List of works - Kristina Schoonjans

A SIRT7-dependent acetylation switch of GABPβ1 controls mitochondrial function

scientific article published on 4 September 2014

A multiscale study of the role of dynamin in the regulation of glucose uptake

scientific article published on 30 August 2017

A sharper image of SHP.

scientific article published in August 2002

Activation of the peroxisome proliferator-activated receptor alpha protects against myocardial ischaemic injury and improves endothelial vasodilatation

scientific article

Adipose tissue expression of the lipid droplet-associating proteins S3-12 and perilipin is controlled by peroxisome proliferator-activated receptor-gamma

scientific article

Adipose tissue-specific inactivation of the retinoblastoma protein protects against diabesity because of increased energy expenditure

scholarly article

An Integrated Systems Genetics and Omics Toolkit to Probe Gene Function

scientific article

Bile Acids Trigger GLP-1 Release Predominantly by Accessing Basolaterally Located G Protein-Coupled Bile Acid Receptors

scientific article

Bile acid binding resin improves metabolic control through the induction of energy expenditure

scientific article

Bile acid-FXRα pathways regulate male sexual maturation in mice

scientific article published on 3 February 2016

Bile acids alter male fertility through G-protein-coupled bile acid receptor 1 signaling pathways in mice

scientific article published on September 2014

Bile acids and the membrane bile acid receptor TGR5--connecting nutrition and metabolism

scientific article published on February 2008

Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation

scientific article

Cell cycle-dependent regulation of extra-adrenal glucocorticoid synthesis in murine intestinal epithelial cells

scientific article

Cholesterol supply and SREBPs modulate transcription of the Niemann-Pick C-1 gene in steroidogenic tissues

scientific article

Compromised intestinal lipid absorption in mice with a liver-specific deficiency of liver receptor homolog 1.

scientific article

Differential regulation of glucocorticoid synthesis in murine intestinal epithelial versus adrenocortical cell lines

scientific article published on 14 December 2006

Dual farnesoid X receptor/TGR5 agonist INT-767 reduces liver injury in the Mdr2-/- (Abcb4-/-) mouse cholangiopathy model by promoting biliary HCO⁻₃ output

scientific article published on October 2011

Eliciting the mitochondrial unfolded protein response by nicotinamide adenine dinucleotide repletion reverses fatty liver disease in mice

scientific article published on 24 September 2015

Emerging actions of the nuclear receptor LRH-1 in the gut ⬇️

scientific article published on December 29, 2010

Farnesoid X receptor inhibits glucagon-like peptide-1 production by enteroendocrine L cells

scientific article

Hepatic glucose sensing and integrative pathways in the liver

scientific article

Histone methyl transferases and demethylases; can they link metabolism and transcription?

scientific article published on October 2010

Identification of the link between the hypothalamo-pituitary axis and the testicular orphan nuclear receptor NR0B2 in adult male mice

scientific article

Impaired SUMOylation of nuclear receptor LRH-1 promotes nonalcoholic fatty liver disease

scientific article published on 17 January 2017

Impaired expression of the peroxisome proliferator-activated receptor alpha during hepatitis C virus infection.

scientific article published on February 2005

Inhibiting poly ADP-ribosylation increases fatty acid oxidation and protects against fatty liver disease

scientific article published on 20 September 2016

Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance

scientific article

LRH-1-dependent glucose sensing determines intermediary metabolism in liver

scientific article

LRH-1-mediated glucocorticoid synthesis in enterocytes protects against inflammatory bowel disease

scholarly article

LRH-1: an orphan nuclear receptor involved in development, metabolism and steroidogenesis

scientific article

Liver receptor homolog 1 contributes to intestinal tumor formation through effects on cell cycle and inflammation

scientific journal article

Liver receptor homolog 1 controls the expression of carboxyl ester lipase

scientific article

Liver receptor homolog 1 controls the expression of the scavenger receptor class B type I.

scientific article

Liver receptor homolog 1 is essential for ovulation

scientific article

Liver receptor homolog-1 is essential for pregnancy

scientific article published on 30 June 2013

Local glucocorticoid production in the mouse lung is induced by immune cell stimulation ⬇️

scientific article published on November 24, 2011

Loss of Sirt1 function improves intestinal anti-bacterial defense and protects from colitis-induced colorectal cancer

scientific article

Lowering bile acid pool size with a synthetic farnesoid X receptor (FXR) agonist induces obesity and diabetes through reduced energy expenditure

scientific article

Mechano-modulatory synthetic niches for liver organoid derivation

scientific article published on 10 July 2020

Metabolic characterization of a Sirt5 deficient mouse model

scientific article published on 30 September 2013

Mitochondrial matrix pH controls oxidative phosphorylation and metabolism-secretion coupling in INS-1E clonal beta cells

scientific article published on 20 July 2010

Molecular basis for the regulation of the nuclear receptor LRH-1.

scientific article

Molecular field analysis and 3D-quantitative structure-activity relationship study (MFA 3D-QSAR) unveil novel features of bile acid recognition at TGR5.

scientific article published on 13 August 2008

Muscle or liver-specific Sirt3 deficiency induces hyperacetylation of mitochondrial proteins without affecting global metabolic homeostasis

scientific article

NAD⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice

scientific article

NCoR1 is a conserved physiological modulator of muscle mass and oxidative function

scientific article

NR5A2 regulates Lhb and Fshb transcription in gonadotrope-like cells in vitro, but is dispensable for gonadotropin synthesis and fertility in vivo

scientific article

Novel potent and selective bile acid derivatives as TGR5 agonists: biological screening, structure-activity relationships, and molecular modeling studies

scientific article

Pancreatic-duodenal homeobox 1 regulates expression of liver receptor homolog 1 during pancreas development

scientific article

Peroxisome proliferator-activated receptor (PPAR)-beta/delta stimulates differentiation and lipid accumulation in keratinocytes

scientific article

Pharmacological Inhibition of poly(ADP-ribose) polymerases improves fitness and mitochondrial function in skeletal muscle

scientific article

Phosphorylation of the nuclear receptor corepressor 1 by protein kinase B switches its corepressor targets in the liver in mice

scientific article

Progesterone receptor knockout mice have an improved glucose homeostasis secondary to beta -cell proliferation

scientific article

Redefining the TGR5 triterpenoid binding pocket at the C-3 position

scientific article published on December 2010

Role of peroxisome proliferator-activated receptor alpha in epidermal development in utero

scientific journal article

SIRT2 deficiency modulates macrophage polarization and susceptibility to experimental colitis

scientific article

SUMOylation-dependent LRH-1/PROX1 interaction promotes atherosclerosis by decreasing hepatic reverse cholesterol transport

scientific article

Shp deletion prevents hepatic steatosis and when combined with Fxr loss protects against type 2 diabetes

scientific article published on 06 June 2017

Sirtuin functions in health and disease

scientific article

Sirtuins: the 'magnificent seven', function, metabolism and longevity

scientific article published on January 2007

Structure-activity relationship study of betulinic acid, a novel and selective TGR5 agonist, and its synthetic derivatives: potential impact in diabetes

scientific article published on January 2010

Structure-based design of a superagonist ligand for the vitamin D nuclear receptor

scientific article

Synergy between LRH-1 and beta-catenin induces G1 cyclin-mediated cell proliferation

scientific article published on August 2004

Systems genetics of metabolism: the use of the BXD murine reference panel for multiscalar integration of traits

scientific article

TGR5 activation inhibits atherosclerosis by reducing macrophage inflammation and lipid loading

scientific article

TGR5 and Immunometabolism: Insights from Physiology and Pharmacology

scientific article published on 04 September 2015

TGR5 potentiates GLP-1 secretion in response to anionic exchange resins

scientific article

TGR5 reduces macrophage migration through mTOR-induced C/EBPβ differential translation

scientific article

TGR5-mediated bile acid sensing controls glucose homeostasis

scientific article

Targeting bile-acid signalling for metabolic diseases

scientific article published on August 2008

The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity

scientific article published on June 2012

The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

scientific article

The Sirt1 activator SRT3025 provides atheroprotection in Apoe-/- mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression

scientific article

The bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammation

scientific article published on 9 December 2010

The bile acid membrane receptor TGR5: a valuable metabolic target

scientific article

The genetic ablation of SRC-3 protects against obesity and improves insulin sensitivity by reducing the acetylation of PGC-1{alpha}.

scholarly article

The metabolic footprint of aging in mice

scientific article published on 31 October 2011

The orphan nuclear receptor LRH-1/NR5a2 critically regulates T cell functions

scientific article published on 17 July 2019

The orphan nuclear receptor small heterodimer partner mediates male infertility induced by diethylstilbestrol in mice

scientific article

The receptor TGR5 mediates the prokinetic actions of intestinal bile acids and is required for normal defecation in mice

scientific article

The receptor TGR5 protects the liver from bile acid overload during liver regeneration in mice

scientific article published on 19 August 2013

The role of PPAR-gamma/RXR-alpha heterodimers in the regulation of human trophoblast invasion

scientific article

The small heterodimer partner interacts with the liver X receptor alpha and represses its transcriptional activity

scientific article (publication date: September 2002)

Topical peroxisome proliferator activated receptor-alpha activators reduce inflammation in irritant and allergic contact dermatitis models

scientific article published in January 2002

Transcriptional regulation of adipocyte formation by the liver receptor homologue 1 (Lrh1)-Small hetero-dimerization partner (Shp) network

scientific article published on 16 March 2013

Vitamin D and energy homeostasis: of mice and men.

scientific article

List of works by Kristina Schoonjans

A SIRT7-dependent acetylation switch of GABPβ1 controls mitochondrial function

A multiscale study of the role of dynamin in the regulation of glucose uptake

A sharper image of SHP.

Activation of the peroxisome proliferator-activated receptor alpha protects against myocardial ischaemic injury and improves endothelial vasodilatation

Adipose tissue expression of the lipid droplet-associating proteins S3-12 and perilipin is controlled by peroxisome proliferator-activated receptor-gamma

Adipose tissue-specific inactivation of the retinoblastoma protein protects against diabesity because of increased energy expenditure

An Integrated Systems Genetics and Omics Toolkit to Probe Gene Function

Bile Acids Trigger GLP-1 Release Predominantly by Accessing Basolaterally Located G Protein-Coupled Bile Acid Receptors

Bile acid binding resin improves metabolic control through the induction of energy expenditure

Bile acid-FXRα pathways regulate male sexual maturation in mice

Bile acids alter male fertility through G-protein-coupled bile acid receptor 1 signaling pathways in mice

Bile acids and the membrane bile acid receptor TGR5--connecting nutrition and metabolism

Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation

Cell cycle-dependent regulation of extra-adrenal glucocorticoid synthesis in murine intestinal epithelial cells

Cholesterol supply and SREBPs modulate transcription of the Niemann-Pick C-1 gene in steroidogenic tissues

Compromised intestinal lipid absorption in mice with a liver-specific deficiency of liver receptor homolog 1.

Differential regulation of glucocorticoid synthesis in murine intestinal epithelial versus adrenocortical cell lines

Dual farnesoid X receptor/TGR5 agonist INT-767 reduces liver injury in the Mdr2-/- (Abcb4-/-) mouse cholangiopathy model by promoting biliary HCO⁻₃ output

Eliciting the mitochondrial unfolded protein response by nicotinamide adenine dinucleotide repletion reverses fatty liver disease in mice

Emerging actions of the nuclear receptor LRH-1 in the gut ⬇️

Farnesoid X receptor inhibits glucagon-like peptide-1 production by enteroendocrine L cells

Hepatic glucose sensing and integrative pathways in the liver

Histone methyl transferases and demethylases; can they link metabolism and transcription?

Identification of the link between the hypothalamo-pituitary axis and the testicular orphan nuclear receptor NR0B2 in adult male mice

Impaired SUMOylation of nuclear receptor LRH-1 promotes nonalcoholic fatty liver disease

Impaired expression of the peroxisome proliferator-activated receptor alpha during hepatitis C virus infection.

Inhibiting poly ADP-ribosylation increases fatty acid oxidation and protects against fatty liver disease

Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance

LRH-1-dependent glucose sensing determines intermediary metabolism in liver

LRH-1-mediated glucocorticoid synthesis in enterocytes protects against inflammatory bowel disease

LRH-1: an orphan nuclear receptor involved in development, metabolism and steroidogenesis

Liver receptor homolog 1 contributes to intestinal tumor formation through effects on cell cycle and inflammation

Liver receptor homolog 1 controls the expression of carboxyl ester lipase

Liver receptor homolog 1 controls the expression of the scavenger receptor class B type I.

Liver receptor homolog 1 is essential for ovulation

Liver receptor homolog-1 is essential for pregnancy

Local glucocorticoid production in the mouse lung is induced by immune cell stimulation ⬇️

Loss of Sirt1 function improves intestinal anti-bacterial defense and protects from colitis-induced colorectal cancer

Lowering bile acid pool size with a synthetic farnesoid X receptor (FXR) agonist induces obesity and diabetes through reduced energy expenditure

Mechano-modulatory synthetic niches for liver organoid derivation

Metabolic characterization of a Sirt5 deficient mouse model

Mitochondrial matrix pH controls oxidative phosphorylation and metabolism-secretion coupling in INS-1E clonal beta cells

Molecular basis for the regulation of the nuclear receptor LRH-1.

Molecular field analysis and 3D-quantitative structure-activity relationship study (MFA 3D-QSAR) unveil novel features of bile acid recognition at TGR5.

Muscle or liver-specific Sirt3 deficiency induces hyperacetylation of mitochondrial proteins without affecting global metabolic homeostasis

NAD⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice

NCoR1 is a conserved physiological modulator of muscle mass and oxidative function

NR5A2 regulates Lhb and Fshb transcription in gonadotrope-like cells in vitro, but is dispensable for gonadotropin synthesis and fertility in vivo

Novel potent and selective bile acid derivatives as TGR5 agonists: biological screening, structure-activity relationships, and molecular modeling studies

Pancreatic-duodenal homeobox 1 regulates expression of liver receptor homolog 1 during pancreas development

Peroxisome proliferator-activated receptor (PPAR)-beta/delta stimulates differentiation and lipid accumulation in keratinocytes

Pharmacological Inhibition of poly(ADP-ribose) polymerases improves fitness and mitochondrial function in skeletal muscle

Phosphorylation of the nuclear receptor corepressor 1 by protein kinase B switches its corepressor targets in the liver in mice

Progesterone receptor knockout mice have an improved glucose homeostasis secondary to beta -cell proliferation

Redefining the TGR5 triterpenoid binding pocket at the C-3 position

Role of peroxisome proliferator-activated receptor alpha in epidermal development in utero

SIRT2 deficiency modulates macrophage polarization and susceptibility to experimental colitis

SUMOylation-dependent LRH-1/PROX1 interaction promotes atherosclerosis by decreasing hepatic reverse cholesterol transport

Shp deletion prevents hepatic steatosis and when combined with Fxr loss protects against type 2 diabetes

Sirtuin functions in health and disease

Sirtuins: the 'magnificent seven', function, metabolism and longevity

Structure-activity relationship study of betulinic acid, a novel and selective TGR5 agonist, and its synthetic derivatives: potential impact in diabetes

Structure-based design of a superagonist ligand for the vitamin D nuclear receptor

Synergy between LRH-1 and beta-catenin induces G1 cyclin-mediated cell proliferation

Systems genetics of metabolism: the use of the BXD murine reference panel for multiscalar integration of traits

TGR5 activation inhibits atherosclerosis by reducing macrophage inflammation and lipid loading

TGR5 and Immunometabolism: Insights from Physiology and Pharmacology

TGR5 potentiates GLP-1 secretion in response to anionic exchange resins

TGR5 reduces macrophage migration through mTOR-induced C/EBPβ differential translation

TGR5-mediated bile acid sensing controls glucose homeostasis

Targeting bile-acid signalling for metabolic diseases

The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity

The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

The Sirt1 activator SRT3025 provides atheroprotection in Apoe-/- mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression

The bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammation

The bile acid membrane receptor TGR5: a valuable metabolic target

The genetic ablation of SRC-3 protects against obesity and improves insulin sensitivity by reducing the acetylation of PGC-1{alpha}.

The metabolic footprint of aging in mice

The orphan nuclear receptor LRH-1/NR5a2 critically regulates T cell functions