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List of works by Giovanna Scapin

4-aminophenylalanine and 4-aminocyclohexylalanine derivatives as potent, selective, and orally bioavailable inhibitors of dipeptidyl peptidase IV

scientific article

4-arylcyclohexylalanine analogs as potent, selective, and orally active inhibitors of dipeptidyl peptidase IV

scientific article

Aminopiperidine-fused imidazoles as dipeptidyl peptidase-IV inhibitors

scientific article

Design and synthesis of potent, orally bioavailable dihydroquinazolinone inhibitors of p38 MAP kinase

scientific article

Design, synthesis, and biological evaluation of triazolopiperazine-based beta-amino amides as potent, orally active dipeptidyl peptidase IV (DPP-4) inhibitors

scientific article

Discovery of MK-7655, a β-lactamase inhibitor for combination with Primaxin®

scientific article

Discovery of new binding elements in DPP-4 inhibition and their applications in novel DPP-4 inhibitor design

scientific article

Fluoroolefins as amide bond mimics in dipeptidyl peptidase IV inhibitors

scientific article

Functional characterization and crystal structure of the C215D mutant of protein-tyrosine phosphatase-1B

scientific article (publication date: August 2003)

Lattice stabilization and enhanced diffraction in human p38 alpha crystals by protein engineering

scientific article

Omarigliptin (MK-3102): a novel long-acting DPP-4 inhibitor for once-weekly treatment of type 2 diabetes

scientific article

Rational design of a novel, potent, and orally bioavailable cyclohexylamine DPP-4 inhibitor by application of molecular modeling and X-ray crystallography of sitagliptin

scientific article

Scaffold-hopping from xanthines to tricyclic guanines: A case study of dipeptidyl peptidase 4 (DPP4) inhibitors

scientific article

Side chain SAR of bicyclic β-lactamase inhibitors (BLIs). 2. N-Alkylated and open chain analogs of MK-8712

scientific article published on May 27, 2011

Structural basis for p38alpha MAP kinase quinazolinone and pyridol-pyrimidine inhibitor specificity

scientific article

Structural biology and drug discovery

scientific article (publication date: 2006)

Structure of full-length human anti-PD1 therapeutic IgG4 antibody pembrolizumab

scientific article

The Structural Basis for the Selectivity of Benzotriazole Inhibitors of PTP1B

scientific article published on October 7, 2003

The discovery of novel 5,6,5- and 5,5,6-tricyclic pyrrolidines as potent and selective DPP-4 inhibitors

scientific article

The structure of JNK3 in complex with small molecule inhibitors: structural basis for potency and selectivity

scientific article

The structure of PTP-1B in complex with a peptide inhibitor reveals an alternative binding mode for bisphosphonates

scientific article

The three-dimensional structure of MAP kinase p38beta: different features of the ATP-binding site in p38beta compared with p38alpha

scientific article

The three-dimensional structures of the Mycobacterium tuberculosis dihydrodipicolinate reductase-NADH-2,6-PDC and -NADPH-2,6-PDC complexes. Structural and mutagenic analysis of relaxed nucleotide specificity

scientific article