List of works - Paul Saftig

A role for the lysosomal membrane protein LGP85 in the biogenesis and maintenance of endosomal and lysosomal morphology

scientific journal article

Array-based gene discovery with three unrelated subjects shows SCARB2/LIMP-2 deficiency causes myoclonus epilepsy and glomerulosclerosis

scientific article

At the acidic edge: emerging functions for lysosomal membrane proteins

scientific article (publication date: March 2003)

Cathepsin B-mediated autophagy flux facilitates the anthrax toxin receptor 2-mediated delivery of anthrax lethal factor into the cytoplasm

scientific article

Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE)

scientific article

Cellular depletion of major cathepsin proteases reveals their concerted activities for lysosomal proteolysis

scientific article published in 2024

Cellular mechanotransduction relies on tension-induced and chaperone-assisted autophagy

scientific article

Control of peripheral nerve myelination by the beta-secretase BACE1

scientific article

Enzyme replacement therapy with recombinant pro-CTSD (cathepsin D) corrects defective proteolysis and autophagy in neuronal ceroid lipofuscinosis

scientific article published on 16 July 2019

Furin-, ADAM 10-, and gamma-secretase-mediated cleavage of a receptor tyrosine phosphatase and regulation of beta-catenin's transcriptional activity

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

LIMP-2 is a receptor for lysosomal mannose-6-phosphate-independent targeting of beta-glucocerebrosidase

scientific article

LIMP-2/LGP85 deficiency causes ureteric pelvic junction obstruction, deafness and peripheral neuropathy in mice

scientific article (publication date: 15 March 2003)

Lung emphysema and impaired macrophage elastase clearance in mucolipin 3 deficient mice

scientific article published on 14 January 2022

Lysosomal integral membrane protein 2 is a novel component of the cardiac intercalated disc and vital for load-induced cardiac myocyte hypertrophy

scientific article

Lysosomal membrane proteins and their central role in physiology

scientific article

Lysosomal storage disorders - challenges, concepts and avenues for therapy: beyond rare diseases

scientific article published on 16 January 2019

Molecular characterisation of 'transmembrane protein 192' (TMEM192), a novel protein of the lysosomal membrane

scientific article

Quantitative Proteome Analysis of Mouse Liver Lysosomes Provides Evidence for Mannose 6-phosphate-independent Targeting Mechanisms of Acid Hydrolases in Mucolipidosis II.

scientific article published on 6 January 2017

Regulated ADAM10-dependent ectodomain shedding of gamma-protocadherin C3 modulates cell-cell adhesion

scientific article (publication date: 4 August 2006)

Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b

scientific article

Signal-peptide-peptidase-like 2a (SPPL2a) is targeted to lysosomes/late endosomes by a tyrosine motif in its C-terminal tail

scientific article

Structure of LIMP-2 provides functional insights with implications for SR-BI and CD36

scientific article

The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion

scientific article

The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts

scientific article

The intramembrane protease SPPL2c promotes male germ cell development by cleaving phospholamban

scientific article published on 07 February 2019

The lysosomal polypeptide transporter TAPL is stabilized by interaction with LAMP-1 and LAMP-2

scientific article

The proteome of lysosomes ⬇️

scientific article published on October 19, 2010

The tetraspanin CD63 regulates ESCRT-independent and -dependent endosomal sorting during melanogenesis

scientific article

The transmembrane CXC-chemokine ligand 16 is induced by IFN-gamma and TNF-alpha and shed by the activity of the disintegrin-like metalloproteinase ADAM10

scientific article

List of works by Paul Saftig

A role for the lysosomal membrane protein LGP85 in the biogenesis and maintenance of endosomal and lysosomal morphology

Array-based gene discovery with three unrelated subjects shows SCARB2/LIMP-2 deficiency causes myoclonus epilepsy and glomerulosclerosis

At the acidic edge: emerging functions for lysosomal membrane proteins

Cathepsin B-mediated autophagy flux facilitates the anthrax toxin receptor 2-mediated delivery of anthrax lethal factor into the cytoplasm

Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE)

Cellular depletion of major cathepsin proteases reveals their concerted activities for lysosomal proteolysis

Cellular mechanotransduction relies on tension-induced and chaperone-assisted autophagy

Control of peripheral nerve myelination by the beta-secretase BACE1

Enzyme replacement therapy with recombinant pro-CTSD (cathepsin D) corrects defective proteolysis and autophagy in neuronal ceroid lipofuscinosis

Furin-, ADAM 10-, and gamma-secretase-mediated cleavage of a receptor tyrosine phosphatase and regulation of beta-catenin's transcriptional activity

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

LIMP-2 is a receptor for lysosomal mannose-6-phosphate-independent targeting of beta-glucocerebrosidase

LIMP-2/LGP85 deficiency causes ureteric pelvic junction obstruction, deafness and peripheral neuropathy in mice

Lung emphysema and impaired macrophage elastase clearance in mucolipin 3 deficient mice

Lysosomal integral membrane protein 2 is a novel component of the cardiac intercalated disc and vital for load-induced cardiac myocyte hypertrophy

Lysosomal membrane proteins and their central role in physiology

Lysosomal storage disorders - challenges, concepts and avenues for therapy: beyond rare diseases

Molecular characterisation of 'transmembrane protein 192' (TMEM192), a novel protein of the lysosomal membrane

Quantitative Proteome Analysis of Mouse Liver Lysosomes Provides Evidence for Mannose 6-phosphate-independent Targeting Mechanisms of Acid Hydrolases in Mucolipidosis II.

Regulated ADAM10-dependent ectodomain shedding of gamma-protocadherin C3 modulates cell-cell adhesion

Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b

Signal-peptide-peptidase-like 2a (SPPL2a) is targeted to lysosomes/late endosomes by a tyrosine motif in its C-terminal tail

Structure of LIMP-2 provides functional insights with implications for SR-BI and CD36

The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion

The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts

The intramembrane protease SPPL2c promotes male germ cell development by cleaving phospholamban

The lysosomal polypeptide transporter TAPL is stabilized by interaction with LAMP-1 and LAMP-2

The proteome of lysosomes ⬇️

The tetraspanin CD63 regulates ESCRT-independent and -dependent endosomal sorting during melanogenesis

The transmembrane CXC-chemokine ligand 16 is induced by IFN-gamma and TNF-alpha and shed by the activity of the disintegrin-like metalloproteinase ADAM10