List of works by Markku Varjosalo

<i>DUX4</i> is a multifunctional factor priming human embryonic genome activation

scientific article published on 22 March 2022

A Family With A20 Haploinsufficiency Presenting With Novel Clinical Manifestations and Challenges for Treatment

scientific article published on 21 January 2020

A proteomics view on integrin-mediated adhesions

scientific article

Absence of YbeY RNase compromises the growth and enhances the virulence plasmid gene expression of Yersinia enterocolitica O:3.

scientific article published on 21 November 2014

Agonist-specific Protein Interactomes of Glucocorticoid and Androgen Receptor as Revealed by Proximity Mapping

scientific article published on 13 June 2017

An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations.

scientific article published on 22 March 2018

An Activating STAT3 Mutation Causes Neonatal Diabetes through Premature Induction of Pancreatic Differentiation

scientific article

Anagrelide for Gastrointestinal Stromal Tumor

scientific article published on 07 December 2018

Analysis of human brain tissue derived from DBS surgery

scientific article published on 13 April 2022

Application of active and kinase-deficient kinome collection for identification of kinases regulating hedgehog signaling

scientific article

Assembly of the β4-integrin interactome based on proximal biotinylation in the presence and absence of heterodimerization

scientific article published on 07 November 2018

Association of host protein VARICOSE with HCPro within a multiprotein complex is crucial for RNA silencing suppression, translation, encapsidation and systemic spread of potato virus A infection

scientific article published on 12 October 2020

Biallelic mutations in human NHLRC2 enhance myofibroblast differentiation in FINCA disease

scientific article published on 01 December 2018

Bidirectional Interplay between Vimentin Intermediate Filaments and Contractile Actin Stress Fibers.

scientific article published on 28 May 2015

Candidate proteins from predegenerated nerve exert time-specific protection of retinal ganglion cells in glaucoma.

scientific article published on 6 November 2017

Characterization of the clinical and immunological phenotype and management of 157 individuals with 56 distinct heterozygous NFKB1 mutations

scientific article published on 09 April 2020

Colonic metaproteomic signatures of active bacteria and the host in obesity.

scientific article published on 10 August 2015

Combined immunodeficiency and hypoglycemia associated with mutations in hypoxia upregulated 1.

scientific article published on 29 November 2016

Combined proximity labeling and affinity purification-mass spectrometry workflow for mapping and visualizing protein interaction networks

scientific article published on 10 August 2020

Complement Factor H Binds to Human Serum Apolipoprotein E and Mediates Complement Regulation on High Density Lipoprotein Particles.

scientific article

Comprehensive evaluation of coding region point mutations in microsatellite‐unstable colorectal cancer

scientific article published on 14 August 2018

Damaging heterozygous mutations in NFKB1 lead to diverse immunologic phenotypes

scientific article published on 20 January 2017

Design, synthesis and characterization of a PEGylated stanozolol for potential therapeutic applications

scientific article published on 09 November 2019

Divergence of hedgehog signal transduction mechanism between Drosophila and mammals

scientific article

Dominant TOM1 mutation associated with combined immunodeficiency and autoimmune disease

scientific article published on 27 June 2019

ER-Targeted Beclin 1 Supports Autophagosome Biogenesis in the Absence of ULK1 and ULK2 Kinases

scientific article published on 17 May 2019

EphA2 cleavage by MT1-MMP triggers single cancer cell invasion via homotypic cell repulsion

scientific article

Expression of the Yersinia enterocolitica O:3 LPS O-antigen and outer core gene clusters is RfaH-dependent

scientific article published on 12 March 2015

FGF receptor-4 (FGFR4) polymorphism acts as an activity switch of a membrane type 1 matrix metalloproteinase-FGFR4 complex

scientific article

FGFR4 phosphorylates MST1 to confer breast cancer cells resistance to MST1/2-dependent apoptosis

scientific article published on 22 March 2019

Fibroblast growth factor receptor 4 regulates tumor invasion by coupling fibroblast growth factor signaling to extracellular matrix degradation

scientific article

Functional and structural properties of a novel protein and virulence factor (Protein sHIP) in Streptococcus pyogenes

scientific article

Gain-of-function CEBPE mutation causes noncanonical autoinflammatory inflammasomopathy

scientific article published on 13 June 2019

Genome-wide analysis of ETS-family DNA-binding in vitro and in vivo

scientific article

Gremlin-1 associates with fibrillin microfibrils in vivo and regulates mesothelioma cell survival through transcription factor slug.

scientific article published on 26 August 2013

HB-GAM (pleiotrophin) reverses inhibition of neural regeneration by the CNS extracellular matrix

scientific article

Haploinsufficiency of A20 impairs protein-protein interactome and leads into caspase-8-dependent enhancement of NLRP3 inflammasome activation

scientific article published on 17 October 2018

Hedgehog signaling.

scientific article published on January 2007

Human Receptors Patched and Smoothened Partially Transduce Hedgehog Signal When Expressed inDrosophilaCells

scientific article published in Journal of Biological Chemistry

Human transcription factor protein interaction networks

scientific article published on 09 February 2022

Identification of candidate oncogenes in human colorectal cancers with microsatellite instability

scientific article

Identification of pathways regulating cell size and cell-cycle progression by RNAi

scientific article

Increased intraocular pressure alters the cellular distribution of HuR protein in retinal ganglion cells - A possible sign of endogenous neuroprotection failure

scientific article

Interaction proteome of human Hippo signaling: modular control of the co-activator YAP1

scientific article

Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS

scientific article

MKRN3 Interacts With Several Proteins Implicated in Puberty Timing but Does Not Influence Expression

scientific article published on 08 February 2019

Missing-in-metastasis MIM/MTSS1 promotes actin assembly at intercellular junctions and is required for integrity of kidney epithelia

scientific journal article

Molecular Atlas of Postnatal Mouse Heart Development

article

Molecular insights into the function of the viral RNA silencing suppressor HCPro.

scientific article

Molecular pathogenesis of rhegmatogenous retinal detachment

scientific article published on 13 January 2021

Myosin-18B Promotes the Assembly of Myosin II Stacks for Maturation of Contractile Actomyosin Bundles

scientific article published on 20 December 2018

Navigating through metaproteomics data: a logbook of database searching

scientific article published on 16 March 2015

New insights into the molecular mechanisms of ROR1, ROR2, and PTK7 signaling from the proteomics and pharmacological modulation of ROR1 interactome

scientific article published on 04 May 2022

Novel TMEM173 Mutation and the Role of Disease Modifying Alleles

scientific article published on 05 December 2019

Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing

scientific article published on 17 April 2019

Oncogenic Herpesvirus Utilizes Stress-Induced Cell Cycle Checkpoints for Efficient Lytic Replication

scientific article published on 18 February 2016

One-step purification of twin-strep-tagged proteins and their complexes on strep-tactin resin cross-linked with bis(sulfosuccinimidyl) suberate (BS3).

scientific article published on 20 April 2014

P85Combined transcriptomics, proteomics and metabolomics analysis identifies metabolic pathways associated with the loss of cardiac regeneration

PWP1 Mediates Nutrient-Dependent Growth Control through Nucleolar Regulation of Ribosomal Gene Expression.

scientific article

Pharmacologically diverse antidepressants facilitate TRKB receptor activation by disrupting its interaction with the endocytic adaptor complex AP-2

scientific article published on 20 October 2019

Phosphorylation of Notch1 by Pim kinases promotes oncogenic signaling in breast and prostate cancer cells.

scientific article published on 07 May 2016

Physical and functional interactome atlas of human receptor tyrosine kinases

scientific article published on 05 April 2022

Pool-seq driven proteogenomic database for Group G Streptococcus

scientific article published on 20 April 2019

Predegenerated Schwann cells--a novel prospect for cell therapy for glaucoma: neuroprotection, neuroregeneration and neuroplasticity.

scientific article published on April 2016

Probiotic supplementation restores normal microbiota composition and function in antibiotic-treated and in caesarean-born infants

article

Protein composition of 6K2-induced membrane structures formed during Potato virus A infection.

scientific article published on 17 November 2015

Protein secretome of moss plants (Physcomitrella patens) with emphasis on changes induced by a fungal elicitor

scientific article published on 6 December 2013

Proximity-Dependent Biotinylation (BioID) of Integrin Interaction Partners

scientific article published on 01 January 2021

Quantitative Proteomics Analysis of Vitreous Humor from Diabetic Retinopathy Patients.

scientific article

RTN4B interacting protein FAM134C promotes ER membrane curvature and has a functional role in autophagy

scientific article published on 07 April 2021

Rapid genome editing by CRISPR-Cas9-POLD3 fusion

scientific article published on 13 December 2021

Recognition of malondialdehyde-modified proteins by the C terminus of complement factor H is mediated via the polyanion binding site and impaired by mutations found in atypical hemolytic uremic syndrome

scientific article

Redox regulation of GRPEL2 nucleotide exchange factor for mitochondrial HSP70 chaperone

Regulation of PTEN activity by p38δ-PKD1 signaling in neutrophils confers inflammatory responses in the lung

scientific article

Release of transcriptional repression via ErbB2-induced, SUMO-directed phosphorylation of myeloid zinc finger-1 serine 27 activates lysosome redistribution and invasion

scientific article published on 08 January 2019

Rho-kinase inhibitor Y-27632 increases cellular proliferation and migration in human foreskin fibroblast cells.

scientific article published on 15 June 2015

Ribosome profiles and riboproteomes of healthy and potato virus A and Agrobacterium -infected Nicotiana benthamiana plants

article

Role for formin-like 1-dependent acto-myosin assembly in lipid droplet dynamics and lipid storage.

scientific article

SARS-CoV-2-host proteome interactions for antiviral drug discovery

scientific article published on 01 November 2021

SUMOylation regulates the protein network and chromatin accessibility at glucocorticoid receptor-binding sites

scientific article published on 01 February 2021

Several Hfq-dependent alterations in physiology of Yersinia enterocolitica O:3 are mediated by derepression of the transcriptional regulator RovM.

scientific article published on 23 December 2016

Skeletal muscle proteomes reveal downregulation of mitochondrial proteins in transition from prediabetes into type 2 diabetes

scientific article published on 10 June 2021

Somatic MED12 Nonsense Mutation Escapes mRNA Decay and Reveals a Motif Required for Nuclear Entry

scientific article

Somatic MED12 mutations in prostate cancer and uterine leiomyomas promote tumorigenesis through distinct mechanisms.

scientific article published on 18 September 2015

Structure and interactions of the endogenous human Commander complex

scientific article published in 2024

Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.

scientific article

Systems pathology analysis identifies neurodegenerative nature of age-related vitreoretinal interface diseases

scholarly article by Tiina Öhman et al published October 2018 in Aging Cell

Talin-mediated force transmission and talin rod domain unfolding independently regulate adhesion signaling

scientific article published on 03 April 2019

Tamoxifen mechanically reprograms the tumor microenvironment via HIF-1A and reduces cancer cell survival

scientific article published on 11 December 2018

The F1 loop of the talin head domain acts as a gatekeeper in integrin activation and clustering

scientific article published on 12 October 2020

The comprehensive interactomes of human adenosine RNA methyltransferases and demethylases reveal distinct functional and regulatory features

scientific article published on 01 November 2021

The human long non-coding RNA gene RMRP has pleiotropic effects and regulates cell-cycle progression at G2

scientific article published on 24 September 2019

The protein interaction landscape of the human CMGC kinase group

scientific article

Tropomodulins Control the Balance between Protrusive and Contractile Structures by Stabilizing Actin-Tropomyosin Filaments

scientific article published on 06 February 2020

Two missense mutations in KCNQ1 cause pituitary hormone deficiency and maternally inherited gingival fibromatosis.

scientific article published on 3 November 2017

UNC-45a promotes myosin folding and stress fiber assembly.

scientific article

Uterine leiomyoma-linked MED12 mutations disrupt mediator-associated CDK activity.

scientific article

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