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List of works by Jolanda van der Velden

'Integrative Physiology 2.0': integration of systems biology into physiology and its application to cardiovascular homeostasis.

scientific article published on 04 January 2011

A mutation in the glutamate-rich region of RNA-binding motif protein 20 causes dilated cardiomyopathy through missplicing of titin and impaired Frank-Starling mechanism.

scientific article published on 5 August 2016

A novel phosphorylation site, Serine 199, in the C-terminus of cardiac troponin I regulates calcium sensitivity and susceptibility to calpain-induced proteolysis

scientific journal article

A piece of the human heart: variance of protein phosphorylation in left ventricular samples from end-stage primary cardiomyopathy patients

scientific article published on December 2009

ADP-stimulated contraction: A predictor of thin-filament activation in cardiac disease.

scientific article

Absence of Thrombospondin-2 Causes Age-Related Dilated Cardiomyopathy

scientific article published on 05 October 2009

Activation of Autophagy Ameliorates Cardiomyopathy in Mybpc3-Targeted Knockin Mice

scientific article

Alterations in contractile protein composition and function in human atrial dilatation and atrial fibrillation

article

Alterations in excitation-contraction coupling in chronically ischemic or hibernating myocardium

scientific article published on January 2005

Alterations in myofilament function contribute to left ventricular dysfunction in pigs early after myocardial infarction

scientific article published on 4 November 2004

Altered myocardial substrate metabolism is associated with myocardial dysfunction in early diabetic cardiomyopathy in rats: studies using positron emission tomography.

scientific article published on 22 July 2009

Analysis of cardiac myosin binding protein-C phosphorylation in human heart muscle

scientific article

Animal models and animal-free innovations for cardiovascular research: current status and routes to be explored. Consensus document of the ESC Working Group on Myocardial Function and the ESC Working Group on Cellular Biology of the Heart

scientific article published in 2022

BIO FOr CARE: biomarkers of hypertrophic cardiomyopathy development and progression in carriers of Dutch founder truncating MYBPC3 variants-design and status

scientific article published on 02 February 2021

Bisoprolol Delays Progression Towards Right Heart Failure in Experimental Pulmonary Hypertension

scientific article published on 09 December 2011

Bone Morphogenetic Protein Receptor Type 2 Mutation in Pulmonary Arterial Hypertension: A View on the Right Ventricle.

scientific article published on 16 March 2016

Burst-Like Transcription of Mutant and Wildtype MYH7-Alleles as Possible Origin of Cell-to-Cell Contractile Imbalance in Hypertrophic Cardiomyopathy

scientific article published on 9 April 2018

Calcium sensitivity of force in human ventricular cardiomyocytes from donor and failing hearts.

scientific article published in January 2002

Calpain-I induced alterations in the cytoskeletal structure and impaired mechanical properties of single myocytes of rat heart

scientific article published on 01 March 2000

Cardiac Disorders and Pathophysiology of Sarcomeric Proteins

scientific article published on 01 January 2019

Cardiac Myosin Binding Protein-C Autoantibodies are Potential Early Indicators of Cardiac Dysfunction and Patient Outcome in Acute Coronary Syndrome

scientific article

Cardiac myosin binding protein C phosphorylation in cardiac disease.

scientific article

Cardiac myosin-binding protein C mutations and hypertrophic cardiomyopathy: haploinsufficiency, deranged phosphorylation, and cardiomyocyte dysfunction

scientific article (publication date: 24 March 2009)

Cardiac myosin-binding protein C: hypertrophic cardiomyopathy mutations and structure-function relationships

scientific article

Cardiac remodelling in a swine model of chronic thromboembolic pulmonary hypertension: comparison of right vs. left ventricle

scientific article published on 25 July 2019

Cardiomyocyte Stiffness in Diastolic Heart Failure

scientific article published on 07 February 2005

Cardiovascular Function of Modern Pigs Does not Comply with Allometric Scaling Laws.

scientific article published on 15 January 2018

Carriers of the hypertrophic cardiomyopathy MYBPC3 mutation are characterized by reduced myocardial efficiency in the absence of hypertrophy and microvascular dysfunction

scientific article

Cellular mechanisms of contractile dysfunction in hibernating myocardium

scientific article published on 4 March 2004

Cellular, mitochondrial and molecular alterations associate with early left ventricular diastolic dysfunction in a porcine model of diabetic metabolic derangement

scientific article published on 06 August 2020

Clinical Characteristics and Long-Term Outcome of Hypertrophic Cardiomyopathy in Individuals With a MYBPC3 (Myosin-Binding Protein C) Founder Mutation.

scientific article published in August 2017

Comparison of the effects of a truncating and a missense MYBPC3 mutation on contractile parameters of engineered heart tissue

scientific article published on 21 April 2016

Complex roads from genotype to phenotype in dilated cardiomyopathy: scientific update from the Working Group of Myocardial Function of the European Society of Cardiology

scientific article published on 01 August 2018

Contractile Dysfunction of Left Ventricular Cardiomyocytes in Patients With Pulmonary Arterial Hypertension

scientific article published on 01 July 2014

Contractile dysfunction irrespective of the mutant protein in human hypertrophic cardiomyopathy with normal systolic function

scientific article

Contribution of Impaired Parasympathetic Activity to Right Ventricular Dysfunction and Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension.

scientific article published on 22 November 2017

Detrimental effect of combined exercise training and eNOS overexpression on cardiac function after myocardial infarction

scientific article published on 13 March 2009

Dexrazoxane pre-treatment protects skinned rat cardiac trabeculae against delayed doxorubicin-induced impairment of crossbridge kinetics.

scientific article

Diabetes mellitus worsens diastolic left ventricular dysfunction in aortic stenosis through altered myocardial structure and cardiomyocyte stiffness.

scientific article

Diastolic Stiffness of the Failing Diabetic Heart

scientific article published on 10 December 2007

Diastolic myofilament dysfunction in the failing human heart.

scientific article

Disease Stage-Dependent Changes in Cardiac Contractile Performance and Oxygen Utilization Underlie Reduced Myocardial Efficiency in Human Inherited Hypertrophic Cardiomyopathy

scientific article published on May 2017

Distinct mechanisms for diastolic dysfunction in diabetes mellitus and chronic pressure-overload

scientific article published on 01 May 2011

Distinct myocardial effects of beta-blocker therapy in heart failure with normal and reduced left ventricular ejection fraction

scientific article

Distinguish mutation-specific pathogenic effects from secondary disease remodelling: an essential but often overlooked concept

scientific article published on 01 August 2017

ENerGetIcs in hypertrophic cardiomyopathy: traNslation between MRI, PET and cardiac myofilament function (ENGINE study).

scientific article published on December 2013

Early Exercise Training Normalizes Myofilament Function and Attenuates Left Ventricular Pump Dysfunction in Mice With a Large Myocardial Infarction

scientific article published on 08 March 2007

Effect of levosimendan on the contractility of muscle fibers from nemaline myopathy patients with mutations in the nebulin gene.

scientific article published on 28 April 2015

Effect of protein kinase A on calcium sensitivity of force and its sarcomere length dependence in human cardiomyocytes

scientific article published on 01 June 2000

Effect of troponin I Ser23/24 phosphorylation on Ca2+-sensitivity in human myocardium depends on the phosphorylation background

scientific article published on 15 January 2010

Effects of Ca2+ -sensitizers in permeabilized cardiac myocytes from donor and end-stage failing human hearts

scientific article published in January 2004

Effects of chronic atrial fibrillation on active and passive force generation in human atrial myofibrils.

scientific article published on 13 May 2010

Effects of contractile protein phosphorylation on force development in permeabilized rat cardiac myocytes.

scientific article published on 05 June 2007

End-diastolic force pre-activates cardiomyocytes and determines contractile force: role of titin and calcium

scientific article published on 30 July 2019

Enhanced myofilament responsiveness upon β-adrenergic stimulation in post-infarct remodeled myocardium

scientific article published on 13 December 2010

Erythropoietin Induces Neovascularization and Improves Cardiac Function in Rats With Heart Failure After Myocardial Infarction

scientific article published in July 2005

Exercise training does not improve cardiac function in compensated or decompensated left ventricular hypertrophy induced by aortic stenosis

scientific article published in February 2011

Exercise training in adverse cardiac remodeling

scientific article published on 27 February 2014

FHL2 expression and variants in hypertrophic cardiomyopathy

scientific article

Familial hypertrophic cardiomyopathy: Functional effects of myosin mutation R723G in cardiomyocytes

scholarly article by Theresia Kraft published in April 2013

Faster cross-bridge detachment and increased tension cost in human hypertrophic cardiomyopathy with the R403Q MYH7 mutation

scientific article published on 13 June 2014

Frequency-dependent myofilament Ca2+ desensitization in failing rat myocardium

scientific article published on 03 May 2007

Functional effects of protein kinase C-mediated myofilament phosphorylation in human myocardium.

scientific article published on 27 December 2005

Functional significance of myofilament protein oxidationThe opinions expressed in this article are not necessarily those of the Editors of the European Heart Journal or of the European Society of Cardiology

scientific article published on 24 January 2006

GSK3β phosphorylates newly identified site in the proline-alanine-rich region of cardiac myosin-binding protein C and alters cross-bridge cycling kinetics in human: short communication

scientific article

Gene-specific increase in the energetic cost of contraction in hypertrophic cardiomyopathy caused by thick filament mutations

article

Genome-Wide Polyadenylation Maps Reveal Dynamic mRNA 3'-End Formation in the Failing Human Heart

scientific article published on 15 December 2015

Genotype-specific pathogenic effects in human dilated cardiomyopathy.

scientific article

Heart failure with preserved ejection fraction: current status and challenges for the future

scientific article published on 3 March 2016

Heart failure: a special issue

scientific article published on 14 May 2014

Heterozygous loss of Rbm24 in the adult mouse heart increases sarcomere slack length but does not affect function

scientific article published on 06 May 2020

High Fibroblast Growth Factor 23 concentrations in experimental renal failure impair calcium handling in cardiomyocytes.

scientific article

High-sensitivity cardiac troponin T is an independent predictor of inhospital mortality in emergency department patients with suspected infection: a prospective observational derivation study

scientific article

Historical perspective on heart function: the Frank-Starling Law.

scientific article

How do hypertrophic cardiomyopathy mutations affect myocardial function in carriers with normal wall thickness? Assessment with cardiovascular magnetic resonance.

scientific article

Hypophosphorylation of the Stiff N2B titin isoform raises cardiomyocyte resting tension in failing human myocardium.

scientific article published on 29 January 2009

Impact of site-specific phosphorylation of protein kinase A sites Ser23 and Ser24 of cardiac troponin I in human cardiomyocytes

scientific article published on 9 November 2012

Impaired cardiac functional reserve in type 2 diabetic db/db mice is associated with metabolic, but not structural, remodelling

scientific article published on 17 February 2010

Impaired diastolic function after exchange of endogenous troponin I with C-terminal truncated troponin I in human cardiac muscle

scientific article

In vitro model to study the effects of matrix stiffening on Ca2+ handling and myofilament function in isolated adult rat cardiomyocytes.

scientific article published on 9 May 2017

In-vivo T1 cardiovascular magnetic resonance study of diffuse myocardial fibrosis in hypertrophic cardiomyopathy

scientific article

Increased Ca2+-sensitivity of the contractile apparatus in end-stage human heart failure results from altered phosphorylation of contractile proteins

scientific article (publication date: 2003)

Increased Myocardial Oxygen Consumption Precedes Contractile Dysfunction in Hypertrophic Cardiomyopathy Caused by Pathogenic TNNT2 Gene Variants

scientific article published on 15 April 2020

Increased cardiovascular risk in rats with primary renal dysfunction; mediating role for vascular endothelial function

scientific article published on 19 January 2012

Increased left ventricular torsion in hypertrophic cardiomyopathy mutation carriers with normal wall thickness.

scientific article

Increased nitrosative/oxidative stress lowers myocardial protein kinase G activity in heart failure with preserved ejection fraction.

scientific article published on 29 August 2013

Integrative Functional Annotation of 52 Genetic Loci Influencing Myocardial Mass Identifies Candidate Regulatory Variants and Target Genes

article

Intrinsic MYH7 expression regulation contributes to tissue level allelic imbalance in hypertrophic cardiomyopathy

scientific article published on 3 November 2017

Lack of specificity of antibodies directed against human beta-adrenergic receptors

scientific article published on 22 January 2009

Lamin A/C-Related Cardiac Disease: Late Onset With a Variable and Mild Phenotype in a Large Cohort of Patients With the Lamin A/C p.(Arg331Gln) Founder Mutation.

scientific article published on August 2017

Left ventricular outflow tract gradient is associated with reduced capillary density in hypertrophic cardiomyopathy irrespective of genotype.

scientific article published on 7 October 2015

Length-dependent activation is modulated by cardiac troponin I bisphosphorylation at Ser23 and Ser24 but not by Thr143 phosphorylation

scientific article

Low myocardial protein kinase G activity in heart failure with preserved ejection fraction

scientific article published on 17 July 2012

MYBPC3 mutations are associated with a reduced super-relaxed state in patients with hypertrophic cardiomyopathy.

scientific article published on 28 June 2017

Massive expansion and cryopreservation of functional human induced pluripotent stem cell-derived cardiomyocytes

scientific article published on 09 February 2021

Metabolic changes in hypertrophic cardiomyopathies: scientific update from the Working Group of Myocardial Function of the European Society of Cardiology

scientific article published on 01 August 2018

MicroRNA transcriptome profiling in cardiac tissue of hypertrophic cardiomyopathy patients with MYBPC3 mutations

scientific article published on 29 September 2013

Mimicking the cardiac cycle in intact cardiomyocytes using diastolic and systolic force clamps; measuring power output

scientific article published in April 2016

More severe cellular phenotype in human idiopathic dilated cardiomyopathy compared to ischemic heart disease.

scientific article

Multi-omics integration identifies key upstream regulators of pathomechanisms in hypertrophic cardiomyopathy due to truncating MYBPC3 mutations

scientific article published on 23 March 2021

Multiple common co-morbidities produce left ventricular diastolic dysfunction associated with coronary microvascular dysfunction, oxidative stress and myocardial stiffening.

scientific article published on 8 February 2018

Multiple myocardial crypts on modified long-axis view are a specific finding in pre-hypertrophic HCM mutation carriers

scientific article published on 24 January 2012

Muscle physiology: move to translation

scientific article published on 01 February 2014

Mutations in MYH7 reduce the force generating capacity of sarcomeres in human familial hypertrophic cardiomyopathy

scientific article published on 13 May 2013

Myocardial Structure and Function Differ in Systolic and Diastolic Heart Failure

scientific article published on 17 April 2006

Myocardial adaptation after surgical therapy differs for aortic valve stenosis and hypertrophic obstructive cardiomyopathy.

scientific article published in March 2019

Myocardial adaptations in the failing heart: cause or consequence?

scientific article published on January 2008

Myocardial contraction is 5-fold more economical in ventricular than in atrial human tissue

scientific article

Myocardial efficiency is an important determinant of functional improvement after aortic valve replacement in aortic valve stenosis patients: a combined PET and CMR study

scientific article published on 13 February 2015

Myofilament Remodeling and Function Is More Impaired in Peripartum Cardiomyopathy Compared with Dilated Cardiomyopathy and Ischemic Heart Disease.

scientific article

Myofilament degradation and dysfunction of human cardiomyocytes in Fabry disease.

scientific article published on 8 May 2008

Myofilament dysfunction in cardiac disease from mice to men.

scientific article published on January 2008

Myosin heavy chain composition and the economy of contraction in healthy and diseased human myocardium

scientific article

Myosin light chain composition in non-failing donor and end-stage failing human ventricular myocardium.

scientific article published on January 2003

NOX5 expression is increased in intramyocardial blood vessels and cardiomyocytes after acute myocardial infarction in humans

scientific article published on 10 April 2012

No direct effect of creatine phosphate on the cross-bridge cycle in cardiac myofibrils

scientific article published on 5 January 2006

Osteoglycin prevents the development of age-related diastolic dysfunction during pressure overload by reducing cardiac fibrosis and inflammation

scientific article published on 25 September 2017

Oxidation of myofilament protein sulfhydryl groups reduces the contractile force and its Ca2+ sensitivity in human cardiomyocytes

scientific article published in July 2008

Oxidative Stress in Dilated Cardiomyopathy Caused by MYBPC3 Mutation.

scientific article

PKCα-specific phosphorylation of the troponin complex in human myocardium: a functional and proteomics analysis

scientific article

Peripartum cardiomyopathy and dilated cardiomyopathy: different at heart.

scientific article

Peroxynitrite-induced alpha-actinin nitration and contractile alterations in isolated human myocardial cells

scientific article published on 26 April 2005

Perturbed length-dependent activation in human hypertrophic cardiomyopathy with missense sarcomeric gene mutations

scientific article

Phosphorylation of protein kinase C sites Ser42/44 decreases Ca(2+)-sensitivity and blunts enhanced length-dependent activation in response to protein kinase A in human cardiomyocytes

scientific article (publication date: 15 July 2014)

Post-tetanic potentiation increases energy cost to a higher extent than work in rat fast skeletal muscle

scientific article published in January 2001

Posttranslational modifications of cardiac troponin T: an overview

scientific article

Preserved cross-bridge kinetics in human hypertrophic cardiomyopathy patients with MYBPC3 mutations

scientific article published on 2 November 2013

Pressure-overload-induced right heart failure

scientific article published on February 2014

Prevention of myofilament dysfunction by beta-blocker therapy in postinfarct remodeling

scientific article published on 25 March 2009

Protein Aggregation Is an Early Manifestation of Phospholamban p.(Arg14del)-Related Cardiomyopathy: Development of PLN-R14del-Related Cardiomyopathy

scientific article published on 30 September 2021

Protein changes contributing to right ventricular cardiomyocyte diastolic dysfunction in pulmonary arterial hypertension

scientific article

Protein kinase C alpha and epsilon phosphorylation of troponin and myosin binding protein C reduce Ca2+ sensitivity in human myocardium

scientific article

Protein phosphatase 2A affects myofilament contractility in non-failing but not in failing human myocardium

scientific article

Proteomic and Functional Studies Reveal Detyrosinated Tubulin as Treatment Target in Sarcomere Mutation-Induced Hypertrophic Cardiomyopathy

scientific article published on 12 January 2021

Quantitative analysis of myofilament protein phosphorylation in small cardiac biopsies

article

RBM20 Regulates Circular RNA Production From the Titin Gene.

scientific article published on 16 August 2016

RV pressure overload: from hypertrophy to failure.

scientific article published in October 2017

Rapid frequency-dependent changes in free mitochondrial calcium concentration in rat cardiac myocytes.

scientific article

Rate of tension redevelopment is not modulated by sarcomere length in permeabilized human, murine, and porcine cardiomyocytes

scientific article published on 16 November 2006

Reduced force generating capacity in myocytes from chronically ischemic, hibernating myocardium

scientific article published on 18 January 2007

Research priorities in sarcomeric cardiomyopathies

scientific article

Right Ventricular Myocardial Stiffness in Experimental Pulmonary Arterial Hypertension: Relative Contribution of Fibrosis and Myofibril Stiffness.

scientific article published on July 2016

Right ventricular diastolic impairment in patients with pulmonary arterial hypertension

scientific article published on 20 September 2013

Right ventricular oxygen delivery as a determinant of right ventricular functional reserve during exercise in juvenile swine with chronic pulmonary hypertension

scientific article published on 09 August 2019

S-glutathiolation impairs phosphoregulation and function of cardiac myosin-binding protein C in human heart failure.

scientific article published on 2 February 2016

Sarcomeric dysfunction in heart failure.

scientific article published on 30 November 2007

Selective phosphorylation of PKA targets after β-adrenergic receptor stimulation impairs myofilament function in Mybpc3-targeted HCM mouse model.

scientific article published on 29 January 2016

Sex Differences at the Time of Myectomy in Hypertrophic Cardiomyopathy

scientific article published on 01 June 2018

Sex differences in hypertrophic cardiomyopathy: new insights

scientific article published on 01 May 2019

Sex-dependent pathophysiological mechanisms in hypertrophic cardiomyopathy: implications for rhythm disorders.

scientific article

Sexual dimorphic response to exercise in hypertrophic cardiomyopathy-associated MYBPC3-targeted knock-in mice.

scientific article published on 11 July 2014

Synergistic role of ADP and Ca(2+) in diastolic myocardial stiffness ⬇️

scientific article published on 12 June 2015

Tachycardia-induced silencing of subcellular Ca2+ signaling in atrial myocytes

scientific article

Targeting High Oxygen Consumption to Prevent Cardiac Dysfunction in Patients With Aortic Valve Stenosis.

scientific article published in October 2017

Targets for therapy in sarcomeric cardiomyopathies

scientific article

The E3 ubiquitin ligase Asb2β is downregulated in a mouse model of hypertrophic cardiomyopathy and targets desmin for proteasomal degradation

scientific article published on 3 September 2015

The Frank-Starling Law: a jigsaw of titin proportions

scientific article

The development of familial hypertrophic cardiomyopathy: from mutation to bedside

scientific article published on 15 December 2010

The effect of inhibition of the Na+/H+ exchanger on the development of hypertrophy in hypertrophic cardiomyopathy.

scientific article

The effect of myosin light chain 2 dephosphorylation on Ca2+ -sensitivity of force is enhanced in failing human hearts

scientific article (publication date: February 2003)

The homozygous K280N troponin T mutation alters cross-bridge kinetics and energetics in human HCM

scientific article published on 21 December 2018

The innate immune system in chronic cardiomyopathy: a European Society of Cardiology (ESC) scientific statement from the Working Group on Myocardial Function of the ESC.

scientific article published on 15 January 2018

The microRNA-15 family inhibits the TGFβ-pathway in the heart

scientific article published on 7 August 2014

The young ones and the old: past & future of science.

scientific article

Titin gene mutations are common in families with both peripartum cardiomyopathy and dilated cardiomyopathy

scientific article published on 20 February 2014

Transmural heterogeneity of myofilament function and sarcomeric protein phosphorylation in remodeled myocardium of pigs with a recent myocardial infarction

scientific article published on 24 November 2011

Troponin I phosphorylation in human myocardium in health and disease.

scientific article

Untying the knot: protein quality control in inherited cardiomyopathies

scientific article published on 14 August 2018

Value of Genetic Testing for the Prediction of Long-Term Outcome in Patients With Hypertrophic Cardiomyopathy.

scientific article published on 27 June 2016

Why does troponin I have so many phosphorylation sites? Fact and fancy

scientific article

Z-disc protein CHAPb induces cardiomyopathy and contractile dysfunction in the postnatal heart

scientific article published on 5 December 2017

[Hypertrophic cardiomyopathy]

scientific article published on 07 February 2019

miR-132/212 Impairs Cardiomyocytes Contractility in the Failing Heart by Suppressing SERCA2a

scientific article published on 19 March 2021

β-adrenergic receptor signalling and its functional consequences in the diseased heart.

scientific article published on 4 February 2016

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