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List of works by Michael Schwake

A carboxy-terminal domain determines the subunit specificity of KCNQ K+ channel assembly

scientific article

A critical histidine residue within LIMP-2 mediates pH sensitive binding to its ligand β-glucocerebrosidase.

scientific article

A mutation in the Golgi Qb-SNARE gene GOSR2 causes progressive myoclonus epilepsy with early ataxia

scientific article

Action myoclonus-renal failure syndrome: diagnostic applications of activity-based probes and lipid analysis

scientific article published on 8 November 2013

An internalization signal in ClC-5, an endosomal Cl-channel mutated in dent's disease

scientific article published on 14 December 2000

BACE1 modulates gating of KCNQ1 (Kv7.1) and cardiac delayed rectifier KCNQ1/KCNE1 (IKs)

scientific article published on 08 October 2015

BET1 variants establish impaired vesicular transport as a cause for muscular dystrophy with epilepsy

scientific article published on 15 November 2021

Bimodal effects of the Kv7 channel activator retigabine on vascular K+ currents

scientific article published on 9 June 2008

Cathepsin F mutations cause Type B Kufs disease, an adult-onset neuronal ceroid lipofuscinosis

scientific article

Characterization of the complex formed by β-glucocerebrosidase and the lysosomal integral membrane protein type-2.

scientific article published on 21 March 2016

ClC-5 Cl- -channel disruption impairs endocytosis in a mouse model for Dent's disease

scientific article published in November 2000

Deafness in LIMP2-deficient mice due to early loss of the potassium channel KCNQ1/KCNE1 in marginal cells of the stria vascularis

scientific article published on 10 August 2006

Design and Synthesis of Potent Quinazolines as Selective β-Glucocerebrosidase Modulators

scientific article published on 6 September 2016

Expression profile and characterisation of a truncated KCNQ5 splice variant.

scientific article published on 5 May 2008

Functional assays for the assessment of the pathogenicity of variants of GOSR2, an ER-to-Golgi SNARE involved in progressive myoclonus epilepsies.

scientific article published on 5 October 2017

GRIN2B mutations in West syndrome and intellectual disability with focal epilepsy

scientific article

Impaired Lysosomal Integral Membrane Protein 2-dependent Peroxiredoxin 6 Delivery to Lamellar Bodies Accounts for Altered Alveolar Phospholipid Content in Adaptor Protein-3-deficient pearl Mice

scientific article published on 23 February 2016

Increased expression of (pro)renin receptor does not cause hypertension or cardiac and renal fibrosis in mice

scientific article published on 21 July 2014

Involvement of lysosomal storage-induced p38 MAP kinase activation in the overproduction of nitric oxide by microglia in cathepsin D-deficient mice

scientific article published on 10 May 2007

LIMP-2 expression is critical for β-glucocerebrosidase activity and α-synuclein clearance

scientific journal article

LIMP-2 is a receptor for lysosomal mannose-6-phosphate-independent targeting of beta-glucocerebrosidase

scientific article

Lysosomal integral membrane protein 2 is a novel component of the cardiac intercalated disc and vital for load-induced cardiac myocyte hypertrophy

scientific article

Lysosomal integral membrane protein type-2 (LIMP-2/SCARB2) is a substrate of cathepsin-F, a cysteine protease mutated in type-B-Kufs-disease

scientific article

Lysosomal integral membrane protein-2 as a phospholipid receptor revealed by biophysical and cellular studies.

scientific article published on 4 December 2017

Lysosomal membrane proteins and their central role in physiology

scientific article

Mannose 6-phosphate-independent Lysosomal Sorting of LIMP-2.

scientific article published on 29 July 2015

Molecular determinants of KCNQ (Kv7) K+ channel sensitivity to the anticonvulsant retigabine.

scientific article published in May 2005

Mutations in GRIN2A cause idiopathic focal epilepsy with rolandic spikes

scientific article published on 11 August 2013

Mutations in the X-linked ATP6AP2 cause a glycosylation disorder with autophagic defects

scientific article

Neurocognitive and psychotiform behavioral alterations and enhanced hippocampal long-term potentiation in transgenic mice displaying neuropathological features of human alpha-mannosidosis

scientific journal article

Parallel regulation of renin and lysosomal integral membrane protein 2 in renin-producing cells: further evidence for a lysosomal nature of renin secretory vesicles

scientific article published on 11 December 2012

Pharmacological dissection of Kv7.1 channels in systemic and pulmonary arteries ⬇️

scientific article published on June 1, 2012

Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice

scientific article published on 29 June 2005

Polo-like kinase 2, a novel ADAM17 signaling component, regulates tumor necrosis factor α ectodomain shedding

scientific article published on 13 December 2013

Progranulin-mediated deficiency of cathepsin D results in FTD and NCL-like phenotypes in neurons derived from FTD patients

scientific article published on 25 September 2017

Proliferation-based T-cell selection for immunotherapy and graft-versus-host-disease prophylaxis in the context of bone marrow transplantation.

scientific article published on July 2006

Refinement of the binding site and mode of action of the anticonvulsant Retigabine on KCNQ K+ channels.

scientific article published on 17 November 2008

SCARB2/LIMP2 deficiency in action myoclonus-renal failure syndrome.

scientific article

Self-assembly of the isolated KCNQ2 subunit interaction domain

scientific article published on 16 March 2007

Sorting receptor Rer1 controls surface expression of muscle acetylcholine receptors by ER retention of unassembled α-subunits ⬇️

scientific article published on December 27, 2010

Structural determinants of M-type KCNQ (Kv7) K+ channel assembly.

scientific article published in April 2006

Structure of LIMP-2 provides functional insights with implications for SR-BI and CD36

scientific article

Surface expression and single channel properties of KCNQ2/KCNQ3, M-type K+ channels involved in epilepsy

scientific article (publication date: 5 May 2000)

Tetraspanin15 regulates cellular trafficking and activity of the ectodomain sheddase ADAM10.

scientific article published on 25 March 2012

The new KCNQ2 activator 4-Chlor-N-(6-chlor-pyridin-3-yl)-benzamid displays anticonvulsant potential.

scientific article published on March 2013

Tubular proteinuria in mice and humans lacking the intrinsic lysosomal protein SCARB2/Limp-2

scientific article

VPS13C regulates phospho-Rab10-mediated lysosomal function in human dopaminergic neurons

scientific article published in 2024

Vacuolar ATPase in phagosome-lysosome fusion.

scientific article published on 22 April 2015

β-Secretase BACE1 regulates hippocampal and reconstituted M-currents in a β-subunit-like fashion.

scientific article published in February 2015

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