List of works - Patrik Verstreken

A Parkinson disease modifier screen identifies dominant suppressors that rescue pink1 associated mitochondrial defects

scholarly article by Melissa Vos⁎ & Patrik Verstreken published July 2011 in Mitochondrion

A Single-Cell Transcriptome Atlas of the Aging Drosophila Brain

article by Kristofer Davie et al published 9 August 2018 in Cell

A genome-wide search for synaptic vesicle cycle proteins in Drosophila

scientific article published in April 2000

A single-cell catalogue of regulatory states in the ageing Drosophila brain

Aberrant lysosomal carbohydrate storage accompanies endocytic defects and neurodegeneration in Drosophila benchwarmer

scientific article

Aconitase causes iron toxicity in Drosophila pink1 mutants

scientific article

Activity-independent prespecification of synaptic partners in the visual map of Drosophila

scientific article published on September 2006

Alternative oxidase rescues mitochondria-mediated dopaminergic cell loss in Drosophila.

scientific article published on 7 March 2012

Autophagy in the presynaptic compartment in health and disease

scientific article

CEP89 is required for mitochondrial metabolism and neuronal function in man and fly.

scientific article published on 10 April 2013

Chaperoning the synapse--NMNAT protects Bruchpilot from crashing

scientific article published on 30 November 2012

Chronological requirements of TDP-43 function in synaptic organization and locomotive control

scientific article published in August 2014

Conditional depletion of intellectual disability and Parkinsonism candidate gene ATP6AP2 in fly and mouse induces cognitive impairment and neurodegeneration

scientific article

Conditional mutagenesis in Drosophila

scientific article

Construction and Expression of Tetracysteine-Tagged Proteins for FlAsH-FALI

Correction: Ubiquitin Ligase HUWE1 Regulates Axon Branching through the Wnt/β-Catenin Pathway in a Drosophila Model for Intellectual Disability.

scientific article published on 3 January 2014

Dap160/intersectin acts as a stabilizing scaffold required for synaptic development and vesicle endocytosis

scientific article published in July 2004

De novo loss-of-function mutations in WAC cause a recognizable intellectual disability syndrome and learning deficits in Drosophila

scientific article

Development of an enzyme-linked immunosorbent assay for detection of cellular and in vivo LRRK2 S935 phosphorylation

scientific article published on 16 December 2012

Directing traffic into the future

scientific article

Drosophila NMNAT maintains neural integrity independent of its NAD synthesis activity

scientific article published in November 2006

Drosophila fragile X protein, DFXR, regulates neuronal morphology and function in the brain

scientific article published in June 2002

Drosophila parkin mutants have decreased mass and cell size and increased sensitivity to oxygen radical stress

scientific article published on 8 April 2004

Drosophila rugose is a functional homolog of mammalian Neurobeachin and affects synaptic architecture, brain morphology, and associative learning.

scientific article

Drosophila transgenic RNAi screen of genes implicated in human neurological disease

article

Dynamin photoinactivation blocks Clathrin and α-adaptin recruitment and induces bulk membrane retrieval

scientific article

ELP3 controls active zone morphology by acetylating the ELKS family member Bruchpilot

scientific article

Endophilin mutations block clathrin-mediated endocytosis but not neurotransmitter release

scientific article (publication date: 5 April 2002)

Endophilin promotes a late step in endocytosis at glial invaginations in Drosophila photoreceptor terminals.

scientific article published in November 2003

Erratum: In vivo single-molecule imaging of syntaxin1A reveals polyphosphoinositide- and activity-dependent trapping in presynaptic nanoclusters

scientific article published on 9 February 2017

FM 1-43 labeling of synaptic vesicle pools at the Drosophila neuromuscular junction

scientific article published on January 2008

Fast and efficient Drosophila melanogaster gene knock-ins using MiMIC transposons

scientific article published on 8 October 2014

FlAsH-FALI inactivation of a protein at the third-instar neuromuscular junction.

scientific article published in April 2011

Flies with Parkinson's disease

scientific article

HDAC6 is a Bruchpilot deacetylase that facilitates neurotransmitter release

scientific article published on 26 June 2014

Human intellectual disability genes form conserved functional modules in Drosophila.

scientific article

Huntingtin-interacting protein 14, a palmitoyl transferase required for exocytosis and targeting of CSP to synaptic vesicles

scientific article published on 24 December 2007

Impaired Autonomic Regulation of Resistance Arteries in Mice With Low Vascular Endothelial Growth Factor or Upon Vascular Endothelial Growth Factor Trap Delivery

scientific article published on 06 July 2010

In Vivo Single-Molecule Tracking at the Drosophila Presynaptic Motor Nerve Terminal

scientific article

In vivo single-molecule imaging of syntaxin1A reveals polyphosphoinositide- and activity-dependent trapping in presynaptic nanoclusters

scientific article

Inactivation of clathrin heavy chain inhibits synaptic recycling but allows bulk membrane uptake

scientific article published on September 2008

LRRK2 controls an EndoA phosphorylation cycle in synaptic endocytosis

scientific article

LRRK2 functions in synaptic vesicle endocytosis through a kinase-dependent mechanism

scientific article

Loss of Bin1 Promotes the Propagation of Tau Pathology

scientific article published in October 2016

Loss of skywalker reveals synaptic endosomes as sorting stations for synaptic vesicle proteins

scientific article

Mapping Drosophila mutations with molecularly defined P element insertions

scientific article

Meaningless minis? Mechanisms of neurotransmitter-receptor clustering

scientific article

Membrane Lipids in Presynaptic Function and Disease

scientific article published on April 2016

Metabolic channeling of carbamoyl phosphate, a thermolabile intermediate: evidence for physical interaction between carbamate kinase-like carbamoyl-phosphate synthetase and ornithine carbamoyltransferase from the hyperthermophile Pyrococcus furiosus

scientific article published on 13 March 2002

Mitochondria at the synapse

scientific article published on August 2006

Mutations in Drosophila sec15 reveal a function in neuronal targeting for a subset of exocyst components

scientific article published in April 2005

Mutations in the intellectual disability gene Ube2a cause neuronal dysfunction and impair parkin-dependent mitophagy

scientific article published on 16 May 2013

Near-infrared 808 nm light boosts complex IV-dependent respiration and rescues a Parkinson-related pink1 model

scientific article (publication date: 2013)

Neurons eat glutamate to stay alive

scientific article published on 15 March 2017

Neurons generated from APP/APLP1/APLP2 triple knockout embryonic stem cells behave normally in vitro and in vivo: lack of evidence for a cell autonomous role of the amyloid precursor protein in neuronal differentiation

scientific article published in March 2010

Neuroscience. The meaning of a mini

scientific article published in July 2001

New approaches for studying synaptic development, function, and plasticity using Drosophila as a model system

scientific article

P1-457: Neuronal differentiation of APP/APLP1/APLP2 triple knockout (tKO) embryonic stem (ES) cells

PINK1 loss-of-function mutations affect mitochondrial complex I activity via NdufA10 ubiquinone uncoupling

scientific journal article

PIWIL1 protein power targets tau therapy

scientific article published on 01 March 2014

Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function

scientific article

Parkinson's disease: convergence on synaptic homeostasis

scientific article published on 31 July 2018

Phosphoinositides at the neuromuscular junction of Drosophila melanogaster: a genetic approach

scientific article published on January 2012

Presynaptic protein homeostasis and neuronal function

scientific article published on 14 February 2017

Recombineering-mediated tagging of Drosophila genomic constructs for in vivo localization and acute protein inactivation

scientific article published on August 2008

Reduced synaptic vesicle protein degradation at lysosomes curbs TBC1D24/sky-induced neurodegeneration

scientific article

Shar-pei mediates cell proliferation arrest during imaginal disc growth in Drosophila

scientific article published in December 2002

Shawn, the Drosophila Homolog of SLC25A39/40, Is a Mitochondrial Carrier That Promotes Neuronal Survival.

scientific article

Skywalker-TBC1D24 has a lipid-binding pocket mutated in epilepsy and required for synaptic function

scientific article

Stimulation of electron transport as potential novel therapy in Parkinson's disease with mitochondrial dysfunction

scientific article published on April 2015

Studying Synaptic Transmission at the Drosophila Neuromuscular Junction Using Advanced FM 1-43 Technology

article

Sub-diffraction imaging on standard microscopes through photobleaching microscopy with non-linear processing

article by Sebastian Munck et al published 22 February 2012 in Journal of Cell Science

Suppression of neurodegeneration and increased neurotransmission caused by expanded full-length huntingtin accumulating in the cytoplasm

scientific article published on January 2008

Synaptic PI(3,4,5)P3 is required for Syntaxin1A clustering and neurotransmitter release

scientific article published in March 2013

Synaptic Vesicle Endocytosis

Synaptic mitochondria are critical for mobilization of reserve pool vesicles at Drosophila neuromuscular junctions

scientific article (publication date: 4 August 2005)

Synaptic mitochondria in synaptic transmission and organization of vesicle pools in health and disease

scientific article

Synaptic vesicle retrieval: still time for a kiss

scientific article published in November 2002

Synaptic vesicle trafficking and Parkinson's disease

scientific article

Synaptogyrin-3 Mediates Presynaptic Dysfunction Induced by Tau.

scientific article published on 31 January 2018

Synaptojanin is recruited by endophilin to promote synaptic vesicle uncoating

scientific article (publication date: 13 November 2003)

Tau association with synaptic vesicles causes presynaptic dysfunction

scientific article

The SAC1 domain in synaptojanin is required for autophagosome maturation at presynaptic terminals

scientific article published on 22 March 2017

The deubiquitinase USP15 antagonizes Parkin-mediated mitochondrial ubiquitination and mitophagy

scientific article

The v-ATPase V0 subunit a1 is required for a late step in synaptic vesicle exocytosis in Drosophila.

scientific article

The yeast complex I equivalent NADH dehydrogenase rescues pink1 mutants

scientific article (publication date: 2012)

Therapeutic strategies in Parkinson's disease: what we have learned from animal models

scientific article

Torsin and NEP1R1-CTDNEP1 phosphatase affect interphase nuclear pore complex insertion by lipid-dependent and lipid-independent mechanisms

scientific article published on 27 July 2021

Trapping of Syntaxin1a in Presynaptic Nanoclusters by a Clinically Relevant General Anesthetic

scientific article published in January 2018

Tweek, an evolutionarily conserved protein, is required for synaptic vesicle recycling

scientific article published on July 2009

Ubiquitin ligase HUWE1 regulates axon branching through the Wnt/β-catenin pathway in a Drosophila model for intellectual disability

scientific article

Ultrafast Synaptic Endocytosis Cycles to the Center Stage

Variants of the elongator protein 3 (ELP3) gene are associated with motor neuron degeneration

scientific article

Vitamin K2 is a mitochondrial electron carrier that rescues pink1 deficiency

scientific article

WASP is activated by phosphatidylinositol-4,5-bisphosphate to restrict synapse growth in a pathway parallel to bone morphogenetic protein signaling

scientific article

straightjacket is required for the synaptic stabilization of cacophony, a voltage-gated calcium channel alpha1 subunit

scientific article published on April 2008

List of works by Patrik Verstreken

A Parkinson disease modifier screen identifies dominant suppressors that rescue pink1 associated mitochondrial defects

A Single-Cell Transcriptome Atlas of the Aging Drosophila Brain

A genome-wide search for synaptic vesicle cycle proteins in Drosophila

A single-cell catalogue of regulatory states in the ageing Drosophila brain

Aberrant lysosomal carbohydrate storage accompanies endocytic defects and neurodegeneration in Drosophila benchwarmer

Aconitase causes iron toxicity in Drosophila pink1 mutants

Activity-independent prespecification of synaptic partners in the visual map of Drosophila

Alternative oxidase rescues mitochondria-mediated dopaminergic cell loss in Drosophila.

Autophagy in the presynaptic compartment in health and disease

CEP89 is required for mitochondrial metabolism and neuronal function in man and fly.

Chaperoning the synapse--NMNAT protects Bruchpilot from crashing

Chronological requirements of TDP-43 function in synaptic organization and locomotive control

Conditional depletion of intellectual disability and Parkinsonism candidate gene ATP6AP2 in fly and mouse induces cognitive impairment and neurodegeneration

Conditional mutagenesis in Drosophila

Construction and Expression of Tetracysteine-Tagged Proteins for FlAsH-FALI

Correction: Ubiquitin Ligase HUWE1 Regulates Axon Branching through the Wnt/β-Catenin Pathway in a Drosophila Model for Intellectual Disability.

Dap160/intersectin acts as a stabilizing scaffold required for synaptic development and vesicle endocytosis

De novo loss-of-function mutations in WAC cause a recognizable intellectual disability syndrome and learning deficits in Drosophila

Development of an enzyme-linked immunosorbent assay for detection of cellular and in vivo LRRK2 S935 phosphorylation

Directing traffic into the future

Drosophila NMNAT maintains neural integrity independent of its NAD synthesis activity

Drosophila fragile X protein, DFXR, regulates neuronal morphology and function in the brain

Drosophila parkin mutants have decreased mass and cell size and increased sensitivity to oxygen radical stress

Drosophila rugose is a functional homolog of mammalian Neurobeachin and affects synaptic architecture, brain morphology, and associative learning.

Drosophila transgenic RNAi screen of genes implicated in human neurological disease

Dynamin photoinactivation blocks Clathrin and α-adaptin recruitment and induces bulk membrane retrieval

ELP3 controls active zone morphology by acetylating the ELKS family member Bruchpilot

Endophilin mutations block clathrin-mediated endocytosis but not neurotransmitter release

Endophilin promotes a late step in endocytosis at glial invaginations in Drosophila photoreceptor terminals.

Erratum: In vivo single-molecule imaging of syntaxin1A reveals polyphosphoinositide- and activity-dependent trapping in presynaptic nanoclusters

FM 1-43 labeling of synaptic vesicle pools at the Drosophila neuromuscular junction

Fast and efficient Drosophila melanogaster gene knock-ins using MiMIC transposons

FlAsH-FALI inactivation of a protein at the third-instar neuromuscular junction.

Flies with Parkinson's disease

HDAC6 is a Bruchpilot deacetylase that facilitates neurotransmitter release

Human intellectual disability genes form conserved functional modules in Drosophila.

Huntingtin-interacting protein 14, a palmitoyl transferase required for exocytosis and targeting of CSP to synaptic vesicles

Impaired Autonomic Regulation of Resistance Arteries in Mice With Low Vascular Endothelial Growth Factor or Upon Vascular Endothelial Growth Factor Trap Delivery

In Vivo Single-Molecule Tracking at the Drosophila Presynaptic Motor Nerve Terminal

In vivo single-molecule imaging of syntaxin1A reveals polyphosphoinositide- and activity-dependent trapping in presynaptic nanoclusters

Inactivation of clathrin heavy chain inhibits synaptic recycling but allows bulk membrane uptake

LRRK2 controls an EndoA phosphorylation cycle in synaptic endocytosis

LRRK2 functions in synaptic vesicle endocytosis through a kinase-dependent mechanism

Loss of Bin1 Promotes the Propagation of Tau Pathology

Loss of skywalker reveals synaptic endosomes as sorting stations for synaptic vesicle proteins

Mapping Drosophila mutations with molecularly defined P element insertions

Meaningless minis? Mechanisms of neurotransmitter-receptor clustering

Membrane Lipids in Presynaptic Function and Disease

Metabolic channeling of carbamoyl phosphate, a thermolabile intermediate: evidence for physical interaction between carbamate kinase-like carbamoyl-phosphate synthetase and ornithine carbamoyltransferase from the hyperthermophile Pyrococcus furiosus

Mitochondria at the synapse

Mutations in Drosophila sec15 reveal a function in neuronal targeting for a subset of exocyst components

Mutations in the intellectual disability gene Ube2a cause neuronal dysfunction and impair parkin-dependent mitophagy

Near-infrared 808 nm light boosts complex IV-dependent respiration and rescues a Parkinson-related pink1 model

Neurons eat glutamate to stay alive

Neurons generated from APP/APLP1/APLP2 triple knockout embryonic stem cells behave normally in vitro and in vivo: lack of evidence for a cell autonomous role of the amyloid precursor protein in neuronal differentiation

Neuroscience. The meaning of a mini

New approaches for studying synaptic development, function, and plasticity using Drosophila as a model system

P1-457: Neuronal differentiation of APP/APLP1/APLP2 triple knockout (tKO) embryonic stem (ES) cells

PINK1 loss-of-function mutations affect mitochondrial complex I activity via NdufA10 ubiquinone uncoupling

PIWIL1 protein power targets tau therapy

Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function

Parkinson's disease: convergence on synaptic homeostasis

Phosphoinositides at the neuromuscular junction of Drosophila melanogaster: a genetic approach

Presynaptic protein homeostasis and neuronal function

Recombineering-mediated tagging of Drosophila genomic constructs for in vivo localization and acute protein inactivation

Reduced synaptic vesicle protein degradation at lysosomes curbs TBC1D24/sky-induced neurodegeneration

Shar-pei mediates cell proliferation arrest during imaginal disc growth in Drosophila

Shawn, the Drosophila Homolog of SLC25A39/40, Is a Mitochondrial Carrier That Promotes Neuronal Survival.

Skywalker-TBC1D24 has a lipid-binding pocket mutated in epilepsy and required for synaptic function

Stimulation of electron transport as potential novel therapy in Parkinson's disease with mitochondrial dysfunction

Studying Synaptic Transmission at the Drosophila Neuromuscular Junction Using Advanced FM 1-43 Technology

Sub-diffraction imaging on standard microscopes through photobleaching microscopy with non-linear processing

Suppression of neurodegeneration and increased neurotransmission caused by expanded full-length huntingtin accumulating in the cytoplasm

Synaptic PI(3,4,5)P3 is required for Syntaxin1A clustering and neurotransmitter release

Synaptic Vesicle Endocytosis

Synaptic mitochondria are critical for mobilization of reserve pool vesicles at Drosophila neuromuscular junctions

Synaptic mitochondria in synaptic transmission and organization of vesicle pools in health and disease

Synaptic vesicle retrieval: still time for a kiss

Synaptic vesicle trafficking and Parkinson's disease