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List of works by Johan Auwerx

1.P.174 The mitochondrion is the principal target for nutritional and pharmacological control of triglyceride metabolism

scholarly article by R.K. Berge et al published October 1997 in Atherosclerosis

1.P.194 Thiazolidinediones exert a hypotriglyceridemic effect by a distinct, but complementary mechanism relative to fibrates

3-Hydroxy-3-methylglutaryl CoA reductase inhibitors reduce serum triglyceride levels through modulation of apolipoprotein C-III and lipoprotein lipase

scientific journal article

4.P.263 Coordinate regulation of the expression of the fatty acid transporter protein (FATP) and acyl CoA synthetase (ACS) genes by PPARα and PPARγ activators

article

4.P.304 HDL (high density lipoprotein) and LDL (low density lipoprotein) receptors regulation in human adrenal cortex

A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity

scientific article

A SIRT7-dependent acetylation switch of GABPβ1 controls mitochondrial function

scientific article published on 4 September 2014

A biosensor for measuring NAD+ levels at the point of care

scientific article published on 13 December 2019

A functional polymorphism in a STAT5B site of the human PPAR gamma 3 gene promoter affects height and lipid metabolism in a French population

scientific article published in February 2003

A guide to analysis of mouse energy metabolism

scientific article published on 28 December 2011

A method to identify and validate mitochondrial modulators using mammalian cells and the worm C. elegans

scientific article

A multiscale study of the role of dynamin in the regulation of glucose uptake

scientific article published on 30 August 2017

A sharper image of SHP.

scientific article published in August 2002

A unique PPARgamma ligand with potent insulin-sensitizing yet weak adipogenic activity

scientific article

AMP-activated protein kinase and its downstream transcriptional pathways

scientific article published on 17 July 2010

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

scientific article

AP-1 (Fos-Jun) regulation by IP-1: effect of signal transduction pathways and cell growth

scientific article published on November 1, 1992

Absence of N-glycosylation at asparagine 43 in human lipoprotein lipase induces its accumulation in the rough endoplasmic reticulum and alters this cellular compartment ⬇️

scientific article published on 01 May 1995

Absence of the steroid receptor coactivator-3 induces B-cell lymphoma

scientific article

Activation of PPARdelta alters lipid metabolism in db/db mice.

scientific article

Activation of PPARΓ protects against colon inflammation by inhibiting TNFA signaling pathways

Activation of junB by PKC and PKA signal transduction through a novel cis-acting element

scientific article

Activation of the peroxisome proliferator-activated receptor alpha protects against myocardial ischaemic injury and improves endothelial vasodilatation

scientific article

Acute RyR1 Ca<sup>2+</sup> leak enhances NADH-linked mitochondrial respiratory capacity

scientific article published on 10 December 2021

Adipocyte NCoR knockout decreases PPARγ phosphorylation and enhances PPARγ activity and insulin sensitivity

scientific article

Adipose tissue expression of the lipid droplet-associating proteins S3-12 and perilipin is controlled by peroxisome proliferator-activated receptor-gamma

scientific article

Adipose tissue-specific inactivation of the retinoblastoma protein protects against diabesity because of increased energy expenditure

scholarly article

Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respiration

scientific article published on November 2008

Ageing: longevity hits a roadblock

scientific article

Alterations in lipoprotein metabolism in peroxisome proliferator-activated receptor alpha-deficient mice

scientific article published on October 1997

An E-box in pGL3 reporter vectors precludes their use for the study of sterol regulatory element-binding proteins.

scientific article

An Integrated Systems Genetics and Omics Toolkit to Probe Gene Function

scientific article

An acetylation rheostat for the control of muscle energy homeostasis

scientific article

An automated microfluidic platform for C. elegans embryo arraying, phenotyping, and long-term live imaging

scientific article

An evolutionarily conserved role for the aryl hydrocarbon receptor in the regulation of movement

scientific article

An unbiased silencing screen in muscle cells identifies miR-320a, miR-150, miR-196b, and miR-34c as regulators of skeletal muscle mitochondrial metabolism.

scientific article published on 31 August 2017

An update on the mechanisms of action of the peroxisome proliferator-activated receptors (PPARs) and their roles in inflammation and cancer

scientific article

Analysis of mtDNA/nDNA Ratio in Mice.

scientific article

Antibiotic use and abuse: a threat to mitochondria and chloroplasts with impact on research, health, and environment

scientific article

Apolipoprotein A-IV messenger ribonucleic acid abundance is regulated in a tissue-specific manner

scientific article published in April 1990

Attenuation of colon inflammation through activators of the retinoid X receptor (RXR)/peroxisome proliferator-activated receptor gamma (PPARgamma) heterodimer. A basis for new therapeutic strategies

scientific article

Automated longitudinal monitoring of in vivo protein aggregation in neurodegenerative disease C. elegans models

scientific article (publication date: 2016)

Autophagy defect is associated with low glucose-induced apoptosis in 661W photoreceptor cells

scientific article

Bayesian association scan reveals loci associated with human lifespan and linked biomarkers

scientific article

Bile acid binding resin improves metabolic control through the induction of energy expenditure

scientific article

Bile acids and the membrane bile acid receptor TGR5--connecting nutrition and metabolism

scientific article published on February 2008

Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation

scientific article

Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c

scientific article

Bioavailable copper modulates oxidative phosphorylation and growth of tumors

scientific article

C3, hormone-sensitive lipase, and peroxisome proliferator-activated receptor gamma expression in adipose tissue of familial combined hyperlipidemia patients

scientific article (publication date: May 2002)

CREB and ChREBP oppositely regulate SIRT1 expression in response to energy availability

scientific article (publication date: 30 September 2011)

Caloric restriction, SIRT1 and longevity

scientific article published on 25 August 2009

Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans

scientific article

Calorie Restriction: Is AMPK a Key Sensor and Effector? ⬇️

scientific article published on August 1, 2011

Cell biology. FGF21 takes a fat bite

scientific article published on May 2012

Changes in IgG Fc receptor expression induced by phorbol 12-myristate 13-acetate treatment of THP-1 monocytic leukemia cells

scientific article published in January 1992

Cholesterol metabolism modulators and the future of atherosclerosis therapy

scientific article

Clking on PGC-1alpha to inhibit gluconeogenesis

scientific article published on January 2010

Collection of blood and plasma from the mouse

scientific article published in August 2006

Compensation by the muscle limits the metabolic consequences of lipodystrophy in PPAR gamma hypomorphic mice

scientific article

Compromised intestinal lipid absorption in mice with a liver-specific deficiency of liver receptor homolog 1.

scientific article

Conjugated bile acids associate with altered rates of glucose and lipid oxidation after Roux-en-Y gastric bypass

scientific article published on September 2012

Coordinate regulation of the expression of the fatty acid transport protein and acyl-CoA synthetase genes by PPARalpha and PPARgamma activators

scientific article published on November 1997

Coupled and uncoupled induction of fos and jun transcription by different second messengers in cells of hematopoietic origin

scientific article published in January 1990

Cross-species functional modules link proteostasis to human normal aging

Cycle Sequencing on Large DNA Templates ⬇️

scientific article published on December 1, 1997

Cytosolic Proteostasis Networks of the Mitochondrial Stress Response

scientific article published on 31 May 2017

De novo NAD synthesis enhances mitochondrial function and improves health

scientific article published in Nature

Degradation of PHLPP2 by KCTD17, via a Glucagon-Dependent Pathway, Promotes Hepatic Steatosis

scientific article published on 28 August 2017

Deguelin exerts potent nematocidal activity via the mitochondrial respiratory chain

scientific article published on 7 July 2017

Deletion of Sirt3 does not affect atherosclerosis but accelerates weight gain and impairs rapid metabolic adaptation in LDL receptor knockout mice: implications for cardiovascular risk factor development

scientific article published on 27 December 2013

Dependence of hippocampal function on ERRγ-regulated mitochondrial metabolism

scientific article

Depot-Specific Differences in Adipose Tissue Gene Expression in Lean and Obese Subjects ⬇️

scientific article published on 01 January 1998

Development, food intake, and ethinylestradiol influence hepatic triglyceride lipase and LDL-receptor mRNA levels in rats.

scientific article published in July 1990

Developmental extinction of liver lipoprotein lipase mRNA expression might be regulated by an NF-1-like site

scientific article published on August 1993

Diet1 functions in the FGF15/19 enterohepatic signaling axis to modulate bile acid and lipid levels

scientific journal article

Differential regulation of peroxisome proliferator activated receptor gamma1 (PPARgamma1) and PPARgamma2 messenger RNA expression in the early stages of adipogenesis.

scientific article published on January 1999

DisSIRTing on LXR and cholesterol metabolism

scientific article published in November 2007

Down-regulation of hepatic lipase gene expression and activity by fenofibrate ⬇️

scientific article published on January 24, 1992

E2F transcription factor-1 regulates oxidative metabolism

scientific article published on 14 August 2011

E2Fs regulate adipocyte differentiation

scientific article published on July 2002

ERRγ Preserves Brown Fat Innate Thermogenic Activity.

scientific article published in March 2018

Editorial overview: Cell regulation: cell biology, fueling a renaissance in metabolism

scientific article published on 17 March 2015

Effective treatment of mitochondrial myopathy by nicotinamide riboside, a vitamin B3

scientific article

Effects of sex steroids on hepatic and lipoprotein lipase activity and mRNA in the rat.

scientific article published in January 1993

Eliciting the mitochondrial unfolded protein response by nicotinamide adenine dinucleotide repletion reverses fatty liver disease in mice

scientific article published on 24 September 2015

Emerging actions of the nuclear receptor LRH-1 in the gut ⬇️

scientific article published on December 29, 2010

Emerging roles of the corepressors NCoR1 and SMRT in homeostasis

scientific article published on April 2013

Endocrine functions of bile acids

scientific article

Enhanced bone formation in lipodystrophic PPARgamma(hyp/hyp) mice relocates haematopoiesis to the spleen

scientific article

Enhanced longevity and metabolism by brown adipose tissue with disruption of the regulator of G protein signaling 14.

scientific article published on 14 April 2018

Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity

scientific article published on 6 December 2017

Enoxacin induces oxidative metabolism and mitigates obesity by regulating adipose tissue miRNA expression

scientific article published on 02 December 2020

Eosinophils regulate adipose tissue inflammation and sustain physical and immunological fitness in old age

scientific article published on 06 July 2020

Erratum: Corrigendum: Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

scientific article published in Nature

Estrogen-related receptor-α (ERRα) deficiency in skeletal muscle impairs regeneration in response to injury

scientific article

Evaluation of energy homeostasis

scientific article

Evaluation of glucose homeostasis

scientific article published on January 2007

Evidence That the Apolipoprotein E-Genotype Effects on Lipid Levels Can Change with Age in Males: A Longitudinal Analysis ⬇️

scientific article published on July 1, 1997

Evidence for a direct effect of the NAD+ precursor acipimox on muscle mitochondrial function in humans

scientific article

Exploring the therapeutic space around NAD+.

scientific article

Expression and regulation of the lipoprotein lipase gene in human adrenal cortex

scientific article

Expression of the peroxisome proliferator-activated receptor gamma (PPARgamma) in human atherosclerosis and regulation in macrophages by colony stimulating factors and oxidized low density lipoprotein

scientific article published on June 1998

Farnesol stimulates differentiation in epidermal keratinocytes via PPARalpha

scientific article

Fibrates downregulate apolipoprotein C-III expression independent of induction of peroxisomal acyl coenzyme A oxidase. A potential mechanism for the hypolipidemic action of fibrates

scientific article

Fibrates increase human apolipoprotein A-II expression through activation of the peroxisome proliferator-activated receptor

scientific article published on August 1995

Fibrates influence the expression of genes involved in lipoprotein metabolism in a tissue-selective manner in the rat

scientific journal article

Genetic background determines metabolic phenotypes in the mouse

scientific article

Genetic cartography of longevity in humans and mice: Current landscape and horizons

scientific article published in February 2018

Genetic influences on age-related change in total cholesterol, low density lipoprotein-cholesterol, and triglyceride levels: longitudinal apolipoprotein E genotype effects

scientific article published in January 1994

Genetically altering organismal metabolism by leptin-deficiency benefits a mouse model of amyotrophic lateral sclerosis

scientific article

Glucocorticoids induce the expression of the leptin gene through a non-classical mechanism of transcriptional activation

scientific article

Glucose restriction: longevity SIRTainly, but without building muscle?

scientific article published in May 2008

Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis.

scientific article published on 16 December 2016

High level expression of PPARγ in differentiated colon epithelium

Histone methyl transferases and demethylases; can they link metabolism and transcription?

scientific article published on October 2010

Human peroxisome proliferator-activated receptor-gamma2: genetic mapping, identification of a variant in the coding sequence, and exclusion as the gene responsible for lipoatrophic diabetes ⬇️

scientific article published on 01 March 1998

Hypercalcemia: increasing diagnostic possibilities to cope with an increasing list of etiologies.

scientific article

Hypolipidemic effects of R103757, a potent stereoselective inhibitor of microsomal triglyceride transfer protein (MTP)

IL-13 attenuates gastrointestinal candidiasis in normal and immunodeficient RAG-2(-/-) mice via peroxisome proliferator-activated receptor-gamma activation

scientific article published in April 2008

Identification of the UBP1 locus as a critical blood pressure determinant using a combination of mouse and human genetics

scientific article

Identifying gene function and module connections by the integration of multispecies expression compendia

scientific article published on 21 November 2019

Imp2 controls oxidative phosphorylation and is crucial for preserving glioblastoma cancer stem cells

scientific article

Impact of the apolipoprotein E polymorphism, age and sex on neurogenesis in mice: pathophysiological relevance for Alzheimer's disease?

scientific article published on 16 October 2013

Impaired expression of peroxisome proliferator-activated receptor gamma in ulcerative colitis

scientific article published in May 2003

Impaired expression of the peroxisome proliferator-activated receptor alpha during hepatitis C virus infection.

scientific article published on February 2005

Impaired myogenesis in estrogen-related receptor γ (ERRγ)-deficient skeletal myocytes due to oxidative stress

scientific article

Impaired pancreatic growth, beta cell mass, and beta cell function in E2F1 (-/- )mice

scientific article published on May 2004

In vivo imaging reveals selective PPAR activity in the skin of peroxisome proliferator-activated receptor responsive element-luciferase reporter mice

scientific article published in February 2013

Increased Hepatic PDGF-AA Signaling Mediates Liver Insulin Resistance in Obesity Associated Type 2 Diabetes.

scientific article

Induction of LPL gene expression by sterols is mediated by a sterol regulatory element and is independent of the presence of multiple E boxes

scientific article

Induction of ob gene expression by corticosteroids is accompanied by body weight loss and reduced food intake

scientific article

Induction of plasminogen activator inhibitor 1 by the PPARα ligand, Wy-14,643, is dependent on ERK1/2 signaling pathway ⬇️

scientific article published on 01 October 2003

Induction of the acyl-coenzyme A synthetase gene by fibrates and fatty acids is mediated by a peroxisome proliferator response element in the C promoter

scientific article

Induction of the fatty acid transport protein 1 and acyl-CoA synthase genes by dimer-selective rexinoids suggests that the peroxisome proliferator-activated receptor-retinoid X receptor heterodimer is their molecular target

scientific article

Influence of development, estrogens, and food intake on apolipoprotein A-I, A-II, and E mRNA in rat liver and intestine

scientific journal article

Inhibiting poly ADP-ribosylation increases fatty acid oxidation and protects against fatty liver disease

scientific article published on 20 September 2016

Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle

scientific article published on March 2010

Interference between PARPs and SIRT1: a novel approach to healthy ageing?

scientific article

International Union of Pharmacology. LXI. Peroxisome proliferator-activated receptors

scientific article

Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia

scientific article published on 6 February 2017

Intestinal antiinflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator-activated receptor-gamma

scientific article

Is SIRT2 required for necroptosis?

scientific article published on February 2014

Joint mouse-human phenome-wide association to test gene function and disease risk

scientific article

KAT2B Is Required for Pancreatic Beta Cell Adaptation to Metabolic Stress by Controlling the Unfolded Protein Response

scientific article published on 20 April 2016

LRH-1-dependent glucose sensing determines intermediary metabolism in liver

scientific article

LRH-1-mediated glucocorticoid synthesis in enterocytes protects against inflammatory bowel disease

scholarly article

LRH-1: an orphan nuclear receptor involved in development, metabolism and steroidogenesis

scientific article

LRP1 controls intracellular cholesterol storage and fatty acid synthesis through modulation of Wnt signaling

scientific article

LRP1 functions as an atheroprotective integrator of TGFbeta and PDFG signals in the vascular wall: implications for Marfan syndrome

scientific article

Label-free three-dimensional imaging of Caenorhabditis elegans with visible optical coherence microscopy

scientific article published on 20 July 2017

Lecithin:cholesterol acyltransferase gene expression is regulated in a tissue-selective manner by fibrates.

scientific article published in May 1992

Leptin, a pleiotropic hormone: physiology, pharmacology, and strategies for discovery of leptin modulators

scientific article published in December 1998

Leptin: cutting the fat off the bone

scientific article published on November 2003

Ligand-dependent contribution of RXRbeta to cholesterol homeostasis in Sertoli cells.

scientific article

Lipid and bile acid analysis

scientific article published in August 2006

Lipoprotein lipase expression in undifferentiated hepatoma cells is regulated by progesterone and protein kinase A.

scientific article published on October 1992

Lipoprotein lipase: recent contributions from molecular biology

scientific article published on January 1992

Liver X receptors: Xcreting Xol to combat atherosclerosis

scientific article published in October 2002

Liver receptor homolog 1 contributes to intestinal tumor formation through effects on cell cycle and inflammation

scientific journal article

Liver receptor homolog 1 controls the expression of carboxyl ester lipase

scientific article

Liver receptor homolog 1 controls the expression of the scavenger receptor class B type I.

scientific article

Liver receptor homolog 1 is essential for ovulation

scientific article

Localization of the human OB gene (OBS) to chromosome 7q32 by fluorescence in situ hybridization

scientific article

Long noncoding RNA SNHG12 integrates a DNA-PK-mediated DNA damage response and vascular senescence

scientific article published on 01 February 2020

Loss of Sirt1 function improves intestinal anti-bacterial defense and protects from colitis-induced colorectal cancer

scientific article

Loss of the RNA polymerase III repressor MAF1 confers obesity resistance

scientific article published on May 2015

Lower cognitive performance in normal older adult male twins carrying the apolipoprotein E epsilon 4 allele

scientific article published in December 1994

Lowering bile acid pool size with a synthetic farnesoid X receptor (FXR) agonist induces obesity and diabetes through reduced energy expenditure

scientific article

Mature-onset obesity and insulin resistance in mice deficient in the signaling adapter p62.

scientific article

Mechanism of action of fibrates on lipid and lipoprotein metabolism

scientific article

Metabolic characterization of a Sirt5 deficient mouse model

scientific article published on 30 September 2013

Metabolic effects of rexinoids: tissue-specific regulation of lipoprotein lipase activity.

scientific article

Metabolic networks of longevity

scientific article published on July 2010

Metabolomics-assisted proteomics identifies succinylation and SIRT5 as important regulators of cardiac function

scientific article published on 5 April 2016

Mild endothelial dysfunction in Sirt3 knockout mice fed a high-cholesterol diet: protective role of a novel C/EBP-β-dependent feedback regulation of SOD2

scientific article published on 12 April 2016

Mild inborn errors of metabolism in commonly used inbred mouse strains

scientific article published on 24 January 2019

Mitocellular communication: Shaping health and disease

scientific article published on 14 November 2019

Mitochondria and Epigenetics - Crosstalk in Homeostasis and Stress

scientific article published on 5 March 2017

Mitochondrial function is impaired in the skeletal muscle of pre-frail elderly.

scientific article

Mitochondrial haplotypes affect metabolic phenotypes in the Drosophila Genetic Reference Panel

scientific article published on 09 December 2019

Mitochondrial sirtuins and metabolic homeostasis

scientific article published on 31 May 2012

Mitochondrion is the principal target for nutritional and pharmacological control of triglyceride metabolism ⬇️

scientific article published on 01 September 1997

Mitonuclear communication in homeostasis and stress

scientific article published on 9 March 2016

Mitonuclear protein imbalance as a conserved longevity mechanism

scientific article published on May 2013

Modulating NAD+ metabolism, from bench to bedside.

scientific article published on 7 August 2017

Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors

scientific article

Molecular field analysis and 3D-quantitative structure-activity relationship study (MFA 3D-QSAR) unveil novel features of bile acid recognition at TGR5.

scientific article published on 13 August 2008

Mouse functional genomics requires standardization of mouse handling and housing conditions

scientific article

Mouse phenogenomics: the fast track to "systems metabolism".

scientific article

Multilayered genetic and omics dissection of mitochondrial activity in a mouse reference population

scientific article

Multiprotein bridging factor-1 (MBF-1) is a cofactor for nuclear receptors that regulate lipid metabolism

scientific article

Murine gut microbiota is defined by host genetics and modulates variation of metabolic traits

scientific article

Muscle or liver-specific Sirt3 deficiency induces hyperacetylation of mitochondrial proteins without affecting global metabolic homeostasis

scientific article

NAD(+) Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus

scientific article published on 25 June 2015

NAD(+)-dependent activation of Sirt1 corrects the phenotype in a mouse model of mitochondrial disease

scientific article

NAD+ as a Signaling Molecule Modulating Metabolism ⬇️

scientific article published on January 1, 2011

NAD+ homeostasis in health and disease

scientific article published on 20 January 2020

NAD⁺ metabolism: a therapeutic target for age-related metabolic disease

scientific article published on 06 June 2013

NAD⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice

scientific article

NCoR repression of LXRs restricts macrophage biosynthesis of insulin-sensitizing omega 3 fatty acids

scientific article

NCoR1 is a conserved physiological modulator of muscle mass and oxidative function

scientific article

NCoR1 restrains thymic negative selection by repressing Bim expression to spare thymocytes undergoing positive selection.

scientific article published on 16 October 2017

NR5A2 regulates Lhb and Fshb transcription in gonadotrope-like cells in vitro, but is dispensable for gonadotropin synthesis and fertility in vivo

scientific article

Negative regulation of Jun/AP-1: conserved function of glycogen synthase kinase 3 and the Drosophila kinase shaggy

scientific article

Negative regulation of the human apolipoprotein A-I promoter by fibrates can be attenuated by the interaction of the peroxisome proliferator-activated receptor with its response element.

scientific article published on December 1994

Neonatal extinction of liver lipoprotein lipase expression

scientific article published in July 1992

New insights into apolipoprotein B and low density lipoprotein physiology; implications for atherosclerosis

scientific article

New insights into obesity genes

scientific article published on December 1996

Nongenomic actions of bile acids. Synthesis and preliminary characterization of 23- and 6,23-alkyl-substituted bile acid derivatives as selective modulators for the G-protein coupled receptor TGR5.

scientific article published on 9 August 2007

Novel potent and selective bile acid derivatives as TGR5 agonists: biological screening, structure-activity relationships, and molecular modeling studies

scientific article

Nuclear receptor corepressor 1 represses cardiac hypertrophy

scientific article published on 18 September 2019

Nuclear receptor/microRNA circuitry links muscle fiber type to energy metabolism

scientific article published on 8 May 2013

Nuclear receptors and the control of metabolism

scientific article

Nuclear receptors. I. PPAR gamma in the gastrointestinal tract: gain or pain?

scientific article

Obesity: New life for antidiabetic drugs

scientific article published on July 2010

Oncogenic steroid receptor coactivator-3 is a key regulator of the white adipogenic program

scholarly article

Opposite effects of statins on mitochondria of cardiac and skeletal muscles: a 'mitohormesis' mechanism involving reactive oxygen species and PGC-1.

scientific article

Opposite regulation of hepatic lipase and lecithin: cholesterol acyltransferase by glucocorticoids in rats

scientific journal article

Opposite regulation of human versus mouse apolipoprotein A-I by fibrates in human apolipoprotein A-I transgenic mice

scientific article published on June 1996

Overexpression of placental leptin in diabetic pregnancy: a critical role for insulin ⬇️

scientific article published on 01 May 1998

Oxidative stress and mitochondrial dynamics malfunction are linked in Pelizaeus-Merzbacher disease

scientific article

PARP inhibition protects against alcoholic and non-alcoholic steatohepatitis

scientific article

PARP-2 regulates SIRT1 expression and whole-body energy expenditure

scientific article

PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure

scientific article published on April 2009

PGC-1alpha: turbocharging mitochondria

scientific article published in October 2004

PHD3 Loss Promotes Exercise Capacity and Fat Oxidation in Skeletal Muscle

scientific article published on 09 July 2020

PON3 knockout mice are susceptible to obesity, gallstone formation, and atherosclerosis

scientific article

PPAR agonists in the treatment of atherosclerosis

scientific article

PPAR gamma/RXR alpha heterodimers are involved in human CG beta synthesis and human trophoblast differentiation

scientific article published in October 2001

PPAR(gamma) and glucose homeostasis

scientific article

PPAR-alpha effects on the heart and other vascular tissues

scientific article

PPAR-gamma: a thrifty transcription factor

scientific article

PPARalpha and PPARgamma activators direct a distinct tissue-specific transcriptional response via a PPRE in the lipoprotein lipase gene

scientific article

PPARalpha downregulates airway inflammation induced by lipopolysaccharide in the mouse

scientific article

PPARgamma activators improve glucose homeostasis by stimulating fatty acid uptake in the adipocytes

scientific article published in April 1998

PPARgamma controls cell proliferation and apoptosis in an RB-dependent manner

scientific article published on July 2003

PPARgamma in human and mouse physiology

scientific article

PPARgamma, an X-ceptor for Xs.

scientific article

PPARgamma/RXRalpha heterodimers control human trophoblast invasion

scientific article

PPARgamma3 mRNA: a distinct PPARgamma mRNA subtype transcribed from an independent promoter

scientific article published on October 1998

PPARβ/δ activation of CD300a controls intestinal immunity

scientific article

PPARδ Promotes Running Endurance by Preserving Glucose

scientific article (publication date: May 2017)

Pancreatic secretion in man with subclinical vitamin D deficiency

scientific article published in January 1986

Pancreatic-duodenal homeobox 1 regulates expression of liver receptor homolog 1 during pancreas development

scientific article

Peroxisome proliferator-activated receptor (PPAR)-beta/delta stimulates differentiation and lipid accumulation in keratinocytes

scientific article

Peroxisome proliferator-activated receptor gamma is induced during differentiation of colon epithelium cells.

scientific article

Peroxisome proliferator-activated receptor-alpha regulates lipid homeostasis, but is not associated with obesity: studies with congenic mouse lines

scientific article published on 8 August 2001

Peroxisome proliferator-activated receptor-gamma calls for activation in moderation: lessons from genetics and pharmacology

scientific article

Peroxisome proliferator-activated receptor-gamma: from adipogenesis to carcinogenesis

scientific article

Peroxisome proliferator-activated receptor-gamma: too much of a good thing causes harm

scientific article

Peroxisome proliferator-activated receptors alpha and gamma down-regulate allergic inflammation and eosinophil activation

scientific article

Peroxisome proliferator-activated receptors, orphans with ligands and functions

scientific article published on June 1997

Peroxisome proliterator-activated receptors, orphans with ligands and functions

Perturbation of developmental gene expression in rat liver by fibric acid derivatives: lipoprotein lipase and alpha-fetoprotein as models ⬇️

scientific article published on August 1, 1992

Pharmacological Inhibition of poly(ADP-ribose) polymerases improves fitness and mitochondrial function in skeletal muscle

scientific article

Pharmacological approaches to restore mitochondrial function

scientific article published on 13 May 2013

Phosphorylation of the nuclear receptor corepressor 1 by protein kinase B switches its corepressor targets in the liver in mice

scientific article

Pleiotropic effects of mitochondria in aging

scientific article published in 2022

Poly(ADP-ribose) polymerase-2 [corrected] controls adipocyte differentiation and adipose tissue function through the regulation of the activity of the retinoid X receptor/peroxisome proliferator-activated receptor-gamma [corrected] heterodimer

scientific article

Ppargamma2 is a key driver of longevity in the mouse

scientific article

Progesterone receptor knockout mice have an improved glucose homeostasis secondary to beta -cell proliferation

scientific article

Protective effects of sirtuins in cardiovascular diseases: from bench to bedside

scientific article

Protein acetylation in metabolism - metabolites and cofactors

scientific article

Protein deacetylation by SIRT1: an emerging key post-translational modification in metabolic regulation

scientific article published on 21 December 2009

Quantifying and Localizing the Mitochondrial Proteome Across Five Tissues in A Mouse Population

scientific article published on 26 June 2018

Redefining the TGR5 triterpenoid binding pocket at the C-3 position

scientific article published on December 2010

Regulation of PGC-1α, a nodal regulator of mitochondrial biogenesis

scientific article published on 02 February 2011

Regulation of adipocyte differentiation ⬇️

scientific article published on November 1, 2001

Regulation of apo A-I gene expression by fibrates ⬇️

scientific article published on April 1, 1998

Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β

scientific article by H. Cho et al., published in March 2012

Regulation of gene expression by activation of the peroxisome proliferator-activated receptor gamma with rosiglitazone (BRL 49653) in human adipocytes

scientific article

Regulation of ob gene expression in rodents and humans

scientific article

Regulation of peroxisome proliferator-activated receptor gamma expression by adipocyte differentiation and determination factor 1/sterol regulatory element binding protein 1: implications for adipocyte differentiation and metabolism

scientific article

Regulation of rat liver apolipoprotein A-I, apolipoprotein A-II and acyl-coenzyme A oxidase gene expression by fibrates and dietary fatty acids

scientific journal article

Regulation of steatohepatitis and PPARγ signaling by distinct AP-1 dimers

scientific article

Regulation of triglyceride metabolism by PPARs: fibrates and thiazolidinediones have distinct effects

scientific article published on January 1996

Relation between 25-hydroxyvitamin D3, apolipoprotein A-I, and high density lipoprotein cholesterol

scientific article published in June 1992

Reliability, robustness, and reproducibility in mouse behavioral phenotyping: a cross-laboratory study

scientific article

Repairing Mitochondrial Dysfunction in Disease

scientific article published on 27 September 2017

Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha

scientific article

Retinoids increase human apolipoprotein A-11 expression through activation of the retinoid X receptor but not the retinoic acid receptor

scientific article

Reversible acetylation of PGC-1: connecting energy sensors and effectors to guarantee metabolic flexibility

scientific article published on 07 June 2010

Reversible and long-term immobilization in a hydrogel-microbead matrix for high-resolution imaging of Caenorhabditis elegans and other small organisms.

scientific article published on 6 March 2018

Role of peroxisome proliferator-activated receptor alpha in epidermal development in utero

scientific journal article

Role of peroxisome proliferator-activated receptor gamma and retinoid X receptor heterodimer in hepatogastroenterological diseases

scientific article

Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression

scientific article

Récepteurs à la Provençale. EMBO workshop on the biology of nuclear receptors

scientific article published on 21 November 2003

SIRT1 mRNA expression may be associated with energy expenditure and insulin sensitivity

scientific article

SIRT1/PGC-1: a neuroprotective axis?

scientific article

SIRT2 deficiency modulates macrophage polarization and susceptibility to experimental colitis

scientific article

SRT1720 improves survival and healthspan of obese mice

scientific article

Scaffold attachment factor B1 directly interacts with nuclear receptors in living cells and represses transcriptional activity

scientific article published in December 2005

Selective cyclo-oxygenase-2 inhibitors impair adipocyte differentiation through inhibition of the clonal expansion phase

scientific article

Serum bile acids are higher in humans with prior gastric bypass: potential contribution to improved glucose and lipid metabolism

scientific article

Short term response of circulating leptin to feeding and fasting in man: influence of circadian cycle ⬇️

scientific article published on 01 August 1998

Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling

scientific article

Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase

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Sirtuin 2 Deficiency Increases Bacterial Phagocytosis by Macrophages and Protects from Chronic Staphylococcal Infection

scientific article published on 28 August 2017

Sirtuin functions in health and disease

scientific article

Sirtuins as regulators of metabolism and healthspan

scientific article

Sirtuins: the 'magnificent seven', function, metabolism and longevity

scientific article published on January 2007

Skeletal muscle enhancer interactions identify genes controlling whole-body metabolism

scientific article published on 01 June 2020

Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation

scientific article

Sterols and gene expression: control of affluence

scientific article

Stimulation of PPARalpha promotes epidermal keratinocyte differentiation in vivo

scientific article published on September 2000

Structure-activity relationship study of betulinic acid, a novel and selective TGR5 agonist, and its synthetic derivatives: potential impact in diabetes

scientific article published on January 2010

Studies of the common DIO2 Thr92Ala polymorphism and metabolic phenotypes in 7342 Danish white subjects

scientific article published on 31 October 2006

Study of a new PPARgamma2 promoter polymorphism and haplotype analysis in a French population

scientific article published on June 2005

Super-resolution biological microscopy using virtual imaging by a microsphere nanoscope

scientific article

Suppression of allergen-induced airway inflammation and immune response by the peroxisome proliferator-activated receptor-alpha agonist fenofibrate

scientific article

Synergy between LRH-1 and beta-catenin induces G1 cyclin-mediated cell proliferation

scientific article published on August 2004

Systems Phytohormone Responses to Mitochondrial Proteotoxic Stress

scientific article published in November 2017

Systems genetics of metabolism: the use of the BXD murine reference panel for multiscalar integration of traits

scientific article

Systems proteomics of liver mitochondria function

scientific article

TGR5 activation inhibits atherosclerosis by reducing macrophage inflammation and lipid loading

scientific article

TGR5 potentiates GLP-1 secretion in response to anionic exchange resins

scientific article

TGR5-mediated bile acid sensing controls glucose homeostasis

scientific article

Targeting bile-acid signalling for metabolic diseases

scientific article published on August 2008

Targeting sirtuin 1 to improve metabolism: all you need is NAD(+)?

scientific article

Targeting the TGR5-GLP-1 pathway to combat type 2 diabetes and non-alcoholic fatty liver disease

scientific article published on April 2010

Tetracycline antibiotics impair mitochondrial function and its experimental use confounds research

scientific article

Tetracyclines Disturb Mitochondrial Function across Eukaryotic Models: A Call for Caution in Biomedical Research

scientific article

The C-type lectin receptors dectin-1, MR, and SIGNR3 contribute both positively and negatively to the macrophage response to Leishmania infantum

scientific article

The Convergence of Systems and Reductionist Approaches in Complex Trait Analysis

scientific article

The Detection of Early Epigenetic Inheritance of Mitochondrial Stress in C. Elegans with a Microfluidic Phenotyping Platform

scientific article published on 17 December 2019

The European dimension for the mouse genome mutagenesis program

scientific article

The Movement Tracker: A Flexible System for Automated Movement Analysis in Invertebrate Model Organisms

scientific article

The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity

scientific article published on June 2012

The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

scientific article

The Pro12A1a substitution in the peroxisome proliferator activated receptor gamma 2 is associated with an insulin-sensitive phenotype in families with familial combined hyperlipidemia and in nondiabetic elderly subjects with dyslipidemia

scientific article published in August 2000

The Pro12Ala PPARgamma2 variant determines metabolism at the gene-environment interface

scientific article

The Sirt1 activator SRT3025 provides atheroprotection in Apoe-/- mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression

scientific article

The adipocyte specific transcription factor C/EBPalpha modulates human ob gene expression

scientific article

The bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammation

scientific article published on 9 December 2010

The bile acid membrane receptor TGR5: a valuable metabolic target

scientific article

The chromatin remodeling factor ISW-1 integrates organismal responses against nuclear and mitochondrial stress

scientific article published on 28 November 2017

The corepressor NCoR1 antagonizes PGC-1α and estrogen-related receptor α in the regulation of skeletal muscle function and oxidative metabolism

scientific article

The effects of fibrates and thiazolidinediones on plasma triglyceride metabolism are mediated by distinct peroxisome proliferator activated receptors (PPARs).

scientific article published on February 1997

The enterohepatic nuclear receptors are major regulators of the enterohepatic circulation of bile salts

scientific article

The expression of ob gene is not acutely regulated by insulin and fasting in human abdominal subcutaneous adipose tissue

scientific article published on July 1996

The expression of the p85alpha subunit of phosphatidylinositol 3-kinase is induced by activation of the peroxisome proliferator-activated receptor gamma in human adipocytes

scientific article

The generation of monoclonal antibodies against human peroxisome proliferator-activated receptors (PPARs).

scientific article published on January 2002

The genetic ablation of SRC-3 protects against obesity and improves insulin sensitivity by reducing the acetylation of PGC-1{alpha}.

scholarly article

The gut microbiota influences skeletal muscle mass and function in mice

scientific article published on 01 July 2019

The human fatty acid transport protein-1 (SLC27A1; FATP-1) cDNA and gene: organization, chromosomal localization, and expression

scientific article

The intestinal nuclear receptor signature with epithelial localization patterns and expression modulation in tumors.

scientific article

The journey of resveratrol from yeast to human

scientific article

The metabolic footprint of aging in mice

scientific article published on 31 October 2011

The mitochondrial unfolded protein response in mammalian physiology

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The mitochondrial unfolded protein response, a conserved stress response pathway with implications in health and disease

scientific article published on January 2014

The mitochondrial unfolded protein response—synchronizing genomes

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The mouse metallomic landscape of aging and metabolism

scientific article published on 01 February 2022

The mutant Asn291 → Ser human lipoprotein lipase is associated with reduced catalytic activity and does not influence binding to heparin ⬇️

scientific article published on July 3, 1995

The nuclear receptor corepressor NCoR1 regulates hematopoiesis and leukemogenesis in vivo

article published in 2019

The organization, promoter analysis, and expression of the human PPARgamma gene

scientific article (publication date: 25 July 1997)

The orphan nuclear receptor small heterodimer partner mediates male infertility induced by diethylstilbestrol in mice

scientific article

The peroxisome proliferator activated receptors (PPARS) and their effects on lipid metabolism and adipocyte differentiation

scientific article published on July 1996

The pleiotropic functions of peroxisome proliferator-activated receptor gamma

scientific article

The pollutant diethylhexyl phthalate regulates hepatic energy metabolism via species-specific PPARalpha-dependent mechanisms

scientific article

The retinoblastoma-histone deacetylase 3 complex inhibits PPARgamma and adipocyte differentiation

scientific article (publication date: December 2002)

The role of PPAR-gamma/RXR-alpha heterodimers in the regulation of human trophoblast invasion

scientific article

The role of mitochondria in stem cell fate and aging

scientific article published on 13 April 2018

The role of sirtuins in the control of metabolic homeostasis

scientific article published on September 2009

The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways

scientific article

The small heterodimer partner interacts with the liver X receptor alpha and represses its transcriptional activity

scientific article (publication date: September 2002)

The virtuous cycle of human genetics and mouse models in drug discovery

scientific article published on 01 April 2019

Thiazolidinediones repress ob gene expression in rodents via activation of peroxisome proliferator-activated receptor gamma

scientific article

Thiazolidinediones: an update.

scientific article

Tissue distribution and quantification of the expression of mRNAs of peroxisome proliferator-activated receptors and liver X receptor-alpha in humans: no alteration in adipose tissue of obese and NIDDM patients

scientific article

Tissue distribution and quantification of the expression of mRNAs of peroxisome proliferator-activated receptors and liver X receptor-alpha in humans: no alteration in adipose tissue of obese and NIDDM patients

article by D. Auboeuf et al published 1 August 1997 in Diabetes

Topical peroxisome proliferator activated receptor-alpha activators reduce inflammation in irritant and allergic contact dermatitis models

scientific article published in January 2002

Track C. Biomedical Instrumentation & Micro and Nano Systems

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Transcription factors and nuclear receptors interact with the SWI/SNF complex through the BAF60c subunit

scientific article

Transcription, adipocyte differentiation, and obesity

scientific article published on July 1996

Transcription, adipocyte differentiation, and obesity

scholarly article by Johan Auwerx et al published July 1996 in Journal of Molecular Medicine

Transcriptional activation of the lipoprotein lipase and apolipoprotein E genes accompanies differentiation in some human macrophage-like cell lines ⬇️

scientific article published on April 19, 1988

Transcriptional control of triglyceride metabolism: fibrates and fatty acids change the expression of the LPL and apo C-III genes by activating the nuclear receptor PPAR.

scientific article published on July 1996

Transcriptional coregulators in the control of energy homeostasis

scientific article published on May 2007

Transcriptional coregulators: fine-tuning metabolism

scientific article

Transcriptional induction of rat liver apolipoprotein A-I gene expression by glucocorticoids requires the glucocorticoid receptor and a labile cell-specific protein

scientific article published on July 1996

Transcriptional regulation of adipocyte formation by the liver receptor homologue 1 (Lrh1)-Small hetero-dimerization partner (Shp) network

scientific article published on 16 March 2013

Transcriptional regulation of apolipoprotein A-I gene expression by the nuclear receptor RORalpha

scientific article published on September 1997

Transcriptional targets of sirtuins in the coordination of mammalian physiology

scientific article published on 28 May 2008

Transient increase in obese gene expression after food intake or insulin administration

scientific article

Two Conserved Histone Demethylases Regulate Mitochondrial Stress-Induced Longevity

scientific article published on 27 April 2016

Two regulatory elements of similar structure and placed in tandem account for the repressive activity of the first intron of the human apolipoprotein A-II gene

scientific article published on September 1996

Type 5 adenylyl cyclase disruption leads to enhanced exercise performance

scientific article

Type 5 adenylyl cyclase increases oxidative stress by transcriptional regulation of manganese superoxide dismutase via the SIRT1/FoxO3a pathway

scientific article published on 27 March 2013

Urolithin A improves muscle function by inducing mitophagy in muscular dystrophy

scientific article published in 2021

Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents

scientific article

Uses of forward and reverse genetics in mice to study gene function

scientific article published in February 2006

Variable effects of different corticosteroids on plasma lipids, apolipoproteins, and hepatic apolipoprotein mRNA levels in rats

scientific journal article

Vitamin D and energy homeostasis: of mice and men.

scientific article

Xol INXS: role of the liver X and the farnesol X receptors

scientific article

eNAMPT actions through nucleus accumbens NAD<sup>+</sup>/SIRT1 link increased adiposity with sociability deficits programmed by peripuberty stress

scientific article published on 02 March 2022

mTOR complex 2 in adipose tissue negatively controls whole-body growth

scholarly article

p300 interacts with the N- and C-terminal part of PPARgamma2 in a ligand-independent and -dependent manner, respectively

scientific journal article

pRb, a switch between bone and brown fat.

scientific article published on September 2010

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