Search filters

List of works by Ivelin S. Georgiev

A Cysteine Zipper Stabilizes a Pre-Fusion F Glycoprotein Vaccine for Respiratory Syncytial Virus

scientific article (publication date: 2015)

A Neutralizing Antibody Recognizing Primarily N-Linked Glycan Targets the Silent Face of the HIV Envelope.

scientific article published on 7 March 2018

A critical analysis of computational protein design with sparse residue interaction graphs

scientific article

A short segment in the HIV-1 gp120 V1/V2 region is a major determinant of neutralization resistance to PG9-like antibodies.

scientific article published on 13 September 2012

A short segment of the HIV-1 gp120 V1/V2 region is a major determinant of resistance to V1/V2 neutralizing antibodies

scientific article

Activation and lysis of human CD4 cells latently infected with HIV-1

scientific article

Adipose Tissue is Enriched for Activated and Late-Differentiated CD8+ T Cells and Shows Distinct CD8+ Receptor Usage, Compared With Blood in HIV-Infected Persons

scientific article

Algorithm for backrub motions in protein design

scientific article published on July 2008

Antibacterial photosensitization through activation of coproporphyrinogen oxidase.

scientific article

Antibodies VRC01 and 10E8 neutralize HIV-1 with high breadth and potency even with Ig-framework regions substantially reverted to germline

scientific article

Antibodyomics: bioinformatics technologies for understanding B-cell immunity to HIV-1.

scientific article published in January 2017

Author Correction: Mosaic nanoparticle display of diverse influenza virus hemagglutinins elicits broad B cell responses

scientific article published on 01 June 2019

BWM*: A Novel, Provable, Ensemble-based Dynamic Programming Algorithm for Sparse Approximations of Computational Protein Design

scientific article published on 08 January 2016

Bispecific Antibodies Targeting Different Epitopes on the HIV-1 Envelope Exhibit Broad and Potent Neutralization.

scientific article

Broad and Potent Neutralizing Antibodies Recognize the Silent Face of the HIV Envelope

scientific article published on 21 May 2019

Broad and potent HIV-1 neutralization by a human antibody that binds the gp41-gp120 interface

scientific article

Broad and potent neutralizing antibody responses elicited in natural HIV-2 infection

scientific article

Broadly Neutralizing Human Immunodeficiency Virus Type 1 Antibody Gene Transfer Protects Nonhuman Primates from Mucosal Simian-Human Immunodeficiency Virus Infection

scientific article published on 3 June 2015

Broadly neutralizing antibodies targeting the HIV-1 envelope V2 apex confer protection against a clade C SHIV challenge

scientific article published on September 2017

CD4-binding-Site Recognition by VH1-46 Germline-derived HIV-1 Neutralizers.

scientific article published in October 2014

Characteristics of HIV-1 gp120 molecules that bind ancestor, intermediate and mature forms of VRC01-like antibodies

article

Characterization of broadly neutralizing antibody responses to HIV-1 in a cohort of long term non-progressors.

scientific article

Comprehensive sieve analysis of breakthrough HIV-1 sequences in the RV144 vaccine efficacy trial

scientific article

Computational prediction of N-linked glycosylation incorporating structural properties and patterns ⬇️

scientific article published on July 10, 2012

Computational structure-based redesign of enzyme activity

scholarly article

Correction for Acharya et al., Heavy Chain-Only IgG2b Llama Antibody Effects Near-Pan HIV-1 Neutralization by Recognizing a CD4-Induced Epitope That Includes Elements of Coreceptor- and CD4-Binding Sites

article

Cross-reactive coronavirus antibodies with diverse epitope specificities and extra-neutralization functions

scientific article published on 20 December 2020

Crystal Structure and Immunogenicity of the DS-Cav1-Stabilized Fusion Glycoprotein From Respiratory Syncytial Virus Subtype B

scientific article published on 11 December 2019

Crystal Structures of GII.10 and GII.12 Norovirus Protruding Domains in Complex with Histo-Blood Group Antigens Reveal Details for a Potential Site of Vulnerability

scientific article

Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env

scientific article

Dead-end elimination with backbone flexibility

scientific article

Delineating antibody recognition in polyclonal sera from patterns of HIV-1 isolate neutralization

scientific article

Design of epitope-specific probes for sera analysis and antibody isolation

scientific article (publication date: 2012)

Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies

scientific article

Early low-titer neutralizing antibodies impede HIV-1 replication and select for virus escape

scientific article

Elicitation of HIV-1-neutralizing antibodies against the CD4-binding site.

scientific article

Eliminating antibody polyreactivity through addition of N-linked glycosylation

scientific article published on 12 May 2015

Enhanced potency of a broadly neutralizing HIV-1 antibody in vitro improves protection against lentiviral infection in vivo

scientific article

Enhancing the Solubility of HIV-1-neutralizing Antibody 10E8.

scientific article published in October 2014

Envelope characteristics in individuals who developed neutralizing antibodies targeting different epitopes in HIV-1 subtype C infection

scientific article published on 25 March 2020

Epitope mapping of broadly neutralizing HIV-2 human monoclonal antibodies

scientific article published on 29 August 2012

Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1

scientific article published on 04 June 2018

Focused Evolution of HIV-1 Neutralizing Antibodies Revealed by Structures and Deep Sequencing

scientific article

Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody

scientific article

Germline VRC01 antibody recognition of a modified clade C HIV-1 envelope trimer and a glycosylated HIV-1 gp120 core

article

Heavy Chain-Only IgG2b Llama Antibody Effects Near-Pan HIV-1 Neutralization by Recognizing a CD4-Induced Epitope That Includes Elements of Coreceptor- and CD4-Binding Sites

scientific article

High-Throughput Mapping of B Cell Receptor Sequences to Antigen Specificity

scientific article published on 28 November 2019

Human antibodies neutralize enterovirus D68 and protect against infection and paralytic disease

scientific article published on 01 July 2020

Hyperglycosylated resurfaced stabilized GP120 core as an immunogen elicits antibodies targeted at the CD4-binding site

Identification of a CD4-Binding-Site Antibody to HIV that Evolved Near-Pan Neutralization Breadth.

scientific article published on November 2016

Immunoglobulin gene insertions and deletions in the affinity maturation of HIV-1 broadly reactive neutralizing antibodies

scientific article

Improved Pruning algorithms and Divide-and-Conquer strategies for Dead-End Elimination, with application to protein design

scientific article published in July 2006

Increased HIV-1 vaccine efficacy against viruses with genetic signatures in Env V2

scientific article

Induction of HIV Neutralizing Antibody Lineages in Mice with Diverse Precursor Repertoires

scientific article published on September 2016

Isolation of Monoclonal Antibodies from a SHIV-AD8 Infected Rhesus Macaque with Broad Neutralizing Activity.

scientific article published in October 2014

Iterative structure-based improvement of a fusion-glycoprotein vaccine against RSV.

scientific article published on August 2016

Kernel-based logistic regression model for protein sequence without vectorialization

scientific article published on 22 December 2014

Longitudinal Analysis Reveals Early Development of Three MPER-Directed Neutralizing Antibody Lineages from an HIV-1-Infected Individual

scientific article published on 12 March 2019

Longitudinal Antibody Responses in People Who Inject Drugs Infected With Similar Human Immunodeficiency Virus Strains

scientific article published on 01 February 2020

Mammalian production of an isotopically enriched outer domain of the HIV-1 gp120 glycoprotein for NMR spectroscopy.

scientific article

Mapping Polyclonal HIV-1 Antibody Responses via Next-Generation Neutralization Fingerprinting

scientific article

Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody

scientific article

Maturation and Diversity of the VRC01-Antibody Lineage over 15 Years of Chronic HIV-1 Infection

scientific article

Mimicry of an HIV broadly neutralizing antibody epitope with a synthetic glycopeptide.

scientific article published on March 2017

Mosaic nanoparticle display of diverse influenza virus hemagglutinins elicits broad B cell responses

scientific article published on 11 February 2019

Multi-Donor Longitudinal Antibody Repertoire Sequencing Reveals the Existence of Public Antibody Clonotypes in HIV-1 Infection.

scientific article published on 31 May 2018

Multidonor Analysis Reveals Structural Elements, Genetic Determinants, and Maturation Pathway for HIV-1 Neutralization by VRC01-Class Antibodies

scientific article

Multiple Antibody Lineages in One Donor Target the Glycan-V3 Supersite of the HIV-1 Envelope Glycoprotein and Display a Preference for Quaternary Binding

scientific article published on 21 September 2016

NEP: web server for epitope prediction based on antibody neutralization of viral strains with diverse sequences

scientific article

NFPws: a web server for delineating broadly neutralizing antibody specificities from serum HIV-1 neutralization data

scientific article published on 01 September 2019

OSPREY Predicts Resistance Mutations Using Positive and Negative Computational Protein Design

scientific article published on January 2017

OSPREY: protein design with ensembles, flexibility, and provable algorithms

scientific article

Optimization of a Clade A Env Outer Domain for Enhanced Binding to Germlines of Diverse VRC01 Class Antibodies

Optimization of the Solubility of HIV-1-Neutralizing Antibody 10E8 through Somatic Variation and Structure-Based Design

scientific article

Partial germline reversions can increase VRC07 potency and breadth.

scientific article published on 13 September 2012

Potent Zika and dengue cross-neutralizing antibodies induced by Zika vaccination in a dengue-experienced donor

scientific article published on 03 February 2020

Potent and broad HIV-neutralizing antibodies in memory B cells and plasma

scientific article published on January 2017

Predicting resistance mutations using protein design algorithms

scientific article

Prediction of VRC01 neutralization sensitivity by HIV-1 gp160 sequence features

article

Prefusion F-specific antibodies determine the magnitude of RSV neutralizing activity in human sera

scientific article

Protein design algorithms predict viable resistance to an experimental antifolate

scientific article

Quantification of the Impact of the HIV-1-Glycan Shield on Antibody Elicitation

scientific article published on April 2017

RV144 HIV-1 vaccination impacts post-infection antibody responses

scientific article published on 08 December 2020

Redesigning the PheA domain of gramicidin synthetase leads to a new understanding of the enzyme's mechanism and selectivity

scientific article published on 19 December 2006

Residue-level prediction of HIV-1 antibody epitopes based on neutralization of diverse viral strains

scientific article published on 10 July 2013

Single-Chain Soluble BG505.SOSIP gp140 Trimers as Structural and Antigenic Mimics of Mature Closed HIV-1 Env.

scientific article published on 4 March 2015

Soluble Prefusion Closed DS-SOSIP.664-Env Trimers of Diverse HIV-1 Strains

scientific article published in December 2017

Somatic Mutations of the Immunoglobulin Framework Are Generally Required for Broad and Potent HIV-1 Neutralization

scientific article

Spontaneous Glycan Reattachment Following N-Glycanase Treatment of Influenza and HIV Vaccine Antigens

scientific article published on 24 January 2020

Structural Basis for Broad Detection of Genogroup II Noroviruses by a Monoclonal Antibody That Binds to a Site Occluded in the Viral Particle

scientific article

Structural Basis for Broad and Potent Neutralization of HIV-1 by Antibody VRC01

scientific article

Structural Basis for HIV-1 Neutralization by 2F5-Like Antibodies m66 and m66.6

scientific article

Structural Basis for Norovirus Inhibition and Fucose Mimicry by Citrate

scientific article

Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors

scientific article

Structural definition of a novel CD4-induced epitope that is targeted by a single-headed immunoglobulin to effect broad and potent HIV neutralization

scientific article published on 13 September 2012

Structure and immune recognition of trimeric pre-fusion HIV-1 Env.

scientific article

Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9

scientific article

Structure-Based Design of a Soluble Prefusion-Closed HIV-1 Env Trimer with Reduced CD4 Affinity and Improved Immunogenicity

scientific article published on 8 March 2017

Structure-based design of head-only fusion glycoprotein immunogens for respiratory syncytial virus

scientific article

Structure-guided modification and optimization of antibody VRC07.

scientific article published on 13 September 2012

Structures of HIV-1 Env V1V2 with broadly neutralizing antibodies reveal commonalities that enable vaccine design

scientific article

Surface-Matrix Screening Identifies Semi-specific Interactions that Improve Potency of a Near Pan-reactive HIV-1-Neutralizing Antibody

scientific article published in February 2018

Sustained Delivery of a Broadly Neutralizing Antibody in Nonhuman Primates Confers Long-Term Protection against Simian/Human Immunodeficiency Virus Infection

scientific article published on 18 March 2015

The Broad Neutralizing Antibody Responses after HIV-1 Superinfection Are Not Dominated by Antibodies Directed to Epitopes Common in Single Infection

scientific article published on 9 July 2015

The minimized dead-end elimination criterion and its application to protein redesign in a hybrid scoring and search algorithm for computing partition functions over molecular ensembles

scientific article

The role of local backrub motions in evolved and designed mutations

scientific article

Thermoresponsive Polymer Nanoparticles Co-deliver RSV F Trimers with a TLR-7/8 Adjuvant.

scientific article

Transforming epitope-specific gp120 monomer-based probes into immunogens with N-linked glycan masking

scientific article published on 13 September 2012

Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B, and G

scientific article

Two-Component Ferritin Nanoparticles for Multimerization of Diverse Trimeric Antigens.

scientific article published on 16 February 2018

Uncleaved Soluble gp140 Constructs with Retained Native-like Trimer Conformation and Antigenicity.

scientific article published in October 2014

Vaccine Induction of Heterologous Tier 2 HIV-1 Neutralizing Antibodies in Animal Models

scientific article published in December 2017

Vaccine-Elicited Tier 2 HIV-1 Neutralizing Antibodies Bind to Quaternary Epitopes Involving Glycan-Deficient Patches Proximal to the CD4 Binding Site

scientific article

Vaccine-Induced Antibodies that Neutralize Group 1 and Group 2 Influenza A Viruses

scientific article

Virus-like Particles Identify an HIV V1V2 Apex-Binding Neutralizing Antibody that Lacks a Protruding Loop

scientific article published on May 2017

Paulina is supported by:

About Paulina

Help