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List of works by Christophe Morisseau

1-Trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) Urea, a Selective and Potent Dual Inhibitor of Soluble Epoxide Hydrolase and p38 Kinase Intervenes in Alzheimer's Signaling in Human Nerve Cells

scientific article published on 19 August 2019

<i>N</i>-Benzyl-linoleamide, a Constituent of <i>Lepidium meyenii</i> (Maca), Is an Orally Bioavailable Soluble Epoxide Hydrolase Inhibitor That Alleviates Inflammatory Pain

scientific article published on 15 December 2020

A potent soluble epoxide hydrolase inhibitor, t-AUCB, acts through PPARγ to modulate the function of endothelial progenitor cells from patients with acute myocardial infarction ⬇️

scientific article published on April 21, 2012

Aberrant soluble epoxide hydrolase and oxylipin levels in a porcine arteriovenous graft stenosis model

scientific article

Alteration in plasma testosterone levels in male mice lacking soluble epoxide hydrolase

scientific article

Anti-Ulcer Efficacy of Soluble Epoxide Hydrolase Inhibitor TPPU on Diclofenac-Induced Intestinal Ulcers

scientific article

Autoantibody response to microsomal epoxide hydrolase in hepatitis C and A

scientific article

Cloning and characterization of a microsomal epoxide hydrolase from Heliothis virescens ⬇️

scientific article published on December 28, 2012

Compensatory mechanism for homeostatic blood pressure regulation in Ephx2 gene-disrupted mice

journal article published in 2007

Crystal structure of the cystic fibrosis transmembrane conductance regulator inhibitory factor Cif reveals novel active-site features of an epoxide hydrolase virulence factor

scientific article

Cyclooxygenase-derived proangiogenic metabolites of epoxyeicosatrienoic acids.

scientific article published on 10 April 2017

Development of 1-((1,4-trans)-4-Aryloxycyclohexyl)-3-arylurea Activators of Heme-Regulated Inhibitor as Selective Activators of the Eukaryotic Initiation Factor 2 Alpha (eIF2α) Phosphorylation Arm of the Integrated Endoplasmic Reticulum Stress Respo

scientific article published on 19 June 2017

Development of an HTS assay for EPHX2 phosphatase activity and screening of nontargeted libraries

scientific article

Development of fluorescent substrates for microsomal epoxide hydrolase and application to inhibition studies

scientific article

Discovery of Soluble Epoxide Hydrolase Inhibitors from Chemical Synthesis and Natural Products

scientific article published on 28 December 2020

Discovery of the First in Vivo Active Inhibitors of the Soluble Epoxide Hydrolase Phosphatase Domain

scientific article published on 17 September 2019

Effect of soluble epoxide hydrolase polymorphism on substrate and inhibitor selectivity and dimer formation

scientific article

Epoxide hydrolases: mechanisms, inhibitor designs, and biological roles

scientific article (publication date: 2005)

Epoxide hydrolases: their roles and interactions with lipid metabolism

scientific article (publication date: 2005)

Epoxide metabolites of arachidonate and docosahexaenoate function conversely in acute kidney injury involved in GSK3β signaling.

scientific article published on 6 November 2017

Expression and characterization of the recombinant juvenile hormone epoxide hydrolase (JHEH) from Manduca sexta ⬇️

scientific article published on May 1, 1998

Expression and regulation of soluble epoxide hydrolase in adipose tissue

scientific article

Heavy chain single-domain antibodies to detect native human soluble epoxide hydrolase

scientific article

Impact of soluble epoxide hydrolase and epoxyeicosanoids on human health

scientific article

Improvement of endothelium-dependent vasodilations by SKA-31 and SKA-20, activators of small- and intermediate-conductance Ca2+-activated K+-channels ⬇️

scientific article published on March 1, 2011

Incorporation of Piperazino Functionality into 1,3-Disubstituted Urea as the Tertiary Pharmacophore Affording Potent Inhibitors of Soluble Epoxide Hydrolase with Improved Pharmacokinetic Properties ⬇️

scientific article published on November 11, 2010

Inhibition of soluble epoxide hydrolase by fulvestrant and sulfoxides

scientific article

Inhibition of soluble epoxide hydrolase contributes to the anti-inflammatory effect of antimicrobial triclocarban in a murine model

scientific article

Inhibition of soluble epoxide hydrolase does not protect against endotoxin-mediated hepatic inflammation

scientific article

Investigation of human exposure to triclocarban after showering and preliminary evaluation of its biological effects

journal article published in 2011

Lipid sulfates and sulfonates are allosteric competitive inhibitors of the N-terminal phosphatase activity of the mammalian soluble epoxide hydrolase

scientific article

Mechanism of Mammalian Soluble Epoxide Hydrolase Inhibition by Chalcone Oxide Derivatives ⬇️

scientific article published on August 15, 1998

Method for sorting and pairwise selection of nanobodies for the development of highly sensitive sandwich immunoassays

journal article published in 2015

Monoclonal antibodies reveal multiple forms of expression of human microsomal epoxide hydrolase ⬇️

scientific article published on January 28, 2012

Nanobody Based Immunoassay for Human Soluble Epoxide Hydrolase Detection Using Polymeric Horseradish Peroxidase (PolyHRP) for Signal Enhancement: The Rediscovery of PolyHRP?

scientific article published on 10 May 2017

Novel and highly sensitive fluorescent assay for leucine aminopeptidases

scientific article

Occurrence of urea-based soluble epoxide hydrolase inhibitors from the plants in the order Brassicales

scientific article

Omeprazole increases the efficacy of a soluble epoxide hydrolase inhibitor in a PGE₂ induced pain model

scientific article

Optimized inhibitors of soluble epoxide hydrolase improve in vitro target residence time and in vivo efficacy

scientific article

Oral treatment of rodents with soluble epoxide hydrolase inhibitor 1-(1-propanoylpiperidin-4-yl)-3-[4-(trifluoromethoxy)phenyl]urea (TPPU): Resulting drug levels and modulation of oxylipin pattern

scientific article

Orally Available Soluble Epoxide Hydrolase/Phosphodiesterase 4 Dual Inhibitor Treats Inflammatory Pain

scientific article published on 3 April 2018

Parabens inhibit fatty acid amide hydrolase: A potential role in paraben-enhanced 3T3-L1 adipocyte differentiation

scientific article

Peripheral FAAH and soluble epoxide hydrolase inhibitors are synergistically antinociceptive

scientific article

Pharmacokinetic optimization of four soluble epoxide hydrolase inhibitors for use in a murine model of inflammation

scientific article

Pharmacokinetic screening of soluble epoxide hydrolase inhibitors in dogs

scientific article

Pharmacological inhibition of soluble epoxide hydrolase ameliorates diet-induced metabolic syndrome in rats

scientific article

Potent natural soluble epoxide hydrolase inhibitors from Pentadiplandra brazzeana baillon: synthesis, quantification, and measurement of biological activities in vitro and in vivo

scientific article

Rational Design of Potent and Selective Inhibitors of an Epoxide Hydrolase Virulence Factor from Pseudomonas aeruginosa

scientific article

Redox regulation of soluble epoxide hydrolase by 15-deoxy-delta-prostaglandin J2 controls coronary hypoxic vasodilation

scientific article

Role of epoxide hydrolases in lipid metabolism ⬇️

scientific article published on June 18, 2012

Role of soluble epoxide hydrolase phosphatase activity in the metabolism of lysophosphatidic acids ⬇️

scientific article published on February 24, 2012

Soluble epoxide hydrolase expression in a porcine model of arteriovenous graft stenosis and anti-inflammatory effects of a soluble epoxide hydrolase inhibitor

scientific article

Soluble epoxide hydrolase in the generation and maintenance of high blood pressure in spontaneously hypertensive rats ⬇️

scientific article published on January 25, 2011

Soluble epoxide hydrolase inhibitor, TPPU, increases regulatory T cells pathway in an arthritis model

scientific article published on 13 May 2020

Soluble epoxide hydrolase: a novel therapeutic target in stroke

scientific article

Structure of human epoxide hydrolase reveals mechanistic inferences on bifunctional catalysis in epoxide and phosphate ester hydrolysis

scientific article

Synthesis and structure–activity relationship of piperidine-derived non-urea soluble epoxide hydrolase inhibitors

scientific article

The molecular structure of epoxide hydrolase B from Mycobacterium tuberculosis and its complex with a urea-based inhibitor

scientific article

The soluble epoxide hydrolase encoded by EPXH2 is a bifunctional enzyme with novel lipid phosphate phosphatase activity

scientific article

Toxicology in the fast lane: application of high-throughput bioassays to detect modulation of key enzymes and receptors

journal article published in 2009

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