with a reduction of viral replicative capacity in vitro.

scientific article published on 13 March 2007

Evaluation of a mosaic HIV-1 vaccine in a multicentre, randomised, double-blind, placebo-controlled, phase 1/2a clinical trial (APPROACH) and in rhesus monkeys (NHP 13-19)

scientific article published in The Lancet

Evaluation of pre-screening methods for the identification of HIV-1 superinfection

scientific article published on 21 February 2010

Evolution of R5 and X4 human immunodeficiency virus type 1 gag sequences in vivo: evidence for recombination ⬇️

scientific article published on September 15, 2003

Evolution of human immunodeficiency virus type 1 in a patient with cross-reactive neutralizing activity in serum

scientific article

First-in-Human Randomized Controlled Trial of Mosaic HIV-1 Immunogens Delivered via a Modified Vaccinia Ankara Vector

scientific article published on 13 April 2018

GB virus C coinfection and HIV-1 disease progression: The Amsterdam Cohort Study

scientific article published on 28 January 2005

Gag sequence variation in a human immunodeficiency virus type 1 transmission cluster influences viral replication fitness ⬇️

scientific article published on November 7, 2012

Genetic composition of replication competent clonal HIV-1 variants isolated from peripheral blood mononuclear cells (PBMC), HIV-1 proviral DNA from PBMC and HIV-1 RNA in serum in the course of HIV-1 infection

scientific article published on 17 July 2010

Genome-wide association scan in HIV-1-infected individuals identifying variants influencing disease course.

scientific article

Genome-wide association studies on HIV susceptibility, pathogenesis and pharmacogenomics

scientific article published on 24 August 2012

Genome-wide association study identifies single nucleotide polymorphism in DYRK1A associated with replication of HIV-1 in monocyte-derived macrophages

scientific article

Genome-wide association study implicates PARD3B-based AIDS restriction

scientific journal article

Genome-wide association study on the development of cross-reactive neutralizing antibodies in HIV-1 infected individuals

scientific article

HIV tropism and CD4+ T-cell depletion

scientific article published on 01 June 2002

HIV-1 Subtype C Gag-Specific T-Cell Responses in Relation to Human Leukocyte Antigens in a Diverse Population of HIV-Infected Ethiopians

article

HIV-1 envelope characteristics that coincide with the development of cross-reactive neutralizing activity in HIV-1 infected patients.

scientific article published on 3 October 2011

HIV-1 envelope diversity 1 year after seroconversion predicts subsequent disease progression

scientific article published on 01 July 2012

HIV-1 envelope glycoprotein resistance to monoclonal antibody 2G12 is subject-specific and context-dependent in macaques and humans

scientific article

HIV-1 envelope glycoprotein signatures that correlate with the development of cross-reactive neutralizing activity.

scientific article published on 23 September 2013

HIV-1 escapes from N332-directed antibody neutralization in an elite neutralizer by envelope glycoprotein elongation and introduction of unusual disulfide bonds

scientific article published on 07 July 2016

HIV-1 isolation from infected peripheral blood mononuclear cells.

scientific article published on January 2014

HIV-1 replication fitness of HLA-B*57/58:01 CTL escape variants is restored by the accumulation of compensatory mutations in gag

scientific article

HIV-1 seroreversion in an HIV-1-seropositive patient treated during acute infection with highly active antiretroviral therapy and mycophenolate mofetil

scientific article published in July 2004

HIV-1 viral rebound dynamics after a single treatment interruption depends on time of initiation of highly active antiretroviral therapy

scientific article

High prevalence of neutralizing activity against multiple unrelated human immunodeficiency virus type 1 (HIV-1) subtype B variants in sera from HIV-1 subtype B-infected individuals: evidence for subtype-specific rather than strain-specific neutraliz

scientific article

Highly active antiretroviral therapy with or without mycophenolate mofetil in treatment-naive HIV-1 patients.

scientific article

Host genetic factors in the clinical course of HIV-1 infection: chemokines and chemokine receptors

scientific article

Identification of Genes Whose Expression Profile Is Associated with Non-Progression towards AIDS Using eQTLs

scientific article published on 14 September 2015

Identification of Sequential Viral Escape Mutants Associated with Altered T-Cell Responses in a Human Immunodeficiency Virus Type 1-Infected Individual ⬇️

scientific article published on December 1, 2003

Immunization with recombinant HLA classes I and II, HIV-1 gp140, and SIV p27 elicits protection against heterologous SHIV infection in rhesus macaques.

scientific article

Immunization with recombinant macaque major histocompatibility complex class I and II and human immunodeficiency virus gp140 inhibits simian-human immunodeficiency virus infection in macaques.

scientific article published on 4 April 2012

Immunogenicity of Stabilized HIV-1 Envelope Trimers with Reduced Exposure of Non-neutralizing Epitopes

scientific article

Impact of CCR5 Delta32/+ deletion on herpes zoster among HIV-1-infected homosexual men

scientific article published on 16 May 2006

Impact of CCR5delta32 Host Genetic Background and Disease Progression on HIV-1 Intrahost Evolutionary Processes: Efficient Hypothesis Testing through Hierarchical Phylogenetic Models ⬇️

scientific article published on December 6, 2010

Impact of host cell variation on the neutralization of HIV-1 in vitro

scientific article published on September 2009

In vivo evolution of X4 human immunodeficiency virus type 1 variants in the natural course of infection coincides with decreasing sensitivity to CXCR4 antagonists

scientific article published on March 2004

Incomplete Neutralization and Deviation from Sigmoidal Neutralization Curves for HIV Broadly Neutralizing Monoclonal Antibodies

scientific article published on 12 August 2015

Increased In Vitro Cytopathicity of CC Chemokine Receptor 5–Restricted Human Immunodeficiency Virus Type 1 Primary Isolates Correlates with a Progressive Clinical Course of Infection ⬇️

scientific article published on April 9, 2003

Increased neutralization sensitivity of recently emerged CXCR4-using human immunodeficiency virus type 1 strains compared to coexisting CCR5-using variants from the same patient.

scientific article published on November 2006

Increased sensitivity to CD4 binding site-directed neutralization following in vitro propagation on primary lymphocytes of a neutralization-resistant human immunodeficiency virus IIIB strain isolated from an accidentally infected laboratory worker

scientific article

Interim Results of a Phase 1-2a Trial of Ad26.COV2.S Covid-19 Vaccine

scientific article

International network for comparison of HIV neutralization assays: the NeutNet report

scientific article

International network for comparison of HIV neutralization assays: the NeutNet report II

scientific article (publication date: 2012)

Intravenous immunoglobulin (IVIG) treatment for modulation of immune activation in human immunodeficiency virus type 1 infected therapy-naive individuals

scientific article published in November 2007

Isolation and propagation of HIV-1 on peripheral blood mononuclear cells

scientific article published on 01 January 2008

Isolation, propagation, and titration of human immunodeficiency virus type 1 from peripheral blood of infected individuals

scientific article

Lack of evidence for an association between a polymorphism in CX3CR1 and the clinical course of HIV infection or virus phenotype evolution

scientific article published in March 2003

Longer V1V2 region with increased number of potential N-linked glycosylation sites in the HIV-1 envelope glycoprotein protects against HIV-specific neutralizing antibodies

scientific article

Longitudinal analysis of early HIV-1-specific neutralizing activity in an elite neutralizer and in five patients who developed cross-reactive neutralizing activity

scientific article published on 7 December 2011

Loss of HIV-1-derived cytotoxic T lymphocyte epitopes restricted by protective HLA-B alleles during the HIV-1 epidemic

scientific article published on September 2011

Low immune activation despite high levels of pathogenic human immunodeficiency virus type 1 results in long-term asymptomatic disease

scientific article

Low incidence of HIV-1 superinfection even after episodes of unsafe sexual behavior of homosexual men in the Amsterdam Cohort Studies on HIV Infection and AIDS

scientific article published on 01 June 2011

Low level of HIV-1 evolution after transmission from mother to child

scientific article published on 28 May 2014

Low levels of human immunodeficiency virus type 1 DNA in high-risk seronegative men

scientific article published on May 2005

Low-level CD4+ T cell activation is associated with low susceptibility to HIV-1 infection

scientific article published on 01 November 2005

Lower Broadly Neutralizing Antibody Responses in Female Versus Male HIV-1 Infected Injecting Drug Users. ⬇️

scientific article published on 25 April 2019

Mini-hemagglutinin vaccination induces cross-reactive antibodies in pre-exposed NHP that protect mice against lethal influenza challenge.

scientific article published on 3 July 2018

Molecular evolution of human immunodeficiency virus type 1 upon transmission between human leukocyte antigen disparate donor-recipient pairs

scientific article

Multicohort genomewide association study reveals a new signal of protection against HIV-1 acquisition

scientific article published on 23 February 2012

Multiple-cohort genetic association study reveals CXCR6 as a new chemokine receptor involved in long-term nonprogression to AIDS.

scientific article published on September 2010

Natural controlled HIV infection: preserved HIV-specific immunity despite undetectable replication competent virus

scientific article

Naturally HIV-1 seroconverters with lowest viral load have best prognosis, but in time lose control of viraemia

scientific article published on 01 March 2002

Neutralizing antibody responses induced by HIV-1 envelope glycoprotein SOSIP trimers derived from elite neutralizers

scientific article published on 30 September 2020

No Treatment versus 24 or 60 Weeks of Antiretroviral Treatment during Primary HIV Infection: The Randomized Primo-SHM Trial ⬇️

scientific article published on March 27, 2012

Novel strategy for the selection of human recombinant Fab fragments to membrane proteins from a phage-display library

scientific article

PER.C6(®) cells as a serum-free suspension cell platform for the production of high titer poliovirus: a potential low cost of goods option for world supply of inactivated poliovirus vaccine

scientific article

Persistence of viral HLA-DR- CD4 T-cell reservoir during prolonged treatment of HIV-1 infection with a five-drug regimen.

scientific article published in March 2002

Phase 1 Safety and Immunogenicity Study of a Respiratory Syncytial Virus Vaccine with an Adenovirus 26 Vector Encoding Pre-Fusion F (Ad26.RSV.preF) in adults 60 years and older

scientific article published on 22 April 2020

Phenotypic and genotypic comparisons of CCR5- and CXCR4-tropic human immunodeficiency virus type 1 biological clones isolated from subtype C-infected individuals

scientific article published on March 2004

Polymorphism in HIV-1 dependency factor PDE8A affects gene expression and HIV-1 replication in primary macrophages.

scientific article published on 3 October 2011

Polymorphism in HIV-1 dependency factor PDE8A affects mRNA level and HIV-1 replication in primary macrophages.

scientific article

Polymorphisms of large effect explain the majority of the host genetic contribution to variation of HIV-1 virus load

scientific article

Prediction of residual time to AIDS and death based on markers and cofactors

scientific article published on April 2003

Prevalence of cross-reactive HIV-1-neutralizing activity in HIV-1-infected patients with rapid or slow disease progression.

scientific article published in November 2009

Prevention of Respiratory Syncytial Virus Infection in Healthy Adults by a Single Immunization of Ad26.RSV.preF in a Human Challenge Study

scientific article published on 05 January 2021

Probability of N332 glycan occupancy on HIV-1 gp120 modulates sensitivity to broadly neutralizing antibodies

scientific article published on June 2016

Protective efficacy of a global HIV-1 mosaic vaccine against heterologous SHIV challenges in rhesus monkeys ⬇️

scientific article published on 24 October 2013

Protective efficacy of adenovirus/protein vaccines against SIV challenges in rhesus monkeys

scientific article

R5 human immunodeficiency virus type 1 infection of fetal thymic organ culture induces cytokine and CCR5 expression

scientific article

Rapid escape from preserved cross-reactive neutralizing humoral immunity without loss of viral fitness in HIV-1-infected progressors and long-term nonprogressors

scientific article

Recombinant low-seroprevalent adenoviral vectors Ad26 and Ad35 expressing the respiratory syncytial virus (RSV) fusion protein induce protective immunity against RSV infection in cotton rats

scientific article published on 26 August 2015

Reconstructing the Dynamics of HIV Evolution within Hosts from Serial Deep Sequence Data

scientific article (publication date: November 2012)

Recovery of viremic control after superinfection with pathogenic HIV type 1 in a long-term elite controller of HIV type 1 infection

scientific article

Rising HIV-1 viral load set point at a population level coincides with a fading impact of host genetic factors on HIV-1 control

scientific article

Safety and Efficacy of Single-Dose Ad26.COV2.S Vaccine against Covid-19

scholarly article by Hanneke Schuitemaker published in 2021

Safety and Immunogenicity of Novel Adenovirus Type 26- and Modified Vaccinia Ankara-Vectored Ebola Vaccines: A Randomized Clinical Trial

scientific article

Safety and Immunogenicity of the Ad26.RSV.preF Investigational Vaccine Coadministered With an Influenza Vaccine in Older Adults

scientific article published on 26 August 2020

Safety and immunogenicity of Ad26 and MVA vaccines in acutely treated HIV and effect on viral rebound after antiretroviral therapy interruption

scientific article published on 23 March 2020

Safety and immunogenicity of two heterologous HIV vaccine regimens in healthy, HIV-uninfected adults (TRAVERSE): a randomised, parallel-group, placebo-controlled, double-blind, phase 1/2a study

scientific article published on 01 October 2020

Screening low-frequency SNPS from genome-wide association study reveals a new risk allele for progression to AIDS

scientific article

Selected HIV-1 Env trimeric formulations act as potent immunogens in a rabbit vaccination model

scientific article

Short communication: No detrimental immunological effects of mycophenolate mofetil and HAART in treatment-naive acute and chronic HIV-1-infected patients

scientific article published in December 2005

Similar Epitope Specificities of IgG and IgA Antibodies Elicited by Ad26 Vector Prime, Env Protein Boost Immunizations in Rhesus Monkeys

scientific article published on 17 July 2018

Single nucleotide polymorphism in gene encoding transcription factor Prep1 is associated with HIV-1-associated dementia

scientific article

Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques

scientific article published on 30 July 2020

Susceptibility of recently transmitted subtype B human immunodeficiency virus type 1 variants to broadly neutralizing antibodies

scientific article

Synthetic virus seeds for improved vaccine safety: Genetic reconstruction of poliovirus seeds for a PER.C6 cell based inactivated poliovirus vaccine

scientific article published on 8 September 2015

T cell line passage can select for pre-existing neutralization-sensitive variants from the quasispecies of primary human immunodeficiency virus type-1 isolates

scientific article published on 18 October 2006

The Neutralizing Antibody Response in an Individual with Triple HIV-1 Infection Remains Directed at the First Infecting Subtype

scientific article

The development of CD4 binding site antibodies during HIV-1 infection

scientific article

The effect of Trim5 polymorphisms on the clinical course of HIV-1 infection

scientific article

The evolution of human immunodeficiency virus type-1 (HIV-1) envelope molecular properties and coreceptor use at all stages of infection in an HIV-1 donor-recipient pair

scientific article published in November 2011

The major genetic determinants of HIV-1 control affect HLA class I peptide presentation

scientific article

The presence of CXCR4-using HIV-1 prior to start of antiretroviral therapy is an independent predictor of delayed viral suppression

scientific article

The presence of the Trim5alpha escape mutation H87Q in the capsid of late stage HIV-1 variants is preceded by a prolonged asymptomatic infection phase

scientific article published on 01 October 2007

The role of innate APOBEC3G and adaptive AID immune responses in HLA-HIV/SIV immunized SHIV infected macaques

scientific article (publication date: 2012)

Time-measured phylogenies of gag, pol and env sequence data reveal the direction and time interval of HIV-1 transmission ⬇️

scientific article published on May 15, 2011

Vaccine protection against acquisition of neutralization-resistant SIV challenges in rhesus monkeys

scientific article published on 4 January 2012

Viral replication capacity as a correlate of HLA B57/B5801-associated nonprogressive HIV-1 infection

scientific article published on 01 September 2007

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