List of works - Frank Porreca

(S)-lacosamide inhibition of CRMP2 phosphorylation reduces postoperative and neuropathic pain behaviors through distinct classes of sensory neurons identified by constellation pharmacology

scientific article published on 09 March 2016

Activation of CB2 cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: pain inhibition by receptors not present in the CNS

scientific article

Activation of TRPA1 on dural afferents: a potential mechanism of headache pain

scientific article

Activation of descending pain-facilitatory pathways from the rostral ventromedial medulla by cholecystokinin elicits release of prostaglandin-E₂ in the spinal cord

scientific article published on 24 October 2011

An efficient intrathecal delivery of small interfering RNA to the spinal cord and peripheral neurons

scientific article

Antinociceptive and nociceptive actions of opioids

scientific article published in October 2004

Biological and conformational evaluation of bifunctional compounds for opioid receptor agonists and neurokinin 1 receptor antagonists possessing two penicillamines

scientific article

Brain Circuits Encoding Reward from Pain Relief

scientific article

CB2 cannabinoid receptor activation produces antinociception by stimulating peripheral release of endogenous opioids

scientific article

CB2 cannabinoid receptor agonists: pain relief without psychoactive effects?

scientific article

CB2 cannabinoid receptor mediation of antinociception.

scientific article published on 23 March 2006

CRISPR/Cas9 editing of Nf1 gene identifies CRMP2 as a therapeutic target in neurofibromatosis type 1-related pain that is reversed by (S)-Lacosamide

scientific article published on 3 July 2017

Cannabilactones: a novel class of CB2 selective agonists with peripheral analgesic activity

scientific article

Cholecystokinin in the rostral ventromedial medulla mediates opioid-induced hyperalgesia and antinociceptive tolerance

scientific journal article

Constitutive activity at the cannabinoid CB1 receptor is required for behavioral response to noxious chemical stimulation of TRPV1: antinociceptive actions of CB1 inverse agonists

scientific article

Contribution of afferent pathways to nerve injury-induced spontaneous pain and evoked hypersensitivity

scientific article published on 26 May 2011

Descending facilitatory pathways from the rostroventromedial medulla mediate naloxone-precipitated withdrawal in morphine-dependent rats

scientific article

Design and synthesis of novel bivalent ligands (MOR and DOR) by conjugation of enkephalin analogues with 4-anilidopiperidine derivatives

scientific article

Design and synthesis of novel hydrazide-linked bifunctional peptides as delta/mu opioid receptor agonists and CCK-1/CCK-2 receptor antagonists

scientific article

Design and synthesis of trivalent ligands targeting opioid, cholecystokinin, and melanocortin receptors for the treatment of pain.

scientific article

Design, synthesis and biological evaluation of multifunctional ligands targeting opioid and bradykinin 2 receptors

scientific article

Development and Characterization of An Injury-free Model of Functional Pain in Rats by Exposure to Red Light

scientific article published on 02 May 2019

Development of potent μ and δ opioid agonists with high lipophilicity

scientific article

Discovery of 5-substituted tetrahydronaphthalen-2yl-methyl with N-phenyl-N-(piperidin-4-yl)propionamide derivatives as potent opioid receptor ligands

scientific article

Discovery of a potent and efficacious peptide derivative for δ/μ opioid agonist/neurokinin 1 antagonist activity with a 2',6'-dimethyl-L-tyrosine: in vitro, in vivo, and NMR-based structural studies

scientific article

Discovery of amphipathic dynorphin A analogues to inhibit the neuroexcitatory effects of dynorphin A through bradykinin receptors in the spinal cord

scientific article

Discovery of tripeptide-derived multifunctional ligands possessing delta/mu opioid receptor agonist and neurokinin 1 receptor antagonist activities

scientific article

Dynorphin A activates bradykinin receptors to maintain neuropathic pain

scientific article

Endogenous adenosine A3 receptor activation selectively alleviates persistent pain states

scientific article

Engagement of descending inhibition from the rostral ventromedial medulla protects against chronic neuropathic pain

scientific article published on 13 July 2011

Erratum to ‛Development and Characterization of An Injury-free Model of Functional Pain in Rats by Exposure to Red Light': The Journal of Pain 20 (2019) 1293-1306

scientific article published on 01 December 2019

Evaluation of green light exposure on headache frequency and quality of life in migraine patients: A preliminary one-way cross-over clinical trial

scientific article published on 09 September 2020

Green Light Exposure Improves Pain and Quality of Life in Fibromyalgia Patients: A Preliminary One-Way Crossover Clinical Trial

scientific article published on 06 November 2020

Improving metabolic stability by glycosylation: bifunctional peptide derivatives that are opioid receptor agonists and neurokinin 1 receptor antagonists

scientific article

In Reply

Induction of pain facilitation by sustained opioid exposure: relationship to opioid antinociceptive tolerance

scientific article

Inhibition of Inflammatory Hyperalgesia by Activation of Peripheral CB2Cannabinoid Receptors ⬇️

scientific article published on October 1, 2003

Inhibition of p38-MAPK signaling pathway attenuates breast cancer induced bone pain and disease progression in a murine model of cancer-induced bone pain.

scientific article published on 20 October 2011

Inhibition of pain responses by activation of CB(2) cannabinoid receptors

scientific article

Is paradoxical pain induced by sustained opioid exposure an underlying mechanism of opioid antinociceptive tolerance?

scientific article

Lesion of the rostral anterior cingulate cortex eliminates the aversiveness of spontaneous neuropathic pain following partial or complete axotomy

scientific article

Long-lasting antinociceptive effects of green light in acute and chronic pain in rats.

scientific article published in February 2017

Multiple actions of systemic artemin in experimental neuropathy ⬇️

scientific article (publication date: November 2003)

Nerve injury-induced tactile allodynia is present in the absence of FOS labeling in retrogradely labeled post-synaptic dorsal column neurons

scientific article

Neuropathic pain is maintained by brainstem neurons co-expressing opioid and cholecystokinin receptors

scientific article

New paradigms and tools in drug design for pain and addiction

scientific article published on 14 July 2006

New potent biphalin analogues containing p-fluoro-L-phenylalanine at the 4,4' positions and non-hydrazine linkers

scientific article

Novel D-amino acid tetrapeptides produce potent antinociception by selectively acting at peripheral kappa-opioid receptors

scientific article

Novel peptide ligands with dual acting pharmacophores designed for the pathophysiology of neuropathic pain

scientific article published on 20 April 2011

Persistent restoration of sensory function by immediate or delayed systemic artemin after dorsal root injury

scientific article

Preclinical Assessment of the Analgesic Pharmacology of NKTR-181 in Rodents

scientific article published on 27 February 2020

Production of paradoxical sensory hypersensitivity by alpha 2-adrenoreceptor agonists

scientific article

Prostaglandin E2 release evoked by intrathecal dynorphin is dependent on spinal p38 mitogen activated protein kinase

scientific article

Regular exercise reverses sensory hypersensitivity in a rat neuropathic pain model: role of endogenous opioids

scientific article published on 01 April 2011

Resolution of disulfide heterogeneity in Nogo receptor 1 fusion proteins by molecular engineering ⬇️

scientific article published on September 1, 2010

Reversal of pancreatitis-induced pain by an orally available, small molecule interleukin-6 receptor antagonist

scientific article published on 4 July 2010

Role of NK-1 neurotransmission in opioid-induced hyperalgesia

scientific article

Spinal NK-1 receptor expressing neurons mediate opioid-induced hyperalgesia and antinociceptive tolerance via activation of descending pathways

scientific article

Spinal NK-1 receptor-expressing neurons and descending pathways support fentanyl-induced pain hypersensitivity in a rat model of postoperative pain.

scientific article published on 5 February 2009

Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors

scientific article

Sustained relief of ongoing experimental neuropathic pain by a CRMP2 peptide aptamer with low abuse potential.

scientific article published on September 2016

Synthesis and biological evaluation of compact, conformationally constrained bifunctional opioid agonist - neurokinin-1 antagonist peptidomimetics

scientific article

Synthesis and biological evaluation of new biphalin analogues with non-hydrazine linkers

scientific article

Synthesis and biological evaluation of new opioid agonist and neurokinin-1 antagonist bivalent ligands

scientific article

Synthesis and evaluation of new endomorphin-2 analogues containing (Z)-alpha,beta-didehydrophenylalanine (Delta(Z)Phe) residues.

scientific article

TRPV1 receptor in expression of opioid-induced hyperalgesia

scientific article

The local antinociceptive actions of nonsteroidal antiinflammatory drugs in the mouse radiant heat tail-flick test

scientific article (publication date: April 2007)

The prolactin receptor long isoform regulates nociceptor sensitization and opioid-induced hyperalgesia selectively in females

scientific article published on 01 February 2020

The role of voltage-gated sodium channels in neuropathic pain

scientific article (publication date: June 2003)

Transient Receptor Potential Vanilloid 1 Antagonists Prevent Anesthesia-induced Hypothermia and Decrease Postincisional Opioid Dose Requirements in Rodents

scientific article published on 14 August 2017

Triptan-induced enhancement of neuronal nitric oxide synthase in trigeminal ganglion dural afferents underlies increased responsiveness to potential migraine triggers

scientific article

Underlying mechanisms of pronociceptive consequences of prolonged morphine exposure

scientific article

Unmasking the tonic-aversive state in neuropathic pain

scientific article

Voltage-gated sodium channels and hyperalgesia

scientific article

List of works by Frank Porreca

(S)-lacosamide inhibition of CRMP2 phosphorylation reduces postoperative and neuropathic pain behaviors through distinct classes of sensory neurons identified by constellation pharmacology

Activation of CB2 cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: pain inhibition by receptors not present in the CNS

Activation of TRPA1 on dural afferents: a potential mechanism of headache pain

Activation of descending pain-facilitatory pathways from the rostral ventromedial medulla by cholecystokinin elicits release of prostaglandin-E₂ in the spinal cord

An efficient intrathecal delivery of small interfering RNA to the spinal cord and peripheral neurons

Antinociceptive and nociceptive actions of opioids

Biological and conformational evaluation of bifunctional compounds for opioid receptor agonists and neurokinin 1 receptor antagonists possessing two penicillamines

Brain Circuits Encoding Reward from Pain Relief

CB2 cannabinoid receptor activation produces antinociception by stimulating peripheral release of endogenous opioids

CB2 cannabinoid receptor agonists: pain relief without psychoactive effects?

CB2 cannabinoid receptor mediation of antinociception.

CRISPR/Cas9 editing of Nf1 gene identifies CRMP2 as a therapeutic target in neurofibromatosis type 1-related pain that is reversed by (S)-Lacosamide

Cannabilactones: a novel class of CB2 selective agonists with peripheral analgesic activity

Cholecystokinin in the rostral ventromedial medulla mediates opioid-induced hyperalgesia and antinociceptive tolerance

Constitutive activity at the cannabinoid CB1 receptor is required for behavioral response to noxious chemical stimulation of TRPV1: antinociceptive actions of CB1 inverse agonists

Contribution of afferent pathways to nerve injury-induced spontaneous pain and evoked hypersensitivity

Descending facilitatory pathways from the rostroventromedial medulla mediate naloxone-precipitated withdrawal in morphine-dependent rats

Design and synthesis of novel bivalent ligands (MOR and DOR) by conjugation of enkephalin analogues with 4-anilidopiperidine derivatives

Design and synthesis of novel hydrazide-linked bifunctional peptides as delta/mu opioid receptor agonists and CCK-1/CCK-2 receptor antagonists

Design and synthesis of trivalent ligands targeting opioid, cholecystokinin, and melanocortin receptors for the treatment of pain.

Design, synthesis and biological evaluation of multifunctional ligands targeting opioid and bradykinin 2 receptors

Development and Characterization of An Injury-free Model of Functional Pain in Rats by Exposure to Red Light

Development of potent μ and δ opioid agonists with high lipophilicity

Discovery of 5-substituted tetrahydronaphthalen-2yl-methyl with N-phenyl-N-(piperidin-4-yl)propionamide derivatives as potent opioid receptor ligands

Discovery of a potent and efficacious peptide derivative for δ/μ opioid agonist/neurokinin 1 antagonist activity with a 2',6'-dimethyl-L-tyrosine: in vitro, in vivo, and NMR-based structural studies

Discovery of amphipathic dynorphin A analogues to inhibit the neuroexcitatory effects of dynorphin A through bradykinin receptors in the spinal cord

Discovery of tripeptide-derived multifunctional ligands possessing delta/mu opioid receptor agonist and neurokinin 1 receptor antagonist activities

Dynorphin A activates bradykinin receptors to maintain neuropathic pain

Endogenous adenosine A3 receptor activation selectively alleviates persistent pain states

Engagement of descending inhibition from the rostral ventromedial medulla protects against chronic neuropathic pain

Erratum to ‛Development and Characterization of An Injury-free Model of Functional Pain in Rats by Exposure to Red Light': The Journal of Pain 20 (2019) 1293-1306

Evaluation of green light exposure on headache frequency and quality of life in migraine patients: A preliminary one-way cross-over clinical trial

Green Light Exposure Improves Pain and Quality of Life in Fibromyalgia Patients: A Preliminary One-Way Crossover Clinical Trial

Improving metabolic stability by glycosylation: bifunctional peptide derivatives that are opioid receptor agonists and neurokinin 1 receptor antagonists

In Reply

Induction of pain facilitation by sustained opioid exposure: relationship to opioid antinociceptive tolerance

Inhibition of Inflammatory Hyperalgesia by Activation of Peripheral CB2Cannabinoid Receptors ⬇️

Inhibition of p38-MAPK signaling pathway attenuates breast cancer induced bone pain and disease progression in a murine model of cancer-induced bone pain.

Inhibition of pain responses by activation of CB(2) cannabinoid receptors

Is paradoxical pain induced by sustained opioid exposure an underlying mechanism of opioid antinociceptive tolerance?

Lesion of the rostral anterior cingulate cortex eliminates the aversiveness of spontaneous neuropathic pain following partial or complete axotomy

Long-lasting antinociceptive effects of green light in acute and chronic pain in rats.

Multiple actions of systemic artemin in experimental neuropathy ⬇️

Nerve injury-induced tactile allodynia is present in the absence of FOS labeling in retrogradely labeled post-synaptic dorsal column neurons

Neuropathic pain is maintained by brainstem neurons co-expressing opioid and cholecystokinin receptors

New paradigms and tools in drug design for pain and addiction

New potent biphalin analogues containing p-fluoro-L-phenylalanine at the 4,4' positions and non-hydrazine linkers

Novel D-amino acid tetrapeptides produce potent antinociception by selectively acting at peripheral kappa-opioid receptors

Novel peptide ligands with dual acting pharmacophores designed for the pathophysiology of neuropathic pain

Persistent restoration of sensory function by immediate or delayed systemic artemin after dorsal root injury

Preclinical Assessment of the Analgesic Pharmacology of NKTR-181 in Rodents

Production of paradoxical sensory hypersensitivity by alpha 2-adrenoreceptor agonists

Prostaglandin E2 release evoked by intrathecal dynorphin is dependent on spinal p38 mitogen activated protein kinase

Regular exercise reverses sensory hypersensitivity in a rat neuropathic pain model: role of endogenous opioids

Resolution of disulfide heterogeneity in Nogo receptor 1 fusion proteins by molecular engineering ⬇️

Reversal of pancreatitis-induced pain by an orally available, small molecule interleukin-6 receptor antagonist

Role of NK-1 neurotransmission in opioid-induced hyperalgesia

Spinal NK-1 receptor expressing neurons mediate opioid-induced hyperalgesia and antinociceptive tolerance via activation of descending pathways

Spinal NK-1 receptor-expressing neurons and descending pathways support fentanyl-induced pain hypersensitivity in a rat model of postoperative pain.

Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors

Sustained relief of ongoing experimental neuropathic pain by a CRMP2 peptide aptamer with low abuse potential.

Synthesis and biological evaluation of compact, conformationally constrained bifunctional opioid agonist - neurokinin-1 antagonist peptidomimetics

Synthesis and biological evaluation of new biphalin analogues with non-hydrazine linkers

Synthesis and biological evaluation of new opioid agonist and neurokinin-1 antagonist bivalent ligands

Synthesis and evaluation of new endomorphin-2 analogues containing (Z)-alpha,beta-didehydrophenylalanine (Delta(Z)Phe) residues.

TRPV1 receptor in expression of opioid-induced hyperalgesia

The local antinociceptive actions of nonsteroidal antiinflammatory drugs in the mouse radiant heat tail-flick test

The prolactin receptor long isoform regulates nociceptor sensitization and opioid-induced hyperalgesia selectively in females

The role of voltage-gated sodium channels in neuropathic pain

Transient Receptor Potential Vanilloid 1 Antagonists Prevent Anesthesia-induced Hypothermia and Decrease Postincisional Opioid Dose Requirements in Rodents

Triptan-induced enhancement of neuronal nitric oxide synthase in trigeminal ganglion dural afferents underlies increased responsiveness to potential migraine triggers

Underlying mechanisms of pronociceptive consequences of prolonged morphine exposure

Unmasking the tonic-aversive state in neuropathic pain

Voltage-gated sodium channels and hyperalgesia