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List of works by Reinhard Fässler

A VASP-Rac-soluble guanylyl cyclase pathway controls cGMP production in adipocytes

scientific article published on 28 August 2012

A firm grip does not always pay off: a new Phact(r) 4 integrin signaling

scientific article

A forceful connection: mechanoregulation of oncogenic YAP.

scientific article

A hypomorphic mouse model of dystrophic epidermolysis bullosa reveals mechanisms of disease and response to fibroblast therapy

scientific article published on May 2008

A molecular toolkit for the functionalization of titanium-based biomaterials that selectively control integrin-mediated cell adhesion

scientific article published on 6 June 2013

A novel role of sphingosine 1-phosphate receptor S1pr1 in mouse thrombopoiesis

scientific article

ADAM12-mediated focal adhesion formation is differently regulated by beta1 and beta3 integrins

scientific article published on 28 September 2005

All four members of the Ten-m/Odz family of transmembrane proteins form dimers

scientific journal article

An essential requirement for β1 integrin in the assembly of extracellular matrix proteins within the vascular wall

scientific article published on 10 February 2012

Analysis of integrin functions in peri-implantation embryos, hematopoietic system, and skin

scientific article published on January 2007

Angiopoietin 2 mediates microvascular and hemodynamic alterations in sepsis

scientific article

Antiangiogenic proteins require plasma fibronectin or vitronectin for in vivo activity

scientific article

Bacteria hijack integrin-linked kinase to stabilize focal adhesions and block cell detachment.

scientific article published in May 2009

Beta1 integrin cytoplasmic tyrosines promote skin tumorigenesis independent of their phosphorylation

scientific article

Beta1 integrin deletion from the basal compartment of the mammary epithelium affects stem cells

scientific article published on 11 May 2008

Beta1 integrin establishes endothelial cell polarity and arteriolar lumen formation via a Par3-dependent mechanism

scientific article

Beta1 integrin expression by podocytes is required to maintain glomerular structural integrity

scientific article published on 31 January 2008

Beta1 integrin-mediated adhesion signalling is essential for epidermal progenitor cell expansion

scientific article

Beta1 integrins activate a MAPK signalling pathway in neural stem cells that contributes to their maintenance

scientific article

Beta1 integrins differentially control extravasation of inflammatory cell subsets into the CNS during autoimmunity

scientific article

Beta1 integrins regulate chondrocyte rotation, G1 progression, and cytokinesis

scientific journal article

Beta1 integrins: zip codes and signaling relay for blood cells

scientific article published on 17 August 2006

Biological role of prolyl 3-hydroxylation in type IV collagen

scientific article published on 24 December 2013

Bral1: its role in diffusion barrier formation and conduction velocity in the CNS

scientific journal article

Brevican-deficient mice display impaired hippocampal CA1 long-term potentiation but show no obvious deficits in learning and memory

scientific article

CD98hc facilitates B cell proliferation and adaptive humoral immunity

scientific article published on 08 March 2009

CDK1-cyclin-B1-induced kindlin degradation drives focal adhesion disassembly at mitotic entry

scientific article published on 25 April 2022

Cartilage oligomeric matrix protein-deficient mice have normal skeletal development

scientific article

Cell-Intrinsic Adaptation Arising from Chronic Ablation of a Key Rho GTPase Regulator

scientific article published on 28 September 2016

Chondroitin sulfate perlecan enhances collagen fibril formation. Implications for perlecan chondrodysplasias

scientific article published on 5 September 2006

Chondromodulin I is dispensable during enchondral ossification and eye development

scientific article published on September 2002

Comparative phenotypic analysis of the two major splice isoforms of phosphatidylinositol phosphate kinase type Iγ in vivo.

scientific article

Complementary roles of glycoprotein VI and alpha2beta1 integrin in collagen-induced thrombus formation in flowing whole blood ex vivo

scientific article published on 5 February 2003

Conditional beta1-integrin gene deletion in neural crest cells causes severe developmental alterations of the peripheral nervous system

scientific article published on 14 July 2004

Consequences of loss of PINCH2 expression in mice

scientific article

Corrigendum: Fibronectin-bound α5β1 integrins sense load and signal to reinforce adhesion in less than a second

scientific article

Cre recombinase induces DNA damage and tetraploidy in the absence of loxP sites

scientific article

Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling

scientific journal article

Defective Rac-mediated proliferation and survival after targeted mutation of the beta1 integrin cytodomain

scientific article

Defective granulation tissue formation in mice with specific ablation of integrin-linked kinase in fibroblasts - role of TGFβ1 levels and RhoA activity ⬇️

scientific article published on October 27, 2010

Differential gene expression between sensory neocortical areas: potential roles for Ten_m3 and Bcl6 in patterning visual and somatosensory pathways

scientific journal article

Differentiation of Embryonal Stem Cells into Keratinocytes: Comparison of Wild-Type and β1Integrin-Deficient Cells

article by Claudia Bagutti et al published October 1996 in Developmental Biology

Disruption of focal adhesions by integrin cytoplasmic domain-associated protein-1 alpha

scientific article

Dissecting the molecular architecture of integrin adhesion sites by cryo-electron tomography ⬇️

scientific article published on August 8, 2010

Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation ⬇️

scientific article published on March 19, 2012

Down-regulation of CYLD expression by Snail promotes tumor progression in malignant melanoma

scientific article published on 05 January 2009

Dystroglycan in skin and cutaneous cells: beta-subunit is shed from the cell surface

scientific article published on June 2004

ESAM supports neutrophil extravasation, activation of Rho, and VEGF-induced vascular permeability

scientific article

Elimination of epiplakin by gene targeting results in acceleration of keratinocyte migration in mice

scientific article

Ena/VASP is required for endothelial barrier function in vivo

scientific article

Endothelium-specific ablation of PDGFB leads to pericyte loss and glomerular, cardiac and placental abnormalities

scientific journal article

Essential functions of Alk3 during AV cushion morphogenesis in mouse embryonic hearts.

scientific article

Fibroblast growth factor receptor signalling is crucial for liver homeostasis and regeneration

scientific article published in July 2003

Fibronectin is required for integrin alphavbeta6-mediated activation of latent TGF-beta complexes containing LTBP-1.

scientific article published in November 2005

Fibronectin-bound α5β1 integrins sense load and signal to reinforce adhesion in less than a second

scientific article published on 6 November 2017

Formation and activation of fibroblast spheroids depend on fibronectin-integrin interaction

scientific article published on 19 September 2008

Functional inactivation of a fraction of excitatory synapses in mice deficient for the active zone protein bassoon

scientific article published in March 2003

Functionalizing αvβ3- or α5β1-selective integrin antagonists for surface coating: a method to discriminate integrin subtypes in vitro

scientific article published on 12 December 2012

Genetic Analyses of Integrin Signaling ⬇️

scientific article published on February 1, 2011

Genetic analysis of beta1 integrin "activation motifs" in mice

scientific article

Genomic organization of profilin-III and evidence for a transcript expressed exclusively in testis

scientific journal article

Glycosylation catalyzed by lysyl hydroxylase 3 is essential for basement membranes

scientific journal article

Guido Tarone, Ph.D. (1951-2015).

scientific article published in August 2015

Homing of mouse spermatogonial stem cells to germline niche depends on beta1-integrin

scientific article published in November 2008

How ILK and kindlins cooperate to orchestrate integrin signaling

scientific article published on 25 June 2009

ILK, PINCH and parvin: the tIPP of integrin signalling

scientific article

Improvement of reporter activity by IRES-mediated polycistronic reporter system

scientific article published on 11 February 2008

In vivo SILAC-based proteomics reveals phosphoproteome changes during mouse skin carcinogenesis

scientific article published on 31 January 2013

Increased tumor cell dissemination and cellular senescence in the absence of beta1-integrin function

scientific article published on 31 May 2007

Induction of membrane circular dorsal ruffles requires co-signalling of integrin-ILK-complex and EGF receptor.

scientific article published in January 2012

Insulin resistance in striated muscle-specific integrin receptor beta1-deficient mice

scientific article

Integrin activation by talin, kindlin and mechanical forces

scientific article published on 02 January 2019

Integrin adhesion and force coupling are independently regulated by localized PtdIns(4,5)2 synthesis

scientific article published on November 2011

Integrin beta1 subunit controls mural cell adhesion, spreading, and blood vessel wall stability

scientific article

Integrin trafficking regulated by Rab21 is necessary for cytokinesis

scientific article published on September 2008

Integrin-linked kinase at a glance ⬇️

scientific article published on April 15, 2012

Integrin-linked kinase controls microtubule dynamics required for plasma membrane targeting of caveolae

scientific article published on October 2010

Integrin-linked kinase controls vascular wall formation by negatively regulating Rho/ROCK-mediated vascular smooth muscle cell contraction

scientific article published on October 2009

Integrin-linked kinase is an adaptor with essential functions during mouse development

scientific article

Integrin-linked kinase is required for epidermal and hair follicle morphogenesis

scientific article

Integrin-linked kinase is required for radial sorting of axons and Schwann cell remyelination in the peripheral nervous system

scientific journal article

Integrin-linked kinase regulates chondrocyte shape and proliferation

scientific article

Integrin-linked kinase regulates p38 MAPK-dependent cell cycle arrest in ureteric bud development ⬇️

scientific article published on October 1, 2010

Integrin-linked kinase stabilizes myotendinous junctions and protects muscle from stress-induced damage

scientific article

Integrin-linked kinase: integrin's mysterious partner

scientific article published in October 2004

Integrin-mediated mechanotransduction

scientific article published on 8 November 2016

Integrin-mediated type II TGF-β receptor tyrosine dephosphorylation controls SMAD-dependent profibrotic signaling

scientific article

Integrins anchor the invasive machinery

scientific article published in August 2009

Integrins are required for the differentiation of visceral endoderm

scientific article published on January 2009

Integrins in invasive growth

scientific article

Integrins synergise to induce expression of the MRTF-A-SRF target gene ISG15 for promoting cancer cell invasion

scientific article published on 12 February 2016

Interactions with fibronectin attenuate the virulence of Streptococcus pyogenes

scientific article

Introduction to the ECR special issue, "Mechanosensing via Cell-Matrix Adhesions".

scientific article published on 27 January 2016

Kank2 activates talin, reduces force transduction across integrins and induces central adhesion formation

scientific article published on 22 August 2016

Kindlin-2 controls bidirectional signaling of integrins

scientific journal article

Kindlin-2 cooperates with talin to activate integrins and induces cell spreading by directly binding paxillin

scientific article

Kindlin-2 recruits paxillin and Arp2/3 to promote membrane protrusions during initial cell spreading.

scientific article published on 14 September 2017

Kindlin-3 is essential for integrin activation and platelet aggregation

scientific journal article

Kindlin-3 is required for beta2 integrin-mediated leukocyte adhesion to endothelial cells

scientific journal article

Kindlin-3 regulates integrin activation and adhesion reinforcement of effector T cells

scientific article

Kindlin-3-mediated integrin adhesion is dispensable for quiescent but essential for activated hematopoietic stem cells

scientific article

Kindlin-3–mediated signaling from multiple integrin classes is required for osteoclast-mediated bone resorption ⬇️

scientific article published on February 28, 2011

Knockdown and knockout of β1-integrin in hepatocytes impairs liver regeneration through inhibition of growth factor signalling

scientific article published on 21 May 2014

Laminin isoforms differentially regulate adhesion, spreading, proliferation, and ERK activation of beta1 integrin-null cells

scientific article published on October 2004

Laminin: the crux of basement membrane assembly

scientific article published on 22 March 2004

Lentiviral transgene vectors

scientific article published on January 2004

Loss of Kindlin-1 causes skin atrophy and lethal neonatal intestinal epithelial dysfunction

scientific article

Loss of alpha10beta1 integrin expression leads to moderate dysfunction of growth plate chondrocytes

scientific article

Loss of migfilin expression has no overt consequences on murine development and homeostasis ⬇️

scientific article published on January 11, 2011

Loss of talin1 in platelets abrogates integrin activation, platelet aggregation, and thrombus formation in vitro and in vivo

scientific article

Loss of the Rap1 effector RIAM results in leukocyte adhesion deficiency due to impaired β2 integrin function in mice

scientific article

Lucky kindlin: A cloverleaf at the integrin tail.

scientific article published on 22 August 2017

Matrix assembly, regulation, and survival functions of laminin and its receptors in embryonic stem cell differentiation

scientific article

Mechanisms that regulate adaptor binding to beta-integrin cytoplasmic tails

scientific article published on January 2009

Mechanoinduction of lymph vessel expansion ⬇️

scientific article published on December 13, 2011

Mechanosensitivity and compositional dynamics of cell-matrix adhesions

scientific article

Membrane tension drives ligand-independent integrin signaling

scientific article published on 17 September 2014

Microenvironment-derived ADAM28 prevents cancer dissemination

article by Catherine Gérard et al published 14 December 2018 in Oncotarget

Mig6 is a negative regulator of EGF receptor-mediated skin morphogenesis and tumor formation

scientific journal article

Minimal amounts of kindlin-3 suffice for basal platelet and leukocyte functions in mice

scientific article published on 5 October 2015

Modulation of Ca2+ sensitivity by cyclic nucleotides in smooth muscle from protein kinase G-deficient mice

scientific article published on 10 November 2003

Molecular cloning of Bral2, a novel brain-specific link protein, and immunohistochemical colocalization with brevican in perineuronal nets☆ ⬇️

scientific article published on September 1, 2003

Molecular dissection of the ILK-PINCH-parvin triad reveals a fundamental role for the ILK kinase domain in the late stages of focal-adhesion maturation

scientific article published on 12 May 2009

Mutations in the paxillin-binding site of integrin-linked kinase (ILK) destabilize the pseudokinase domain and cause embryonic lethality in mice

scientific journal article

Neutrophils direct preexisting matrix to initiate repair in damaged tissues

scientific article published on 30 March 2022

None of the integrins known to be present on the mouse egg or to be ADAM receptors are essential for sperm-egg binding and fusion

scientific journal article

Nonviral in situ green fluorescent protein labeling and culture of primary, adult human hair follicle epithelial progenitor cells

scientific article

PINCH-1 promotes Bcl-2-dependent survival signalling and inhibits JNK-mediated apoptosis in the primitive endoderm.

scientific article

PINCH1 regulates Akt1 activation and enhances radioresistance by inhibiting PP1alpha

scientific article

PINCH1 regulates cell-matrix and cell-cell adhesions, cell polarity and cell survival during the peri-implantation stage

scientific journal article

PINCH2 is a new five LIM domain protein, homologous to PINCHand localized to focal adhesions

scientific journal article

PIPKIγ90 Negatively Regulates LFA-1–Mediated Adhesion and Activation in Antigen-Induced CD4+ T Cells ⬇️

scientific article published on September 20, 2010

Plasma fibronectin deficiency impedes atherosclerosis progression and fibrous cap formation ⬇️

scientific article published on April 19, 2012

Plasma fibronectin promotes thrombus growth and stability in injured arterioles

scientific article

Profilin 1 is required for abscission during late cytokinesis of chondrocytes

scientific article

Profilin1 regulates sternum development and endochondral bone formation

scientific article published on 6 July 2012

Protein kinase G controls brown fat cell differentiation and mitochondrial biogenesis

scientific article published in December 2009

Proteinase 3 and neutrophil elastase enhance inflammation in mice by inactivating antiinflammatory progranulin

scientific article

Quantitative proteomics of the integrin adhesome show a myosin II‐dependent recruitment of LIM domain proteins ⬇️

scientific article published on February 11, 2011

Regulation of B cell homeostasis and activation by the tumor suppressor gene CYLD

scientific article published on 8 October 2007

Regulation of integrin activity by MIA.

scientific article published on 3 March 2006

Regulation of membrane traffic by integrin signaling ⬇️

scientific article published on March 26, 2011

Regulation of neural progenitor proliferation and survival by beta1 integrins

scientific article

Role of collagen type II and perlecan in skeletal development.

scientific article

SILAC mouse for quantitative proteomics uncovers kindlin-3 as an essential factor for red blood cell function

scientific article published in July 2008

Sensing the mechano-chemical properties of the extracellular matrix

scientific article published on 4 April 2017

Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry

scientific article published on December 2008

Sorting nexin 31 binds multiple β integrin cytoplasmic domains and regulates β1 integrin surface levels and stability

scientific article

Staphylococcus aureus fibronectin binding protein-A induces motile attachment sites and complex actin remodeling in living endothelial cells

scientific article

Talin regulates integrin β1-dependent and -independent cell functions in ureteric bud development

scientific article

Targeted disruption of the murine zyxin gene

scientific article

Ten_m3 regulates eye-specific patterning in the mammalian visual pathway and is required for binocular vision

scientific article (publication date: September 2007)

Tenomodulin is necessary for tenocyte proliferation and tendon maturation

scientific article

The Kank family proteins in adhesion dynamics

article

The Kindlin protein family: new members to the club of focal adhesion proteins

scientific article published on 18 September 2009

The Kindlins: subcellular localization and expression during murine development

scientific journal article

The RGD motif in fibronectin is essential for development but dispensable for fibril assembly

scientific article

The contribution of beta1 integrins to neuronal migration and differentiation depends on extracellular matrix molecules

scientific article published on 26 October 2005

The fibronectin-binding integrins alpha5beta1 and alphavbeta3 differentially modulate RhoA-GTP loading, organization of cell matrix adhesions, and fibronectin fibrillogenesis

scientific article

The focal adhesion protein PINCH-1 associates with EPLIN at integrin adhesion sites

scientific article

The integrin adhesome: from genes and proteins to human disease

scientific article published on April 2014

The integrin coactivator Kindlin-3 is not required for lymphocyte diapedesis

scientific article published on 26 August 2013

The integrin-actin connection, an eternal love affair

scientific article

The kindlin family: functions, signaling properties and implications for human disease

scientific article

The kindlins at a glance

scientific article published on July 2010

The mechanism of kindlin-mediated activation of integrin αIIbβ3.

scientific article published on 7 November 2013

The murine Ten-m/Odz genes show distinct but overlapping expression patterns during development and in adult brain

scientific article

The role of integrin binding sites in fibronectin matrix assembly in vivo

scientific article published on 21 July 2008

The role of integrin-linked kinase in the molecular architecture of focal adhesions

scientific article published on 10 July 2013

The role of laminin in embryonic cell polarization and tissue organization

scientific article

The stimulation of dendrite growth by Sema3A requires integrin engagement and focal adhesion kinase.

scientific article

The tail of integrins, talin, and kindlins

scientific article

The vascular basement membrane: a niche for insulin gene expression and Beta cell proliferation

scientific article published on March 2006

Threonine 788 in integrin subunit beta1 regulates integrin activation

scientific article published on 6 January 2006

Trps1 regulates proliferation and apoptosis of chondrocytes through Stat3 signaling

scientific article published on 10 October 2007

Type IX collagen knock-out mouse shows progressive hearing loss

scientific journal article

Ultrastructural cartilage abnormalities in MIA/CD-RAP-deficient mice

scientific journal article

Versican V2 assembles the extracellular matrix surrounding the nodes of ranvier in the CNS.

scientific article

beta1 integrin is necessary for ureteric bud branching morphogenesis and maintenance of collecting duct structural integrity

scientific article

beta1 integrins are not required for the maintenance of lymphocytes within intestinal epithelia

scientific article published in June 2005

gamma-Parvin is dispensable for hematopoiesis, leukocyte trafficking, and T-cell-dependent antibody response

scientific article published on March 2006

β1 integrin signaling promotes neuronal migration along vascular scaffolds in the post-stroke brain

scientific article

β1 integrins with individually disrupted cytoplasmic NPxY motifs are embryonic lethal but partially active in the epidermis

scientific article

β1- and αv-class integrins cooperate to regulate myosin II during rigidity sensing of fibronectin-based microenvironments

scientific article published on 26 May 2013

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