List of works - Josephine Lai

Activation of CB2 cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: pain inhibition by receptors not present in the CNS

scientific article

Activation of descending pain-facilitatory pathways from the rostral ventromedial medulla by cholecystokinin elicits release of prostaglandin-E₂ in the spinal cord

scientific article published on 24 October 2011

An efficient intrathecal delivery of small interfering RNA to the spinal cord and peripheral neurons

scientific article

Antinociceptive and nociceptive actions of opioids

scientific article published in October 2004

Biological and conformational evaluation of bifunctional compounds for opioid receptor agonists and neurokinin 1 receptor antagonists possessing two penicillamines

scientific article

CB2 cannabinoid receptor activation produces antinociception by stimulating peripheral release of endogenous opioids

scientific article

CB2 cannabinoid receptor agonists: pain relief without psychoactive effects?

scientific article

CB2 cannabinoid receptor mediation of antinociception

scientific article published on 23 March 2006

Cholecystokinin in the rostral ventromedial medulla mediates opioid-induced hyperalgesia and antinociceptive tolerance

scientific journal article

Constitutive activity at the cannabinoid CB1 receptor is required for behavioral response to noxious chemical stimulation of TRPV1: antinociceptive actions of CB1 inverse agonists

scientific article

Design and synthesis of novel bivalent ligands (MOR and DOR) by conjugation of enkephalin analogues with 4-anilidopiperidine derivatives

scientific article

Development of Potent μ and δ Opioid Agonists with High Lipophilicity ⬇️

scientific article published on December 3, 2010

Discovery of 5-substituted tetrahydronaphthalen-2yl-methyl with N-phenyl-N-(piperidin-4-yl)propionamide derivatives as potent opioid receptor ligands

scientific article

Discovery of a potent and efficacious peptide derivative for δ/μ opioid agonist/neurokinin 1 antagonist activity with a 2',6'-dimethyl-L-tyrosine: in vitro, in vivo, and NMR-based structural studies

scientific article

Discovery of amphipathic dynorphin A analogues to inhibit the neuroexcitatory effects of dynorphin A through bradykinin receptors in the spinal cord

scientific article

Discovery of tripeptide-derived multifunctional ligands possessing delta/mu opioid receptor agonist and neurokinin 1 receptor antagonist activities

scientific article

Engagement of descending inhibition from the rostral ventromedial medulla protects against chronic neuropathic pain

scientific article published on 13 July 2011

Improving metabolic stability by glycosylation: bifunctional peptide derivatives that are opioid receptor agonists and neurokinin 1 receptor antagonists

scientific article

Induction of pain facilitation by sustained opioid exposure: relationship to opioid antinociceptive tolerance

scientific article

Is paradoxical pain induced by sustained opioid exposure an underlying mechanism of opioid antinociceptive tolerance?

scientific article

Multiple actions of systemic artemin in experimental neuropathy ⬇️

scientific article (publication date: November 2003)

Neuropathic pain is maintained by brainstem neurons co-expressing opioid and cholecystokinin receptors

scientific article

New paradigms and tools in drug design for pain and addiction

scientific article published on 14 July 2006

Novel D-amino acid tetrapeptides produce potent antinociception by selectively acting at peripheral kappa-opioid receptors

scientific article

Novel peptide ligands with dual acting pharmacophores designed for the pathophysiology of neuropathic pain

scientific article published on 20 April 2011

Production of paradoxical sensory hypersensitivity by alpha 2-adrenoreceptor agonists

scientific article

Role of NK-1 neurotransmission in opioid-induced hyperalgesia

scientific article

Spinal NK-1 receptor expressing neurons mediate opioid-induced hyperalgesia and antinociceptive tolerance via activation of descending pathways

scientific article

Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors

scientific article

Synthesis and biological evaluation of new opioid agonist and neurokinin-1 antagonist bivalent ligands ⬇️

scientific article published on August 24, 2011

TRPV1 receptor in expression of opioid-induced hyperalgesia

scientific article

Underlying mechanisms of pronociceptive consequences of prolonged morphine exposure

scientific article

Unmasking the tonic-aversive state in neuropathic pain

scientific article

List of works by Josephine Lai

Activation of CB2 cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: pain inhibition by receptors not present in the CNS

Activation of descending pain-facilitatory pathways from the rostral ventromedial medulla by cholecystokinin elicits release of prostaglandin-E₂ in the spinal cord

An efficient intrathecal delivery of small interfering RNA to the spinal cord and peripheral neurons

Antinociceptive and nociceptive actions of opioids

Biological and conformational evaluation of bifunctional compounds for opioid receptor agonists and neurokinin 1 receptor antagonists possessing two penicillamines

CB2 cannabinoid receptor activation produces antinociception by stimulating peripheral release of endogenous opioids

CB2 cannabinoid receptor agonists: pain relief without psychoactive effects?

CB2 cannabinoid receptor mediation of antinociception

Cholecystokinin in the rostral ventromedial medulla mediates opioid-induced hyperalgesia and antinociceptive tolerance

Constitutive activity at the cannabinoid CB1 receptor is required for behavioral response to noxious chemical stimulation of TRPV1: antinociceptive actions of CB1 inverse agonists

Design and synthesis of novel bivalent ligands (MOR and DOR) by conjugation of enkephalin analogues with 4-anilidopiperidine derivatives

Development of Potent μ and δ Opioid Agonists with High Lipophilicity ⬇️

Discovery of 5-substituted tetrahydronaphthalen-2yl-methyl with N-phenyl-N-(piperidin-4-yl)propionamide derivatives as potent opioid receptor ligands

Discovery of a potent and efficacious peptide derivative for δ/μ opioid agonist/neurokinin 1 antagonist activity with a 2',6'-dimethyl-L-tyrosine: in vitro, in vivo, and NMR-based structural studies

Discovery of amphipathic dynorphin A analogues to inhibit the neuroexcitatory effects of dynorphin A through bradykinin receptors in the spinal cord

Discovery of tripeptide-derived multifunctional ligands possessing delta/mu opioid receptor agonist and neurokinin 1 receptor antagonist activities

Engagement of descending inhibition from the rostral ventromedial medulla protects against chronic neuropathic pain

Improving metabolic stability by glycosylation: bifunctional peptide derivatives that are opioid receptor agonists and neurokinin 1 receptor antagonists

Induction of pain facilitation by sustained opioid exposure: relationship to opioid antinociceptive tolerance

Is paradoxical pain induced by sustained opioid exposure an underlying mechanism of opioid antinociceptive tolerance?

Multiple actions of systemic artemin in experimental neuropathy ⬇️

Neuropathic pain is maintained by brainstem neurons co-expressing opioid and cholecystokinin receptors

New paradigms and tools in drug design for pain and addiction

Novel D-amino acid tetrapeptides produce potent antinociception by selectively acting at peripheral kappa-opioid receptors

Novel peptide ligands with dual acting pharmacophores designed for the pathophysiology of neuropathic pain

Production of paradoxical sensory hypersensitivity by alpha 2-adrenoreceptor agonists

Role of NK-1 neurotransmission in opioid-induced hyperalgesia

Spinal NK-1 receptor expressing neurons mediate opioid-induced hyperalgesia and antinociceptive tolerance via activation of descending pathways

Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors

Synthesis and biological evaluation of new opioid agonist and neurokinin-1 antagonist bivalent ligands ⬇️

TRPV1 receptor in expression of opioid-induced hyperalgesia

Underlying mechanisms of pronociceptive consequences of prolonged morphine exposure

Unmasking the tonic-aversive state in neuropathic pain